DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and ATM1

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001154628.2	Gene:	ATM1 / 821534	AraportID:	AT3G19960	Length:	1176	Species:	Arabidopsis thaliana

Alignment Length:	1184	Identity:	380/1184 - (32%)
Similarity:	590/1184 - (49%)	Gaps:	208/1184 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKPVANQEDEDPTPYLFVSLEQRRIDQSKPYDSKK--SCWIPDEKEGYLLGEIKATKGDIVSVG 63
            ||.|   |.||            ||...:..|..||  ..||......:.||:|.:|.|:...:.
plant    93 MPLP---QSDE------------RRWSDTSAYARKKILQSWIQLPNGNWELGKILSTSGEESVIS 142

  Fly    64 LQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINP 128
            |..|:|..:.||.:...||...:.::|:..::.||.|.||:||..||...:|||.:|...||:||
plant   143 LPEGKVIKVISETLVPANPDILDGVDDLMQLSYLNEPSVLYNLNYRYNQDMIYTKAGPVLVAVNP 207

  Fly   129 YKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLI---------------- 177
            :|..|:|.||..:.|| |:.|| .||::||:|.|..:|:.:.||||::|
plant   208 FKEVPLYGNRYIEAYR-KKSNE-SPHVYAIADTAIREMIRDEVNQSIIIRCICIHESMTYSISSS 270

  Fly   178 TGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSR 242
            :|||||||||..|..:.|.|.:|..          ..:|.::::|||:|||||||||:|||||||
plant   271 SGESGAGKTETAKIAMQYLAALGGG----------SGIEYEILKTNPILEAFGNAKTLRNDNSSR 325

  Fly   243 FGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIY 307
            |||.|.|||..:||::||.|:|:||||:||:.....|||||||||:.:|:.|.:::...|| :.:
plant   326 FGKLIEIHFSESGKISGAQIQTFLLEKSRVVQCAEGERSYHIFYQLCAGASPALREKLNLT-SAH 389

  Fly   308 DYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQ 371
            :|..:.|.. .::..:||||.|....:|.||:..:|:::|.|:.:.|||:.:|.:.|.....|..
plant   390 EYKYLGQSNCYSINGVDDAERFHTVKEALDIVHVSKEDQESVFAMLAAVLWLGNVSFTVIDNENH 454

  Fly   372 AEQDGEEEG---------------------GRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRN 415
            .|...:|..                     ..|:||.||:..||...|.|..::|.|:.:.|...
plant   455 VEPVADESFLFHSLGSWCWKQECLLHNMCLSTVAKLIGCNINELTLTLSKRNMRVRNDTIVQKLT 519

  Fly   416 VQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQ-HFIGVLDIAGFEIFEYNGFEQLCINF 479
            :.|..::..||.|.::..||.|||::.|::|...::|. ..|.:|||.|||.|:.|.|||.|||:
plant   520 LPQAIDARDALAKSIYSCLFDWLVEQINKSLAVGKRRTGRSISILDIYGFESFDKNSFEQFCINY 584

  Fly   480 TNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEEESMFPKAT 543
            .||:|||.||.|:|.||||||.::||||..:|| .|...|:.|.| ||:|:||:|:|||.||..|
plant   585 ANERLQQHFNRHLFKLEQEEYIQDGIDWTRVDF-EDNQNCLSLFEKKPLGLLSLLDEESTFPNGT 648

  Fly   544 DQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQ 608
            |.|.:.|| ..||..::.|:       |.:...|.:.||||.|:|..||:||||:|.|:...: |
plant   649 DLTLANKL-KQHLQSNSCFR-------GDKGKLFTVVHYAGEVTYETTGFLEKNRDLLHSDSI-Q 704

  Fly   609 FKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGF----ATVSSAYKEQLNSLMTTLRSTQPH 669
            ...|.:.||.:.||  :......|:...|...|.||.    .:|::.:|.||..||..|.:|.||
plant   705 LLSSCSCLLPQAFA--SSMLIQSEKPVVGPLYKAGGADSQRLSVATKFKSQLFQLMQRLGNTTPH 767

  Fly   670 FVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGV 734
            |:|||.||.::.|||.:..||:.||.|.||||                       ::|    :|.
plant   768 FIRCIKPNNIQSPGVYEQGLVLQQLRCCGVLE-----------------------VLC----KGP 805

  Fly   735 EKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKG 799
            .|......|:.:|..||| .|::|.||:|||.|.:|.:|:.|:..|..|:. :|:..|||.:|..
plant   806 YKRFFIIAILHQFNILPE-MYQVGYTKLFFRTGQIGVLEDTRNRTLHGILR-VQSSFRGYQARCL 868

  Fly   800 FKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAA 864
            .|:|:.   .:.::|..:|.                      .:|..|.|.|..:.|.|..:.:
plant   869 LKELKR---GISILQSFVRG----------------------EKIRKEFAELRRRHKAAATIQS- 907

  Fly   865 EVKVRKELEALNAKLLAEKTALLDS---------LSGEKG--------------------ALQDY 900
              :|:.::..:..|.:|:.:.::.|         .||:.|                    .|.:.
plant   908 --QVKSKIARIQYKGIADASVVIQSAIRGWLVRRCSGDIGWLKSGGAKTNELGEVLVKASVLSEL 970

  Fly   901 QERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQ 965
            |.|..|..|...:.|.:...:|:||.|.|:..:: ::.|.|:.:||  .:|.:..|:.::..|::
plant   971 QRRVLKAEAALREKEEENDILQQRLQQYENRWSE-YETKMKSMEEI--WQKQMRSLQSSLSIAKK 1032

  Fly   966 DKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTL 1030
            ..|.:| ..|| :|...:..:..:..:...:.:.:|:...|..||.....::           .:
plant  1033 SLAVED-SARN-SDASVNASDATDWDSSSNQFRSQTSNGVGSRLQPMSAGLS-----------VI 1084

  Fly  1031 DELEDSLEREKKVRGD-----VEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQ--RKD----- 1083
            ..|.:..|:..:|.||     ||....:||.:|        |.:|..:.|:|..:  :||
plant  1085 GRLAEEFEQRAQVFGDDAKFLVEVKSGQVEANL--------DPDRELRRLKQMFETWKKDYGGRL 1141

  Fly  1084 KELSSITAKLEDEQ 1097
            :|...|.:||..|:
plant  1142 RETKLILSKLGSEE 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	11/38 (29%)
		MYSc	81..777	CDD:214580	284/739 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	274/708 (39%)
		Myosin_tail_1	842..1897	CDD:279860	61/297 (21%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
ATM1	NP_001154628.2	MYSc	160..847	CDD:214580	284/739 (38%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	274/708 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I246
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960