DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myh7l

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001070932.2	Gene:	myh7l / 768300	ZFINID:	ZDB-GENE-061027-393	Length:	1936	Species:	Danio rerio

Alignment Length:	1914	Identity:	1068/1914 - (55%)
Similarity:	1413/1914 - (73%)	Gaps:	6/1914 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEK 79
            |||..|.::|...|:|.:|.||.|::||..|.::...:.:.:||.|:|..|||:...:|...|.:
Zfish    14 PYLRKSEKERLEAQTKAFDLKKECFVPDAIEEFVKATVVSREGDKVTVETQGGKTVTVKEADVLQ 78

  Fly    80 VNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYR 144
            .|||||:||||||.:|.|:.|.||.||::||.|.:||||||||||.:||||..|||.......||
Zfish    79 QNPPKFDKIEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVIAYR 143

  Fly   145 GKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAA 209
            ||.|.|.||||::|||.||..||.:..|||:|||||||||||.|||:||.|||:|.||....:..
Zfish   144 GKERTEAPPHIYSISDNAYQYMLADRENQSILITGESGAGKTVNTKRVIQYFASVAASGGKKDQD 208

  Fly   210 KSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVIS 274
            |:||:||||::|.||.|||||||||:||||||||||||||||...||||.||||||||||:||..
Zfish   209 KNKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHFDTRGKLASADIETYLLEKSRVTF 273

  Fly   275 QQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILG 339
            |...||.|||||||:|...|.:.::.|:|.|.|||..:|||:.||.||||::|...||.||||||
Zfish   274 QLKAERDYHIFYQILSNKKPEILEMLLVTSNPYDYAFISQGETTVPSIDDSDELMATDSAFDILG 338

  Fly   340 FTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIK 404
            ||::||..||::|.|:||.|.|||||:.||||||.||.|:..:.:.|.|.::|:|.|.|..||:|
Zfish   339 FTQEEKNSVYKLTGAIMHYGNMKFKQKQREEQAEADGTEDADKSAYLMGLNSADLIKGLCHPRVK 403

  Fly   405 VGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEY 469
            ||||:||:|:|||||..:||||.|.|::::|.|:|.:.|::|:|:|.||:|||||||||||||::
Zfish   404 VGNEWVTKGQNVQQVNYAIGALSKAVYEKMFLWMVVRINQSLETKQPRQYFIGVLDIAGFEIFDF 468

  Fly   470 NGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILE 534
            |.||||||||||||||||||||||||||||||:|||:|.||||||||.||||||||||||:||||
Zfish   469 NTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILE 533

  Fly   535 EESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKD 599
            ||.|||||:|.||..||.:.|||||..||||:..| |:..||||:.||||.|.|||..||.||:|
Zfish   534 EECMFPKASDATFKAKLYDNHLGKSNNFQKPRLVK-GKPEAHFALVHYAGTVDYNINNWLVKNED 597

  Fly   600 PLNDTVVDQFKKSQNKLLIEIFADHAG-QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTL 663
            |||:|||..::||..|||..:||::|| .|..|:..|..:.|||..|.|||:.::|.||.|||.|
Zfish   598 PLNETVVGLYQKSSLKLLSNLFANYAGADSATGDGGKKEKKKKGSSFQTVSALHRENLNKLMTNL 662

  Fly   664 RSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCP 728
            |||.||||||:||||.|.||.::..||||||.||||||||||||||||||::|.|||.||:|:.|
Zfish   663 RSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNP 727

  Fly   729 KLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAW 790
            ..:   |.:: .||..|.::..:|:...|||.|:|||||:||:|||:||.|||||.||::.:||.
Zfish   728 AAIPEGQFID-SKKGAEKLLGSLDIDHQQYRFGHTKVFFKAGLLGQLEEMRDERLSKIITGIQAK 791

  Fly   791 ARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKA 855
            :||.|||..:.|:.|:|.||.|:|.|:|.::.::.|||.||:.|:||||..:..|.|:|.::|:.
Zfish   792 SRGLLSRAEYIKMVERRDALLVIQWNVRAFMAVKNWPWMKLFFKIKPLLRSAEAEKEMANMKEEF 856

  Fly   856 KKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRD 920
            .|.:|.:|.....|||||.....||.||..|...:..|:..|.|.:||...|...|..:|.:.::
Zfish   857 LKLKEAYAKSEARRKELEEKMVTLLQEKNDLQLQVQAEQDNLCDAEERCEGLIKNKIQMEAKAKE 921

  Fly   921 IQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQD 985
            :.|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|..|
Zfish   922 LTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAALD 986

  Fly   986 ELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKS 1050
            ::|.||.||||...|.:|:|.::||:.|||:|.|.|.|.||||.:|:||.|||:|||:|.|:|::
Zfish   987 DIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKIRMDLERA 1051

  Fly  1051 KRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIE 1115
            |||:|||||||||::.|||.:|::||:.:::||.|:|.:.:|::|||.::::.|:::||||||:|
Zfish  1052 KRKLEGDLKLTQESIMDLENDKQQLEEKLKKKDFEISQLNSKIDDEQSIIIQLQKKLKELQARVE 1116

  Fly  1116 ELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEA 1180
            |||||:||||.||||.||.||||||||||:.||||||||||:||||:|||||||..|||||||||
Zfish  1117 ELEEELEAERAARAKVEKPRADLARELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEA 1181

  Fly  1181 NIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQE 1245
            .:|||:|.|.||||..|:|||:.||:|.|.::|.|.||||:|...:|:|:.:.::||...|...|
Zfish  1182 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELRLELDDVASSMEHIVKSKTNME 1246

  Fly  1246 KIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQ 1310
            |:.:.|:..:||.::|.:|..|:||||...|.||..||.:..|||||.||.||||::.|.|.:.|
Zfish  1247 KVNRTLEDQMNEYRNKCEEYQRSLNDFTTQKAKLQAENDEFSRQLEEKESLVSQLTRGKNSFSQQ 1311

  Fly  1311 LEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYE 1375
            |||.||..|||.:.:..|....::..||.|.||||.|||.|.||:|||.:||||.|...||:|||
Zfish  1312 LEDLKRQLDEEIKAKNALAHALQSARHDTDLLREQYEEEQEAKAELQRSMSKANTEVAQWRTKYE 1376

  Fly  1376 SDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANA 1440
            :|.:.|:|||||||:||..||.||||.:|::|.||..|||||.||..|:|||.::|:|:|..|.:
Zfish  1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNTAAAS 1441

  Fly  1441 AEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLA 1505
            .:|||:.|||||.|||.|.::...||::||||.|:.|||||:||.:|||..:.||.::||||.|.
Zfish  1442 LDKKQRHFDKIISEWKQKYEESQCELESSQKEARSLSTELFKLKNSYEESMDHLETMKRENKILQ 1506

  Fly  1506 DEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQE 1570
            :|:.||.:|:||||:.|||:||.||:||.||.|:||||||||.:||.||.|:||.|||.:|::.:
Zfish  1507 EEISDLTEQLGEGGKTIHELEKVRKQLEQEKAEIQAALEEAEGSLEHEEGKILRTQLEFNQIKAD 1571

  Fly  1571 IDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKAN 1635
            |:|::.||:||.|..::|.||.:|::|::||:|...:.||||:|||:|.|:||:||.|..||:..
Zfish  1572 IERKLSEKDEEMEQVKRNQQRTIDTLQSALESETHSRNEALRIKKKMEGDLNEMEIQLSQANRQA 1636

  Fly  1636 AEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQ 1700
            |||||.:|..|..|||.|..|::..|:.||.:|...|.|||...||.||||.|.:|||.:|||:.
Zfish  1637 AEAQKQLKSVQAHLKDSQLQLDDSLRSNDDLKENTAIVERRNALLQAELEELRAVLEQTERGRKL 1701

  Fly  1701 AEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLA 1765
            |||||.|..|::..:.:||.|:...|:|||::|....::::|.:.|.:|:|||||||:.|||.:|
Zfish  1702 AEQELLDVTERVQLLHSQNTSLINQKKKLETDLSQFQTEVEEAVQECRNAEEKAKKAITDAAMMA 1766

  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830
            :||:.|||.:...|:::|.:||.||:||.||||||..|:|||||.:||||.||||||.|::.||:
Zfish  1767 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLEARVRELECEVEAEQK 1831

  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895
            |.:::.|.:||.|||:|||::|:||||||..|:||||||||.|:|.|||..||:||.|.::|.||
Zfish  1832 RSSESVKGIRKYERRIKELTYQTEEDRKNIARLQDLVDKLQLKVKAYKRAAEESEEQANVHLGKF 1896

  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.|.||:|||||||:||..::|.|||.|
Zfish  1897 RKLQHELDEAEERADIAESQVNKLRAKSR 1925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	12/36 (33%)
		MYSc	81..777	CDD:214580	441/699 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	420/668 (63%)
		Myosin_tail_1	842..1897	CDD:279860	552/1054 (52%)
		V_Alix_like	1557..1877	CDD:187408	165/319 (52%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	49/85 (58%)
myh7l	NP_001070932.2	Myosin_N	35..72	CDD:280832	12/36 (33%)
		Myosin_head	87..766	CDD:278492	427/680 (63%)
		MYSc_class_II	99..766	CDD:276951	420/668 (63%)
		Myosin_tail_1	846..1923	CDD:279860	568/1076 (53%)
		RILP-like	961..1094	CDD:304877	65/132 (49%)
		MM_CoA_mutase	<1132..1293	CDD:294532	91/160 (57%)
		MIT_CorA-like	<1295..>1407	CDD:294313	62/111 (56%)
		COG6	1372..>1505	CDD:303003	75/132 (57%)
		ATP-synt_B	<1500..1608	CDD:304375	59/107 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1098	1.000	Domainoid score	I20
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68044
Inparanoid	1	1.050	2094	1.000	Inparanoid score	I40
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24867
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970