DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myo19

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_079690.2	Gene:	Myo19 / 66196	MGIID:	1913446	Length:	963	Species:	Mus musculus

Alignment Length:	889	Identity:	269/889 - (30%)
Similarity:	428/889 - (48%)	Gaps:	137/889 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GYLLG---EIKAT-KGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNL 106
            |:.||   |.:|: |||:..  ..|||:...:.:.:.||||...|              .||..|
Mouse     7 GHSLGSDAEGRASLKGDLRE--FLGGEIPLHQLDDLTKVNPVTLE--------------TVLRCL 55

  Fly   107 RQRYYAKLIYTYSGLFCVAINPYKRYP-VYTNRCAKMYR-GKRRNEVPPHIFAISDGAY--VDML 167
            :.||...:.||.:|...||:||:|..| :|.....:.|. ..:..::.||||.:.:..|  |..|
Mouse    56 QARYTEDIFYTNAGCTLVALNPFKHVPQLYAPELMQEYHAAPQPQKLKPHIFTVGEQTYRNVKSL 120

  Fly   168 TNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNA 232
            ...||||::::||||||||..::.::.::|.|.||..:.|..|....:|.:::.:|||:||||||
Mouse   121 IEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVAASPTSCENHKIAERIEQRILNSNPVMEAFGNA 185

  Fly   233 KTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVK 297
            .|:||.|||||||||::......::.||.::||||||.||..|.|.||::||||||..|:.
Mouse   186 CTLRNSNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFHIFYQICKGAT---- 246

  Fly   298 DICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDI-------LGFTKQEKEDVYRITAAV 355
                 .|....:|: .:|  |..|.....|.||.:..|::       ||.....:.:::::.|.:
Mouse   247 -----KDERLQWHL-PEG--TAFSWLPNPESSLEEDCFEVTREAMLHLGIDTPTQNNIFKVLAGL 303

  Fly   356 MHMGGMKFKQRGREEQA----EQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNV 416
            :|:|.:.|..  .|::|    ..|..:...|.|.|.    .:|.:.:|...:::  ..:..|:..
Mouse   304 LHLGNVHFVD--SEDEALPCQVMDDTKVSVRTSALL----LQLPEKMLLESMQI--RTIKAGKQQ 360

  Fly   417 Q---------QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKR-QHFIGVLDIAGFEIFEYNG 471
            |         :.......|.|.::.|||.|||...|.::....|. ..|||:||:.|||.|..|.
Mouse   361 QVFQKPCSRAECDTRRDCLAKLIYARLFDWLVSVINSSICADSKSWTAFIGLLDVYGFESFPNNS 425

  Fly   472 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KPMGILSILEE 535
            .||||||:.||||||.|..|....:||||:.||::|:|::: .|...|:||:| .|:.|.|::.|
Mouse   426 LEQLCINYANEKLQQHFVAHYLRAQQEEYEVEGLEWSFVNY-QDNQTCLDLLEGSPISICSLINE 489

  Fly   536 ESMF--PKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNK 598
            |...  |.:..| ...::.:|..|:..........:|.     |.:.|:||.|.|:..|.:||||
Mouse   490 ECRLNRPSSAAQ-LQTRIESTLAGRPCLGHNKLSREPS-----FVVVHFAGPVRYHTAGLVEKNK 548

  Fly   599 DPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTL 663
            ||:...:.:..::||:.||..:|..:..:....|.:    |:......||.|.:|..|..|:..|
Mouse   549 DPVPPELTELLQQSQDPLLTMLFPANPEEKTQEELS----GQSRAPALTVVSKFKASLEQLLQVL 609

  Fly   664 RSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI--- 725
            .:|.||::|||.||...||.......|::||...|::|.|.|...|||.|:.:.:|..|||:
Mouse   610 HNTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEACGLVETIHISAAGFPIRVSHQNFIERYKLLRR 674

  Fly   726 MCPKL---LQGVEKDKKATE----------------------IIIKFIDLPEDQYR-------LG 758
            :.|::   |.|:|..:.::|                      .:|:....|.|..:       .|
Mouse   675 LGPRMSSGLGGLEPAEGSSEQPLCAKEATLQPLLQDILHALPALIQTAATPSDPAKNTQIPLYCG 739

  Fly   759 NTKVFFRAGVLGQMEEFRDERLGKIMSWMQ-AWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQ 822
            .||:|....:|..:|..|.:.|.:....:| .|.|..|     :|.::||.|..::|...|.:|.
Mouse   740 RTKIFMTDSMLELLECGRAQMLEQCARCIQCGWRRHRL-----QKQEKQRRAAVLIQAAFRSWLT 799

  Fly   823 LR------------TWPWYKLWQKVKPLLNVSRIEDEIARLEEK 854
            .:            ...|:| | :::.....|:   |:..:|||
Mouse   800 RKHIRRLHIAATVIKHAWHK-W-RIRMACLASK---ELDGMEEK 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	11/30 (37%)
		MYSc	81..777	CDD:214580	235/758 (31%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	230/727 (32%)
		Myosin_tail_1	842..1897	CDD:279860	5/13 (38%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Myo19	NP_079690.2	MYSc_Myo19	49..746	CDD:276846	231/741 (31%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	602..624		10/21 (48%)
		IQ	784..804	CDD:366194	5/19 (26%)
		MyMOMA region. /evidence=ECO:0000250\|UniProtKB:Q96H55	829..963		5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000