Protein Alignment Mhc and VIIIB

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001328307.1
• Gene: VIIIB / 828845
• AraportID: AT4G27370
• Length: 1136
• Species: Arabidopsis thaliana
• Alignment Length: 1176
• Identity: 361/1176 - (30%)
• Similarity: 591/1176 - (50%)
• Gaps: 194/1176 - (16%)

  Fly    26 IDQSKPYDSKKSC-WIPDEKEG-YLLGEIKAT-KGDIVSVGLQGGETRDLKKDLLQQV---NPPK 84
            |:.::.:..:|.| |......| :.||:|.:| ..|.|.|.|...:  |:.|..::::   ||..
plant   102 INSAEYFVREKLCVWCRVAANGQWHLGKIHSTSSSDDVCVMLSAND--DVVKVAMEEIFPANPEI 164

  Fly    85 YEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
            .|..||::.|:|||:.|:|:|||.||...|||:.:|...:|:||:|...:|.......|   ::|
plant   165 LEGVEDLTQLSYLNEPSLLYNLRVRYSQDLIYSKAGPVLIAVNPFKNVQIYGEEFLSAY---QKN 226

  Fly   150 EV-PPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKG 213
            .: .||::|::|.||.||:....|||::|:|||||||||..|..:.|...:|.           |
plant   227 ALDAPHVYAVADAAYDDMMREEKNQSIIISGESGAGKTETAKYAMQYLEALGG-----------G 280

  Fly   214 S--LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQ 276
            |  :|:::::||.:|||||||||.||||||||||.:.|||...||:.||.:||:.|:::||....
plant   281 SFGVENEILKTNCILEAFGNAKTSRNDNSSRFGKLMEIHFSAKGKICGAKLETFSLDQSRVAQLC 345

  Fly   277 SLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGF 340
            :.||.||||||:.:|:.|.:|: .|......:|:.::|.. :|:...|||::|....:||:|:..
plant   346 NGERCYHIFYQLCAGASPILKE-RLKIKAASEYNYLNQSNCLTIDRTDDAQKFHKLMEAFNIVQI 409

  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405
            .::.:|..:.:.|||:.:|.:.|:....|...|...:|....|:.|.||::.:|...|...:::.
plant   410 PQEYQERTFALLAAVLWLGNVSFEVIDNENHVEVVADEAVTNVAMLMGCNSKKLMVVLSTCKLQA 474

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQ-HFIGVLDIAGFEIFEY 469
            |.:.:.:...::|.|:...:|.|.::..||.|||::.|.:|:....|. ..|.:|||.|||.|:.
plant   475 GRDCIAKRLTLRQATDMRDSLAKIIYASLFNWLVEQINISLEVGNSRTGRSISILDIYGFESFKD 539

  Fly   470 NGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSIL 533
            |.|||.|||:.||:|||.||.|:|.||||||:.:||:||.::| :|.|.|::||| ||:|::|:|
plant   540 NSFEQFCINYANERLQQHFNRHLFKLEQEEYEGDGIDWTKVEF-IDNQECLNLIEKKPIGLVSLL 603

  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNK 598
            .|||.||||||.||:.|| ..||..::.|:       |::...|.|.||||.|.||..|:||||:
plant   604 NEESNFPKATDTTFANKL-KQHLNANSCFK-------GERGRGFRIKHYAGEVLYNTNGFLEKNR 660

  Fly   599 DPLNDTVVDQFKKSQNKLL-------------IEIFADHAGQSGGGEQAKGGRGKKGGGFATVSS 650
            |||:..::......:.:||             ...|:|...||                   |.:
plant   661 DPLHVDLIQLLSLCKCQLLNLFSTKMHHDFLKPATFSDSMNQS-------------------VIA 706

  Fly   651 AYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMM 715
            .:|.||..||..|..|.|||:|||.||..:.||:.:.:.|:.||.|.||||.:||.|.|:|.|:.
plant   707 KFKGQLFKLMNKLEDTTPHFIRCIKPNSNQLPGLYEENHVLQQLRCCGVLEIVRISRSGYPTRLT 771

  Fly   716 YPDFKMRYKIMCPKLLQGVEKDKKAT-EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDER 779
            :.:..:||.  |..|...:.:|..:| :.|:|..:||.:.|::|.||::.|.||:..:||.:...
plant   772 HQELAVRYG--CLLLDTRISQDPLSTSKAILKQCNLPPEMYQVGYTKIYLRTGVISVLEERKKYV 834

  Fly   780 LGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRI 844
            |..|:. :|...|||.:|:.|..::...|.|:                              |.|
plant   835 LRGILG-LQKQFRGYQTREYFHNMRNAAVILQ------------------------------SYI 868

  Fly   845 EDEIAR-----LEEKAKKAEELHAAEVKVRKELEA------LNAKLLAEKTALLDSLSGEKGALQ 898
            ..|.||     :.|.|       .....:.|||:|      :..|.||.|  ||:|
plant   869 RGENARRNYIVVGESA-------IVSTAITKELDAAIHLQYMVRKWLARK--LLNS--------- 915

  Fly   899 DYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKA 963
                     |.|||...|:.:..:.:.|:......:|..::.:....:      :.||:..|.|.
plant   916 ---------TQQKNKPRNEKKKTRRKSTKRVSEDKELLSEQFEVQPCV------LADLQSRVLKV 965

  Fly   964 EQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQ 1028
            |.....|:      ::..|.|:||  :..:|:.::.||..|:.|:                ..::
plant   966 EAAIMQKE------DENTALQEEL--QRFEERWLENETRMKSMED----------------TWQK 1006

  Fly  1029 TLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKL 1093
            .:..::.||....||....:.:....:      .|.........|||:.::    .::::::.:.
plant  1007 HMSSMQMSLAAACKVLAPDKTASHGTD------SEDTMSFGTPTKELKGSL----SDVNNLSTEF 1061

  Fly  1094 EDEQVVVLKHQRQIKELQA-RIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATS 1157
            :...|::.:..:.:.|::: .|...::..|..|:.:::.||.:.|....|.|           |.
plant  1062 DQRSVIIHEDPKSLVEVKSDSISNRKQHAEELRRLKSRFEKWKKDYKTRLRE-----------TK 1115

  Fly  1158 AQIELN 1163
            |::.||
plant  1116 ARVRLN 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	13/44 (30%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	260/684 (38%)
		Myosin_tail_1	842..1922	CDD:460256	62/334 (19%)
VIIIB	NP_001328307.1	MYSc_Myo8	180..820	CDD:276834	260/684 (38%)