DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and XIB

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_171912.2	Gene:	XIB / 839246	AraportID:	AT1G04160	Length:	1500	Species:	Arabidopsis thaliana

Alignment Length:	1642	Identity:	466/1642 - (28%)
Similarity:	769/1642 - (46%)	Gaps:	286/1642 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKV--EKVNPPKFEKIEDMADMTVLNTPC 101
            |:.|..|.:|.||:....||.:.|....|:...:|...:  :.|..|. ..:|||..:..|:.|.
plant    14 WVEDPDEAWLDGEVVEINGDQIKVLCASGKQVVVKDSNIYPKDVEAPA-SGVEDMTRLAYLHEPG 77

  Fly   102 VLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGAYVD 165
            ||.||:.||....||||:|...:|:||::|.| :|::.....|:|....|:.||.||::|.||..
plant    78 VLQNLQSRYDINEIYTYTGSILIAVNPFRRLPHLYSSHMMTQYKGASLGELSPHPFAVADAAYRQ 142

  Fly   166 MLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKG-SLEDQVVQTNPVLEAF 229
            |:...|:||:|::|||||||||:||.::.|.|.:|.     ..|.::| ::|.:|:::|||||||
plant   143 MVNEGVSQSILVSGESGAGKTESTKLLMRYLAFMGG-----RGAATEGRTVEQKVLESNPVLEAF 202

  Fly   230 GNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVP 294
            ||||||:|:||||||||:.|.|..:|:::||.|.|||||::||......||:||.||.:.:....
plant   203 GNAKTVKNNNSSRFGKFVEIQFDQSGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAAPEE 267

  Fly   295 GVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHM 358
            ..|...|....|  ||.::|.| :.:.:::||||:..|.:|.|::|.:.:|::.::|:.|:::|:
plant   268 DAKKFKLGDPKI--YHYLNQSKCIQLDAMNDAEEYHATKKAMDVVGISSEEQDAIFRVVASILHL 330

  Fly   359 GGMKFKQRGREEQAEQDGEEEG----GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQV 419
            |.::| .:|.|..:....:|:.    ...::|..|:...|..:|.|..:...:|.:|:..:.:..
plant   331 GNIEF-AKGTEIDSSIPRDEKSWFHLKTAAELLMCNEKSLEDSLCKRIMATRDETITKTLDPEAA 394

  Fly   420 TNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKL 484
            ..|..||.|.::.|||.|||:|.|.::......::.||||||.|||.|:.|.|||.|||.|||||
plant   395 LLSRDALAKVMYSRLFDWLVEKINTSIGQDPDSKYLIGVLDIYGFESFKTNSFEQFCINLTNEKL 459

  Fly   485 QQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQTFS 548
            ||.||.|:|.:||||||:|.|:|::|:| :|....:|||| ||.||:::|:|..|||::|.:||:
plant   460 QQHFNQHVFKMEQEEYKKEEINWSYIEF-VDNQDILDLIEKKPGGIIALLDEACMFPRSTHETFA 523

  Fly   549 EKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQ 613
            :||..|:..... |.|||..:     :.|.|.||||.|:|....:|:|||    |.|:.:.:...
plant   524 QKLYQTYKNHKR-FTKPKLAR-----SDFTICHYAGDVTYQTELFLDKNK----DYVIAEHQALL 578

  Fly   614 NKLLIEIFAD-HAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPN 677
            |.......|: ....|...:|:|         |:::.:.:|:||.||:..|.:|:||::|||.||
plant   579 NASTCSFVANLFPPVSDDSKQSK---------FSSIGTRFKQQLVSLLEILNTTEPHYIRCIKPN 634

  Fly   678 EMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATE 742
            .:.:||:.:...|:.||.|.||:|.|||...|:|.|..:.:|..|:.|:.|::|     ||.:.|
plant   635 NLLKPGIFENQNVLQQLRCGGVMEAIRISCAGYPTRKHFDEFLNRFGIIAPQVL-----DKNSNE 694

  Fly   743 --IIIKFIDLPE-DQYRLGNTKVFFRAGVLGQMEEFRDERLG--------KIMSWM--------- 787
              ...|.:|... :.|::|.:|||.|||.:..::..|.|.||        |:.|::
plant   695 PAACKKLLDKAGLEGYQIGKSKVFLRAGQMADLDTRRTEILGRSASIIQRKVRSYLAQKTFIQLR 759

  Fly   788 ------QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIED 846
                  ||..||||:|..::.::.:..||| :||:|||:|..:.:.  :|:...  :|..:.:..
plant   760 ISATQIQAVCRGYLARSIYEGMRREAAALK-IQRDLRKFLARKAYT--ELFSAT--ILIQAGMRG 819

  Fly   847 EIAR----LEEKAKKA-----------EELHAAEVK--------------VRKELEALNAKLLAE 882
            .::|    |..:.|.|           ..||..::|              .||||:  |.|:.|.
plant   820 MVSRKELCLRRQTKAATIIQTRCRVYLARLHYRKLKKAAITTQCAWRGKVARKELK--NLKMAAR 882

  Fly   883 KTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKAD---- 943
            :|          ||||:          .||.||.|:.::..||..|:..|..|.:.||:.:
plant   883 ET----------GALQE----------AKNKLEKQVEELTWRLQLEKRMRTDLEEAKKQENAKYE 927

  Fly   944 ---QEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQD-ELINKLNKEKKMQGETNQK 1004
               :||....|:.|.|.:.    |::.|....::..:..|:...| ||:.||..|       |:|
plant   928 SSLEEIQNKFKETEALLIK----EREAAKTVSEVLPIIKEVPVVDQELMEKLTNE-------NEK 981

  Fly  1005 TGEELQAAEDKINHLNKVKAKLEQTL----DELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAV 1065
            ....:.:.|.||:...|   :|.:|.    |.|:.:|..|.||        .|::..::..:|.:
plant   982 LKGMVSSLEIKIDETAK---ELHETARISQDRLKQALAAESKV--------AKLKTAMQRLEEKI 1035

  Fly  1066 ADLERNKK-ELEQTIQRKDKELSSITAKLEDEQVVVLKH--QRQIKELQ----ARIEELEEEVEA 1123
            :|:|..|: .|:|||             |......|..|  ...||.|:    ..:|....|||.
plant  1036 SDMETEKQIMLQQTI-------------LNTPVKSVAGHPPTATIKNLENGHRTNLENQFNEVEV 1087

  Fly  1124 ERQA-RAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHEST 1187
            ...| ::.||:|..::...::.:.|.:..:.|...|...:.|                .:.|...
plant  1088 NGNAGKSAAERQLENVDTLIDCVKENIGFSNGKPIAAFTIYK----------------CLLHWKC 1136

  Fly  1188 LANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQ 1252
            ..:.:....|.:.||         :.:..|.|.:.  |.|      ...:||..|....:.|.|:
plant  1137 FESEKTSAFDRLIEM---------IGSAIENEDDN--GHL------AYWLTNTSALLFLLQKSLK 1184

  Fly  1253 HT-LNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKR 1316
            .. .....||......:|    ..:..||..:|..|....|| :.::.:..::......|...:.
plant  1185 PAGAGATASKKPPITTSL----FGRMALSFRSSPNLAAAAEA-AALAVIRPVEAKYPALLFKQQL 1244

  Fly  1317 LADEESRERATLLGKFR-NLEHDLDNLREQ-VEEEAEGKADLQRQLSKANAEAQV--WRSKYESD 1377
            .|..|.     :.|..| ||:.:|..|... ::.....|..:||.......::..  |:|..  |
plant  1245 AAYVEK-----IFGMIRDNLKKELSALISMCIQAPRISKGGIQRSARSLGKDSPAIHWQSII--D 1302

  Fly  1378 GVARSEELEEAKRKLQARLAEAEE-------------------TIESLNQKCIGLE----KTKQR 1419
            |             |.:.||..::                   .::..|...:..|    ...:.
plant  1303 G-------------LNSLLAILKDNYVPLVLIQKIHTQTFSFVNVQLFNSLLLRKECCTFSNGEF 1354

  Fly  1420 LSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIG------EWKLKVDDLAAEL------DASQKE 1472
            :.:.:.:|:|...:.|..|..:..:.|...:.:|      ::::..||:..:|      ....:.
plant  1355 VKSGLAELELWCGQVNEYAGPSWDELKHIRQAVGFLVIHQKYRVSYDDIVHDLCPILSVQQLYRI 1419

  Fly  1473 CRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKD 1537
            |..|..:.:..:...:|....:.|:..|..|.||....|||.......:|.||..:..    |||
plant  1420 CTLYWDDCYNTRSVSQEVISSMRALMTEESNDADSNSFLLDDNSSIPFSIDEISNSMH----EKD 1480

  Fly  1538 ELQAALEEAEAALEQEE 1554
              .|:::.|:..||..|
plant  1481 --FASVKPAKELLENPE 1495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/33 (30%)
		MYSc	81..777	CDD:214580	270/707 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	262/676 (39%)
		Myosin_tail_1	842..1897	CDD:279860	160/802 (20%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
XIB	NP_171912.2	Myosin_N	11..48	CDD:280832	10/33 (30%)
		MYSc	57..731	CDD:214580	271/707 (38%)
		MYSc_Myo11	76..720	CDD:276835	262/676 (39%)
		IQ	830..852	CDD:197470	4/21 (19%)
		Tropomyosin	877..1053	CDD:278679	57/230 (25%)
		MyosinXI_CBD	1097..1470	CDD:271259	69/430 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910