Protein Alignment Mhc and MYO3

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1233
• Identity: 343/1233 - (27%)
• Similarity: 568/1233 - (46%)
• Gaps: 230/1233 - (18%)

  Fly    65 QGGETRDLK---------KDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSG 120
            :|...:|:|         |......|..|.....|::.|:.::|.|:..||::|:.|.:||||.|
Yeast     6 KGARRKDVKEPKKRSAKIKKATFDANKKKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIG 70

  Fly   121 LFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGK 185
            ...:::||::...:|||...:.|:||.|.|||||:|||::..|.::.:.:.||.::|:|||||||
Yeast    71 HVLISVNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGK 135

  Fly   186 TENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIH 250
            ||..|:::.|.|....|.     ::|.|.::|.|:.|||:||:||.|||:||:||||.||::.|.
Yeast   136 TEAAKRIMQYIAAASNSH-----SESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIK 195

  Fly   251 FGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKD---ICLLTDNIYDYHIV 312
            |....:....:|..|||||.||:.|...||::|||||...|:....|.   :.:....||   ..
Yeast   196 FNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMPEQYIY---TA 257

  Fly   313 SQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGE 377
            :.|..|..:|||.:::..|.:|...:|..::|::.::|:.||::.:|.:.|.:  .||...|.|:
Yeast   258 AAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIE--NEEGNAQVGD 320

  Fly   378 EE-GGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGR------NVQQVTNSIGALCKGVFDRLF 435
            .. ...|:.|...|.:.|.|.|:: ||...:..:.:|.      |..|.|....||.|.:::.||
Yeast   321 TSVTDFVAYLLQVDASLLVKCLVE-RIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLF 384

  Fly   436 KWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEY 500
            .|:|.:.|.:|.........||:|||.||||||:|.|||:|||:.||||||.|.......|||.|
Yeast   385 DWIVDRVNVSLQAFPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETY 449

  Fly   501 QREGIEWTFIDFGMDLQLCIDLIE--KPMGILSILEEE----SMFPKATDQTFSEKLTNTHLGKS 559
            :||.|:||.|.: .|.::..||||  .|.|||:.:.:.    .....|.||.|:::|   :|..|
Yeast   450 EREKIKWTPIKY-FDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRL---NLFNS 510

  Fly   560 APFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADH 624
            .|:.:.:..|       |.|.||||.|:|:|.|..:||||.|...:::....:.|..|..||.|.
Yeast   511 NPYFELRANK-------FVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPDD 568

  Fly   625 AGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHL 689
            ..:.       ..|.....|...:.||     |.|:.||...:|.::|.|.||:.|.|...|.|.
Yeast   569 VDKD-------SKRRPPTAGDKIIKSA-----NELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQ 621

  Fly   690 VMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVE-----KDKKATEIIIKFID 749
            |:||:...|:.|.:||.|.||..|..:..|..|:.::.|......:     ...:|.::|::...
Yeast   622 VLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAM 686

  Fly   750 LPEDQYRLGNTKVFFRA-GVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRV--ALK 811
            :||.:::||.|.||.:. ..|..:|:.||:      .|....||   .::.:::..::|:  |:|
Yeast   687 IPEKEFQLGVTSVFIKTPESLFALEDMRDK------YWYNMAAR---IQRAWRRFLQRRIDAAIK 742

  Fly   812 VVQRNLR------KYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVK--- 867
             :||.:|      ||::||.:.        ..||...:....::.|..:|...:.|...|.|
Yeast   743 -IQRTIREKKGGNKYVKLRDYG--------TKLLAGKKERRSMSLLGYRAFMGDYLSCNESKTKG 798

  Fly   868 --VRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAK-------LTAQKNDLENQLRDIQE 923
              :|::        :..|..::.|:.||  .|.....|:|:       ||.:...:..|
Yeast   799 SYIRRQ--------VGIKDKVVFSIKGE--CLHSKFGRSAQRLKKVFILTKKTFYIIGQ------ 847

  Fly   924 RLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDE-------- 980
              |:|::|                  .|..:|.:::|.|.:|...|      ||.|:
Yeast   848 --TREQNA------------------MKYTQDYKIDVGKIKQVSLT------NLQDDWMGVILVN 886

  Fly   981 IAHQDELINK------LNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            ....|.|||.      :.:.||:..:...|.|..::..:.. |.|:.|::|:..:..:.
Yeast   887 STQSDPLINTPFKTELMTRLKKLNEKIMIKVGPTIEYHKQP-NKLHTVRSKISDSAPKY------ 944

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
                 ||:.||     ..:.:.:...|:.:.||         |.|....::.|
Yeast   945 -----GDIYKS-----STIYVRRGHPANSKSNK---------KPKNPGGLSGK------------ 978

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
             .||..:::.:...:...:.|..|..|:||.....:.:..|      :..||:||...|.|.:..
Yeast   979 -PIKSKKSKHKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPL------SLAATAAQAAYNPKPDKT 1036

  Fly  1170 L---------------------SKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNK 1211
            :                     ||.:..:::|:..|:|:.|    |.|......::.|:: ||
Yeast  1037 VPIKSSAIPAAKVSSKHSSKPSSKEKVAVKKASSSHKSSSA----KQNQVSMPPSKGVEK-NK 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	3/18 (17%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	240/685 (35%)
		Myosin_tail_1	842..1922	CDD:460256	75/417 (18%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	343/1233 (28%)