DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and XIE

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_175858.1 Gene:XIE / 841898 AraportID:AT1G54560 Length:1529 Species:Arabidopsis thaliana


Alignment Length:1631 Identity:458/1631 - (28%)
Similarity:724/1631 - (44%) Gaps:345/1631 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEK----IEDMADMTVLNT 99
            ||.|....::.|.::...|..|.|....|:.   .:.|:.|:.|...|.    ::||..::.|:.
plant    17 WIEDSDVAWIDGLVEKINGQDVEVQATNGKK---ITAKLSKIYPKDMEAPAGGVDDMTKLSYLHE 78

  Fly   100 PCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGAY 163
            |.||.||:.||....||||:|...:||||::|.| :|.....:.|:|....|:.||:||::|.||
plant    79 PGVLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPFGELSPHVFAVADVAY 143

  Fly   164 VDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEA 228
            ..|:....:.|:|::|||||||||.||.::.|.|.:|....|:..     ::|.||:::||||||
plant   144 RAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRAVTEGR-----TVEQQVLESNPVLEA 203

  Fly   229 FGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSV 293
            |||||||||:||||||||:.|.|...|:::||.:.|||||::||......||:||.||.:.:...
plant   204 FGNAKTVRNNNSSRFGKFVEIQFDKQGRISGAAVRTYLLERSRVCQISDPERNYHCFYLLCAAPQ 268

  Fly   294 PGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMH 357
            ..::...|  .:...:|.::|.| ..:..|.||.::..|.:|.||:|.:::|:|.::|:.||::|
plant   269 EELEKYKL--GHPKTFHYLNQSKCFELVGISDAHDYIATRRAMDIVGMSEKEQEAIFRVVAAILH 331

  Fly   358 MGGMKFKQRGREEQAEQDGEEEG----GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQ 418
            :|.::| .:|:|..:....:::.    ..|::|..||...|...|.|..:....|.:.:..:.|.
plant   332 LGNVEF-TKGKEVDSSVPKDDKSKFHLNTVAELLMCDVKALEDALCKRVMVTPEEVIKRSLDPQS 395

  Fly   419 VTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEK 483
            ...|...|.|.::.|||.|||:|.|.::......:..||||||.|||.|:.|.|||.||||||||
plant   396 ALISRDGLAKTIYSRLFDWLVEKINVSIGQDATSRSLIGVLDIYGFESFKTNSFEQFCINFTNEK 460

  Fly   484 LQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQTF 547
            |||.||.|:|.:|||||.:|.|||::|:| :|....:|||| ||.||:::|:|..||||:|.:||
plant   461 LQQHFNQHVFKMEQEEYTKEAIDWSYIEF-VDNQDVLDLIEKKPGGIVALLDEACMFPKSTHETF 524

  Fly   548 SEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKS 612
            :.||..| ......|.|||..:     ..||:|||||.|.|....:|:||||.:.....|....|
plant   525 ANKLYQT-FKTHKRFIKPKLSR-----TDFAVAHYAGEVQYQSDLFLDKNKDYVIPEHQDLLGAS 583

  Fly   613 QNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPN 677
            :...::.:|.....::           .|...|:::.|.:|.||..||.||.||:||::||:.||
plant   584 KCPFVVGLFPPLPEET-----------SKSSKFSSIGSRFKLQLQQLMETLNSTEPHYIRCVKPN 637

  Fly   678 EMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATE 742
            .:.:|.|.:...:|.||.|.||||.|||...|:|.|..:.:|..|:.::.|:.|:|..::|.|.:
plant   638 NLLKPAVFENVNIMQQLRCGGVLEAIRISCAGYPTRKPFFEFINRFGLLYPRALEGNYEEKAAAQ 702

  Fly   743 IIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRD-------------------ER----LGKIM 784
            .|:..|.|  ..|::|.||||.|||.:.:::..|.                   :|    |.|..
plant   703 KILDNIGL--KGYQVGKTKVFLRAGQMAELDARRTMVLSAAAKKIQRRIRTHQAQRRFILLRKAT 765

  Fly   785 SWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIA 849
            ..:||..||.||.|.|..|:.|..|:| :|:|.|                               
plant   766 ISLQALCRGRLSSKIFDNLRRQAAAVK-IQKNAR------------------------------- 798

  Fly   850 RLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDL 914
            ||..: |..:.||.|.:.|:..|.|:.|                     ..|.|..|.|.....:
plant   799 RLHSR-KSYKNLHVAALVVQTGLRAMAA---------------------HKQFRFRKQTKAATTI 841

  Fly   915 ENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLND 979
            :.|.|          ..|..|:.:|         |||.:                          
plant   842 QAQFR----------CHRATLYFKK---------LKKGV-------------------------- 861

  Fly   980 EIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVR 1044
                       :..:.:.:|:..::...:|:.|..:...|.:.|..||:.::||....:.||:.|
plant   862 -----------ILSQTRWRGKLARRELRQLKMASRETGALKEAKDMLEKKVEELTYRAQLEKRSR 915

  Fly  1045 GDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKE 1109
            .|:|:.|.:   ::|..|   :.||..:|::::|.....||..:....:|:...||.:.|..:::
plant   916 VDLEEEKNQ---EIKKLQ---SSLEEMRKKVDETNGLLVKEREAAKKAIEEAPPVVTETQVLVED 974

  Fly  1110 LQARIEELEEEVEAERQARAKAEKQRADLA-RELEELGERLEEAGGATSAQIELNKKREAELSKL 1173
            .| :||.|.||||. .:|..:.||||||.| |:.:|..|..|:           .||:..:..|.
plant   975 TQ-KIEALTEEVEG-LKANLEQEKQRADDATRKFDEAQESSED-----------RKKKLEDTEKK 1026

  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKL---KAKAEKEKNEYYGQLN-DLRAGV 1234
            .:.|:|:..:.|....|| :..|..:.:.|..:.. ||.   ::::..::....|.|: |.|..:
plant  1027 AQQLQESVTRLEEKCNNL-ESENKVLRQQAVSIAP-NKFLSGRSRSILQRGSESGHLSVDARPSL 1089

  Fly  1235 D---HITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLL--------- 1287
            |   |..|.:...| :..:.|.:|||.|.                     ||.:||         
plant  1090 DLHSHSINRRDLSE-VDDKPQKSLNEKQQ---------------------ENQELLIRCIVQHLG 1132

  Fly  1288 -------------------RQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFR 1333
                               |..|...:.|.......|....:.:|...:........:|||    
plant  1133 FQGKRPVTACIIYKCLLQWRSFEVERTSVFDRIIQTIGQAIETQDNNNILAYWLSNASTLL---- 1193

  Fly  1334 NLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAE 1398
                    |..|...:|.|.|.:..|..::::.....|......|..:...|        |.:..
plant  1194 --------LLLQRTLKASGAAGMAPQRRRSSSATLFGRMTQSFRGTPQGVNL--------AMING 1242

  Fly  1399 AEETIESLNQKCIGLEKTKQRLSTEVE--------DLQLEV-------------DRANAIANAAE 1442
            ..:|:..:..|...| ..||:|:..||        :|:.|:             .||:.:..|:.
plant  1243 GVDTLRQVEAKYPAL-LFKQQLTAYVEKIYGMIRDNLKKEISPLLGLCIQAPRTSRASLVKGASR 1306

  Fly  1443 K--KQKAFDKIIGEWKLKVDDLAAELD-------------------------------ASQKECR 1474
            .  ...|...:|..|:..|..|...|:                               ..::||.
plant  1307 SVGNTAAQQALIAHWQGIVKSLTNFLNNLKSNHVPPFLVRKVFTQIFSFINVQLFNSLLLRRECC 1371

  Fly  1475 NYSTELFRLKGAY-EEGQEQLE-----AVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLE 1533
            ::|      .|.| :.|..:||     |......:..||:|.:...|  |...||  :|.:|.|:
plant  1372 SFS------NGEYVKAGLAELEHWCYNATDEYAGSSWDELKHIRQAI--GFLVIH--QKPKKTLD 1426

  Fly  1534 AEKDEL 1539
            ....||
plant  1427 EISHEL 1432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/33 (24%)
MYSc 81..777 CDD:214580 273/706 (39%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 265/671 (39%)
Myosin_tail_1 842..1897 CDD:279860 156/794 (20%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
XIENP_175858.1 Myosin_N 14..51 CDD:280832 8/36 (22%)
MYSc 66..734 CDD:214580 271/695 (39%)
MYSc_Myo11 79..723 CDD:276835 265/671 (39%)
type_I_hlyD 723..>980 CDD:130902 73/373 (20%)
ApoLp-III_like <889..1026 CDD:304399 46/155 (30%)
TPR_MLP1_2 907..1054 CDD:285204 47/166 (28%)
bZIP <1016..1052 CDD:304365 9/36 (25%)
MyosinXI_CBD 1114..1495 CDD:271259 64/371 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - mtm946
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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