DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH13

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_003793.2	Gene:	MYH13 / 8735	HGNCID:	7571	Length:	1938	Species:	Homo sapiens

Alignment Length:	1922	Identity:	1053/1922 - (54%)
Similarity:	1417/1922 - (73%)	Gaps:	13/1922 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEK 76
            :..|||....::|...|::|:||||:|::.|.||.|:.|.|:..:.|.|.|......:..:.:::
Human    12 EAAPYLRKPEKERIEAQNRPFDSKKACFVADNKEMYVKGMIQTRENDKVIVKTLDDRMLTLNNDQ 76

  Fly    77 VEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            |..:|||||:||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||......
Human    77 VFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASK 203
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:   |..|
Human   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKK 206

  Fly   204 KTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLE 268
            |..:..|.:|:||||::|.||:|||||||||||||||||||||||||||.|||||.|||||||||
Human   207 KETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLE 271

  Fly   269 KARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQ 333
            |:||..|.|.||||||||||||...|.:.|:.|::.|.:|:..||||:||||||||:||...||.
Human   272 KSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDN 336

  Fly   334 AFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNL 398
            |.|||||:.:||..:|::|.||||.|.|||||:.||||||.||.|...:...|.|.::||:.|.|
Human   337 AIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGL 401

  Fly   399 LKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAG 463
            ..||:|||||:||:|:||||||||:|||.|.|::::|.|:|.:.|:.|||:|.||:|||||||||
Human   402 CCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAG 466

  Fly   464 FEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMG 528
            ||||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:|||||||
Human   467 FEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMG 531

  Fly   529 ILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGW 593
            |.||||||.|||||||.:|..||.:.|||||..||||||.| |:..|||::.||||.|.|||.||
Human   532 IFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAK-GKAEAHFSLVHYAGTVDYNIAGW 595

  Fly   594 LEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGG--GEQAKGGRGKKGGGFATVSSAYKEQL 656
            |:|||||||:|||..::||..|||..:|:::||...|  |...|||: |||..|.|||:.::|.|
Human   596 LDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGK-KKGSSFQTVSAVFRENL 659

  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721
            |.|||.||||.||||||:||||.|.|||:|.:||||||.||||||||||||||||:|::|.|||.
Human   660 NKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQ 724

  Fly   722 RYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKI 783
            ||:|:....:   |.:: .|.|:|.::..||:..:|:|.|||||||:||:||.:||.|||:|..:
Human   725 RYRILNASAIPEGQFID-SKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLEEMRDEKLVTL 788

  Fly   784 MSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEI 848
            |:..||..||||.|..|||:.|:|.::..:|.|:|.::.::.|||..|:.|:||||..:..|.|:
Human   789 MTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEM 853

  Fly   849 ARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKN 912
            |.::|..::. |||..:|.: |||||.....||.||..|...:..|...|.|.:||...|...|.
Human   854 ATMKEDFERTKEELARSEAR-RKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917

  Fly   913 DLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNL 977
            .||.:::::.|||.:||:..::|..:|:..:.:.|.||:||:||||.:.|.|::|...:::::||
Human   918 LLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNL 982

  Fly   978 NDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKK 1042
            ::|:...:|.|:||.||||...|.:|:|.::||..|||:|.|.|:.|||||..|:||.|||:|||
Human   983 SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKK 1047

  Fly  1043 VRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQI 1107
            :|.|:|::|||:|||||::||::.|||.:|:::|:.:::|:.|||.:.||::||||..|:.|::|
Human  1048 LRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKI 1112

  Fly  1108 KELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSK 1172
            |||||||||||||:|||...|||.||||:||||||||:.||||||.||||||||:|||||||..|
Human  1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177

  Fly  1173 LRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHI 1237
            :|||||||.:|||:|.|.||||..|:|||:.||:|.|.::|.|.||||:|...:::|:.:.::.:
Human  1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242

  Fly  1238 TNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSK 1302
            :..|:..|:..:.::...:|:::|.::..:.::|.:..|.:|..:|.:|..::||.||.:|||:|
Human  1243 SKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307

  Fly  1303 IKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEA 1367
            .|.:||.|||:.||..:||::.:..:....::..||.|.||||.|||.|.||:|||.|||||:|.
Human  1308 SKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372

  Fly  1368 QVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVD 1432
            ..||:|||:|.:.|:|||||||:||..||.||||..|:.|.||..||||||||..|||||..:::
Human  1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437

  Fly  1433 RANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAV 1497
            |::......:|||:.|||::.|||.|:|:..|||:|:|||.|:.|||||:::.||||..:|||.:
Human  1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502

  Fly  1498 RRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQL 1562
            |||||||.:|:.||.:||.|.|:|:.|.||.:|.:|.||.:||.||||.|.:||.||:|:||.||
Human  1503 RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567

  Fly  1563 ELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIA 1627
            |||||:.|:||::.||:||.|..::|.|||.:::|:.|:||.:.:.:|||:|||:|.|:||:||.
Human  1568 ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQ 1632

  Fly  1628 LDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLE 1692
            |.|:|:..||.||:::..|.||||.|..|::..|:.:|.:|||.|.|||...|..||||.:..||
Human  1633 LGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALE 1697

  Fly  1693 QADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKA 1757
            |.:|.||.:||||.||.:::..:.:||.|:...|:|||:::....::::..:.|::|:|||||||
Human  1698 QTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762

  Fly  1758 MVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELE 1822
            :.|||.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.||||||
Human  1763 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE 1827

  Fly  1823 NELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEI 1887
            ||||.||:|.|:|.|...|.||:|||:::|:|||.||..|:||||||||.|:|:||||.|||||.
Human  1828 NELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892

  Fly  1888 AALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            |...|::.|:.|.|||||.||||:||..::|.|||.|
Human  1893 ANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSR 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	11/36 (31%)
		MYSc	81..777	CDD:214580	455/703 (65%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	434/672 (65%)
		Myosin_tail_1	842..1897	CDD:279860	530/1055 (50%)
		V_Alix_like	1557..1877	CDD:187408	167/319 (52%)
		ATP-synt_B	<1671..1771	CDD:304375	43/99 (43%)
		TMPIT	1739..>1825	CDD:285135	51/85 (60%)
MYH13	NP_003793.2	Myosin_N	36..73	CDD:280832	11/36 (31%)
		Myosin_head	88..770	CDD:278492	442/684 (65%)
		MYSc_Myh13	100..770	CDD:276887	434/672 (65%)
		Actin-binding. /evidence=ECO:0000250	659..681		17/21 (81%)
		Actin-binding. /evidence=ECO:0000250	761..775		10/13 (77%)
		Myosin_tail_1	850..1927	CDD:279860	545/1077 (51%)
		RILP-like	<1273..1399	CDD:304877	61/125 (49%)
		TMPIT	1744..>1837	CDD:285135	56/92 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1917..1938		7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I20
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I44
Isobase	1	0.950	-	0	Normalized mean entropy	S1242
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41736
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.920