Protein Alignment Mhc and MYO2

DIOPT Version :9

• Sequence 1: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_014971.1
• Gene: MYO2 / 854504
• SGDID: S000005853
• Length: 1574
• Species: Saccharomyces cerevisiae
• Alignment Length: 1579
• Identity: 454/1579 - (28%)
• Similarity: 723/1579 - (45%)
• Gaps: 352/1579 - (22%)

  Fly    38 CWIPDEKEGYLLGEI--------------KATKGDIVSVGLQGGEVRDIKSEKVEKV----NPPK 84
            ||.|.::.|::..|:              :....:||||     :.:|:.::|.:.:    |||.
Yeast     9 CWYPHKELGWIGAEVIKNEFNDGKYHLELQLEDDEIVSV-----DTKDLNNDKDQSLPLLRNPPI 68

  Fly    85 FEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRY-PVYTNRCAKMYRGKRR 148
            .|..||:..::.||.|.|||.::|||....||||||:..:|.||:.|. .:||....:.|.||||
Yeast    69 LEATEDLTSLSYLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRR 133

  Fly   149 NEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-GASKKTDEAAKSK 212
            .|:.||:|||::.||..|..:..||:::::||||||||.:.|.::.|||:| ..:..|.:.....
Yeast   134 GELEPHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEM 198

  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277
            ...|.:::.|||::||||||||.||||||||||::.|.|.....:.||.|.|||||::|::.|..
Yeast   199 SETEQKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPP 263

  Fly   278 LERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVT-VASIDDAEEFSLTDQAFDILGFT 341
            :||:||||||:|:|.....|:...||| ..||..::||..| :..||||:|:.:|..|..::|.|
Yeast   264 IERNYHIFYQLMAGLPAQTKEELHLTD-ASDYFYMNQGGDTKINGIDDAKEYKITVDALTLVGIT 327

  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVG 406
            |:.:..:::|.||::|:|.::.|:...:.....| |.......:|.|.|.....|.:.|.:|...
Yeast   328 KETQHQIFKILAALLHIGNIEIKKTRNDASLSAD-EPNLKLACELLGIDAYNFAKWVTKKQIITR 391

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKK-----CNETLDTQQKRQHFIGVLDIAGFEI 466
            :|.:....|..|...:..::.|.::..||.|||:.     ||..::.|  ...|||||||.|||.
Yeast   392 SEKIVSNLNYSQALVAKDSVAKFIYSALFDWLVENINTVLCNPAVNDQ--ISSFIGVLDIYGFEH 454

  Fly   467 FEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILS 531
            ||.|.|||.|||:.||||||.||.|:|.||||||.:|.|:|:||:|. |...||||||..:||||
Yeast   455 FEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFN-DNQPCIDLIENKLGILS 518

  Fly   532 ILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEK 596
            :|:|||..|..:|:::::||..| |.||...:....|:.||  ..|.::|||..|:|::.|::||
Yeast   519 LLDEESRLPAGSDESWTQKLYQT-LDKSPTNKVFSKPRFGQ--TKFIVSHYALDVAYDVEGFIEK 580

  Fly   597 NKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK-----GGRGKKGGGFATVS------S 650
            |:|.::|..::..|.|.|:.||.|.......:...|:||     ....||.|...||:      |
Yeast   581 NRDTVSDGHLEVLKASTNETLINILEGLEKAAKKLEEAKKLELEQAGSKKPGPIRTVNRKPTLGS 645

  Fly   651 AYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMM 715
            .:|:.|..||.|:.||..|::|||.||..|:....|..:|:.||...||||.|||...|||:|..
Yeast   646 MFKQSLIELMNTINSTNVHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWT 710

  Fly   716 YPDFKMRYKIMCP-KLLQGVEKDKKATE-----IIIKFIDL---PEDQYRLGNTKVFFRAGVLGQ 771
            :.:|.:||.|:.| :....:.|.|:.||     ::...:|.   .:.:|::||||:||:||:|..
Yeast   711 FEEFVLRYYILIPHEQWDLIFKKKETTEEDIISVVKMILDATVKDKSKYQIGNTKIFFKAGMLAY 775

  Fly   772 MEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVK 836
            :|:.|..::...:..:|...|....||.:.::.:   |:|.:|.|::.:: :|
Yeast   776 LEKLRSNKMHNSIVMIQKKIRAKYYRKQYLQISQ---AIKYLQNNIKGFI-IR------------ 824

  Fly   837 PLLNVSRIEDEI----ARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGAL 897
                 .|:.||:    |.|.:.|.:...:.|....|.:.:..|..|:..|.         ::..|
Yeast   825 -----QRVNDEMKVNCATLLQAAYRGHSIRANVFSVLRTITNLQKKIRKEL---------KQRQL 875

  Fly   898 QDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQK 962
            :...|.||.:|     :::::|..:.|         ..|.:.||
Yeast   876 KQEHEYNAAVT-----IQSKVRTFEPR---------SRFLRTKK--------------------- 905

  Fly   963 AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLE 1027
                            |.:..| .||.:...::|:         ::|:|....:|||.:|..|||
Yeast   906 ----------------DTVVVQ-SLIRRRAAQRKL---------KQLKADAKSVNHLKEVSYKLE 944

  Fly  1028 QTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAK 1092
            ..:                           ::|||...:.::.||:..|
Yeast   945 NKV---------------------------IELTQNLASKVKENKEMTE---------------- 966

  Fly  1093 LEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEEL-GERLEEAGGAT 1156
                         :|||||.::||                  .|.|...||.: .|.|.:.....
Yeast   967 -------------RIKELQVQVEE------------------SAKLQETLENMKKEHLIDIDNQK 1000

  Fly  1157 SAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKN 1221
            |..:||.|..|..|....:.|::|.::    |.::.|:|::...|..:|:::|.:.|    |...
Yeast  1001 SKDMELQKTIENNLQSTEQTLKDAQLE----LEDMVKQHDELKEESKKQLEELEQTK----KTLV 1057

  Fly  1222 EYYGQLNDLRAGVDHITNE-KAAQEKIAK-QLQHTLNEV-QSKLDETNRTLNDF---DASK-KKL 1279
            ||.....||:       || |:.:|:||: |...:|..| .|.|.:|  .|.|.   .||. ..:
Yeast  1058 EYQTLNGDLQ-------NEVKSLKEEIARLQTAMSLGTVTTSVLPQT--PLKDVMGGGASNFNNM 1113

  Fly  1280 SIENSDL------LRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGK--FRNLE 1336
            .:|||||      |:......|..:.:..:.:             |.|:...||.:.:  :|.||
Yeast  1114 MLENSDLSPNDLNLKSRSTPSSGNNHIDSLSV-------------DRENGVNATQINEELYRLLE 1165

  Fly  1337 HDLDNLREQVEEE-AEG----KADLQRQLSKANAE----------AQVWRSKYESDGVARSEELE 1386
             |.:.|.:::.|. .:|    .|.:..||||.:..          :::||.     |:.:..|
Yeast  1166 -DTEILNQEITEGLLKGFEVPDAGVAIQLSKRDVVYPARILIIVLSEMWRF-----GLTKQSE-- 1222

  Fly  1387 EAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKI 1451
                   :.||:...||              |::.|:::...|.......:||..|.
Yeast  1223 -------SFLAQVLTTI--------------QKVVTQLKGNDLIPSGVFWLANVREL-------- 1258

  Fly  1452 IGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIG 1516
                                    ||..:|.|.....|...:......|.|.....|.:|.|...
Yeast  1259 ------------------------YSFVVFALNSILTEETFKNGMTDEEYKEYVSLVTELKDDFE 1299

  Fly  1517 EGGRNIHEI--EKARKRLE 1533
            ....||:.|  :|.:|:|:
Yeast  1300 ALSYNIYNIWLKKLQKQLQ 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/48 (21%)
		MYSc	81..777	CDD:214580	290/723 (40%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	277/692 (40%)
		Myosin_tail_1	842..1897	CDD:279860	143/729 (20%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	454/1579 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910