DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and ATM2

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001078755.1	Gene:	ATM2 / 835516	AraportID:	AT5G54280	Length:	1220	Species:	Arabidopsis thaliana

Alignment Length:	1303	Identity:	399/1303 - (30%)
Similarity:	620/1303 - (47%)	Gaps:	266/1303 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PVANQEDEDPTPYLF--VSLEQRRIDQSKP---------YDSKKS--CWIPDEKEGYLLGEIKAT 55
            |.|.:::|:......  |||.:...:.:||         |..||.  .|.......:.||:|::|
plant   118 PYAAEKEEEGVKISIAKVSLVENTEEHNKPESEWNNNVEYFIKKKLRVWCRVSNGQWQLGKIQST 182

  Fly    56 KGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSG 120
            ..|...|.|....|..:.:|::...||...|.:||:..::.||.|.||:|||.||...:||:.:|
plant   183 SADTSLVMLSTANVVKVSTEELFPANPDILEGVEDLIQLSYLNEPSVLYNLRVRYLQDVIYSKAG 247

  Fly   121 LFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGK 185
            ...:|:||:|...:|.|.....|:.|..:  .||::|::|.||.:|:....|||::|:|||||||
plant   248 PVLIAVNPFKNVEIYGNDVISAYQKKVMD--APHVYAVADAAYDEMMREEKNQSLIISGESGAGK 310

  Fly   186 TENTKKVIAYFATVGASKKTDEAAKSKGS--LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIR 248
            ||..|..:.|.|.:|.           ||  :|.::::|..:|||||||||.||.|||||||.|.
plant   311 TETAKFAMQYLAALGG-----------GSCGVEYEILKTTCILEAFGNAKTSRNANSSRFGKLIE 364

  Fly   249 IHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKD-ICLLTDNIYDYHIV 312
            |||...||:.||.:||:||||:||:...:.||||||||::.:|:.|.:|: :.|.|.:.|.|  :
plant   365 IHFSAMGKICGAKLETFLLEKSRVVQLFNGERSYHIFYELCAGASPILKERLKLKTASEYTY--L 427

  Fly   313 SQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDG 376
            ||.. :|:|.:|||::|....:||||:...|:.:|..:.:.|||:.:|.:.|:....|...|...
plant   428 SQSDCLTIAGVDDAQKFHKLLEAFDIVQIPKEHQERAFALLAAVLWLGNVSFRVTDNENHVEVVA 492

  Fly   377 EEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKK 441
            :|.....:.|.||:|.||...|...:::.|.:.:.:...::|.|:....:.|.::..||.|||::
plant   493 DEAVANAAMLMGCNTEELMVVLSTRKLQAGTDCIAKKLTLRQATDMRDGIAKFIYANLFDWLVEQ 557

  Fly   442 CNETLDTQQKRQ-HFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGI 505
            .|..|:..:.|. ..|.:|||.|||.|:.|.|||.|||:.||:|||.||.|:|.||||||:.:||
plant   558 INIALEVGKSRTGRSISILDIYGFESFKNNSFEQFCINYANERLQQHFNRHLFKLEQEEYEEDGI 622

  Fly   506 DWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPK 569
            ||..::| :|...|:|||| ||:|:||:|:|||.||||||.||:.|| ..||..::.|:
plant   623 DWTKVEF-VDNQECLDLIEKKPIGLLSLLDEESNFPKATDLTFANKL-KQHLKTNSCFK------ 679

  Fly   570 PGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFK----------------KSQNKLLI 618
             |::...|.:.||||.|.|:..|:||||:|||...:::...                |||..|::
plant   680 -GERGRAFRVNHYAGEVLYDTNGFLEKNRDPLPADLINLLSSCDCQLLKLFSTKMRGKSQKPLML 743

  Fly   619 EIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPG 683
               :|...|                   ||.:.:|.||..||..|.:|.|||:|||.||..:.|.
plant   744 ---SDSTNQ-------------------TVGTKFKGQLFKLMNKLENTSPHFIRCIKPNSKQLPR 786

  Fly   684 VVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATE------ 742
            |.:..||:.||.|.||||.:||.|.|:|.|:.:.:|..||..:.        .|||..:
plant   787 VYEEDLVLQQLRCCGVLEVVRISRSGYPTRLTHQEFAGRYGFLL--------SDKKVAQDPLSVS 843

  Fly   743 -IIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQ 806
             .::|..|:..:.|::|.||::.|.|.:|..|:.|.:.|..|:. :|...||:|||..|:.:::.
plant   844 IAVLKQYDVHPEMYQVGYTKLYLRTGQIGIFEDRRKKVLQGIVG-LQKHFRGHLSRAYFQNMRKV 907

  Fly   807 RVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIAR--LEEKAKKAEELHAAEVKVR 869
            .:.|:                              |.|..|.||  .:.:||    .||..|.
plant   908 TLVLQ------------------------------SYIRGENARRLFDTEAK----FHADSVS-- 936

  Fly   870 KELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQK--NDLENQLRDIQERLTQEEDAR 932
               ||...:|    :|::...|..:|.|           |:|  |.::.|           ::.|
plant   937 ---EASTDEL----SAVIHLQSAVRGWL-----------ARKHFNSMQRQ-----------KELR 972

  Fly   933 NQLFQQKKKADQEISGLKKDIEDLELNVQKAE-QDKATKDHQIRNLNDEIAHQDELINKLNKEKK 996
            |...:.|:||.:.||      ||.::.:::.: |..:..|.|.|.|..|.|        |::::
plant   973 NVATKSKRKAGRRIS------EDKDIPLEQPQVQPTSMSDLQKRILKSEAA--------LSQKE- 1022

  Fly   997 MQGETNQKTGEELQAAEDKINHLNKVKAKLEQT----LDELEDSLEREKKVRGDVEKSKRKVEGD 1057
               |.|....|:|:..|::.:..:.....:|:|    :..|:.||...:|
plant  1023 ---EENTALREQLRQFEERWSEYDIKMKSMEETWQKQMSSLQMSLAAARK--------------- 1069

  Fly  1058 LKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQR---------QIKELQAR 1113
             .|..|::..         |...|:|..:|......||.........|         ...||  |
plant  1070 -SLAAESITG---------QAGGRQDTSISPFGYDSEDTMSTGTPGVRTPTNKFTNGNTPEL--R 1122

  Fly  1114 IEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLE 1178
            |.||...:.|...           ||||.:               |..||...:|      |.:.
plant  1123 IRELNGSLNAVNH-----------LAREFD---------------QRRLNFDEDA------RAIV 1155

  Fly  1179 EANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAA 1243
            |..:..::|....:::|.:         |:..:||.:.|..|.:|..:|.|.:|.:..:..:|..
plant  1156 EVKLGPQATPNGQQQQHPE---------DEFRRLKLRFETWKKDYKARLRDTKARLHRVDGDKGR 1211

  Fly  1244 QEK 1246
            ..|
plant  1212 HRK 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	10/38 (26%)
		MYSc	81..777	CDD:214580	279/724 (39%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	268/693 (39%)
		Myosin_tail_1	842..1897	CDD:279860	88/423 (21%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
ATM2	NP_001078755.1	MYSc	208..879	CDD:214580	279/724 (39%)
ATM2	NP_001078755.1	MYSc_Myo8	227..867	CDD:276834	268/693 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I246
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960