DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyt-b5-r and fads2

DIOPT Version :9

Sequence 1:	NP_001260514.1	Gene:	Cyt-b5-r / 35008	FlyBaseID:	FBgn0000406	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_571720.2	Gene:	fads2 / 140615	ZFINID:	ZDB-GENE-011212-1	Length:	444	Species:	Danio rerio

Alignment Length:	420	Identity:	83/420 - (19%)
Similarity:	158/420 - (37%)	Gaps:	108/420 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TTHSWQKGKRQDDGAEGLWRINDGIYDFTSFIDKHPGGPFWIRETKGTDITEAFEAHHLTTAPEK 89
            ::::|::.::.....:....:...:|:.:.::.:||||...:....|.|.||||.|.|    |..
Zfish    19 SSYTWEEMQKHTKHGDQWVVVERKVYNVSQWVKRHPGGLRILGHYAGEDATEAFTAFH----PNL 79

  Fly    90 MIAKYKVR-------DAAEP---RIYTLTLEEGGFYKTLKERVREQ--LKTIDKRPKKKSDLIHL 142
            .:.:..::       :|:||   |.....|.|.  ::.|:||:..:  .||     :.....:||
Zfish    80 QLMRKYLKPLLIGELEASEPSQDRQKNAALVED--FRALRERLEAEGCFKT-----QPLFFALHL 137

  Fly   143 GLVVSLYLLGIASAKY------NSLLALVLASVALCWTVIVSHNYFH------RRDNWQMYAFNL 195
            |.::.|..:......|      |:|:..|:.:.|......:.|::.|      ...|..::.|.:
Zfish   138 GHILLLEAIAFVMVWYFGTGWINTLIVAVILATAQSQAGWLQHDFGHLSVFKTSGMNHLVHKFVI 202

  Fly   196 GMMNFAA---WRVSHALSHHIYPNSY-FDLELSMFEPLLCWVPNPHIKSKLMRYVSWVTEPVAYA 256
            |.:..|:   |...| ..||..||.: .|.:::|                |..:|....:||.|.
Zfish   203 GHLKGASAGWWNHRH-FQHHAKPNIFKKDPDVNM----------------LNAFVVGNVQPVEYG 250

  Fly   257 LAFFIQMGTRIFYSLRHTNILYWHDLL-----PLTIPIAIYLGTGGSL---GIWI----C----V 305
            :.           .::|....:.|...     ||.||:........::   |:|:    |    |
Zfish   251 VK-----------KIKHLPYNHQHKYFFFIGPPLLIPVYFQFQIFHNMISHGMWVDLLWCISYYV 304

  Fly   306 RQWLAMTSIASFSFCLIGLN---------------AAHHDPEIYHEGDANREDRDWGLFQVDTII 355
            |.:|..|......:.:|..|               .:.....|.:|     :::||...|   ::
Zfish   305 RYFLCYTQFYGVFWAIILFNFVRFMESHWFVWVTQMSRIPMNIDYE-----QNQDWLSMQ---LV 361

  Fly   356 DRGDLKWSQF--LVLTHFGDHVLHHLFPTL 383
            ...:::.|.|  ....|....:.||||||:
Zfish   362 ATCNIEQSAFNDWFSGHLNFQIEHHLFPTM 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyt-b5-r	NP_001260514.1	Cyt-b5	26..98	CDD:278597	15/78 (19%)
		FA_desaturase	161..408	CDD:278890	51/266 (19%)
		Membrane-FADS-like	<328..385	CDD:294412	14/58 (24%)
fads2	NP_571720.2	PLN03199	21..439	CDD:178740	83/418 (20%)
		Cyt-b5	21..94	CDD:278597	15/76 (20%)
		Delta6-FADS-like	162..412	CDD:239583	51/266 (19%)
		Histidine box-1	180..184		1/3 (33%)
		Histidine box-2	217..221		1/4 (25%)
		Histidine box-3	382..386		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820