DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and DLG5

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	1062	Identity:	218/1062 - (20%)
Similarity:	390/1062 - (36%)	Gaps:	323/1062 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1068 LERNKKEL----EQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEE---VEAER 1125
            :|..::||    :|::.:...|:.::...||....:....:||          |:||   .:||.
Human     1 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQ----------LDEEAGGAKAEL 55

  Fly  1126 QARAKAEKQR---ADLARELEELGERL---------------EEAGGATSAQI------------ 1160
            ..:....|:|   .||...||:....|               .|..|:|.:.:
Human    56 LLKLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS 120

  Fly  1161 --------------------ELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQ 1205
                                ::|:|.|....:||....|.|        .|||:...|....|..
Human   121 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERN--------ELRKRLAFATHGTAFD 177

  Fly  1206 VDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQ--LQHTLNEVQSKLDETNRT 1268
            ....::|....|:.|.:....::||::..:..||.....|::||:  ..|||:  ...|.:..|.
Human   178 KRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLH--SRLLSDQTRL 240

  Fly  1269 LNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRE----RA--- 1326
            .:|.|..::    ||..|||:              :..|....||.|||.:|:.:|    ||
Human   241 KDDVDMLRR----ENGQLLRE--------------RNLLQQSWEDMKRLHEEDQKEIGDLRAQQQ 287

  Fly  1327 -----------------TLLGKFRNLEHDLDNLREQVEEE-AEGKADLQR--QLSKANAEAQVWR 1371
                             |.:.|...::.|.|.||::..|: |...|||.|  ||.:.|...
Human   288 QVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRL---- 348

  Fly  1372 SKYESDGVARSEELEEAKR---KLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDR 1433
                   :.::|.|.:.:.   :||.:.|.:....|:::.:........:.|..|:|.||.|:..
Human   349 -------LKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTE 406

  Fly  1434 ANA----IANAAEKKQKAFDKIIGEWKL---KVDDLAAELDASQKECRNYSTELFRLKGAYEEGQ 1491
            ...    .|..:||.::..|.:..|:||   :.|.:.:|||..|.|.....::|.......:...
Human   407 LRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAAN 471

  Fly  1492 EQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAA------L 1550
            |::||:|        ::||.:..  :.||...|:|..||:.:|...||:.||:||:.|      .
Human   472 EEMEALR--------QIKDTVTM--DAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWA 526

  Fly  1551 EQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKK 1615
            .||.:|::   .|...:|...|           |.|:...||:..:           |||||
Human   527 FQERDKIV---AERDSIRTLCD-----------NLRRERDRAVSEL-----------AEALR--- 563

  Fly  1616 KLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANAL 1680
                       :||...|...:..:.:|..::|:   ::.||:|.|.|     ||.......:|:
Human   564 -----------SLDDTRKQKNDVSRELKELKEQM---ESQLEKEARFR-----QLMAHSSHDSAI 609

  Fly  1681 QNELEESRTLLEQADRGRRQAEQELA--DAHEQLNE-----------VSAQNASISAAKRKLESE 1732
            ..:..|..|.:.:.:|.....:.:..  |..|.:||           ......||:..:.::...
Human   610 DTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDW 674

  Fly  1733 LQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQI-------- 1789
            |..: :|:| |:|:.|   ::|.||:::.          :.......:.||:|..::
Human   675 LLRI-NDVD-LINKDK---KQAIKALLNG----------EGAINMVVRRRKSLGGKVVTPLHINL 724

  Fly  1790 ---KELQVRLDE-------------AEANALKGG------------KKAIQKLEQRVRELENEL- 1825
               |:..:.|:.             |:..:|..|            .|::.:.|..:|..::.|
Human   725 SGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLT 789

  Fly  1826 -------------DGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLV---DKLQQKI 1874
                         .|:     :..:|::.|:   |.|||::..........::|:   :..|..|
Human   790 LSLLKVFPQSSSWSGQ-----NIFENIKDSD---KMLSFRAHGPEVQAHNKRNLIQHNNSTQTDI 846

  Fly  1875 KTYKRQIEEAEEI-----AALNLAK------FRKAQQELEEAEERADLAEQAISKFRAKGRAGSV 1928
             .|..::|:.:|.     ::..|.|      .:...|....|.||      ::|.||:.. :|..
Human   847 -FYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASER------SLSSFRSDA-SGDR 903

  Fly  1929 G------RGASP-APRATSVRP 1943
            |      ||..| .|..|.|.|
Human   904 GFGLVDVRGRRPLLPFETEVGP 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874
		Myosin_tail_1	842..1897	CDD:279860	202/1007 (20%)
		V_Alix_like	1557..1877	CDD:187408	65/385 (17%)
		ATP-synt_B	<1671..1771	CDD:304375	19/112 (17%)
		TMPIT	1739..>1825	CDD:285135	19/121 (16%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142		3/43 (7%)
		Takusan	130..212	CDD:282652	18/89 (20%)
		TPR_MLP1_2	231..353	CDD:285204	34/150 (23%)
		COG1340	295..587	CDD:224259	81/354 (23%)
		FliJ	310..449	CDD:304890	36/149 (24%)
		BAR	417..601	CDD:299863	60/240 (25%)
		PDZ_signaling	620..707	CDD:238492	16/101 (16%)
		DegQ	<702..771	CDD:223343	8/68 (12%)
		PDZ_signaling	722..790	CDD:238492	9/67 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306
		PDZ	1347..1429	CDD:214570
		dbPDZ_assoc	1427..1499	CDD:293216
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910