DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and Myo18b

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_083177.2 Gene:Myo18b / 74376 MGIID:1921626 Length:2605 Species:Mus musculus


Alignment Length:1946 Identity:453/1946 - (23%)
Similarity:843/1946 - (43%) Gaps:440/1946 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LEQRRI-----------DQSKPYDSK----KSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVR 70
            :|:::|           |..:.|:.:    :..|:. :|:|:.|..:  .|.|..:.....|.||
Mouse   524 MEEKQILQDPDRGGQSGDSDQAYEDRWYEAQKVWLV-QKDGFTLATV--LKPDEGTADPPAGRVR 585

  Fly    71 ----------DIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVA 125
                      ::..|:|...||.:.::.||:|.:..:|...|::.|.|||.|:|.||.||...:.
Mouse   586 LCIDADRTVIEVDEEQVHPANPSELDQAEDLASLVSVNESSVMNTLLQRYRAQLPYTCSGPDLIT 650

  Fly   126 INPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTK 190
            :.|   .........|:.|| |::.:|.|:.:::..||..:|:...:||::..|.||||||...:
Mouse   651 LQP---QTTTVPSSGKVPRG-RQDGLPAHVTSLAQRAYWALLSQRRDQSIVALGRSGAGKTTCCE 711

  Fly   191 KVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTG 255
            :|:.:.  ||.:...|    .:.|:| ::..|..||.|||...|..:..::||...:.:.|..||
Mouse   712 QVLEHL--VGMAGSVD----GRVSVE-KLRATFTVLRAFGCVSTGHSRRATRFAMVMSLDFNATG 769

  Fly   256 KLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQ----GK 316
            ::..|.::|.|||.:||..|...|.::.:|.|:::|     .|:.|.|:  .:.|.:::    |.
Mouse   770 RVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAG-----MDVDLRTE--LNLHQMAESSAFGM 827

  Fly   317 VTVASIDD----AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGE 377
            ...:..:|    |..||....|.::||.::.|::.::|:.||:.|:|.....:.||::...   .
Mouse   828 GLWSKPEDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVGRKQFMR---F 889

  Fly   378 EEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNS-------------IGALCKG 429
            |.....::..|||..||.....|..::...|.:|.|...|.:.::             :..:..|
Mouse   890 EWANHAAEALGCDYEELNTATFKHHLRQIIEQMTSGPQRQGLQDNEACSGLKMTGVECVEGMASG 954

  Fly   430 VFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNG------FEQLCINFTNEKLQQFF 488
            ::..||..:|...|.:..:.......|.|:|..||:...:.|      ||:||.|:..|:||..|
Mouse   955 LYQELFVAVVSLINRSFSSHHLSMASIMVVDTPGFQNPRHQGKDRAATFEELCYNYAQERLQLLF 1019

  Fly   489 NHHMFVLEQEEYKREGIDWAFIDFGMDL--------LACIDL------------IEKPMGILSIL 533
            .|..||...|.||.|||...|     ||        :|.:|.            .|...|:..:|
Mouse  1020 YHRTFVSTLERYKEEGIPVPF-----DLPESSPGTTVAVVDQNPSQVHLPAGRGAEDAGGLFWVL 1079

  Fly   534 EEESMFPKATDQTFSEKLTNTHLGKSAPFQKPK------PP--KPGQQAAHFAIAHYAG--CVSY 588
            :||.....::|.|..|:|       .|.|:|.|      ||  :..:|.....:.|..|  .|.|
Mouse  1080 DEEVRVQGSSDSTVLERL-------RAAFEKKKEAGAEEPPSMRTCEQPLQCELFHQLGRDPVRY 1137

  Fly   589 NITGWLEKNKDPL----NDTVVDQFKKSQNKLLIEIFAD-------HAGQSGGGEQAKGGRGKKG 642
            ::||||.:.|..|    ...::.|.|:.:.:.|.:..|.       .||..|..:||........
Mouse  1138 DLTGWLRRAKPNLAALEAPQILQQSKREELQSLFQARAKLPPVCRAVAGLEGTSQQALHRSRVVR 1202

  Fly   643 GGFATVSSAYKE---------QLNSLMTTLRSTQPHFVRCIIPNEMK------------------ 680
            ..||:..:|.|.         |:::|::.||.::.||:.|::|..::                  
Mouse  1203 RAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTPSPSQPSGDQG 1267

  Fly   681 ---QPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVE------K 736
               :|..:|...:..||..:.:||.:|:.|.|:...|....|:.|::::.|.||:.::      .
Mouse  1268 VANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLKKLDLTSEELD 1332

  Fly   737 DKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFK 801
            ::|..|.::|.:||.:....:|:::||.:|||:.::|..|::.:.:.:...||..||:|||:.:|
Mouse  1333 ERKVVEELLKTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAACRGFLSRQEYK 1397

  Fly   802 KLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLN-------VSRIEDEIARLEEKAKKAE 859
            ||:.:|:|...:|:||..:|:::.|||:.|...::|||:       :...|:|:..|.:|.:|:|
Mouse  1398 KLKIRRLATLCIQKNLAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELTLLRQKLQKSE 1462

  Fly   860 ELHAAEVKVRKELEALNAKLLAEKTALLDSLSGE--KG-----ALQDYQERNAKLTAQKNDLENQ 917
            .   :..::|:..:.|.:|:    |.|...|:.|  ||     ||:  .||..:|.|        
Mouse  1463 N---SRSELRQNTDLLESKI----TDLTSELADERFKGDVACQALE--SERAERLQA-------- 1510

  Fly   918 LRDIQERLT---QEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLND 979
            ||::||..|   |.:||..::.:|.::|.|.|.|                          .||.:
Mouse  1511 LREVQELKTKYQQVQDALGEVQKQLEEAQQRIQG--------------------------ANLEE 1549

  Fly   980 EIA-HQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043
            :.| ..||...:|:. .:|:.:..:|   .||..|::::...|.:.:|||.|.||:.:.|..||:
Mouse  1550 KPAGGADEWQMRLDC-AQMENDFLRK---RLQQCEERLDSEMKARTELEQKLGELQSAYEEAKKM 1610

  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIK 1108
            ...:::....:..||:.|:..:.:.:....|||:..::.|.:|:                     
Mouse  1611 AHQLKRKCHHLTWDLEDTRVLLENQQSRNHELEKRQKKFDLQLA--------------------- 1654

  Fly  1109 ELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173
              ||..|.:     .|:..|.|..::...:..||.:|.::||:              :|.|.|||
Mouse  1655 --QALGESM-----FEKSLREKVSQENNGVRWELGQLQQQLEQ--------------KEQEASKL 1698

  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHIT 1238
            ::::|....| :..|.:.....:..||.:.|:|.:|                :.|.|.       
Mouse  1699 KQEVERLQGQ-KRELLSCASVGDQGVASLKERVWEL----------------ETNALE------- 1739

  Fly  1239 NEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKI 1303
                 |:||..|.::|:.:::..            ..:.:|.||....:.| ::.|.|..:|..:
Mouse  1740 -----QQKIHSQQENTIKQLEQL------------RQRFELEIERMKQMHQ-KDREDQEEELEDV 1786

  Fly  1304 KISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQV-EEEAEGKADLQRQLSKANA-- 1365
            :.|...:|...:...::|..|:...|.:..:||..:..|.:|: ..:.:.:..|:|.|.:.:|  
Mouse  1787 RQSCQKRLRQLEMQLEQEYEEKQVALHEKHDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALL 1851

  Fly  1366 -EAQVWRSKYESDGVARS-EELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQ 1428
             :.|:..:..|....:.| ||||:...:|:...|:.|:.:           ||::.|:.::|::.
Mouse  1852 SDVQLLLATIEDSKTSISKEELEKVHSQLEQSEAKCEDAL-----------KTQKVLTADLENMH 1905

  Fly  1429 LEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQ 1493
            .|::      |....|.            .||:                 :|:||:   .|..:.
Mouse  1906 SELE------NVTRSKS------------LVDE-----------------QLYRLQ---FERADL 1932

  Fly  1494 LEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVL 1558
            |:.:..:..:|.|.::...|.|.:...:|.:|:           |||..|||.     ::|.:.|
Mouse  1933 LKRIDEDQGDLNDLMQKHKDLIAQSAADIGQIQ-----------ELQLQLEET-----KKEKQKL 1981

  Fly  1559 RAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMK-KKLEADIN 1622
            |.||.::|:      |||..|:      ...:||:.|.|.::..:.:.|.|..::: |:.|..:.
Mouse  1982 REQLHMAQL------RIQYLEQ------STVERAIVSRQEAIICDLENKTEFQKVQIKRFEVLVI 2034

  Fly  1623 ELEIA-------LDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANAL 1680
            .|..:       |..|.||.|:.::|.:.|||:|::::..::|..:..::|       .||...|
Mouse  2035 RLRDSMIKMGEELSRAVKAEAQQRENSQYYQQRLEELKAEMQELAQREEEA-------SRRCMEL 2092

  Fly  1681 QNELEESRTLLEQADRGRRQAEQELADAHEQLNEV--------SAQNA------------SISAA 1725
            :..:||..|:.:........:.:.:||....|.||        |.|.|            ::|..
Mouse  2093 EKYVEELATVRQTLQTDLETSIRRIADLQAALEEVVSSDSDTESVQTAVDCSSRSGKEGDNVSVI 2157

  Fly  1726 KRKLESELQTLHSDLDELLNEAKN--SEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKA 1784
            ..:.|..||:..|....|..::..  |.:....:...:.|:::|       |...|:||.|
Mouse  2158 SSQPEGSLQSWMSCSLSLATDSVRIPSGQSVVSSSFHSPRVSEE-------AGDSERLRTA 2211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/46 (20%)
MYSc 81..777 CDD:214580 205/799 (26%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 195/768 (25%)
Myosin_tail_1 842..1897 CDD:279860 209/989 (21%)
V_Alix_like 1557..1877 CDD:187408 58/258 (22%)
ATP-synt_B <1671..1771 CDD:304375 23/121 (19%)
TMPIT 1739..>1825 CDD:285135 9/48 (19%)
Myo18bNP_083177.2 PHA03247 <55..472 CDD:223021
COG5022 606..2126 CDD:227355 419/1767 (24%)
MYSc_Myo18 625..1361 CDD:276837 195/768 (25%)
CEP170_C 2123..>2365 CDD:373735 20/96 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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