Protein Alignment Mhc and YPR089W

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_015414.2
• Gene: YPR089W / 856204
• SGDID: S000006293
• Length: 888
• Species: Saccharomyces cerevisiae
• Alignment Length: 1003
• Identity: 186/1003 - (18%)
• Similarity: 343/1003 - (34%)
• Gaps: 285/1003 - (28%)

  Fly  1091 AKLEDEQV---VVLKH-QRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEE 1151
            |::||..|   |...| |.::..:::.:.:|::|...|..:..:..|...|
Yeast     8 ARIEDRTVDKPVGSSHAQEKLALVKSTLFKLDQEDRPECDSWVQLVKLICD-------------- 58

  Fly  1152 AGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKA 1216
                        :.||.|.:..:..|.|....::.::..:...|...|.:.|:.::.|:...:.|
Yeast    59 ------------EDREEEFTTFKELLREVKNVNDKSVTGVALIHYIIVFDRADYIELLHDNPSGA 111

  Fly  1217 EKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLN--------DFD 1273
            :.:.|.           ||.|..........:.|.::...|:.:..||.|..:.        |..
Yeast   112 KLDLNL-----------VDDIVGYTPLMWSFSLQRRNCCLELFNAFDEINFNMTNKAGLTAWDMV 165

  Fly  1274 ASKKKLS--IENSDLLRQLEEAESQVSQLSKIK-ISLTTQLED--TKRLADEESRERATLL---G 1330
            .....||  :|.:::.|...|.:.::.|:|:.| .||....||  ||...|....:.|.|.   |
Yeast   166 PPYSPLSEFLEQNNMFRYRTEVKHEIPQISQPKDTSLLMSNEDSTTKETFDNIDLQVAGLTLSPG 230

  Fly  1331 KFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQAR 1395
            ...|:..|.|   |:....::|.|.|   :.....|.  :...::.|.::..:.||.:...:...
Yeast   231 ANDNMFLDSD---EKNMNHSQGAATL---IDPTYTED--YHGTFDYDKLSPDQYLEFSDFDIPQI 287

  Fly  1396 LAEAEETIESLNQK--------------CIGLEKTKQRLSTEVEDL-QLEVDR------ANAIAN 1439
            |    ..:.||.||              ||.....|.:....||.| .|.:.:      :|..|.
Yeast   288 L----NLLISLPQKEPHMTTYPAGLIYQCIRYADHKIKSKPLVESLINLSLTKILTSVSSNGAAG 348

  Fly  1440 --AAEKKQKAFDKII-GEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRREN 1501
              :.|...:|.|.:: ..|...:..|...|      ||:.|  .|:...:..  ||.:..:....
Yeast   349 LVSTEASLQAGDIVLQSYWLSCLSFLYYYL------CRDDS--FFKRHPSVL--QELINTIHSII 403

  Fly  1502 KNLADEVK----DLLDQIGEGGRNIHEIEKA---------RKRLEAEKDELQAALEEAEAALEQE 1553
            ..|...:.    .|:|........|.::::.         :||            ::|:..|:::
Yeast   404 IELTSSIHCRLISLIDSTLLAYTTIQDVKQTLYKRDWNFFKKR------------KQAKLLLKEK 456

  Fly  1554 ENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLE 1618
            ..|.|:     .|.::|:.|:.|.:|        ||:.. :..|...:::.:....
Yeast   457 NRKQLK-----EQQKKELHRKSQGQE--------NHEEE-EGQQDGNDSDDRASTN--------- 498

  Fly  1619 ADINELEIALDHANKANAEAQKNIKR------YQQQLKD-----------IQTALEEEQRARDDA 1666
             |.|...::|.:        .|.|.|      :::|:|.           :...|...|......
Yeast   499 -DDNNSSVSLFY--------DKEILRHLYPPSFEEQMKPSPLKIVQIFGALSYVLNLHQTHPIFQ 554

  Fly  1667 REQLGISER-RANALQNELEESRTLLEQADRGRRQAEQELADAHE---QLN----EVSAQNASIS 1723
            ::.|.||.. .|..|.|::.:        |:.:|    .|:.||.   :||    |...||....
Yeast   555 QQCLSISVNWFATTLFNKILK--------DKKKR----SLSRAHAIQIRLNLSTLESWIQNNDFC 607

  Fly  1724 AAKRKLESEL------QTLHSDLDE-------LLNEA--KNSEEKAKKAMVDAA----------- 1762
            ..|..|..:.      .||..|:.|       |.|.|  |..:|..|..:.|.:
Yeast   608 VPKPMLIDDFMWQRFPMTLIRDVGEIDLSDPILRNVATYKPIDENNKDLIYDTSNSLFYYQPFHK 672

  Fly  1763 ----------------RLADELRAEQDHAQTQEKLRK----ALEQQIKELQVRLDEAEANALKGG 1807
                            ::|..|.:|:....|...|.:    .|.:.:::....|:|.:.|:
Yeast   673 IAQIHLEPVFQLLQWLQVATTLDSEESLISTMNLLPRITPVQLLKSMEKYNYELNENKFNS---- 733

  Fly  1808 KKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSE------RRVKELSFQSEEDRKNHERMQDL 1866
                 ||:   :.|.|::...:...|||.  |::.|      ..:.|::....:...:|.....|
Yeast   734 -----KLK---KFLNNKIKDSKMSKADAY--LQEHEIPYLVLPTIPEMTDLYSKGPDSHSFQPFL 788

  Fly  1867 VDKLQQKIKTYK------RQIEEAEEIAALN--LAKFR----KAQQELEEAEERADLAEQAISKF 1919
            ...:|..:  |:      :|.:...:|:..|  .:.|.    |||.|.|...|..|:.|..
Yeast   789 PGSIQDDV--YEIHDVNFKQRQNEPQISRTNSGTSDFTGDEDKAQYETEGVGESIDINETV---- 847

  Fly  1920 RAKGRAGSVGRG----ASPAPRATSVRP 1943
            ..:..|.:||..    ....|.:|:.||
Yeast   848 EPESNAFNVGNDDYFKELNIPSSTAQRP 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874
		Myosin_tail_1	842..1922	CDD:460256	179/976 (18%)
YPR089W	NP_015414.2	Ank_2	67..152	CDD:463710	16/95 (17%)
		Myo5p-like_CBD_DIL_ANK	275..776	CDD:271257	104/584 (18%)