DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and XIC

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_172349.2 Gene:XIC / 837394 AraportID:AT1G08730 Length:1538 Species:Arabidopsis thaliana


Alignment Length:1621 Identity:454/1621 - (28%)
Similarity:733/1621 - (45%) Gaps:321/1621 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 WIPDEKEGYLLGEIKATKG-DIVSVGLQGGEVRDIKSEKVEKVNPPKFEK----IEDMADMTVLN 98
            |..|.:..::.||::...| ::|.....|.:|    :.|:.|:.|...|.    ::||..::.|:
plant    22 WFEDPEVAWIDGEVEKINGQEVVIQATTGKKV----TAKLSKIYPKDVEAPAGGVDDMTKLSYLH 82

  Fly    99 TPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGA 162
            .|.||.||:.||....||||:|...:||||::|.| :|.....:.|:|....|:.||:||::|.|
plant    83 EPGVLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPLGELSPHVFAVADVA 147

  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227
            |..|:....:.|:|::|||||||||.||.::.|.|.:|....|:..     ::|.||:::|||||
plant   148 YRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRAVTEGR-----TVEQQVLESNPVLE 207

  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292
            ||||||||||:||||||||:.|.|...|:::||.|.|||||::||......||:||.||.:.:..
plant   208 AFGNAKTVRNNNSSRFGKFVEIQFDKQGRISGAAIRTYLLERSRVCQISDPERNYHCFYLLCAAP 272

  Fly   293 VPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVM 356
            ...::...|  .:...:|.::|.| ..:..|.||.::..|.:|.||:|.:::|:|.::|:.||::
plant   273 QEEIEKYKL--GHPKTFHYLNQSKCFELVGISDAHDYLATRRAMDIVGISEKEQEAIFRVVAAIL 335

  Fly   357 HMGGMKFKQRGREEQAEQDGEEEG----GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ 417
            |:|.:.| .:|:|..:....:|:.    ...::|..||...|...|.|..:....|.:.:..:.|
plant   336 HIGNIDF-TKGKEVDSSVPKDEKSKFHLKTAAELLMCDLKALEDALCKRVMITPEEVIKRSLDPQ 399

  Fly   418 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNE 482
            ....|...|.|.|:.|||.|||.|.|:::......:..||||||.|||.|:.|.|||.|||||||
plant   400 SAVTSRDGLAKTVYSRLFDWLVDKINKSIGQDANSRSLIGVLDIYGFESFKTNSFEQFCINFTNE 464

  Fly   483 KLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQT 546
            ||||.||.|:|.:|||||.:|.|||::|:| :|....:|||| ||.||:::|:|..||||:|.:|
plant   465 KLQQHFNQHVFKMEQEEYTKEAIDWSYIEF-VDNQDVLDLIEKKPGGIVALLDEACMFPKSTHET 528

  Fly   547 FSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611
            |:.||..| ......|.|||..:     ..||:|||||.|.|....:|:||||.:.....|....
plant   529 FANKLYQT-FKTHKRFIKPKLSR-----TDFAVAHYAGEVLYQSELFLDKNKDYVIPEHQDLLGA 587

  Fly   612 SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIP 676
            |:...::.:|.....::           .|...|:::.|.:|.||..||.||..|:||::||:.|
plant   588 SKCPFVVGLFPPLPEET-----------SKSSKFSSIGSRFKLQLQQLMETLNCTEPHYIRCVKP 641

  Fly   677 NEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKAT 741
            |.:.:|.:.:...:|.||.|.||||.|||...|:|.|..:.:|..|:.::.|..|:|...:|.|.
plant   642 NNLLKPAIFENVNIMQQLRCGGVLEAIRISCAGYPTRKPFFEFINRFGLLSPAALEGNFDEKVAC 706

  Fly   742 EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLG-----------------------KI 783
            :.|:..:.|  ..|::|.||||.|||.:.:::..|.|.|.                       |.
plant   707 QKILDNMGL--KGYQIGKTKVFLRAGQMAELDARRAEVLSSAAKKIQRRIRTHQAQKRFIVLRKA 769

  Fly   784 MSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEI 848
            ...:||..||.||.|.:..|:.:..|:|:.:...|.|                     ||     
plant   770 TISLQAICRGRLSCKHYDNLRREAAAVKIQKNGRRHY---------------------SR----- 808

  Fly   849 ARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913
                   |..::||.|.:.|:..|.|:.|:.                                  
plant   809 -------KSYKKLHVASLVVQTGLRAMAARK---------------------------------- 832

  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978
                    |.|..::..|.. :.|.:.:..:.||..||                      ::|  
plant   833 --------QFRFRKQTKAAT-IVQAQWRCHRAISYYKK----------------------LKN-- 864

  Fly   979 DEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043
                      ..:..:.:.:|...::...:|:.|..:...|.:.|..||:.::||...::.||:.
plant   865 ----------GVVLSQTRWRGRLAKRELRKLKMAARETGALKEAKDMLEKKVEELTYRVQLEKRS 919

  Fly  1044 RGDVEKSKRKVEGDLKLTQEAV---ADLERNKKELEQT--IQRKDKELSSITAKLEDEQVVVLKH 1103
            |||:|::|         |||.:   :..|..:|::::|  :..|::|.:.   |..:|...|:|.
plant   920 RGDLEEAK---------TQEILKLKSSFEEMRKKVDETNALLLKEREAAK---KAAEEAPPVIKE 972

  Fly  1104 QRQIKELQARIEELEEEVEAERQARAKAEKQRADLA-RELEELGERLEEAGGATSAQIELNKKRE 1167
            .:.:.|...:||.:.||:|:.: ...:.||||||.| |:.||..|.||:           .||:.
plant   973 TQILVEDTKKIELMTEELESVK-VTLENEKQRADDAVRKFEEAQESLED-----------KKKKL 1025

  Fly  1168 AELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKL---KAKAEKEKNEYYGQLN- 1228
            .|..|..:.|:|:..:.|...:|| :..|..:.:.|..:.. ||.   ::::..::....|.|. 
plant  1026 EETEKKGQQLQESLTRMEEKCSNL-ESENKVLRQQAVSMAP-NKFLSGRSRSILQRGSESGHLAV 1088

  Fly  1229 DLRAGVD---HITNEKAAQEKIAKQLQHTLNEVQSKLDET-------------NRTL-------- 1269
            |.|:.:|   |..|.:...| :..:.|.:|||.|.:..:.             ||.:        
plant  1089 DARSNLDLHSHSINHRDPSE-VEDKPQKSLNEKQQENQDLLIRSIVQHLGFQGNRPITACIIYKC 1152

  Fly  1270 ----NDFDASKKKL----------SIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADE 1320
                ..|:..:..:          :||..|....|....|..|.| .:.:..|.:......:|.:
plant  1153 LLQWRSFEVERTSVFDRIIQTIGHAIETQDNNNTLAYWLSNTSTL-LLLLQRTLKASGAAGMAPQ 1216

  Fly  1321 ESR-ERATLLGK----FRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVA 1380
            ..| ..|||.|:    ||.....: || ..:...|.|.||..||:          .:||.:  :.
plant  1217 RRRSSSATLFGRMSQSFRGAPPGV-NL-AMINGAAGGGADTFRQV----------EAKYPA--LL 1267

  Fly  1381 RSEELEEAKRKLQARLAE-AEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKK 1444
            ..::|.....|:...:.: .::.|..|...||...:|.:        ..|....:.::.|.|   
plant  1268 FKQQLTAYVEKIYGMIRDNLKKEISPLLGLCIQAPRTSR--------ASLVKGASRSVGNTA--- 1321

  Fly  1445 QKAFDKIIGEWKLKVDDLAAELDASQKE------CRNYSTELFRL-------------------K 1484
              |...:|..|:..|..|...|:..:..      .|...|::|..                   .
plant  1322 --AQQALIAHWQGIVKSLTNFLNTLKSNNVPSFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSN 1384

  Fly  1485 GAY-EEGQEQLE-----AVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDEL 1539
            |.| :.|..:||     |......:..||:|.:...|  |...:|  :|.:|.|:....:|
plant  1385 GEYVKAGLSELEHWCFKATNEYAGSSWDELKHIRQAI--GFLVVH--QKPKKTLDEISHDL 1441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/34 (24%)
MYSc 81..777 CDD:214580 272/706 (39%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 264/671 (39%)
Myosin_tail_1 842..1897 CDD:279860 156/783 (20%)
V_Alix_like 1557..1877 CDD:187408
ATP-synt_B <1671..1771 CDD:304375
TMPIT 1739..>1825 CDD:285135
XICNP_172349.2 Myosin_N 19..56 CDD:280832 8/37 (22%)
MYSc 71..739 CDD:214580 270/695 (39%)
MYSc_Myo11 84..728 CDD:276835 264/671 (39%)
Rabaptin 726..>1055 CDD:281520 96/463 (21%)
MyosinXI_CBD 1119..1504 CDD:271259 66/355 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - mtm946
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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