DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and VIIIB

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001328307.1	Gene:	VIIIB / 828845	AraportID:	AT4G27370	Length:	1136	Species:	Arabidopsis thaliana

Alignment Length:	1174	Identity:	358/1174 - (30%)
Similarity:	585/1174 - (49%)	Gaps:	190/1174 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 IDQSKPYDSKKSC-WIPDEKEG-YLLGEIKAT-KGDIVSVGLQGG-EVRDIKSEKVEKVNPPKFE 86
            |:.::.:..:|.| |......| :.||:|.:| ..|.|.|.|... :|..:..|::...||...|
plant   102 INSAEYFVREKLCVWCRVAANGQWHLGKIHSTSSSDDVCVMLSANDDVVKVAMEEIFPANPEILE 166

  Fly    87 KIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEV 151
            .:||:..::.||.|.:|:|||.||...|||:.:|...:|:||:|...:|.......|   ::|.:
plant   167 GVEDLTQLSYLNEPSLLYNLRVRYSQDLIYSKAGPVLIAVNPFKNVQIYGEEFLSAY---QKNAL 228

  Fly   152 -PPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGS- 214
             .||::|::|.||.||:....|||::|:|||||||||..|..:.|...:|.           ||
plant   229 DAPHVYAVADAAYDDMMREEKNQSIIISGESGAGKTETAKYAMQYLEALGG-----------GSF 282

  Fly   215 -LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSL 278
             :|:::::||.:|||||||||.||||||||||.:.|||...||:.||.:||:.|:::||....:.
plant   283 GVENEILKTNCILEAFGNAKTSRNDNSSRFGKLMEIHFSAKGKICGAKLETFSLDQSRVAQLCNG 347

  Fly   279 ERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTK 342
            ||.||||||:.:|:.|.:|: .|......:|:.::|.. :|:...|||::|....:||:|:...:
plant   348 ERCYHIFYQLCAGASPILKE-RLKIKAASEYNYLNQSNCLTIDRTDDAQKFHKLMEAFNIVQIPQ 411

  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGN 407
            :.:|..:.:.|||:.:|.:.|:....|...|...:|....|:.|.||::.:|...|...:::.|.
plant   412 EYQERTFALLAAVLWLGNVSFEVIDNENHVEVVADEAVTNVAMLMGCNSKKLMVVLSTCKLQAGR 476

  Fly   408 EFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQ-HFIGVLDIAGFEIFEYNG 471
            :.:.:...::|.|:...:|.|.::..||.|||::.|.:|:....|. ..|.:|||.|||.|:.|.
plant   477 DCIAKRLTLRQATDMRDSLAKIIYASLFNWLVEQINISLEVGNSRTGRSISILDIYGFESFKDNS 541

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEE 535
            |||.|||:.||:|||.||.|:|.||||||:.:||||..::| :|...|::||| ||:|::|:|.|
plant   542 FEQFCINYANERLQQHFNRHLFKLEQEEYEGDGIDWTKVEF-IDNQECLNLIEKKPIGLVSLLNE 605

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            ||.||||||.||:.|| ..||..::.|:       |::...|.|.||||.|.||..|:||||:||
plant   606 ESNFPKATDTTFANKL-KQHLNANSCFK-------GERGRGFRIKHYAGEVLYNTNGFLEKNRDP 662

  Fly   601 LNDTVVDQFKKSQNKLL-------------IEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAY 652
            |:..::......:.:||             ...|:|...||                   |.:.:
plant   663 LHVDLIQLLSLCKCQLLNLFSTKMHHDFLKPATFSDSMNQS-------------------VIAKF 708

  Fly   653 KEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYP 717
            |.||..||..|..|.|||:|||.||..:.||:.:.:.|:.||.|.||||.:||.|.|:|.|:.:.
plant   709 KGQLFKLMNKLEDTTPHFIRCIKPNSNQLPGLYEENHVLQQLRCCGVLEIVRISRSGYPTRLTHQ 773

  Fly   718 DFKMRYKIMCPKLLQGVEKDKKAT-EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLG 781
            :..:||.  |..|...:.:|..:| :.|:|..:||.:.|::|.||::.|.||:..:||.:...|.
plant   774 ELAVRYG--CLLLDTRISQDPLSTSKAILKQCNLPPEMYQVGYTKIYLRTGVISVLEERKKYVLR 836

  Fly   782 KIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIED 846
            .|:. :|...|||.:|:.|..::...|.|:                              |.|..
plant   837 GILG-LQKQFRGYQTREYFHNMRNAAVILQ------------------------------SYIRG 870

  Fly   847 EIAR-----LEEKAKKAEELHAAEVKVRKELEA------LNAKLLAEKTALLDSLSGEKGALQDY 900
            |.||     :.|.|       .....:.|||:|      :..|.||.|  ||:|
plant   871 ENARRNYIVVGESA-------IVSTAITKELDAAIHLQYMVRKWLARK--LLNS----------- 915

  Fly   901 QERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQ 965
                   |.|||...|:.:..:.:.|:......:|..::.:....:      :.||:..|.|.|.
plant   916 -------TQQKNKPRNEKKKTRRKSTKRVSEDKELLSEQFEVQPCV------LADLQSRVLKVEA 967

  Fly   966 DKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTL 1030
            ....|:      ::..|.|:||  :..:|:.::.||..|:.|:                ..::.:
plant   968 AIMQKE------DENTALQEEL--QRFEERWLENETRMKSMED----------------TWQKHM 1008

  Fly  1031 DELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLED 1095
            ..::.||....||....:.:....:      .|.........|||:.::    .::::::.:.:.
plant  1009 SSMQMSLAAACKVLAPDKTASHGTD------SEDTMSFGTPTKELKGSL----SDVNNLSTEFDQ 1063

  Fly  1096 EQVVVLKHQRQIKELQA-RIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQ 1159
            ..|::.:..:.:.|::: .|...::..|..|:.:::.||.:.|....|.|           |.|:
plant  1064 RSVIIHEDPKSLVEVKSDSISNRKQHAEELRRLKSRFEKWKKDYKTRLRE-----------TKAR 1117

  Fly  1160 IELN 1163
            :.||
plant  1118 VRLN 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	13/40 (33%)
		MYSc	81..777	CDD:214580	271/715 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	259/684 (38%)
		Myosin_tail_1	842..1897	CDD:279860	62/334 (19%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
VIIIB	NP_001328307.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I246
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.960