DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYO18B

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_011528760.1	Gene:	MYO18B / 84700	HGNCID:	18150	Length:	2610	Species:	Homo sapiens

Alignment Length:	1988	Identity:	479/1988 - (24%)
Similarity:	866/1988 - (43%)	Gaps:	420/1988 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KPVANQEDED-PTPYLFVSLEQRRIDQSKP---------YDSKKSCWIPDEKEGYLLGEIKATKG 57
            :|...:|::| |.|.     |:.:..||:.         |:::| .|:. :|:|:.|..:  .|.
Human   519 RPRIRKENQDGPAPQ-----EEGKGGQSRDSDQAPEDRWYEAEK-VWLA-QKDGFTLATV--LKP 574

  Fly    58 DIVSVGLQGGEVR----------DIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYA 112
            |..:..|..|.||          ::..|.|.:.|||:.:::||:|.:..:|...||:.|.|||.|
Human   575 DEGTADLPAGRVRLWIDADKTITEVDEEHVHRANPPELDQVEDLASLISVNESSVLNTLLQRYKA 639

  Fly   113 KLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLI 177
            :|::|.:|...:.:.|  |.|...: ..|:.:| ||:.:|.||.:::..||..:|....:||::.
Human   640 QLLHTCTGPDLIVLQP--RGPSVPS-AGKVPKG-RRDGLPAHIGSMAQRAYWALLNQRRDQSIVA 700

  Fly   178 TGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSR 242
            .|.||||||...::|:.:.  ||.:...|    .:.|:| ::..|..||.|||:.....:.:::|
Human   701 LGWSGAGKTTCCEQVLEHL--VGMAGSVD----GRVSVE-KIRATFTVLRAFGSVSMAHSRSATR 758

  Fly   243 FGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTD-NI 306
            |...:.:.|..||::..|.::|.||||:||..|...|.::.:|.|:::|     .|:.|.|: |:
Human   759 FSMVMSLDFNATGRITAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAG-----LDLDLRTELNL 818

  Fly   307 YDYHIVSQGKVTVASIDD-----AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQR 366
            :.....|...:.|.|..:     |..|:....|.::||.::.|:..|:|:.||:.|:|.....:.
Human   819 HQMADSSSFGMGVWSKPEDKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKV 883

  Fly   367 GREEQAEQDGEEEGGRVSKLFGCDTAEL----YKNLLKPRIK----------VGNEFVTQGRNVQ 417
            ||::...   .|.....::..||:..||    :|:.|:..|:          :.:|..:.|..:.
Human   884 GRKQFMR---FEWANYAAEALGCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETSSGLKMT 945

  Fly   418 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG------FEQLC 476
            .| :.:..:..|::..||..:|...|.:..:.......|.|:|..||:...:.|      ||:||
Human   946 GV-DCVEGMASGLYQELFAAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRAATFEELC 1009

  Fly   477 INFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDL--------LACIDLIEKP------- 526
            .|:.:|:||..|....||...:.|:.||:...|     ||        :|.:|  :.|
Human  1010 HNYAHERLQLLFYQRTFVSTLQRYQEEGVPVQF-----DLPDPSPGTTVAVVD--QNPSQQVRLP 1067

  Fly   527 --------MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYA 583
                    .|:..:|:||.....::|....|:|......|.|..:.....:..:|.....|.|..
Human  1068 AGGGAQDARGLFWVLDEEVHVEGSSDSVVLERLCAAFEKKGAGTEGSSALRTCEQPLQCEIFHQL 1132

  Fly   584 GC--VSYNITGWLEKNKDPLN----DTVVDQFKKSQNKLLIEIFAD-------HAGQSGGGEQA- 634
            |.  |.|::||||.:.|..|:    ..|:.|.|:.:.:.|.:..|.       .||..|..:||
Human  1133 GWDPVRYDLTGWLHRAKPNLSALDAPQVLHQSKREELRSLFQARAKLPPVCRAVAGLEGTSQQAL 1197

  Fly   635 ---KGGRGKKGGGFATV-----SSAYKEQLNSLMTTLRSTQPHFVRCIIPNEM------------ 679
               :..|.......|.|     .|..|.|:::|.:.::.::.||:.|::||.:
Human  1198 QRSRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIHCLVPNPVVESRSGQESPPP 1262

  Fly   680 KQPG----------VVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL--- 731
            .|||          .:|...:..||....:||.:|:.|.|:.:.|....|:.:::::...||
Human  1263 PQPGRDKPGAGGPLALDIPALRVQLAGFHILEALRLHRTGYADHMGLTRFRRQFQVLDAPLLKKL 1327

  Fly   732 ----QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
                :|:: ::||.|.:::.:||.:....:|:::||.:|||:.::|:.|::.:.:.:...||..:
Human  1328 MSTSEGID-ERKAVEELLETLDLEKKAVAVGHSQVFLKAGVISRLEKQREKLVSQSIVLFQAACK 1391

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVS-------RIEDEIAR 850
            |:|||:.||||:.:|:|.:.:|:|:..:|.::.|||::|...::|||:.:       ..|:|:..
Human  1392 GFLSRQEFKKLKIRRLAAQCIQKNVAVFLAVKDWPWWQLLGSLQPLLSATIGTEQLRAKEEELTT 1456

  Fly   851 LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTA-LLDSLSGE--KG--ALQDYQ-ERNAKLTA 909
            |..|.:|:|       |:|.||.. |..||..|.| |...|:.|  ||  |.|..: ||..:|.|
Human  1457 LRRKLEKSE-------KLRNELRQ-NTDLLESKIADLTSDLADERFKGDVACQVLESERAERLQA 1513

  Fly   910 QKNDLENQLRDIQERLTQEEDARNQL---FQQKKKADQEISGLKKDIEDLELN-VQKAEQDKATK 970
                    .|::||..::.|..:.:|   .:|.::|.|:|     .:.|||.| ...|::.:...
Human  1514 --------FREVQELKSKHEQVQKKLGDVNKQLEEAQQKI-----QLNDLERNPTGGADEWQMRF 1565

  Fly   971 D-HQIRN--LNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAED---KINHLNKVKAKLEQT 1029
            | .|:.|  |...:...:|   :|:.|...:.|..||.| |||:|.|   |:.|  ::|.|....
Human  1566 DCAQMENEFLRKRLQQCEE---RLDSELTARKELEQKLG-ELQSAYDGAKKMAH--QLKRKCHHL 1624

  Fly  1030 LDELEDS---LEREKKVRGDVEKSKRKVEGDLKLTQ---EAVADLERNKK-------------EL 1075
            ..:|||:   ||.::....::||.::|.  ||:|.|   |:|.:....:|             :|
Human  1625 TCDLEDTCVLLENQQSRNHELEKKQKKF--DLQLAQALGESVFEKGLREKVTQENTSVRWELGQL 1687

  Fly  1076 EQTIQRKDKELSSITAKLEDEQVVVLKHQRQI-------KELQARIEELEEEVEAERQARAKAEK 1133
            :|.:::|::|.|.:..::|    ::..|:|::       :...|.::|...::|:....:.|.:.
Human  1688 QQQLKQKEQEASQLKQQVE----MLQDHKRELLGSPSLGENCVAGLKERLWKLESSALEQQKIQS 1748

  Fly  1134 QRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDA 1198
            |:.:..::||:|.:|.|         :|:.:.::.. .|.|.|.||       .|.::|:.....
Human  1749 QQENTIKQLEQLRQRFE---------LEIERMKQMH-QKDREDQEE-------ELEDVRQSCQKR 1796

  Fly  1199 VAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHT---LNEVQS 1260
            :.::..|::|..:.|.....||.:..|.:..|...:.|  .:...::::.:.|:.|   |::||.
Human  1797 LHQLEMQLEQEYEEKQMVLHEKQDLEGLIGTLCDQIGH--RDFDVEKRLRRDLRRTHALLSDVQL 1859

  Fly  1261 KLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLED----------TK 1315
            .|.    |:.|...|..|..:|.  :..|||::|::..:..|.:..||..||.          .|
Human  1860 LLG----TMEDGKTSVSKEELEK--VHSQLEQSEAKCEEALKTQKVLTADLESMHSELENMTRNK 1918

  Fly  1316 RLADEE----SRERATLLGKFRNLEHDLDNLREQVEEE----AEGKAD------LQRQLSKANAE 1366
            .|.||:    ..|:|.||   :.::.|.|:|.|.:::.    |:..||      ||.||
Human  1919 SLVDEQLYRLQFEKADLL---KRIDEDQDDLNELMQKHKDLIAQSAADIGQIQELQLQL------ 1974

  Fly  1367 AQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEV 1431
                            ||.::.|.|||.:|..|:..||.|.|..:.               :..|
Human  1975 ----------------EEAKKEKHKLQEQLQVAQMRIEYLEQSTVD---------------RAIV 2008

  Fly  1432 DRANAIANAAEKKQKAFDKI-IGEWKLKV----DDL---------AAELDASQKECRNYSTELFR 1482
            .|..|:....|.|.: |.|: |..:::.|    |.|         ||..::.|:|...|
Human  2009 SRQEAVICDLENKTE-FQKVQIKRFEVLVIRLRDSLIKMGEELSQAATSESQQRESSQY------ 2066

  Fly  1483 LKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALE--- 1544
                |:...|:|:|          ::::|:.:..|..|...|:||..:.|.|.:..||..||
Human  2067 ----YQRRLEELKA----------DMEELVQREAEASRRCMELEKYVEELAAVRQTLQTDLETSI 2117

  Fly  1545 ----EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAK 1605
                :.:||||:    |..:..:...|:..:|.. ....:|.:|......:...|:|:.|.....
Human  2118 RRIADLQAALEE----VASSDSDTESVQTAVDCG-SSGRKEMDNVSILSSQPEGSLQSWLSCTLS 2177

  Fly  1606 GKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQL 1670
            ...:.:|...:..|..:.:                           :...:.||  |.|..|.|.
Human  2178 LATDTMRTPSRQSATSSRI---------------------------LSPRINEE--AGDTERTQS 2213

  Fly  1671 GISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQT 1735
            .::..||.:.....:.|..........|||......|            ..:.|.:||....|:.
Human  2214 ALALSRARSTNVHSKTSGDKPVSPHFVRRQKYCHFGD------------GEVLAVQRKSTERLEP 2266

  Fly  1736 LHSDL-DELLNEAKNSEEKAKKAMVDAARLADELRAEQ 1772
            ..|.| ....|.:..|.||........:...:.||.::
Human  2267 ASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKR 2304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	11/46 (24%)
		MYSc	81..777	CDD:214580	203/795 (26%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	192/764 (25%)
		Myosin_tail_1	842..1897	CDD:279860	231/1029 (22%)
		V_Alix_like	1557..1877	CDD:187408	35/217 (16%)
		ATP-synt_B	<1671..1771	CDD:304375	19/100 (19%)
		TMPIT	1739..>1825	CDD:285135	7/35 (20%)
MYO18B	XP_011528760.1	Glutenin_hmw	<114..542	CDD:281191	7/27 (26%)
		MYSc	608..1376	CDD:214580	203/795 (26%)
		MYSc_Myo18	627..1364	CDD:276837	192/764 (25%)
		Smc	1457..>2133	CDD:224117	195/798 (24%)
		GBP_C	<1723..1818	CDD:303769	21/111 (19%)
		coiled coil	1789..1803	CDD:293879	1/13 (8%)
		RILP-like	1923..>2020	CDD:304877	31/136 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810