DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh7b

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_017174700.1	Gene:	Myh7b / 668940	MGIID:	3710243	Length:	1947	Species:	Mus musculus

Alignment Length:	1908	Identity:	1037/1908 - (54%)
Similarity:	1375/1908 - (72%)	Gaps:	17/1908 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PYDSKKSCWIPDEKEGYLLGEIK--ATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMAD 93
            |:|.||..|:|||::.|:..|:|  ||.|. |:|..:..:|..::..:::.:|||:|:.:||||.
Mouse    28 PWDGKKRVWVPDEQDAYVEAEVKTEATGGK-VTVETKDQKVLTVRETEMQPMNPPRFDLLEDMAM 91

  Fly    94 MTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAI 158
            ||.||...|||||||||...:||||||||||.|||||..||||......|:||||:|.||||:|:
Mouse    92 MTHLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTAAVVAAYKGKRRSEAPPHIYAV 156

  Fly   159 SDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-----GASKKTD-EAAKSKGSLED 217
            :|.||.|||.|..|||||||||||||||.|||:||.|||.|     |..||.. .|.|:.|:|||
Mouse   157 ADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLED 221

  Fly   218 QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSY 282
            |:::.||.:||||||||:|||||||||||||||||||||||.|||::|||||:|||.|...||.|
Mouse   222 QIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDSYLLEKSRVIFQLPGERGY 286

  Fly   283 HIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKED 347
            |::|||:||..|.::|:.||:.|.||||..|||..||.::||.||...||.|.|||||:..||..
Mouse   287 HVYYQILSGKKPELQDMLLLSMNPYDYHFCSQGVTTVDNMDDGEELIATDHAMDILGFSVDEKCA 351

  Fly   348 VYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQ 412
            .|:|..|::|.|.|||||:.||||||.||.|...:.:.|.|..:.:|.|.||.||::||||:||:
Mouse   352 CYKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTK 416

  Fly   413 GRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCI 477
            |::|:||..::|||.|..:||||:|||.:.|:||||:..||.||||||||||||||:|.||||||
Mouse   417 GQSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCI 481

  Fly   478 NFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKA 542
            ||||||||||||.|||||||||||||||||.|||||:||..||||||||:|||||||||.|||||
Mouse   482 NFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKA 546

  Fly   543 TDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVD 607
            :|.:|..||.:.|.|||..||:|:|.|..:..|||.:.||||.|.|:|.|||||||||||:|||.
Mouse   547 SDASFRAKLYDNHSGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVP 611

  Fly   608 QFKKSQNKLLIEIFADHAGQSGGGEQAKGG---RGKKGGGFATVSSAYKEQLNSLMTTLRSTQPH 669
            .|:||||:||..::.::|| |...|..|.|   :.||...|.|||..:||.||.|||.||:||||
Mouse   612 IFQKSQNRLLATLYENYAG-SCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPH 675

  Fly   670 FVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL--Q 732
            |||||:|||.|.|||:|:.||:|||.||||||||||||:|||||::|.||:.||:|:.|..:  .
Mouse   676 FVRCIVPNENKTPGVMDSFLVLHQLRCNGVLEGIRICRQGFPNRLLYADFRQRYRILNPSAIPDD 740

  Fly   733 GVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSR 797
            .....:||||.::..:|:...||:.|:|||||:||:||.:||.||:||.|:::.:||.:||.|.|
Mouse   741 TFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFKAGLLGILEELRDQRLAKVLTLLQARSRGRLMR 805

  Fly   798 KGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAE-EL 861
            ..::::...|.||..:|.|:|.:..::.|.|.||:.|:||||..::.|:|:|.|..:.:... .|
Mouse   806 LEYQRMLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGAL 870

  Fly   862 HAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLT 926
            ..||.| |:|||.....:..||..|...|..|:..|.|.:||...|...|..||.:::::.|||.
Mouse   871 ATAEAK-RQELEETQVSVTQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEAKVKELSERLE 934

  Fly   927 QEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKL 991
            .||:....|..:::|.:.|.:.|||||:||||.:.|||::|...:::::||.:|:|..||.:.:|
Mouse   935 DEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDEAVVRL 999

  Fly   992 NKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEG 1056
            .||||...|.:|:...:|||.||:::.|.|.|.:|||.:::||.|||:|||:|.|.|::|||:||
Mouse  1000 TKEKKALQEAHQQALGDLQAEEDRVSALAKAKIRLEQQVEDLECSLEQEKKLRMDTERAKRKLEG 1064

  Fly  1057 DLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEV 1121
            |||||||.|.|..::|::||:.:::||.|||.:..::||||:|.::.|::|||||||.||||||:
Mouse  1065 DLKLTQETVTDTTQDKQQLEEKLKKKDSELSQLNLRVEDEQLVGVQLQKKIKELQARAEELEEEL 1129

  Fly  1122 EAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHES 1186
            ||||.|||:.|||||:.|||||||.|||||||||::.|.|..:||||||.:|||:||||.::||:
Mouse  1130 EAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAVLRHEA 1194

  Fly  1187 TLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQL 1251
            |:|.||:|..|:.||::||||.|.:::.|.||||:|...:::||.|.|:.:...||:.||:.:..
Mouse  1195 TVAALRRKQADSAAELSEQVDSLQRIRQKLEKEKSELRMEVDDLGASVETLARGKASAEKLCRTY 1259

  Fly  1252 QHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKR 1316
            :..|:|.:.|::|..|.|.|....:.:|..||.:|.|.|||.||.:||||:.|.|....||:.:|
Mouse  1260 EDQLSEAKIKVEELQRQLADASTQRGRLQTENGELGRLLEEKESMISQLSRGKTSAAQSLEELRR 1324

  Fly  1317 LADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVAR 1381
            ..:|||:.:..|....:.|.||.|.||||.|||:|.:|:|||.|||||||...||||||:|.:.|
Mouse  1325 QLEEESKAKGALAHAVQALRHDCDLLREQHEEESEAQAELQRLLSKANAEVAQWRSKYEADAIQR 1389

  Fly  1382 SEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQK 1446
            :|||||||:||..||.||||.:|:.|.||..|||.|.||.||.||:.||::||.:.|.|.:|||:
Mouse  1390 TEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQR 1454

  Fly  1447 AFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDL 1511
            ..::.:.|.:.:.:::..||:|:|:|.|...||||||:.::||..|.||.::||||||.:|:.||
Mouse  1455 HLERALEERRRQEEEMQRELEAAQREARGLGTELFRLRHSHEEALEALETLKRENKNLQEEISDL 1519

  Fly  1512 LDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQ 1576
            .||:...|::|.|:|||:|.||.||.||||||||||.|||.||.|.||.|||||||:.|:||::.
Mouse  1520 TDQVSLSGKSIQELEKAKKALEGEKSELQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLA 1584

  Fly  1577 EKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN 1641
            ||:||..|.|:|||||::|:||||:||.:.:.||||:|||:|.|:|:||:.|.||.:...|||..
Mouse  1585 EKDEECTNLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAA 1649

  Fly  1642 IKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELA 1706
            .:..|.|||:.|...:||||...:.|||....||||..|..||||.|..|||.:|.||.|||||.
Mouse  1650 TRLLQAQLKEEQAGRDEEQRLAAELREQGQALERRAALLAAELEELRAALEQGERSRRLAEQELL 1714

  Fly  1707 DAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAE 1771
            :|.|:||.:.:||..:...|:|||.:|..|..:::|...|.:.:|||||||:.|||.:|:||:.|
Mouse  1715 EATERLNLLHSQNTGLLNQKKKLEVDLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKE 1779

  Fly  1772 QDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQ 1836
            ||.:...|:::|.|||.::|||.||:|||..||:||||.:||||.:|||||.|||.||::||:|.
Mouse  1780 QDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL 1844

  Fly  1837 KNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQE 1901
            |.:||.|||||||.:|:||||||..||||||||||.|:|:||||.||||:.|:.||||:||||.|
Mouse  1845 KGVRKHERRVKELVYQTEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQASTNLAKYRKAQHE 1909

  Fly  1902 LEEAEERADLAEQAISKFRAKGR 1924
            |::||||||:||...:|.||:.|
Mouse  1910 LDDAEERADMAETQANKLRARSR 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	14/38 (37%)
		MYSc	81..777	CDD:214580	438/706 (62%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	419/675 (62%)
		Myosin_tail_1	842..1897	CDD:279860	538/1055 (51%)
		V_Alix_like	1557..1877	CDD:187408	176/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	46/85 (54%)
Myh7b	XP_017174700.1	Myosin_N	32..71	CDD:367160	15/39 (38%)
		MYSc_Myh7b	98..773	CDD:276953	419/675 (62%)
		Myosin_tail_1	853..1930	CDD:366712	554/1077 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1105	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2092	1.000	Inparanoid score	I42
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm43784
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820