DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYO3

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_012793.2	Gene:	MYO3 / 853729	SGDID:	S000001612	Length:	1272	Species:	Saccharomyces cerevisiae

Alignment Length:	1233	Identity:	341/1233 - (27%)
Similarity:	567/1233 - (45%)	Gaps:	230/1233 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QGGEVRDIK-----SEKVEK----VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSG 120
            :|...:|:|     |.|::|    .|..|...|.|:..::.::...:..||::|:...:||||.|
Yeast     6 KGARRKDVKEPKKRSAKIKKATFDANKKKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIG 70

  Fly   121 LFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGK 185
            ...:::||::...:|||...:.|:||.|.|||||:|||::..|.::.:.:.||.::|:|||||||
Yeast    71 HVLISVNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGK 135

  Fly   186 TENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIH 250
            ||..|:::.|.|....|.     ::|.|.::|.|:.|||:||:||.|||:||:||||.||::.|.
Yeast   136 TEAAKRIMQYIAAASNSH-----SESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIK 195

  Fly   251 FGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKD---ICLLTDNIYDYHIV 312
            |....:....:|..|||||.||:.|...||::|||||...|:....|.   :.:....||   ..
Yeast   196 FNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMPEQYIY---TA 257

  Fly   313 SQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGE 377
            :.|..|..:|||.:::..|.:|...:|..::|::.::|:.||::.:|.:.|.:  .||...|.|:
Yeast   258 AAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIE--NEEGNAQVGD 320

  Fly   378 EE-GGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGR------NVQQVTNSIGALCKGVFDRLF 435
            .. ...|:.|...|.:.|.|.|:: ||...:..:.:|.      |..|.|....||.|.:::.||
Yeast   321 TSVTDFVAYLLQVDASLLVKCLVE-RIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLF 384

  Fly   436 KWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEY 500
            .|:|.:.|.:|.........||:|||.||||||:|.|||:|||:.||||||.|.......|||.|
Yeast   385 DWIVDRVNVSLQAFPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETY 449

  Fly   501 KREGIDWAFIDFGMDLLACIDLIE--KPMGILSILEEE----SMFPKATDQTFSEKLTNTHLGKS 559
            :||.|.|..|.:..:.:.| ||||  .|.|||:.:.:.    .....|.||.|:::|   :|..|
Yeast   450 EREKIKWTPIKYFDNKVVC-DLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRL---NLFNS 510

  Fly   560 APFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADH 624
            .|:.:.:..|       |.|.||||.|:|:|.|..:||||.|...:::....:.|..|..||.|.
Yeast   511 NPYFELRANK-------FVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPDD 568

  Fly   625 AGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHL 689
            ..:.       ..|.....|...:.||     |.|:.||...:|.::|.|.||:.|.|...|.|.
Yeast   569 VDKD-------SKRRPPTAGDKIIKSA-----NELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQ 621

  Fly   690 VMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVE-----KDKKATEIIIKFID 749
            |:||:...|:.|.:||.|.||..|..:..|..|:.::.|......:     ...:|.::|::...
Yeast   622 VLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAM 686

  Fly   750 LPEDQYRLGNTKVFFRA-GVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRV--ALK 811
            :||.:::||.|.||.:. ..|..:|:.||:      .|....||   .::.:::..::|:  |:|
Yeast   687 IPEKEFQLGVTSVFIKTPESLFALEDMRDK------YWYNMAAR---IQRAWRRFLQRRIDAAIK 742

  Fly   812 VVQRNLR------KYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVK--- 867
             :||.:|      ||::||.:.        ..||...:....::.|..:|...:.|...|.|
Yeast   743 -IQRTIREKKGGNKYVKLRDYG--------TKLLAGKKERRSMSLLGYRAFMGDYLSCNESKTKG 798

  Fly   868 --VRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAK-------LTAQKNDLENQLRDIQE 923
              :|::        :..|..::.|:.||  .|.....|:|:       ||.:...:..|
Yeast   799 SYIRRQ--------VGIKDKVVFSIKGE--CLHSKFGRSAQRLKKVFILTKKTFYIIGQ------ 847

  Fly   924 RLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDE-------- 980
              |:|::|                  .|..:|.:::|.|.:|...|      ||.|:
Yeast   848 --TREQNA------------------MKYTQDYKIDVGKIKQVSLT------NLQDDWMGVILVN 886

  Fly   981 IAHQDELINK------LNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            ....|.|||.      :.:.||:..:...|.|..::..:.. |.|:.|::|:..:..:.
Yeast   887 STQSDPLINTPFKTELMTRLKKLNEKIMIKVGPTIEYHKQP-NKLHTVRSKISDSAPKY------ 944

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
                 ||:.||     ..:.:.:...|:.:.||         |.|....::.|
Yeast   945 -----GDIYKS-----STIYVRRGHPANSKSNK---------KPKNPGGLSGK------------ 978

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
             .||..:::.:...:...:.|..|..|:||.....:.:..|      :..||:||...|.|.:..
Yeast   979 -PIKSKKSKHKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPL------SLAATAAQAAYNPKPDKT 1036

  Fly  1170 L---------------------SKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNK 1211
            :                     ||.:..:::|:..|:|:.|    |.|......::.|:: ||
Yeast  1037 VPIKSSAIPAAKVSSKHSSKPSSKEKVAVKKASSSHKSSSA----KQNQVSMPPSKGVEK-NK 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	2/7 (29%)
		MYSc	81..777	CDD:214580	243/717 (34%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	237/685 (35%)
		Myosin_tail_1	842..1897	CDD:279860	75/417 (18%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	341/1233 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910