DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYA1

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_173201.2	Gene:	MYA1 / 838333	AraportID:	AT1G17580	Length:	1520	Species:	Arabidopsis thaliana

Alignment Length:	1185	Identity:	368/1185 - (31%)
Similarity:	601/1185 - (50%)	Gaps:	159/1185 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEK-----IEDMADMTVLN 98
            |:.|....::.||:....|..|.|..:.|:.      .|..|..||..:     ::||..::.|:
plant    13 WVEDPHLAWIDGEVTRIDGINVHVKTKKGKT------VVTNVYFPKDTEAPSGGVDDMTKLSYLH 71

  Fly    99 TPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGA 162
            .|.||.||..||....||||:|...:|:||::|.| :|.....:.|:|....|:.||:|||.|.|
plant    72 EPGVLRNLETRYELNEIYTYTGNILIAVNPFQRLPHIYETDMMEQYKGIALGELSPHVFAIGDAA 136

  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227
            |..|:....|.|:|::|||||||||.||.::.|.|.:|.....:..     ::|.||:::|||||
plant   137 YRAMINEGKNNSILVSGESGAGKTETTKMLMRYLAFLGGRSGVEGR-----TVEQQVLESNPVLE 196

  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292
            |||||||:||:||||||||:.|.|...|:::||.|.|||||::||......||:||.||.:.:..
plant   197 AFGNAKTLRNNNSSRFGKFVEIQFDKNGRISGAAIRTYLLERSRVCQISDPERNYHCFYLLCAAP 261

  Fly   293 VPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVM 356
            ...:|...|  :|.:.:|.::|.. ..:..:|||.|:..|.:|.|::|.:.:|:|.::|:.||::
plant   262 PEDIKKYKL--ENPHKFHYLNQSSCYKLDGVDDASEYLETRRAMDVVGISNEEQEAIFRVVAAIL 324

  Fly   357 HMGGMKFKQRGREEQ------AEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRN 415
            |:|.:.|   |:.|:      .::|........::|..|:...|...|::..:....|.:|:..:
plant   325 HLGNIDF---GKGEEIDSSVIKDKDSRSHLNMAAELLMCNAQSLEDALIRRVMVTPEEIITRTLD 386

  Fly   416 VQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFT 480
            ......|...|.|.::..||.|:|.|.|.::....:.:..||||||.|||.|:.|.|||.|||||
plant   387 PDNAIASRDTLAKTIYSHLFDWIVNKINTSIGQDPRSKSIIGVLDIYGFESFKCNSFEQFCINFT 451

  Fly   481 NEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATD 544
            ||||||.||.|:|.:|||||.:|.|.|::|:| :|....::||| ||.||:|:|:|..||||:|.
plant   452 NEKLQQHFNQHVFKMEQEEYTKEEIAWSYIEF-IDNQDVLELIEKKPGGIISLLDEACMFPKSTH 515

  Fly   545 QTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQF 609
            :|||:||..| ..:...|.|||..:     ..|.|:||||.|:|....:::||||.:.......|
plant   516 ETFSQKLFQT-FKEHERFAKPKLSR-----TDFTISHYAGEVTYQSNHFIDKNKDYIVAEHQALF 574

  Fly   610 KKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCI 674
            ..|..|.:..:|  ||........:|         |:::.|.:|:||:|||.:|..|:||::|||
plant   575 TASNCKFVAGLF--HALHEDSSRSSK---------FSSIGSRFKQQLHSLMESLNGTEPHYIRCI 628

  Fly   675 IPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKK 739
            .||.:.:||:.:...|:|||.|.||||.|||...|:|.|:.:.||..|:.::.|::|:|...||.
plant   629 KPNNVLKPGIFENFNVIHQLRCGGVLEAIRISCAGYPTRLAFYDFLDRFGLLAPEVLEGNYDDKV 693

  Fly   740 ATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMS------------------- 785
            |.::|:....|.:  |::|.||:|.|||.:.:::..|.|.||....
plant   694 ACQMILDKKSLTD--YQIGKTKIFLRAGQMAELDARRAEVLGNAARVIQRQFRTCMARKNYRSIR 756

  Fly   786 ----WMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIED 846
                .:|::.||.::|...|||:.:..||: ||:|.|:|:..:::    :..:...::..:.:..
plant   757 NAAIVLQSFLRGEIARAVHKKLRIEAAALR-VQKNFRRYVDRKSF----VTTRSSTIVLQTGLRA 816

  Fly   847 EIARLE---EKAKKAEELHAAEVKVRKELE--------------ALNAKLLAEKTALLDSLSGEK 894
            .|||.|   .:.:||..:..|..:.|:...              |...:|...:..:|...:.:.
plant   817 MIARSEFRLRRQRKAAIVLQAHWRGRQAFSYYTRLQKAAIVTQCAWRCRLARRELRMLKMAARDT 881

  Fly   895 GALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELN 959
            |||:|          .||.||.::.::..||..|:..|..|.:.|.   ||::.|::.:..:.|.
plant   882 GALKD----------AKNKLEQRVEELSLRLHLEKRLRTDLEEAKV---QEVAKLQEALHTMRLQ 933

  Fly   960 VQKA------EQDKA----------TKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEE 1008
            :::.      ||:.|          .|:..:....::|   |.|.|::::.|.:......|..|.
plant   934 LKETTAMVVKEQEAARVAIEEASSVNKEPVVVEDTEKI---DSLSNEIDRLKGLLSSETHKADEA 995

  Fly  1009 LQAAEDKINHLNKVKAKLEQT---LDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLER 1070
            ..|.:..:....::..|||:.   :|:|:||::|                     .||.|..||.
plant   996 QHAYQSALVQNEELCKKLEEAGRKIDQLQDSVQR---------------------FQEKVFSLES 1039

  Fly  1071 NKKELEQ---TIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAE 1132
            ..|.|.|   ||....:.|:     |..:..::.:...:.........:|:|....:|..::..:
plant  1040 ENKVLRQQTLTISPTTRALA-----LRPKTTIIQRTPEKDTFSNGETTQLQEPETEDRPQKSLNQ 1099

  Fly  1133 KQRADLARELEELGE 1147
            ||:.:....|:.:.|
plant  1100 KQQENQELLLKSISE 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/33 (24%)
		MYSc	81..777	CDD:214580	272/709 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	264/673 (39%)
		Myosin_tail_1	842..1897	CDD:279860	68/345 (20%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
MYA1	NP_173201.2	Myosin_N	9..47	CDD:397036	9/39 (23%)
		MYSc_Myo11	73..717	CDD:276835	264/673 (39%)
		IQ	850..872	CDD:197470	2/21 (10%)
		Smc	<867..>1114	CDD:224117	57/288 (20%)
		MyosinXI_CBD	1099..1486	CDD:271259	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910