Protein Alignment Mhc and ATM1

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001154628.2
• Gene: ATM1 / 821534
• AraportID: AT3G19960
• Length: 1176
• Species: Arabidopsis thaliana
• Alignment Length: 1184
• Identity: 381/1184 - (32%)
• Similarity: 591/1184 - (49%)
• Gaps: 208/1184 - (17%)

  Fly     1 MPKPVANQEDEDPTPYLFVSLEQRRIDQSKPYDSKK--SCWIPDEKEGYLLGEIKATKGDIVSVG 63
            ||.|   |.||            ||...:..|..||  ..||......:.||:|.:|.|:...:.
plant    93 MPLP---QSDE------------RRWSDTSAYARKKILQSWIQLPNGNWELGKILSTSGEESVIS 142

  Fly    64 LQGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINP 128
            |..|:...:..:.|...||...:..:|:..|:|||:.|||:||..||...:|||.:|...||:||
plant   143 LPEGKVIKVISETLVPANPDILDGVDDLMQLSYLNEPSVLYNLNYRYNQDMIYTKAGPVLVAVNP 207

  Fly   129 YKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLI---------------- 177
            :|..|:|.||..:.|| |:.|| .||::||:|.|..:|:.:.||||::|
plant   208 FKEVPLYGNRYIEAYR-KKSNE-SPHVYAIADTAIREMIRDEVNQSIIIRCICIHESMTYSISSS 270

  Fly   178 TGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSR 242
            :|||||||||..|..:.|.|.:|..          ..:|.::::|||:|||||||||:|||||||
plant   271 SGESGAGKTETAKIAMQYLAALGGG----------SGIEYEILKTNPILEAFGNAKTLRNDNSSR 325

  Fly   243 FGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIY 307
            |||.|.|||..:||::||.|:|:||||:||:.....|||||||||:.:|:.|.:::...|| :.:
plant   326 FGKLIEIHFSESGKISGAQIQTFLLEKSRVVQCAEGERSYHIFYQLCAGASPALREKLNLT-SAH 389

  Fly   308 DYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQ 371
            :|..:.|.. .::..:||||.|....:|.||:..:|:::|.|:.:.|||:.:|.:.|.....|..
plant   390 EYKYLGQSNCYSINGVDDAERFHTVKEALDIVHVSKEDQESVFAMLAAVLWLGNVSFTVIDNENH 454

  Fly   372 AEQDGEEEG---------------------GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRN 415
            .|...:|..                     ..|:||.||:..||...|.|..::|.|:.:.|...
plant   455 VEPVADESFLFHSLGSWCWKQECLLHNMCLSTVAKLIGCNINELTLTLSKRNMRVRNDTIVQKLT 519

  Fly   416 VQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQ-HFIGVLDIAGFEIFEYNGFEQLCINF 479
            :.|..::..||.|.::..||.|||::.|::|...::|. ..|.:|||.|||.|:.|.|||.|||:
plant   520 LPQAIDARDALAKSIYSCLFDWLVEQINKSLAVGKRRTGRSISILDIYGFESFDKNSFEQFCINY 584

  Fly   480 TNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKAT 543
            .||:|||.||.|:|.||||||.::||:||.:|| .|.|.|:.|.| ||:|:||:|:|||.||..|
plant   585 ANERLQQHFNRHLFKLEQEEYIQDGIDWTRVDF-EDNQNCLSLFEKKPLGLLSLLDEESTFPNGT 648

  Fly   544 DQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQ 608
            |.|.:.|| ..||..::.|:       |.:...|.:.||||.|:|..||:||||:|.|:...: |
plant   649 DLTLANKL-KQHLQSNSCFR-------GDKGKLFTVVHYAGEVTYETTGFLEKNRDLLHSDSI-Q 704

  Fly   609 FKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGF----ATVSSAYKEQLNSLMTTLRSTQPH 669
            ...|.:.||.:.||  :......|:...|...|.||.    .:|::.:|.||..||..|.:|.||
plant   705 LLSSCSCLLPQAFA--SSMLIQSEKPVVGPLYKAGGADSQRLSVATKFKSQLFQLMQRLGNTTPH 767

  Fly   670 FVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGV 734
            |:|||.||.::.|||.:..||:.||.|.||||                       ::|    :|.
plant   768 FIRCIKPNNIQSPGVYEQGLVLQQLRCCGVLE-----------------------VLC----KGP 805

  Fly   735 EKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKG 799
            .|......|:.:|..||| .|::|.||:|||.|.:|.:|:.|:..|..|:. :|:..|||.:|..
plant   806 YKRFFIIAILHQFNILPE-MYQVGYTKLFFRTGQIGVLEDTRNRTLHGILR-VQSSFRGYQARCL 868

  Fly   800 FKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAA 864
            .|:|:.   .:.::|..:|.                      .:|..|.|.|..:.|.|..:.:
plant   869 LKELKR---GISILQSFVRG----------------------EKIRKEFAELRRRHKAAATIQS- 907

  Fly   865 EVKVRKELEALNAKLLAEKTALLDS---------LSGEKG--------------------ALQDY 900
              :|:.::..:..|.:|:.:.::.|         .||:.|                    .|.:.
plant   908 --QVKSKIARIQYKGIADASVVIQSAIRGWLVRRCSGDIGWLKSGGAKTNELGEVLVKASVLSEL 970

  Fly   901 QERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQ 965
            |.|..|..|...:.|.:...:|:||.|.|:..:: ::.|.|:.:||  .:|.:..|:.::..|::
plant   971 QRRVLKAEAALREKEEENDILQQRLQQYENRWSE-YETKMKSMEEI--WQKQMRSLQSSLSIAKK 1032

  Fly   966 DKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTL 1030
            ..|.:| ..|| :|...:..:..:..:...:.:.:|:...|..||.....::           .:
plant  1033 SLAVED-SARN-SDASVNASDATDWDSSSNQFRSQTSNGVGSRLQPMSAGLS-----------VI 1084

  Fly  1031 DELEDSLEREKKVRGD-----VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQ--RKD----- 1083
            ..|.:..|:..:|.||     ||....:||.:|        |.:|..:.|:|..:  :||
plant  1085 GRLAEEFEQRAQVFGDDAKFLVEVKSGQVEANL--------DPDRELRRLKQMFETWKKDYGGRL 1141

  Fly  1084 KELSSITAKLEDEQ 1097
            :|...|.:||..|:
plant  1142 RETKLILSKLGSEE 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	11/43 (26%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	275/708 (39%)
		Myosin_tail_1	842..1922	CDD:460256	61/297 (21%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	275/708 (39%)
		MAD	967..>1047	CDD:461677	23/84 (27%)