DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYO1

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_011888.1	Gene:	MYO1 / 856418	SGDID:	S000001065	Length:	1928	Species:	Saccharomyces cerevisiae

Alignment Length:	2124	Identity:	623/2124 - (29%)
Similarity:	1022/2124 - (48%)	Gaps:	445/2124 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KSC------WIPDEKEGYLLGEIKAT---KGDIVSVGLQGGEVRDIKSEKVEK-----------V 80
            :||      |||||||.::.||:.:|   |........|.|.|..:.|.:|..           |
Yeast     5 QSCSSNMIVWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPV 69

  Fly    81 NPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRG 145
            ||..|:|:|:|:::|.||.|.||:||.:||...|||||||||.||||||....:|:.....:|..
Yeast    70 NPSTFDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHN 134

  Fly   146 KR------------RNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT 198
            |.            ..::|||||||::.||.::|:...:||:|:||||||||||||||::.|.|:
Yeast   135 KHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLAS 199

  Fly   199 VGASKKTDEAAKSKGSL----EDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAG 259
            :.:...::.|..|..|:    |.:::|:||:||:||||:||||:|||||||||:|.|...|.:.|
Yeast   200 ITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMING 264

  Fly   260 ADIETYLLEKARVISQQSLERSYHIFYQIMSG-SVPGVKDICLLTDNIYDYHIVS-QGKVTVASI 322
            |.||.|||||:|::.|.|.||:||||||::|| ....:|::.|.:.|:.||.|:| ..:..:..|
Yeast   265 AHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGI 329

  Fly   323 DDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLF 387
            :|.|.|.....|.:|:||:|.:...::::.|.::.:|.::|.. .|.|||  ..:.:...:....
Yeast   330 NDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVS-DRAEQA--SFKNDVSAICSNL 391

  Fly   388 GCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKR 452
            |.|..:....:|:||.|.|.|:|:|.:|.||....:.||.:.:::|||.::|...|:.||.....
Yeast   392 GVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSAT 456

  Fly   453 QHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLL 517
            .::||:||||||||||.|.|||||||:||||||||||:|||||||.||.:|.|.|.:||:|.||.
Yeast   457 LNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQ 521

  Fly   518 ACIDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAI 579
            ..|||||.   |.|:|.:|:||::.||:||::|..||.:|....|:.|::.: .|.|     |.:
Yeast   522 LTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSR-LKNG-----FIL 580

  Fly   580 AHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGG------- 637
            .||||.|.|.:.|||.||||||||.::.....|||.::.::|     |..|.:.:..|
Yeast   581 KHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLF-----QPEGEKSSSAGVEANISN 640

  Fly   638 ----RGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNG 698
                :..:...|.|.||.::||..:|:..|.||.||||||||||.:|:....:..|::.||.|||
Yeast   641 QEVKKSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNG 705

  Fly   699 VLEGIRICRKGFPNRMMYPDFKMRYKIMCP----------KLLQGVEKDKKATEIIIKFIDLPED 753
            ||||||:.|:|:|||:.:.:|..||:|:.|          ||....   |:..|.::..:.|...
Yeast   706 VLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKAST---KQNCEFLLTSLQLDTK 767

  Fly   754 QYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRK----GFKKLQEQRVALKVVQ 814
            .|::||||:||:||||..:|:.:|.:|..||..:.|..|||..||    ..:||::.|    |:.
Yeast   768 VYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTR----VIG 828

  Fly   815 RNLRKYLQL-RTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAK 878
            ...|.|.:| :..||:.|:.::||||..|   :::.|.:   |..|:::    |::.:|:.:.:|
Yeast   829 NTFRLYNRLVKEDPWFNLFIRIKPLLTSS---NDMTRTK---KFNEQIN----KLKNDLQEMESK 883

  Fly   879 LLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEED--ARNQLFQQKKK 941
                |..|              :|:|.|..   |:|||    .|:.|.||::  .:|:....:.|
Yeast   884 ----KKFL--------------EEKNQKTV---NELEN----TQDLLNQEKENLRKNESLLNRVK 923

  Fly   942 ADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTG 1006
            ...|.  |:|..:||     .:|:|:.:::......|.|.|||           |:||  .|:|.
Yeast   924 TSSET--LQKQFDDL-----VSEKDEISREKLEVAQNLEEAHQ-----------KIQG--LQETI 968

  Fly  1007 EELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERN 1071
            .|.:|..:|::..|.   :|.:.:.:|...:.:|:..:..:::||.|:|.::
Yeast   969 REREATLEKLHSKNN---ELIKQISDLNCDISKEQSSQSLIKESKLKLENEI------------- 1017

  Fly  1072 KKELEQTIQRKDKELSSITAKL----EDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAE 1132
             |.|:..|..|::|:.|...||    ||..:.::..::......:|::.|..|....|......:
Yeast  1018 -KRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFK 1081

  Fly  1133 KQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHND 1197
            |::|.|..:|                     |.:|:||.|::..::    .|:..||...|:.:|
Yeast  1082 KEKAALNNQL---------------------KNKESELLKMKEKID----NHKKELATFSKQRDD 1121

  Fly  1198 AV-------AEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTL 1255
            ||       ||:.|...||.:.|:..:|.|.||           .:...|...||
Yeast  1122 AVSEHGKITAELKETRIQLTEYKSNYQKIKEEY-----------SNFQRETKEQE---------- 1165

  Fly  1256 NEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ-------LSKIKI---SLTTQ 1310
               |.|.:....:|||                .:::|.|:::||       |:| :|   |:.|.
Yeast  1166 ---QKKRNSLVESLND----------------SKIKELEARLSQEISLNQYLNK-RISGNSVETN 1210

  Fly  1311 LEDTKRLA--DEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSK 1373
            :..|:|..  .::..::..::.|:.:|:.....:...:|.|.|.|.:|..:|  ...|.::..|.
Yeast  1211 ISSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRL--RFTETRLASSS 1273

  Fly  1374 YESDGVARSEELEEAKRKLQARLAEAEETI---ESLNQ---KCIGLEKTKQRLSTEVEDLQLEVD 1432
            :|      .::::...:||:..:.:.:.:|   ..||:   .|...|....:|..||:.|:.::|
Yeast  1274 FE------DQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKLMLEVDYLKRQLD 1332

  Fly  1433 ---RANAIA-NAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQ 1493
               ||:..| ||.......|.||.||..|.                  |:::::||  :|..:|:
Yeast  1333 IETRAHYDAENAISALHSKFRKIQGESSLS------------------SSDIYKLK--FEASEER 1377

  Fly  1494 LEAVRRENKNLADEVK--DLLDQ----IGEGGRNIHEIEKARKRL---EAEKDELQAALEEAEAA 1549
            :       |:|.|::|  .|.|:    :|:..:|...|.|..:.:   :.|..:||..|.|:...
Yeast  1378 V-------KSLEDKLKTMPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGK 1435

  Fly  1550 LEQ----------------EENKVLRAQLELSQVRQE-IDRRIQEKEEEFEN----TRKNHQRAL 1593
            |.|                |:...|:..||.::.::| :...|::::::|||    .:.|..|..
Yeast  1436 LSQLTLDLRQSKSKEALLSEQLDRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQGNELRLR 1500

  Fly  1594 DSMQASLEAE--AKGKAEAL-------RMKKKLEADINELEIALDHANKANAEAQKNIKRYQQ-- 1647
            :.:.|..:||  .|..|..:       :.|:||   |.|.|:..:.::....|....:||.|.
Yeast  1501 EHIHALKQAEEDVKNMASIIEKLKTQNKQKEKL---IWEREMERNDSDMQLQETLLELKRVQDVK 1562

  Fly  1648 --------QLKDIQTALEEEQRARDD---AREQLGISERRANALQNE-------LEESRT----- 1689
                    .||:..:|:|:..:..|:   .:|:|..|.:....|:.|       ||.|..
Yeast  1563 KILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAK 1627

  Fly  1690 ---LLEQADRGRR-------------QAEQELADAHEQLN----EVSAQNASISAAKRKLESELQ 1734
               ||:|.|...:             .||:||...:|.||    .:..:..|::..|::|||:|.
Yeast  1628 ISDLLKQLDHYTKVVEMLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLN 1692

  Fly  1735 TLHSDLDELLNEAKNSEEKAKKAMVDAARLADE---LRAEQ------------------------ 1772
            . .:|..::.|.|.:|..:..|.:.:..:..:|   |:.||
Yeast  1693 Q-KTDALQISNAALSSSTQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDD 1756

  Fly  1773 ---------DHAQTQEKLRKALEQQIKELQVRL-DEAEANALKGGKKAIQKLEQRVRELENELDG 1827
                     :..||.:||...|:.|:|.|..|| |..|.||..          .::.||||.:..
Yeast  1757 EKQKNIDLYEENQTLQKLNTDLQLQLKNLHERLSDTTEKNAWL----------SKIHELENMVSL 1811

  Fly  1828 EQRRHADAQKNLRKSERRVKELSFQSEED-------RKNHERMQDLVDKLQQKIKTYKRQIEEAE 1885
            |.....:..|..:..||.|:||..::.:.       .||....::...|       |:.||.:.|
Yeast  1812 ETDLKYEEMKKNKSLERAVEELQTKNSQQTDVIELANKNRSEFEEATLK-------YEAQISDLE 1869

  Fly  1886 EIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVG 1929
            :..:....:.:|:.::.....::.....|.|..::::..:..:|
Yeast  1870 KYISQQELEMKKSIRDNSSYRDKVQEMAQEIEFWKSRYESTMIG 1913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	16/45 (36%)
		MYSc	81..777	CDD:214580	314/737 (43%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	299/706 (42%)
		Myosin_tail_1	842..1897	CDD:279860	262/1217 (22%)
		V_Alix_like	1557..1877	CDD:187408	92/422 (22%)
		ATP-synt_B	<1671..1771	CDD:304375	30/134 (22%)
		TMPIT	1739..>1825	CDD:285135	27/122 (22%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	577/1882 (31%)
MYO1	NP_011888.1	Smc	1534..>1890	CDD:224117	79/373 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341986
Domainoid	1	1.000	582	1.000	Domainoid score	I31
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68044
Inparanoid	1	1.050	777	1.000	Inparanoid score	I64
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm46873
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
TreeFam	1	0.960	-	-
	13	12.750