DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and XIJ

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001319790.1	Gene:	XIJ / 824985	AraportID:	AT3G58160	Length:	1242	Species:	Arabidopsis thaliana

Alignment Length:	1281	Identity:	375/1281 - (29%)
Similarity:	606/1281 - (47%)	Gaps:	244/1281 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDI---KSEKVEKVNPPKFEKIEDMADMTVLNTP 100
            |:.|.:..::.|.:...||:...:....|  ||:   .|....|......|.:|||..::.|:.|
plant    12 WVEDPERAWIDGVVLNIKGEEAEIKTNDG--RDVIANLSRLYPKDTEAPSEGVEDMTRLSYLHEP 74

  Fly   101 CVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGAYV 164
            .||.||..||....||||:|...:|:||::..| :|.....:.|:.....|:.||:|||...||.
plant    75 AVLDNLATRYELNEIYTYTGNILIAVNPFQGLPHLYDAEVMEKYKEAYFKELNPHVFAIGGIAYR 139

  Fly   165 DMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAF 229
            :|:....|:.:|::||||:||||.||.::.|.|..|.     ..|....::|:||:::|||||||
plant   140 EMINEGRNKCILVSGESGSGKTETTKMLMRYLAYFGG-----HTAVEGRTVENQVLESNPVLEAF 199

  Fly   230 GNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVP 294
            ||||||:|:||||||||:.|.|...|:::||.|.|||||::||......||:||.||.:.:....
plant   200 GNAKTVKNNNSSRFGKFVEIQFDDVGRISGAAIRTYLLERSRVCQVSDPERNYHCFYLLCAAPPE 264

  Fly   295 GVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHM 358
            .|:...|.....:.|  ::|.. ..:..::||||:..|.:|.|::|.:::|::.::|:.|:::|:
plant   265 DVERFKLGDPKSFRY--LNQSSCYKLDGVNDAEEYLATRRAMDVVGISEKEQDAIFRVVASILHL 327

  Fly   359 GGMKFKQRGREEQAEQDGEEEG----GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQV 419
            |.::| .:|.:..:....:|:.    ...|:|..||...|...|.|..:....|.:.:..:....
plant   328 GNIEF-SKGEDADSSSVKDEQSMFHLQMTSELLMCDPHSLEDALCKRMMVTPEEVIKRSLDPLGA 391

  Fly   420 TNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKL 484
            ..|...|.|.::.|||.|||.|.|.::......:..||||||.|||.|:.|.|||.|||:|||||
plant   392 AVSRDGLAKTIYSRLFDWLVNKINISIGQDSHSRRLIGVLDIYGFESFKTNSFEQFCINYTNEKL 456

  Fly   485 QQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKATDQTFS 548
            ||.||.|:|.:||.||::|.|||::::| :|....:|||| ||.||:::|:|..|.||:|.:|||
plant   457 QQHFNQHVFKMEQGEYQKEEIDWSYVEF-VDNKDVVDLIEKKPGGIIALLDEACMLPKSTPETFS 520

  Fly   549 EKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQ 613
            |||.:|...... |.|||..:     :.|.:.||||.|.|....:|:||||.:.....|....|:
plant   521 EKLYHTFKDHKR-FMKPKLTR-----SDFTLVHYAGDVQYQSDQFLDKNKDYVVAEHQDLLNASK 579

  Fly   614 NKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNE 678
            ...:..:|.....:|...:            |:::.:.:|.||..||.||.||:||::||:.||.
plant   580 CSFVSGLFPPLPKESSKSK------------FSSIGARFKLQLQQLMETLNSTEPHYIRCVKPNN 632

  Fly   679 MKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEI 743
            :.||.|.|...|:|||...||||.||:...|:|....:.:|..|:.|:.|::|:|..:.:.|.:.
plant   633 LLQPTVFDNANVLHQLRSGGVLEAIRVKCAGYPTNRTFIEFLNRFLILAPEILKGEYEAEVACKW 697

  Fly   744 IIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQA------------------- 789
            |::...|  ..|::|.:|||.|||.:.:::..|...||:....:|.
plant   698 ILEKKGL--TGYQIGKSKVFLRAGQMAELDAHRTRVLGESARMIQGQVRTRLTRERFVLMRRASV 760

  Fly   790 -----WARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIA 849
                 | ||.::||..|:::.:..|:| :|:|||:                           :||
plant   761 NIQANW-RGNIARKISKEMRREEAAIK-IQKNLRR---------------------------QIA 796

  Fly   850 RLE-EKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913
            :.: .|.|.:.....:.|:..........||......::.:......|:.||::........|::
plant   797 KKDYGKTKSSALTLQSGVRTMAARHEFRYKLTTRAATVIQAYWRGYSAISDYKKLKRVSLLCKSN 861

  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQ----------EISGLKKDIEDLELNVQKAEQ--- 965
            |..::            ||.|| .|.|:||:          |:|...::..|:.. |..:||
plant   862 LRGRI------------ARKQL-GQSKQADRKEETEKERKVELSNRAEEAVDMSF-VLHSEQSDD 912

  Fly   966 -------------------DKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEEL-- 1009
                               ||::..|..::.::|:.|:.:  .||:.|.: .|.::|...||:
plant   913 AESGHGRKAKLSIESEDGLDKSSVLHSEQSDDEELGHERK--TKLSIESE-DGHSDQSDDEEIEH 974

  Fly  1010 -----------------------QAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
                                   |:.:::|.|..|.|..:     :.||.:|:...|..|  :|.
plant   975 ERKTKHCIQAEDGIEKSYVMHSDQSDDEEIGHKRKTKHSI-----QAEDGIEKSFVVHSD--QSD 1032

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQR-----KDKE------LSSITAKLEDEQVVVLKHQR 1105
            .:..|..:.|:.|:        ::|..||:     .:|.      :|.||:.:.|.:
plant  1033 DEEIGHERKTKHAI--------QVEDGIQKSFVTCSEKPYNTFSVVSQITSPIRDTE-------- 1081

  Fly  1106 QIKELQARIEELEEEVEAERQARAKAEKQRADLAR----ELEELGERLEEAGGATSAQIELNKKR 1166
                    ||.|..|||. .:|..:.||||||::.    |..|||||
plant  1082 --------IESLTAEVEM-LKALLQVEKQRADISERKCAEARELGER------------------ 1119

  Fly  1167 EAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKL 1212
                  .|:.|||.    |..:..|:...|..:..|::|..||..:
plant  1120 ------RRKRLEET----ERRVYQLQDSLNRLLYSMSDQFSQLKSI 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/36 (22%)
		MYSc	81..777	CDD:214580	259/702 (37%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	251/671 (37%)
		Myosin_tail_1	842..1897	CDD:279860	90/444 (20%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
XIJ	NP_001319790.1	Myosin_N	9..46	CDD:397036	8/35 (23%)
		MYSc_Myo11	74..717	CDD:276835	251/671 (37%)
		IQ	829..849	CDD:197470	2/19 (11%)
		DUF460	<1081..>1142	CDD:421465	26/105 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910