Protein Alignment Mhc and MYO19

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_011523588.1
• Gene: MYO19 / 80179
• HGNCID: 26234
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 984
• Identity: 271/984 - (27%)
• Similarity: 409/984 - (41%)
• Gaps: 247/984 - (25%)

  Fly    66 GGETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYK 130
            |||....|.|.|.:|||...|              :||..|:.||.....||.:|...||:||:|
Human    29 GGEVLLYKLDDLTRVNPVTLE--------------TVLRCLQARYMADTFYTNAGCTLVALNPFK 79

  Fly   131 RYP-VYTNRCAKMYR-----------------------GKRRN---------EVPPHIFAISDGA 162
            ..| :|:....:.|.                       |:..|         ::.||:|.:.:..
Human    80 PVPQLYSPELMREYHAAPQPQQCGHSESASATACPIGAGRILNHEELTTGQKKLKPHVFTVGEQT 144

  Fly   163 Y--VDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPV 225
            |  |..|...||||::::||||||||..::.::.::|.|..|..:.|:.|....:|.:::.:|||
Human   145 YRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVATSPASWESHKIAERIEQRILNSNPV 209

  Fly   226 LEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMS 290
            :||||||.|:||:|||||||||::......::.||.::||||||.||..|.|.||::||||||..
Human   210 MEAFGNACTLRNNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFHIFYQICK 274

  Fly   291 GSVPGVKDICLLTDNIYDYHIVSQGKVT-----VASIDDAEEFSLTDQAFDILGFTKQEKEDVYR 350
            |:         ..|....:|:......:     ..|::: :.|.:|.:|...||.....:.::::
Human   275 GA---------SEDERLQWHLPEGAAFSWLPNPERSLEE-DCFEVTREAMLHLGIDTPTQNNIFK 329

  Fly   351 --------------------------------------------ITAAVMHMGGMKFKQRGREEQ 371
                                                        :.|.::|:|.::|.....|.|
Human   330 TAPEQQEGIDRMAWQSRKGGHFREVAMQWKVTLTSRWGLLRHCQVLAGLLHLGNIQFAASEDEAQ 394

  Fly   372 AEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGA----------L 426
            ..|..::.....|.........|.:::|...:::  ..:..||. |||.....|          |
Human   395 PCQPMDDAKCEDSVRTAASLLGLPEDVLLEMVQI--RTIRAGRQ-QQVFRKPCARAECDTRRDCL 456

  Fly   427 CKGVFDRLFKWLVKKCNETL--DTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFN 489
            .|.::.|||.|||...|.::  ||..... |||:||:.|||.|..|..||||||:.||||||.|.
Human   457 AKLIYARLFDWLVSVINSSICADTDSWTT-FIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFV 520

  Fly   490 HHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTN 553
            .|....:||||..||:||:||:: .|.|.|:|||| .|:.|.|::.||....:.:.....:....
Human   521 AHYLRAQQEEYAVEGLEWSFINY-QDNQPCLDLIEGSPISICSLINEECRLNRPSSAAQLQTRIE 584

  Fly   554 THLGKSAPFQKPKPPKPG----QQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQN 614
            |.|..|        |..|    .:...|.:.||||.|.|:..|.:||||||:...:....::||:
Human   585 TALAGS--------PCLGHNKLSREPSFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQD 641

  Fly   615 KLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEM 679
            .||:.:|..:..:....|..    |:......||.|.:|..|..|:..|.||.||::|||.||..
Human   642 PLLMGLFPTNPKEKTQEEPP----GQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQ 702

  Fly   680 KQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIM------------------ 726
            .|........|:.||...|::|.|.|...|||.|:.:.:|..|||::
Human   703 GQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAK 767

  Fly   727 -----CPKLLQGVEKDKKATEIIIKFI-------------------DLPEDQYRLGNTKVFF--- 764
                 ||      ..::...|.:|:.|                   .:|...: .|.||||.
Human   768 GLPEWCP------HSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMH-CGRTKVFMTDS 825

  Fly   765 --------RAGVLGQM-----------EEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVAL 810
                    ||.||.|.           .....||..:.:..:||..|.:|:||..::|......:
Human   826 MLELLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVI 890

  Fly   811 KVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKK----AEELHAAEVKVRKE 871
            |                  :.|||.:            .|:...|.|    .||.|.::......
Human   891 K------------------RAWQKWR------------IRMACLAAKELDGVEEKHFSQAPCSLS 925

  Fly   872 LEALNAKLL 880
            ...|..:||
Human   926 TSPLQTRLL 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	4/8 (50%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	234/818 (29%)
		Myosin_tail_1	842..1922	CDD:460256	9/43 (21%)
MYO19	XP_011523588.1	MYSc_Myo19	49..823	CDD:276846	235/821 (29%)