DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo19

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001122117.1	Gene:	myo19 / 734140	XenbaseID:	XB-GENE-999897	Length:	969	Species:	Xenopus tropicalis

Alignment Length:	978	Identity:	286/978 - (29%)
Similarity:	454/978 - (46%)	Gaps:	200/978 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTV 96
            ::.:...::.|||:.:|..::                         .||||
Frog    28 FEEEVKAFLIDEKQLHLYDDL-------------------------TKVNP-------------- 53

  Fly    97 LNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPV---YTNRCAKMYRGKRRNE-VPPHIFA 157
            :.|..||..|:.||.|.:.||.:|...||:||::  ||   |::...|.|......: ..||||.
Frog    54 VTTATVLKCLQARYSAGVFYTNAGCTVVAVNPFR--PVCKLYSSEVMKEYHAASNPQGCKPHIFT 116

  Fly   158 ISDGAY--VDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASK--KTDEAAKSKGSLEDQ 218
            :::.||  |......||||::::||||||||..::.::.::|||.||:  .|:|..:   .:|.:
Frog   117 VAEQAYKNVQSQIQPVNQSIIVSGESGAGKTWTSRCLMKFYATVSASRCYITNEMVE---RIESR 178

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
            |:.:|||:||||||.|:||.|||||||:|::....|.::.||.|:||||||.||..|..|||::|
Frog   179 VLDSNPVMEAFGNACTLRNHNSSRFGKYIQLQLNRTQQITGASIQTYLLEKTRVAHQAPLERNFH 243

  Fly   284 IFYQIMSG---------SVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILG 339
            ||||::.|         ::|...:...|.:  |:.::            :.::|.:|..|...||
Frog   244 IFYQVVKGASRHEREEWNLPEKANFSWLPN--YENNL------------EEDDFEVTKDAMLHLG 294

  Fly   340 FTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYK----NLLK 400
            ..:..:.::::|.:.::|:|.::|     .:..::....|....::.|....|.|.|    :||:
Frog   295 IDQTTQNNIFKILSGLLHLGNIQF-----SDSVDESQPCEPLNYTQEFASVAASLLKIPVSHLLE 354

  Fly   401 PRIKVGNEFVTQGRNVQQV----------TNSIGALCKGVFDRLFKWLVKKCNETLDTQQKR-QH 454
             |:.:  ..:|.|:  |||          ......|.|.::.|||:|||...||.:..:..| .:
Frog   355 -RLSI--RTITAGK--QQVFKKPCRKSECDTRRDCLAKTIYARLFEWLVTVINENICAEAYRWNN 414

  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLAC 519
            |||:||:.|||.|..|..||||||:.||||||.|..|....:|:||..||::|:||.: .|..:|
Frog   415 FIGLLDVYGFESFPENNLEQLCINYANEKLQQHFVSHYLKSQQDEYAAEGLEWSFISY-QDNQSC 478

  Fly   520 IDLIE-KPMGILSILEEESMFPKATD----QTFSEKLT--NTHLGKSAPFQKPKPPKPGQQAAHF 577
            :|||| .|:.|.|:|.||....:::|    |:..||..  |..:|:....:||          :|
Frog   479 VDLIEGSPISIFSLLNEECRLNRSSDAGQLQSRLEKALSHNKSIGRDKFSKKP----------NF 533

  Fly   578 AIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKG 642
            .::||||.|.|.|....||||||:...::...::|.:.||..:|...     ..:...|....:.
Frog   534 IVSHYAGKVQYQIEDMAEKNKDPVPPELIQLLQESDDHLLQILFPVE-----NNKPVYGATNNRA 593

  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707
            .| .||.|.:|..|.|||..|.||.||::|||.||...|..|.....|:.||...|::|.|.|..
Frog   594 VG-VTVVSKFKGSLESLMQILHSTTPHYIRCIKPNVDCQALVFRQEEVLMQLEACGIVETINISA 657

  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLL---------------QGVEK-DKKATEI----------IIK 746
            .|||.|:.:..|..||.::.|:.:               ||.|| |:..:::          :.|
Frog   658 AGFPIRISFESFVERYSVIAPRQIHMENNFNDCLFLKKKQGFEKTDQLPSKLQTILHAVLSKLCK 722

  Fly   747 FIDLPEDQYRLGNTKVFFRAGVLGQMEE-------------------FRDERLGK---IMSWMQA 789
            ...|.......|.||||....::..:||                   :|..:|.|   ..:.:||
Frog   723 DSTLSNTLVHCGTTKVFLTHLMVELLEERRLEAICSKAVCIQCCWRRYRQRKLAKQNRAATTIQA 787

  Fly   790 WARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEK 854
            ..:|:|::|..:::......:|            |.|   |.|::....|..:.::|.|..:|..
Frog   788 AVKGWLTKKYIERMHNAATVIK------------RIW---KKWKEKMEALAAAELDDSIEDVERT 837

  Fly   855 AKKAEELHAAEVKVRKELEA----LNAKLLAEKTALLDSLSG----EKGALQDYQERNAKLTAQK 911
            .     |.:......|.||:    |..|||.....|.....|    :..|::.|.....:|...:
Frog   838 L-----LLSVPASPVKTLESPKTNLQDKLLTHSAILKFGTLGLVLYKAPAIRKYIVETDELKRNQ 897

  Fly   912 NDL 914
            |.|
Frog   898 NIL 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	4/36 (11%)
		MYSc	81..777	CDD:214580	248/779 (32%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	243/729 (33%)
		Myosin_tail_1	842..1897	CDD:279860	18/81 (22%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
myo19	NP_001122117.1	MYSc	45..752	CDD:214580	250/791 (32%)
myo19	NP_001122117.1	MYSc_Myo19	57..741	CDD:276846	243/729 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910