Protein Alignment Mhc and myhz1.2

DIOPT Version :9

• Sequence 1: NP_001162991.1
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_005171981.1
• Gene: myhz1.2 / 799300
• ZFINID: ZDB-GENE-070705-73
• Length: 1937
• Species: Danio rerio
• Alignment Length: 1922
• Identity: 1073/1922 - (55%)
• Similarity: 1426/1922 - (74%)
• Gaps: 16/1922 - (0%)

  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSV-GLQGGEVRDIKSEKVEKVNPPK 84
            |:.||: |:||:|:|.:|::.|:||.|:.|.||:..|..|:| .|...|.|..|.:.|..:||||
Zfish    21 EKERIEAQNKPFDAKTACYVVDDKELYVKGTIKSRDGGKVTVITLDTKEERVAKEDDVHPMNPPK 85

  Fly    85 FEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
            |:||||||.||.||.|.||:||::||.|.:|||||||||..:||||..|||.......||||:|.
Zfish    86 FDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRM 150

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASKKTDEAA-K 210
            |.|||||::||.||..|||:..|||:|||||||||||.|||:||.|||||   |..||.::|| |
Zfish   151 EAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQAAGK 215

  Fly   211 SKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQ 275
            .:||||||::..||:|||:|||||||||||||||||||||||.:||||.||||||||||:||..|
Zfish   216 MQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQ 280

  Fly   276 QSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGF 340
            ...||.||||||:|:...|.:.::.|:|.|.||:.:.|||::|||||||.||...||.|.|||||
Zfish   281 LPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGF 345

  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405
            ..:||..:|:.|.||:|.|.|||||:.||||||.||.||..::..|.|.::|::.|.|..||:||
Zfish   346 NNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKV 410

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ||||||:|:.|.||.||:.||.|.:::|:|.|:|.:.|:.|||:|:|..|||||||||||||::|
Zfish   411 GNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFN 475

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEE 535
            ..|||||||||||||||||||||||||||||:|||.|.||||||||.|||:|||||:||.|||||
Zfish   476 SMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEE 540

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            |.|||||||.:|..||.:.||||...||||||.| |:..|||::.||||.|.|||:|||:|||||
Zfish   541 ECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAK-GKAEAHFSLVHYAGTVDYNISGWLDKNKDP 604

  Fly   601 LNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRS 665
            ||::||..::||..|||..::.....::|||:  |||: ||||...||||.::|.|..|||.|||
Zfish   605 LNESVVQLYQKSSVKLLATLYPPVVEETGGGK--KGGK-KKGGSMQTVSSQFRENLGKLMTNLRS 666

  Fly   666 TQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL 730
            |.||||||:||||.|.||:::..||:|||.||||||||||||||||:|::|.|||.|||::...:
Zfish   667 THPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASV 731

  Fly   731 L---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
            :   |.:: :|||:|.::..||:..|:||.|:|||||:||:||.:||.|||:|..:::..||..|
Zfish   732 IPEGQFID-NKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQALCR 795

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEK-AK 856
            .||.|:.|.|:.|:|.|:..:|.|:|.::.::.|||.|::.|:||||..:..|.|:|.::|. .|
Zfish   796 AYLMRREFVKMTERRDAIYTIQYNVRSFMNVKHWPWMKVYYKIKPLLKSAETEKELATMKEDFVK 860

  Fly   857 KAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            ..|:|..||.| :||||.....||.||..|..:::.|...|.|.:||...|...|..||.:|::.
Zfish   861 CKEDLAKAEAK-KKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKET 924

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|.|||
Zfish   925 TERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDE 989

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            .|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||:|.|:|::|
Zfish   990 SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1054

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:||||||.||::.|||.:|::.|:.:::||.|.|.:.:|:||||.:..:.|::||||||||||
Zfish  1055 RKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEE 1119

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            ||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||||||:.
Zfish  1120 LEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEST 1184

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :|||:|.|.||||..|:|||:.||:|.|.::|.|.||||:||..:::||.:.::.:...||..||
Zfish  1185 LQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEK 1249

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:.|:..|:|::||.||..|.|||..|.:.:|..||.:..|||||.|:.||||::.|.:.|.|:
Zfish  1250 MCRTLEDQLSEIKSKNDENLRQLNDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQI 1314

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.:||||:|...||:|||:
Zfish  1315 EELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYET 1379

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|:|||||:|:||..||.||||.||::|.||..||||||||..|||||.::|:||||:|...
Zfish  1380 DAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANL 1444

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.|||.|.::..|||:.:|||.|:.|||||::|.:|||..:|||.::||||||..
Zfish  1445 DKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQ 1509

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.:||||.|::|||:||::|.:|.||.|:|.||||||..||.||:|:||.||||:||:.||
Zfish  1510 EISDLTEQIGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEI 1574

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ||::.||:||.|..::|.||..||||::|::|.:.:.:|||:|||:|.|:||:||.|.|||:..|
Zfish  1575 DRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAA 1639

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            ||||.::..|.||||.|..|::..|.::|.:||:.:.|||...:|:|:||.|..|||.:|||:.|
Zfish  1640 EAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVA 1704

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            ||||.||.|::..:.:||.|:...|:|||::|..:.|::::.:.||:|:|:|||||:.|||.:|:
Zfish  1705 EQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAE 1769

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|:::|.||..:|:||.||||||..|:|||||.:||||.||||||:|::.||||
Zfish  1770 ELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRR 1834

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            .|||.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|||||.|..:|:|.|
Zfish  1835 GADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLR 1899

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGAS 1933
            |.|.||||||||||:||..::|.|||.|....|:.|:
Zfish  1900 KVQHELEEAEERADIAESQVNKLRAKSRDSGKGKEAA 1936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	14/37 (38%)
		MYSc	81..777	CDD:214580	438/702 (62%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	416/671 (62%)
		Myosin_tail_1	842..1897	CDD:279860	562/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	171/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	46/99 (46%)
		TMPIT	1739..>1825	CDD:285135	47/85 (55%)
myhz1.2	XP_005171981.1	Myosin_N	35..74	CDD:308391	15/38 (39%)
		MYSc_class_II	101..768	CDD:276951	416/671 (62%)
		SMC_N	848..1925	CDD:330553	579/1077 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1098	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2094	1.000	Inparanoid score	I40
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24867
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.870