DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYO4

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_009373.1	Gene:	MYO4 / 851204	SGDID:	S000000027	Length:	1471	Species:	Saccharomyces cerevisiae

Alignment Length:	1618	Identity:	436/1618 - (26%)
Similarity:	734/1618 - (45%)	Gaps:	319/1618 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CWIPDEKEGYLLGEIKATKGDI------VSVGLQGGEVRDIKSEKVEK----------VNPPKFE 86
            ||.|.:::|::.||:  ||.|.      :.:.|:.||...|::...|.          .|||..|
Yeast     9 CWYPHKEQGWIGGEV--TKNDFFEGTFHLELKLEDGETVSIETNSFENDDDHPTLPVLRNPPILE 71

  Fly    87 KIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNE 150
            ..:|:..::.||.|.|||.:::||....||||||:..:|.||:.:.. :|:....:.|..||::|
Yeast    72 STDDLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSSKRKDE 136

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSL 215
            :.||:|||::.||..|:....||:::::||||||||.:.|.::.|||:|..|... |.......:
Yeast   137 LEPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNR-EGEVEMSQI 200

  Fly   216 EDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLER 280
            |.|::.|||::||||||||.||||||||||:::|.|.....:.|:.|.||||||:|::.|...||
Yeast   201 ESQILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPETER 265

  Fly   281 SYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGFTKQE 344
            :|||||||:.|....||....|: :..|||..:| |:..:|.||:|.|:.:|..|..::|...:.
Yeast   266 NYHIFYQILEGLPEPVKQELHLS-SPKDYHYTNQGGQPNIAGIDEAREYKITTDALSLVGINHET 329

  Fly   345 KEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVS-KLFGCDTAELYKNLLKPRIKVGNE 408
            :..:::|.|.::|:|.::.|.  ....|....||:..::: :|.|.|.....|.::|.:|...:|
Yeast   330 QLGIFKILAGLLHIGNIEMKM--TRNDASLSSEEQNLQIACELLGIDPFNFAKWIVKKQIVTRSE 392

  Fly   409 FVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNET-----LDTQQKRQHFIGVLDIAGFEIFE 468
            .:....|..|...:..::.|.::..||.|||...|:|     ||.|.....|||:|||.|||.||
Yeast   393 KIVTNLNYNQALIARDSVAKFIYSTLFDWLVDNINKTLYDPELDQQDHVFSFIGILDIYGFEHFE 457

  Fly   469 YNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSIL 533
            .|.|||.|||:.||||||.||.|:|.||||||.:|.|:|:||:|. |...||||||..:||||:|
Yeast   458 KNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIEFS-DNQPCIDLIENKLGILSLL 521

  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKP------KPPKPGQQAAHFAIAHYAGCVSYNITG 592
            :|||..|..:|::::.||.:.       |.||      ..|:.||  ..|.::|||..|.|.:.|
Yeast   522 DEESRLPSGSDESWASKLYSA-------FNKPPSNEVFSKPRFGQ--TKFIVSHYAVDVEYEVEG 577

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIF------ADHAGQSGGGEQ-----AKGGRGKKGGGFA 646
            ::|||:|.::...:|.||.:.|.:..:|.      :|.|.:....|:     |:..:.|     .
Yeast   578 FIEKNRDSVSLGHLDVFKATTNPIFKQILDNRELRSDDAPEEQNTEKKIMIPARLSQKK-----P 637

  Fly   647 TVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFP 711
            |:.|.:|:.|..||..:.||..|::|||.||..|:|...|..:|:.||...||||.|||...|||
Yeast   638 TLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFP 702

  Fly   712 NRMMYPDFKMRYKIMCP-KLLQGV----EKDKKATEIIIKFIDLPED-------QYRLGNTKVFF 764
            :|..:.:|..||.::.. .|..|:    :..|:|   |:.|.....|       :|::||||:||
Yeast   703 SRWTFDEFVQRYFLLTDYSLWSGILYNPDLPKEA---IVNFCQSILDATISDSAKYQIGNTKIFF 764

  Fly   765 RAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWY 829
            :||:|..:|:.|..::.:|...:|...|....|..:.:..|   ::|..|..:|..| :||...:
Yeast   765 KAGMLAFLEKLRTNKMNEICIIIQKKIRARYYRLQYLQTME---SIKKCQSQIRSLL-VRTRVDH 825

  Fly   830 KLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEV----------KVRKELEALNAKLLAEKT 884
            :|..:...||..:          .:|....|.:.|.:          |.:..|:::|.|.:....
Yeast   826 ELKTRAAILLQTN----------IRALWKREYYRAAIGQIIKLQCTCKRKLILDSVNRKFMLMAA 880

  Fly   885 ALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEIS-- 947
            .::.|.....|...||:      |.:::.:.     :|..:..:...|..:..||:..::.|.
Yeast   881 VIIQSYIRSYGHKTDYR------TLKRSSIL-----VQSAMRMQLARRRYIVLQKEVEERNIRAS 934

  Fly   948 ---GLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEEL 1009
               ||          :::|.:.|.:....:..|||......:|         :||:.:....::.
Yeast   935 YGIGL----------LEEAIEFKNSFILNLEMLNDSYTRLTQL---------LQGDLSNIPSKQR 980

  Fly  1010 QAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKE 1074
            |..|..:|..|...:||:....|:.::|.::..::    :.|:|....::...:::|.::.||
Yeast   981 QEYETIVNGYNDKISKLKTLQVEIMNTLNKKNALK----ERKKKQSSLIQSHMQSLAAIKGNK-- 1039

  Fly  1075 LEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLA 1139
                           .::|.||          :|.::..:..:|..:..:......|.|.  |..
Yeast  1040 ---------------PSRLSDE----------VKSMKQELAFIENVIAQDFTTTYSANKN--DKV 1077

  Fly  1140 RELEELGERLE---------EAGGATSAQI--ELN----KKREAELSKLRRDLEEAN-------- 1181
            :.|...|::::         |:|.....::  :||    :..|..|.|:  ::.|.|
Yeast  1078 KGLGIAGQQVKPKLVNVIRRESGNPDLLELLMDLNCYTLEVTEGYLKKV--NVTEVNGDNVLGPI 1140

  Fly  1182 ----------------IQHESTLANLRKKHNDAVAEMAEQ---------VDQLNKLKAKAEKEKN 1221
                            ||....::.:.......|..:.:.         :..|::|.|.|..:|.
Yeast  1141 HVITTVVSSLVRNGLLIQSSKFISKVLLTVESIVMSLPKDETMLGGIFWLSNLSRLPAFAANQKT 1205

  Fly  1222 EYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDL 1286
            .|.....|               ||....|.: ||:::      |.||..||      .|.::.|
Yeast  1206 LYEANGGD---------------EKDKLTLIY-LNDLE------NETLKVFD------KIYSTWL 1242

  Fly  1287 LRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAE 1351
            ::.::.|.:.:.....:   |..:|  .|...||:..:..|.|.:|     |....:.||.:...
Yeast  1243 VKFMKHASAHIEIFDMV---LNEKL--FKNSGDEKFAKLFTFLNEF-----DAVLCKFQVVDSMH 1297

  Fly  1352 GKA--DLQRQLSK-------ANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLN 1407
            .|.  |..:.|:.       ....|..|:..||.|            |.::..::..|..||.:.
Yeast  1298 TKIFNDTLKYLNVMLFNDLITKCPALNWKYGYEVD------------RNIERLVSWFEPRIEDVR 1350

  Fly  1408 QKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKE 1472
            ...|       ::...|:.|||::...|                  |:||..|...| |:.:|
Yeast  1351 PNLI-------QIIQAVKILQLKISNLN------------------EFKLLFDFWYA-LNPAQ-- 1387

  Fly  1473 CRNYSTELFRLKGAYEEGQEQL---------EAVRRENKNLADEVKDLLDQIGEGGRN 1521
               ....|.:.|.| .:|:..:         ..::|||.:|..:::.:|....:..:|
Yeast  1388 ---IQAILLKYKPA-NKGEAGVPNEILNYLANVIKRENLSLPGKMEIMLSAQFDSAKN 1441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	12/40 (30%)
		MYSc	81..777	CDD:214580	279/732 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	267/701 (38%)
		Myosin_tail_1	842..1897	CDD:279860	128/761 (17%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	436/1618 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910