Protein Alignment Mhc and myo15b

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_073774764.1
• Gene: myo15b / 795537
• ZFINID: ZDB-GENE-030131-4797
• Length: 3191
• Species: Danio rerio
• Alignment Length: 997
• Identity: 297/997 - (29%)
• Similarity: 491/997 - (49%)
• Gaps: 146/997 - (14%)

  Fly    68 ETRDLKKDLLQ------QVNPP------KYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSG 120
            |:.|..:::|:      ||..|      :.::.||::.|..:.::|||.||::|::...||||.|
Zfish   782 ESEDPTQNMLEERLNSTQVMMPGSSQAVEVDEVEDLAQLEEVCESSVLLNLKKRFHRDSIYTYIG 846

  Fly   121 LFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGK 185
            ...::|||:|...:||....:.|:||.::..||||:||:|.|:....|......::|:|:||:||
Zfish   847 NMLLSINPFKPINIYTEELRQQYQGKEKHNNPPHIYAIADAAFCQSQTTTQEHCIIISGQSGSGK 911

  Fly   186 TENTKKVIAYFATV--GASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIR 248
            ||.||.::.|.:::  |.:.|.           .|.::..|:||:||||||:.|:|||||||::.
Zfish   912 TEATKLIVHYLSSMYQGRNDKL-----------RQPMEVLPILESFGNAKTILNNNSSRFGKYLH 965

  Fly   249 IHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVK-DICLLTDNIYDYHIV 312
            ||. ..|.:.|..:..|||||:|::.|...||:||:||::::|.....| |:.|.....|.|  :
Zfish   966 IHI-LQGVVVGTSLSKYLLEKSRIVFQAKEERNYHVFYELLAGMNEWDKQDLYLQGAETYFY--L 1027

  Fly   313 SQGKV-TVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGRE--EQAEQ 374
            :||:. .:....|.::|.|.....:.:|....:...::.:.::::.:|.:.|.....|  |.|..
Zfish  1028 NQGRACELLGKYDKQDFILLVHCLETIGLHADQLATIWAVLSSILQLGNICFSSYESESFEVARI 1092

  Fly   375 DGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGR-----NVQQVTNSIGALCKGVFDRL 434
            ..|.|..||..|... :||..:.::..|:..    .|..|     :|:....|..|:.|.::..|
Zfish  1093 FSEAEARRVGNLLQV-SAEALQTVITHRVTE----TTYDRIYCPLSVESAIESRDAIAKTLYSVL 1152

  Fly   435 FKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEE 499
            |.||:::.||.| ...:....:|::||.|||....|.||||||||.||:||||.|..:...||||
Zfish  1153 FDWLLERINEWL-IPTEMDSTVGIVDIYGFEDLCVNSFEQLCINFANEQLQQFVNRALVAQEQEE 1216

  Fly   500 YQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQ 563
            |..|.|:|..|.. .|...|:|||. :|.|||.||::::..|:|||.||.:| .:.|.|....:.
Zfish  1217 YSAEHIQWYPIVL-EDSNGCLDLISARPYGILRILDDQTSLPQATDHTFLQK-CHYHHGNCPYYT 1279

  Fly   564 KPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFAD----H 624
            |||.|.|     .|.|.||||.|:|.:..:|.||.|.....|::.|.:|:.:::..:|..    :
Zfish  1280 KPKIPLP-----VFTIYHYAGAVTYQVHNFLNKNHDQFRPEVLELFARSRLQMVSGLFRKVQERY 1339

  Fly   625 AGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHL 689
            ..|...| :|:|.|.:    .:||::.:::.|..|.|.|...:..||||..||.:|.||:.|...
Zfish  1340 IQQKELG-RARGHRNQ----MSTVAANFQQSLTELTTRLERCKTTFVRCFKPNYVKLPGIFDVDY 1399

  Fly   690 VMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPK--LLQGVEKDKKATEIIIKFIDLPE 752
            :..||...|:||.|.|.::|||.|:.:..|..||.::..:  :.|.:|:.   ...:|:.|...:
Zfish  1400 ITTQLRHGGILETIHIRKEGFPIRIPFAQFMERYGVLLSQRPINQSLEEQ---VVTLIETIGAED 1461

  Fly   753 DQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSW--MQAWA--------RGYLSRKGFKKLQEQR 807
            .||:||.||||.:..:..|:||          .|  .|.||        ||::.|:.|:..:::.
Zfish  1462 GQYQLGLTKVFLKETLYQQVEE----------KWSSTQTWAAVTIQRNIRGFICRRNFQFFKKKA 1516

  Fly   808 VALKVVQRNL-----RKYLQLRTWPWYKLWQKVKPLLNVS-----RIEDEIARLEEKAKKAEELH 862
            :   |:|.::     |||.:.....:.:.|..:....|..     :...:.:|::|.||......
Zfish  1517 I---VIQSHIRGHQARKYFKQLKQCFTQFWATMMITRNTIKRRHWKEHTDRSRVKEVAKPTSSSS 1578

  Fly   863 AAEVKVRKELEALNAKLLAEKTALLDSLSG--EKGALQDYQERNAKLTAQKN---DLENQ----- 917
            ..:|.:        .::.||.:|.|.|.||  :...:.:......|...:.:   |::..
Zfish  1579 EMDVGI--------LEIPAELSARLRSSSGRSQGSGVSEVAPPQVKADHKLSLPLDIDRHPFSQY 1635

  Fly   918 ----LRD---------IQERLT--QEEDARNQLFQQKK----KADQEISGLKKDIEDLELNVQKA 963
                |:|         :|..||  ..||||..|...|.    ..|.:::|.::.:....: |:|:
Zfish  1636 ANTVLKDGWCQAQGYPLQRPLTSLDHEDARTALEIYKLILRFTGDSDLNGWQEQMLGNYI-VEKS 1699

  Fly   964 EQDKATKDHQIR-NLNDEIAHQ 984
                     ||| .:.|||..|
Zfish  1700 ---------QIRPGIRDEILAQ 1712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	2/6 (33%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	234/682 (34%)
		Myosin_tail_1	842..1922	CDD:460256	36/178 (20%)
myo15b	XP_073774764.1	None