Protein Alignment Mhc and XIG

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_179619.2
• Gene: XIG / 816548
• AraportID: AT2G20290
• Length: 1493
• Species: Arabidopsis thaliana
• Alignment Length: 1633
• Identity: 447/1633 - (27%)
• Similarity: 738/1633 - (45%)
• Gaps: 309/1633 - (18%)

  Fly    39 WIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLK------KDLLQQVNPPKYEKAEDMSNLTYL 97
            |:.|.:|.::.||:....|:.:.|....|:|...|      ||:  :|.|   ...:||:.|.||
plant    24 WVQDPEEAWIDGEVVEVNGEDIKVQCTSGKTVVAKGSNTYPKDM--EVPP---SGVDDMTTLAYL 83

  Fly    98 NDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDG 161
            ::..||.||:.|||...||||:|...:|:||:|:.| :|.:.....|:|....|:.||.||::|.
plant    84 HEPGVLQNLKSRYYIDEIYTYTGNILIAVNPFKQLPNLYNDHMMAQYKGAALGELSPHPFAVADA 148

  Fly   162 AYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVL 226
            ||..|:...::||:|::|||||||||..|.::.|.|.:|.     .|...:.::||||:::||||
plant   149 AYRQMINEGISQSILVSGESGAGKTETAKMLMKYLAKMGG-----RAVSDRRTVEDQVLESNPVL 208

  Fly   227 EAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG 291
            |||||||||:|:||||||||:.|.|...|:::||.|.|||||::||......||:||.|| ::..
plant   209 EAFGNAKTVKNNNSSRFGKFVEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFY-MLCA 272

  Fly   292 SVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAV 355
            :.|..|....|.|.. ::..::|.. :.:..:||::|::.|.:|..|:|...:|:|.::|:.||:
plant   273 APPEDKRKLKLNDPT-EFRYLNQSHCIKLDGVDDSKEYTKTREAMGIVGINLEEQEAIFRVVAAI 336

  Fly   356 MHMGGMKFKQRGREEQAEQDGEEEGGRV---SKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ 417
            :|:|.::| ..|.|..:....:|....:   ::||.||...|..:|.|..:....|.:::..:..
plant   337 LHLGNIEF-AIGEEPDSSVPTDESKKYLKIAAELFMCDEQALEDSLCKRIMVTPEETISRCLDPN 400

  Fly   418 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNE 482
            ....|..||.|.|:.|||.|:|.|.|.::......:..||||||.|||.|:.|.|||.|||.|||
plant   401 SAALSRDALAKFVYSRLFDWIVNKINNSIGQDPDSKDMIGVLDIYGFESFKTNSFEQFCINLTNE 465

  Fly   483 KLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPM-GILSILEEESMFPKATDQT 546
            ||||.|..|:..:|||||.:|.|||:.|.| .|.:..::||||.. ||:::|:|..|||::|.:|
plant   466 KLQQHFTQHVLKMEQEEYTKEEIEWSQITF-PDNRYVLELIEKKRGGIIALLDEACMFPRSTHKT 529

  Fly   547 FSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611
            ||:||..| |..:..|.|||..:     ..|.|.||||.|:|....:||||||
plant   530 FSQKLYET-LKDNKYFSKPKLSR-----TDFTICHYAGDVTYQTEQFLEKNKD------------ 576

  Fly   612 SQNKLLIEIFADHAGQSGGG-------------EQAKGGRGKKGGGFATVSSAYKEQLNSLMTTL 663
                   .:.|:|....|..             |.|     .|...|::::|.:|:||.||:..|
plant   577 -------YVVAEHQALLGASRCTFIAGLFPPLVEDA-----NKQSKFSSIASQFKQQLASLIEGL 629

  Fly   664 RSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCP 728
            .:|:||::||:.||.:.:|.:.:....:.||.|.||:|.||:||.|:|.|..:.:|..|:.|:..
plant   630 NTTEPHYIRCVKPNNLLKPSIFENQNSLQQLRCGGVMETIRVCRAGYPTRKHFDEFLDRFGILDS 694

  Fly   729 KLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARG 793
            ..|.....:|.|.:.:::.:.|  :.:::|.||||.:||.:.::::.|.|.||:....:|...|.
plant   695 ATLDKSSDEKAACKKLLETVGL--NGFQIGKTKVFLKAGQMAELDDRRTEVLGRAACIIQWKFRS 757

  Fly   794 YLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKA 858
            ||:|:.|..|:...:.::.|.|.                       .|:|...|..|.|
plant   758 YLTRQSFIMLRNAAINIQAVYRG-----------------------QVARYRFENLRRE------ 793

  Fly   859 EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKG-ALQDYQERNAKLTAQKNDLENQLRDIQ 922
                ||.:|:::.|.....:..:...|::...||.:| |.:....|..|.|..   :::..|.::
plant   794 ----AAALKIQRALRIHLDRKRSYIEAVVTVQSGLRGMAARVVLRRKTKATTV---IQSHCRRLR 851

  Fly   923 ERLTQEEDARNQLFQQK----KKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAH 983
            ..|..::..:..:..|.    :.|.:|:..||.|..|..: :|.|:...|.|
plant   852 AELHYKKLKKAAITTQSAWRARLARKELRKLKTDARDTVV-LQAAKSMLAEK------------- 902

  Fly   984 QDELINKLNKEKKMQGETNQKTGEE---LQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRG 1045
            .:||..:|:.||:|:.:......:|   ||.|      |.:::.:.|:|...|...:|..||...
plant   903 VEELTWRLDLEKRMRVDMEVSKAQENAKLQLA------LEEIQLQFEETKVSLLKEVEAAKKTAA 961

  Fly  1046 DVEKSKRKVEGDLKLTQEAVADLERNKK---ELEQTIQRKDKELSSITAKLEDEQV-VVLKHQRQ 1106
            .|...|.....|..|.::..::.|:.|.   .||..|...:|:... |.|:.:|:: ..|..:.:
plant   962 IVPVVKEVPVVDTVLMEKLTSENEKLKSLVTSLELKIDETEKKFEE-TKKISEERLKKALDAENK 1025

  Fly  1107 IKELQARIEELEE---EVEAERQ--------ARAKAEKQRADLARELEELGERLEEAGGATSAQI 1160
            |..|:..:..|||   ||:.|..        ...|....|. |:..|:.|     :.|..||.:.
plant  1026 IDNLKTAMHNLEEKLKEVKLENNFLKESVLTTPVKTASGRF-LSTPLKNL-----QNGLFTSEES 1084

  Fly  1161 ELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYG 1225
            :|:   .||.:...| ::|:....:|..:::..:|.|        ||.|
plant  1085 QLS---GAEFTTPPR-IQESGSDTKSRGSHIDPQHED--------VDAL---------------- 1121

  Fly  1226 QLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKL--SIENSD--- 1285
             :|.:...|.....:..|...|.|.|.|.      |..|..|| |.||...:.:  :|::.|
plant  1122 -INSVTKNVGFSQGKPVAAFTIYKCLLHW------KSFEAERT-NVFDRLVQMIGSAIKDEDNDA 1178

  Fly  1286 --------------LLRQ-----------LEEAESQVSQLSK---------------------IK 1304
                          :|:|           |.::.|.|..::|                     .|
plant  1179 NLAYWLSNTSTLLFMLQQSLKSGGTGATPLRQSPSLVRWMTKGFRSPAAEAIRPVDAKDPALHFK 1243

  Fly  1305 ISLTTQLEDTKRLA-DEESRERATLL---------------------GKFRNLEHDLDNLREQVE 1347
            ..|...:|....:. |...:|..|:|                     ..::::...||.|...::
plant  1244 QQLEAYVEKILGIIWDNLKKELNTVLALCIQAPKTFKGNALISITTANYWQDIIEGLDALLSTLK 1308

  Fly  1348 EEAEGKADLQRQLSKANA--EAQVWRS---KYESDGVARSEELEEAKRKLQARLAEAEETIESLN 1407
            |.......:|:..|:|.:  ..||..|   :.::......|.|:....||:....|.:|  |...
plant  1309 ESFVPPVLIQKIFSQAFSLINVQVCNSLVTRPDNCSFINGEYLKSGLEKLEKWCCETKE--EYAG 1371

  Fly  1408 QKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQ-- 1470
            .....|:.|:|               |.......:|...::|:|       .:||...|...|
plant  1372 SSWDELKHTRQ---------------AVGFLLIHKKYNISYDEI-------ANDLCPNLQIQQHF 1414

  Fly  1471 KECRNYSTELFRLKGAYEEGQEQLEAV---------RRENKNLAD-EVKDLLDQIGEGGRNIHEI 1525
            |.|..|..|::..|...::....:..|         :.::.|:.. .:.||...:.:  ::..::
plant  1415 KLCTLYKDEIYNTKSVSQDVIASMTGVMTDSSDFLLKEDSSNIISLSIDDLCSSMQD--KDFAQV 1477

  Fly  1526 EKARKRLE 1533
            :.|.:.||
plant  1478 KPAEELLE 1485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	10/41 (24%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	256/683 (37%)
		Myosin_tail_1	842..1922	CDD:460256	156/805 (19%)
XIG	NP_179619.2	COG5022	12..1421	CDD:227355	437/1565 (28%)
		MYSc_Myo11	86..729	CDD:276835	256/683 (37%)