DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh2

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001128629.1	Gene:	Myh2 / 691644	RGDID:	620354	Length:	1942	Species:	Rattus norvegicus

Alignment Length:	1925	Identity:	1068/1925 - (55%)
Similarity:	1427/1925 - (74%)	Gaps:	16/1925 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEK 76
            :..|||..|.::|...|::|:|:|.|.::.:.||.::.|.|::.....|:|..:.|....:|.::
  Rat    12 EAAPYLRKSEKERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVKTEAGATLTVKEDQ 76

  Fly    77 VEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            :..:||||::||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||......
  Rat    77 IFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS--KK 204
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:..:  ||
  Rat   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKK 206

  Fly   205 TDE--AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLL 267
            .:|  :.|.:|:||||::..||:|||||||||||||||||||||||||||.|||||.||||||||
  Rat   207 KEEVTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLL 271

  Fly   268 EKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTD 332
            ||:||..|...||||||||||.|...|.:.::.|:|.|.|||..||||:::||||||.||...||
  Rat   272 EKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATD 336

  Fly   333 QAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN 397
            .|.||||||..||..:|::|.||||.|.|||||:.||||||.||.|...:.:.|.|.::|:|.|.
  Rat   337 SAIDILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQGLNSADLLKA 401

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            |..||:|||||:||:|:.|:||||::|||.|.:::::|.|:|.:.|:.|||:|.||:||||||||
  Rat   402 LCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIA 466

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM 527
            |||||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:||||||
  Rat   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPM 531

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            ||.||||||.|||||||.:|..||...||||||.|||||..| |:..|||::.||||.|.|||||
  Rat   532 GIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVK-GKAEAHFSLIHYAGTVDYNITG 595

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIF-----ADHAGQSGGGEQAKGGRGKKGGGFATVSSAY 652
            ||:|||||||:|||..::||..|.|..:|     |:....|||.  ||.|..|||..|.|||:.:
  Rat   596 WLDKNKDPLNETVVGLYQKSSMKTLAYLFSGAQTAEAEASSGGA--AKKGAKKKGSSFQTVSALF 658

  Fly   653 KEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYP 717
            :|.||.|||.||||.|||||||||||.|.||.::..||:|||.||||||||||||||||:|::|.
  Rat   659 RENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYA 723

  Fly   718 DFKMRYKIM-CPKLLQGVEKD-KKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            |||.|||:: ...:.:|...| |||:|.::..||:...||:.|:|||||:||:||.:||.||::|
  Rat   724 DFKQRYKVLNASAIPEGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKL 788

  Fly   781 GKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE 845
            .::::..||..||:|:|..::|:.|:|.::..:|.|:|.::.::.|||.||:.|:||||..:..|
  Rat   789 AQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETE 853

  Fly   846 DEIARLEEKAKKA-EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTA 909
            .|:|.::|:.:|. :||..:|.| |||||.....||.||..|...:..|...|.|.:||..:|..
  Rat   854 KEMATMKEEFQKTKDELAKSEAK-RKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIK 917

  Fly   910 QKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQI 974
            .|..||.:::::.||...||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...::::
  Rat   918 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 982

  Fly   975 RNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            :||.:|:|..||.|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:
  Rat   983 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ 1047

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |||:|.|:|::|||:||||||.||::.|:|..|::|::.:::|:.|:|::.:|:||||.:.::.|
  Rat  1048 EKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQ 1112

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            ::||||||||||||||:||||.:||||||||:||:|||||:.|||||||||||||||:|||||||
  Rat  1113 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1177

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            ..|:|||||||.:|||:|.|.|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.|
  Rat  1178 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV 1242

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            :.::..|...||:.:.|:..::|::||.:|..|.:||....:.:|..|:.:..|||:|.|:.|||
  Rat  1243 ETVSKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQ 1307

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            ||:.|.:.|.|:|:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.|||||
  Rat  1308 LSRGKQAFTQQIEELKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1372

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQL 1429
            :|...||:|||:|.:.|:|||||||:||..||..|||.:|::|.||..||||||||..|||||.|
  Rat  1373 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1437

  Fly  1430 EVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQL 1494
            :|:|.||...|.:|||:.||||:.|||.|.::..|||:|||||.|:..||||::|.||||..:||
  Rat  1438 DVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQL 1502

  Fly  1495 EAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLR 1559
            |.::||||||..|:.||.:||.|||:.|||:||.:|::|.||.|||||||||||:||.||.|:||
  Rat  1503 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1567

  Fly  1560 AQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINEL 1624
            .||||:||:.||||:|.||:||.:..::||.|.::|||::|:||.:.:.:|:|:|||:|.|:||:
  Rat  1568 IQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEM 1632

  Fly  1625 EIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRT 1689
            ||.|:|||:..|||.:|.:..|..|||.|..|::..|.::|.:|||.:.|||||.||.|:||.|.
  Rat  1633 EIQLNHANRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRA 1697

  Fly  1690 LLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKA 1754
            .|||.:|.|:.|||||.||.|::..:..||.|:...|:|||:::..:..::::::.||:|:||||
  Rat  1698 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKA 1762

  Fly  1755 KKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVR 1819
            |||:.|||.:|:||:.|||.:...|:::|.:||.:|:||:||||||..|||||||.|||||.|||
  Rat  1763 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1827

  Fly  1820 ELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEA 1884
            |||.|::.||:|:.:|.|.|||.|||||||::|:||||||..|:||||||||.|:|:||||.|||
  Rat  1828 ELEGEVESEQKRNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1892

  Fly  1885 EEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            ||.:..||:||||.|.||||||||||:||..::|.|.|.|
  Rat  1893 EEQSNTNLSKFRKLQHELEEAEERADIAESQVNKLRVKSR 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/36 (22%)
		MYSc	81..777	CDD:214580	447/706 (63%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	427/675 (63%)
		Myosin_tail_1	842..1897	CDD:279860	559/1055 (53%)
		V_Alix_like	1557..1877	CDD:187408	171/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	47/99 (47%)
		TMPIT	1739..>1825	CDD:285135	50/85 (59%)
Myh2	NP_001128629.1	Myosin_N	35..73	CDD:397036	9/37 (24%)
		Motor_domain	100..773	CDD:419868	427/675 (63%)
		Myosin_tail_1	853..1930	CDD:396244	576/1077 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910