Protein Alignment Mhc and XIC

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_172349.2
• Gene: XIC / 837394
• AraportID: AT1G08730
• Length: 1538
• Species: Arabidopsis thaliana
• Alignment Length: 1618
• Identity: 455/1618 - (28%)
• Similarity: 732/1618 - (45%)
• Gaps: 315/1618 - (19%)

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGE--TRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDAS 101
            |..|.:..::.||::...|..|.:....|:  |..|.|...:.|..|. ...:||:.|:||::..
plant    22 WFEDPEVAWIDGEVEKINGQEVVIQATTGKKVTAKLSKIYPKDVEAPA-GGVDDMTKLSYLHEPG 85

  Fly   102 VLHNLRQRYYNKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGAYVD 165
            ||.||:.||....||||:|...:||||::|.| :|.....:.|:|....|:.||:||::|.||..
plant    86 VLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPLGELSPHVFAVADVAYRA 150

  Fly   166 MLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFG 230
            |:....:.|:|::|||||||||.||.::.|.|.:|....|:..     ::|.||:::||||||||
plant   151 MINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRAVTEGR-----TVEQQVLESNPVLEAFG 210

  Fly   231 NAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPG 295
            |||||||:||||||||:.|.|...|:::||.|.|||||::||......||:||.||.:.:.....
plant   211 NAKTVRNNNSSRFGKFVEIQFDKQGRISGAAIRTYLLERSRVCQISDPERNYHCFYLLCAAPQEE 275

  Fly   296 VKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMG 359
            ::...|  .:...:|.::|.| ..:..|.||.::..|.:|.||:|.:::|:|.::|:.||::|:|
plant   276 IEKYKL--GHPKTFHYLNQSKCFELVGISDAHDYLATRRAMDIVGISEKEQEAIFRVVAAILHIG 338

  Fly   360 GMKFKQRGREEQAEQDGEEEG----GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVT 420
            .:.| .:|:|..:....:|:.    ...::|..||...|...|.|..:....|.:.:..:.|...
plant   339 NIDF-TKGKEVDSSVPKDEKSKFHLKTAAELLMCDLKALEDALCKRVMITPEEVIKRSLDPQSAV 402

  Fly   421 NSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQ 485
            .|...|.|.|:.|||.|||.|.|:::......:..||||||.|||.|:.|.|||.||||||||||
plant   403 TSRDGLAKTVYSRLFDWLVDKINKSIGQDANSRSLIGVLDIYGFESFKTNSFEQFCINFTNEKLQ 467

  Fly   486 QFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKATDQTFSE 549
            |.||.|:|.:|||||.:|.|:|::|:| :|.|..:|||| ||.||:::|:|..||||:|.:||:.
plant   468 QHFNQHVFKMEQEEYTKEAIDWSYIEF-VDNQDVLDLIEKKPGGIVALLDEACMFPKSTHETFAN 531

  Fly   550 KLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQN 614
            ||..| ......|.|||..:     ..||:|||||.|.|....:|:||||.:.....|....|:.
plant   532 KLYQT-FKTHKRFIKPKLSR-----TDFAVAHYAGEVLYQSELFLDKNKDYVIPEHQDLLGASKC 590

  Fly   615 KLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEM 679
            ..::.:|.....::           .|...|:::.|.:|.||..||.||..|:||::||:.||.:
plant   591 PFVVGLFPPLPEET-----------SKSSKFSSIGSRFKLQLQQLMETLNCTEPHYIRCVKPNNL 644

  Fly   680 KQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEII 744
            .:|.:.:...:|.||.|.||||.|||...|:|.|..:.:|..|:.::.|..|:|...:|.|.:.|
plant   645 LKPAIFENVNIMQQLRCGGVLEAIRISCAGYPTRKPFFEFINRFGLLSPAALEGNFDEKVACQKI 709

  Fly   745 IKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLG-----------------------KIMSW 786
            :..:.|  ..|::|.||||.|||.:.:::..|.|.|.                       |....
plant   710 LDNMGL--KGYQIGKTKVFLRAGQMAELDARRAEVLSSAAKKIQRRIRTHQAQKRFIVLRKATIS 772

  Fly   787 MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL 851
            :||..||.||.|.:..|:.:..|:|:.:...|.|                     ||
plant   773 LQAICRGRLSCKHYDNLRREAAAVKIQKNGRRHY---------------------SR-------- 808

  Fly   852 EEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLEN 916
                |..::||.|.:.|:..|.|:.|:.
plant   809 ----KSYKKLHVASLVVQTGLRAMAARK------------------------------------- 832

  Fly   917 QLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEI 981
                 |.|..::..|.. :.|.:.:..:.||..||                      ::|
plant   833 -----QFRFRKQTKAAT-IVQAQWRCHRAISYYKK----------------------LKN----- 864

  Fly   982 AHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGD 1046
                   ..:..:.:.:|...::...:|:.|..:...|.:.|..||:.::||...::.||:.|||
plant   865 -------GVVLSQTRWRGRLAKRELRKLKMAARETGALKEAKDMLEKKVEELTYRVQLEKRSRGD 922

  Fly  1047 VEKSKRKVEGDLKLTQEAV---ADLERNKKELEQT--IQRKDKELSSITAKLEDEQVVVLKHQRQ 1106
            :|::|         |||.:   :..|..:|::::|  :..|::|.:.   |..:|...|:|..:.
plant   923 LEEAK---------TQEILKLKSSFEEMRKKVDETNALLLKEREAAK---KAAEEAPPVIKETQI 975

  Fly  1107 IKELQARIEELEEEVEAERQARAKAEKQRADLA-RELEELGERLEEAGGATSAQIELNKKREAEL 1170
            :.|...:||.:.||:|:.: ...:.||||||.| |:.||..|.||:           .||:..|.
plant   976 LVEDTKKIELMTEELESVK-VTLENEKQRADDAVRKFEEAQESLED-----------KKKKLEET 1028

  Fly  1171 SKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKL---KAKAEKEKNEYYGQLN-DLR 1231
            .|..:.|:|:..:.|...:|| :..|..:.:.|..:.. ||.   ::::..::....|.|. |.|
plant  1029 EKKGQQLQESLTRMEEKCSNL-ESENKVLRQQAVSMAP-NKFLSGRSRSILQRGSESGHLAVDAR 1091

  Fly  1232 AGVD---HITNEKAAQEKIAKQLQHTLNEVQSKLDET-------------NRTL----------- 1269
            :.:|   |..|.:...| :..:.|.:|||.|.:..:.             ||.:
plant  1092 SNLDLHSHSINHRDPSE-VEDKPQKSLNEKQQENQDLLIRSIVQHLGFQGNRPITACIIYKCLLQ 1155

  Fly  1270 -NDFDASKKKL----------SIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESR 1323
             ..|:..:..:          :||..|....|....|..|.| .:.:..|.:......:|.:..|
plant  1156 WRSFEVERTSVFDRIIQTIGHAIETQDNNNTLAYWLSNTSTL-LLLLQRTLKASGAAGMAPQRRR 1219

  Fly  1324 -ERATLLGK----FRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSE 1383
             ..|||.|:    ||.....: || ..:...|.|.||..||:          .:||.:  :...:
plant  1220 SSSATLFGRMSQSFRGAPPGV-NL-AMINGAAGGGADTFRQV----------EAKYPA--LLFKQ 1270

  Fly  1384 ELEEAKRKLQARLAE-AEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKA 1447
            :|.....|:...:.: .::.|..|...||...:|.:        ..|....:.::.|.|     |
plant  1271 QLTAYVEKIYGMIRDNLKKEISPLLGLCIQAPRTSR--------ASLVKGASRSVGNTA-----A 1322

  Fly  1448 FDKIIGEWKLKVDDLAAELDASQKE------CRNYSTELFRL-------------------KGAY 1487
            ...:|..|:..|..|...|:..:..      .|...|::|..                   .|.|
plant  1323 QQALIAHWQGIVKSLTNFLNTLKSNNVPSFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEY 1387

  Fly  1488 -EEGQEQLE-----AVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDEL 1539
             :.|..:||     |......:..||:|.:...|  |...:|  :|.:|.|:....:|
plant  1388 VKAGLSELEHWCFKATNEYAGSSWDELKHIRQAI--GFLVVH--QKPKKTLDEISHDL 1441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	9/37 (24%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	263/671 (39%)
		Myosin_tail_1	842..1922	CDD:460256	156/783 (20%)
XIC	NP_172349.2	Myosin_N	16..60	CDD:460670	9/37 (24%)
		MYSc_Myo11	84..728	CDD:276835	263/671 (39%)
		DUF5401	<747..1058	CDD:375164	89/445 (20%)
		MyosinXI_CBD	1119..1504	CDD:271259	66/355 (19%)