DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and XIK

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001318612.1	Gene:	XIK / 832171	AraportID:	AT5G20490	Length:	1531	Species:	Arabidopsis thaliana

Alignment Length:	1599	Identity:	446/1599 - (27%)
Similarity:	752/1599 - (47%)	Gaps:	280/1599 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGE-----VRDIKSEKVEKVNPPKFEKIEDMADMTVLN 98
            ||.|....::.||:....|:.|......|:     :.::..:..|.  ||  ..::||..::.|:
plant    14 WIEDPGAAWIDGEVVKINGEEVHAHTTNGKTVVANIANVFPKDTEA--PP--GGVDDMTKLSYLH 74

  Fly    99 TPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGA 162
            .|.||:||..||....||||:|...:|:||::|.| :|.....:.|:|....|:.||:|||::.|
plant    75 EPGVLNNLAMRYELNEIYTYTGNILIAVNPFQRLPHLYDTHMMEQYKGAGFGELSPHVFAIAEVA 139

  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227
            |..|:....:.|:|::|||||||||.||.::.|.|.:|.....:..     ::|.||:::|||||
plant   140 YRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRSGVEGR-----TVEQQVLESNPVLE 199

  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGS 292
            |||||||:||:||||||||:.:.|...|:::||.:.|||||::||......||:||.|| ::..:
plant   200 AFGNAKTLRNNNSSRFGKFVELQFDNCGRISGAAVRTYLLERSRVCQISDPERNYHCFY-LLCAA 263

  Fly   293 VPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVM 356
            .|..::...|.|... :|.::|.| ..:..:||.||:..|.:|.||:|.:::|::.::|:.||::
plant   264 PPEEREKFKLGDPKL-FHYLNQSKCYKLDGVDDTEEYLATRRAMDIVGISEEEQDAIFRVVAAIL 327

  Fly   357 HMGGMKFKQRGREEQAEQDGEEEG----GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ 417
            |:|.:.| .:|:|..:....:|:.    ...::|..||..::...|:|..:....|.:|:..:..
plant   328 HLGNVNF-AKGKEIDSSVLKDEKSRYHLDVCAELLRCDAKKMEDALIKRVMVTPEEVITRTLDPD 391

  Fly   418 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNE 482
            ..|.|..||.|.::.|||.|||.|.|.::......:..||||||.|||.|:.|.|||.|||||||
plant   392 SATGSRDALAKTIYSRLFDWLVDKINNSIGQDPNSKTIIGVLDIYGFESFKINSFEQFCINFTNE 456

  Fly   483 KLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQT 546
            ||||.||.|:|.:|||:|.:|.|:|::|:| :|....::||| ||.|::::|:|..||||:|.:|
plant   457 KLQQHFNQHVFKMEQEDYTKEEINWSYIEF-VDNKDVLELIEKKPGGVIALLDEACMFPKSTHET 520

  Fly   547 FSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611
            |::||..|...... |.|||..:     ..|||:||||.|:|....:|:||||.:.....|....
plant   521 FAQKLYQTFKNYKR-FTKPKLSR-----TSFAISHYAGEVTYQADLFLDKNKDYVVAEHQDLLIA 579

  Fly   612 SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIP 676
            |.:..:..:|.....::....:           |:::.|.:|.||.|||.||.||:||::||:.|
plant   580 SSDTFVAGLFPRLPEETSSKTK-----------FSSIGSRFKLQLQSLMETLSSTEPHYIRCVKP 633

  Fly   677 NEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKAT 741
            |.:.:|.:.:...|:.||.|.||||.|||...|:|.:..:.:|..|:.::.|::|:|...||.|.
plant   634 NNVLKPAIFENVNVIQQLRCGGVLEAIRISCAGYPTKRTFYEFLNRFGVLAPEVLEGNYDDKVAC 698

  Fly   742 EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQ 806
            ::::..|.|  ..|.||.||||.|||.:.:::..|.|.||.....:|..:|.:::.|.|:.|
plant   699 KMLLDKIGL--KGYELGKTKVFLRAGQMAELDARRAEVLGNAARRIQRQSRTFIACKEFRAL--- 758

  Fly   807 RVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKE 871
            |.|..|:|.|.|..|                   ...:.:|:.|           .||.||::|
plant   759 RGAAIVLQSNCRGKL-------------------ACNLYEEMRR-----------QAAAVKIQK- 792

  Fly   872 LEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQL- 935
               :..:.:|.::.|              :.|::.:|.|     ..||.:.        |||:.
plant   793 ---IFRRHIARESYL--------------RIRHSTITVQ-----TALRGMV--------ARNEFR 827

  Fly   936 FQQKKKADQEISG-LKKDI-EDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQ 998
            |:::.||...|.. |:..: ......:|||.            |:.:...:..:..|..:..||
plant   828 FRKQMKAATIIQARLRSHLTHSYYKQLQKAA------------LSTQCGWRSRVARKELRTLKM- 879

  Fly   999 GETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQE 1063
                        ||.| ...|.:.|.|||:.::||...|:.||:.|.::|::|.:   :....||
plant   880 ------------AARD-TGALREAKDKLEKRVEELTWRLQLEKRQRTELEEAKTQ---EYAKQQE 928

  Fly  1064 AVADLERNKKELEQTIQRKDKELSSITAKLED------EQVVVLKHQRQIKELQARIEELEEEVE 1122
            |   ||..:.::|:......:|..:....:|:      |..|:::...:|..|.:.:|.|:..::
plant   929 A---LETMRLQVEEANAAVIREREAARKAIEEAPPVIKETPVLVEDTEKINSLTSEVEALKASLQ 990

  Fly  1123 AERQAR-------AKAEKQRADLARELE----------ELGERLEEAGGATSAQIELNKKREAEL 1170
            |||||.       ::||.:.::||.|||          |..:||||....:.::|::.:::...:
plant   991 AERQAAENLRKAFSEAEARNSELATELENATRKADQLHESVQRLEEKLSNSESEIQVLRQQALAI 1055

  Fly  1171 SKLRRDL-------------EEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNE 1222
            |...|.:             |..|..:..|     |...|....:.|.     :.:.|.:|..||
plant  1056 SPTSRTMATRSKTMLLPRTPENGNYLNGGT-----KTTPDMTLAVREP-----ESEEKPQKHLNE 1110

  Fly  1223 YYGQLNDL-----RAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSI- 1281
            ...:..||     ...:.:..::..|...|.|.|.|.      :..|..|| :.||...:.::.
plant  1111 KQQENQDLLVKCISQNLGYNGDKPVAACVIYKCLLHW------RSFEVERT-SVFDRIIQTIATA 1168

  Fly  1282 ----ENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNL 1342
                :|:::|..      .:|..:.:.:.|...|:.|...:....|.|.|....|..:...|
plant  1169 IEVPDNNEVLAY------WLSNSATLLLLLQRTLKATGAASLTPQRRRTTSASLFGRMSQGL--- 1224

  Fly  1343 REQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLN 1407
              :...::.|.:.|.||                  |:.:.::|.:.:.|..|.|.:.:.|  :..
plant  1225 --RGSPQSAGLSFLNRQ------------------GLTKLDDLRQVEAKYPALLFKQQLT--AFL 1267

  Fly  1408 QKCIGLEKTKQRLSTEVEDL------QLEVDRANAIANAAEKKQKAFDKIIGEWK---------- 1456
            :|..|:  .:..|..|:..|      .....||:.:...|:....|...:|..|:
plant  1268 EKIYGM--IRDNLKKEISPLLGLCIQAPRTSRASLVKGRAQANAVAQQALIAHWQSIRKSLNSYL 1330

  Fly  1457 --LKVDD----------------LAAELDAS---QKECRNYSTELFRLKGAYEEGQEQLEAVRRE 1500
              :|.::                :..:|..|   ::||.::|...:...|..|..|..:||....
plant  1331 NLMKANNAPPFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKAGLAELEQWCIEATDEY 1395

  Fly  1501 NKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDEL 1539
            ..:..||::.:...:  |...||  :|.:|.|:....||
plant  1396 AGSAWDELRHIRQAV--GFLVIH--QKPKKTLDEITREL 1430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/38 (21%)
		MYSc	81..777	CDD:214580	267/702 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	259/671 (39%)
		Myosin_tail_1	842..1897	CDD:279860	154/784 (20%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
XIK	NP_001318612.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910