Protein Alignment Mhc and ATM2

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001078755.1
• Gene: ATM2 / 835516
• AraportID: AT5G54280
• Length: 1220
• Species: Arabidopsis thaliana
• Alignment Length: 1303
• Identity: 401/1303 - (30%)
• Similarity: 620/1303 - (47%)
• Gaps: 266/1303 - (20%)

  Fly     4 PVANQEDEDPTPYLF--VSLEQRRIDQSKP---------YDSKKS--CWIPDEKEGYLLGEIKAT 55
            |.|.:::|:......  |||.:...:.:||         |..||.  .|.......:.||:|::|
plant   118 PYAAEKEEEGVKISIAKVSLVENTEEHNKPESEWNNNVEYFIKKKLRVWCRVSNGQWQLGKIQST 182

  Fly    56 KGDIVSVGLQGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSG 120
            ..|...|.|.......:..:.|...||...|..||:..|:|||:.|||:|||.||...:||:.:|
plant   183 SADTSLVMLSTANVVKVSTEELFPANPDILEGVEDLIQLSYLNEPSVLYNLRVRYLQDVIYSKAG 247

  Fly   121 LFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGK 185
            ...:|:||:|...:|.|.....|:.|..:  .||::|::|.||.:|:....|||::|:|||||||
plant   248 PVLIAVNPFKNVEIYGNDVISAYQKKVMD--APHVYAVADAAYDEMMREEKNQSLIISGESGAGK 310

  Fly   186 TENTKKVIAYFATVGASKKTDEAAKSKGS--LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIR 248
            ||..|..:.|.|.:|.           ||  :|.::::|..:|||||||||.||.|||||||.|.
plant   311 TETAKFAMQYLAALGG-----------GSCGVEYEILKTTCILEAFGNAKTSRNANSSRFGKLIE 364

  Fly   249 IHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKD-ICLLTDNIYDYHIV 312
            |||...||:.||.:||:||||:||:...:.||||||||::.:|:.|.:|: :.|.|.:.|.|  :
plant   365 IHFSAMGKICGAKLETFLLEKSRVVQLFNGERSYHIFYELCAGASPILKERLKLKTASEYTY--L 427

  Fly   313 SQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDG 376
            ||.. :|:|.:|||::|....:||||:...|:.:|..:.:.|||:.:|.:.|:....|...|...
plant   428 SQSDCLTIAGVDDAQKFHKLLEAFDIVQIPKEHQERAFALLAAVLWLGNVSFRVTDNENHVEVVA 492

  Fly   377 EEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKK 441
            :|.....:.|.||:|.||...|...:::.|.:.:.:...::|.|:....:.|.::..||.|||::
plant   493 DEAVANAAMLMGCNTEELMVVLSTRKLQAGTDCIAKKLTLRQATDMRDGIAKFIYANLFDWLVEQ 557

  Fly   442 CNETLDTQQKRQ-HFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGI 505
            .|..|:..:.|. ..|.:|||.|||.|:.|.|||.|||:.||:|||.||.|:|.||||||:.:||
plant   558 INIALEVGKSRTGRSISILDIYGFESFKNNSFEQFCINYANERLQQHFNRHLFKLEQEEYEEDGI 622

  Fly   506 EWTFIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPK 569
            :||.::| :|.|.|:|||| ||:|:||:|:|||.||||||.||:.|| ..||..::.|:
plant   623 DWTKVEF-VDNQECLDLIEKKPIGLLSLLDEESNFPKATDLTFANKL-KQHLKTNSCFK------ 679

  Fly   570 PGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFK----------------KSQNKLLI 618
             |::...|.:.||||.|.|:..|:||||:|||...:::...                |||..|::
plant   680 -GERGRAFRVNHYAGEVLYDTNGFLEKNRDPLPADLINLLSSCDCQLLKLFSTKMRGKSQKPLML 743

  Fly   619 EIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPG 683
               :|...|                   ||.:.:|.||..||..|.:|.|||:|||.||..:.|.
plant   744 ---SDSTNQ-------------------TVGTKFKGQLFKLMNKLENTSPHFIRCIKPNSKQLPR 786

  Fly   684 VVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATE------ 742
            |.:..||:.||.|.||||.:||.|.|:|.|:.:.:|..||..:.        .|||..:
plant   787 VYEEDLVLQQLRCCGVLEVVRISRSGYPTRLTHQEFAGRYGFLL--------SDKKVAQDPLSVS 843

  Fly   743 -IIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQ 806
             .::|..|:..:.|::|.||::.|.|.:|..|:.|.:.|..|:. :|...||:|||..|:.:::.
plant   844 IAVLKQYDVHPEMYQVGYTKLYLRTGQIGIFEDRRKKVLQGIVG-LQKHFRGHLSRAYFQNMRKV 907

  Fly   807 RVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIAR--LEEKAKKAEELHAAEVKVR 869
            .:.|:                              |.|..|.||  .:.:||    .||..|.
plant   908 TLVLQ------------------------------SYIRGENARRLFDTEAK----FHADSVS-- 936

  Fly   870 KELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQK--NDLENQLRDIQERLTQEEDAR 932
               ||...:|    :|::...|..:|.|           |:|  |.::.|           ::.|
plant   937 ---EASTDEL----SAVIHLQSAVRGWL-----------ARKHFNSMQRQ-----------KELR 972

  Fly   933 NQLFQQKKKADQEISGLKKDIEDLELNVQKAE-QDKATKDHQIRNLNDEIAHQDELINKLNKEKK 996
            |...:.|:||.:.||      ||.::.:::.: |..:..|.|.|.|..|.|        |::::
plant   973 NVATKSKRKAGRRIS------EDKDIPLEQPQVQPTSMSDLQKRILKSEAA--------LSQKE- 1022

  Fly   997 MQGETNQKTGEELQAAEDKINHLNKVKAKLEQT----LDELEDSLEREKKVRGDVEKSKRKVEGD 1057
               |.|....|:|:..|::.:..:.....:|:|    :..|:.||...:|
plant  1023 ---EENTALREQLRQFEERWSEYDIKMKSMEETWQKQMSSLQMSLAAARK--------------- 1069

  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQR---------QIKELQAR 1113
             .|..|::..         |...|:|..:|......||.........|         ...||  |
plant  1070 -SLAAESITG---------QAGGRQDTSISPFGYDSEDTMSTGTPGVRTPTNKFTNGNTPEL--R 1122

  Fly  1114 IEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLE 1178
            |.||...:.|...           ||||.:               |..||...:|      |.:.
plant  1123 IRELNGSLNAVNH-----------LAREFD---------------QRRLNFDEDA------RAIV 1155

  Fly  1179 EANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAA 1243
            |..:..::|....:::|.:         |:..:||.:.|..|.:|..:|.|.:|.:..:..:|..
plant  1156 EVKLGPQATPNGQQQQHPE---------DEFRRLKLRFETWKKDYKARLRDTKARLHRVDGDKGR 1211

  Fly  1244 QEK 1246
            ..|
plant  1212 HRK 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	10/43 (23%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	269/693 (39%)
		Myosin_tail_1	842..1922	CDD:460256	88/423 (21%)
ATM2	NP_001078755.1	MYSc_Myo8	227..867	CDD:276834	269/693 (39%)
		IQ	944..962	CDD:459869	6/28 (21%)
		MAD	963..>1060	CDD:461677	26/125 (21%)