DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myhz1.1

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001108561.1 Gene:myhz1.1 / 58142 ZFINID:ZDB-GENE-000322-5 Length:1937 Species:Danio rerio


Alignment Length:1922 Identity:1068/1922 - (55%)
Similarity:1427/1922 - (74%) Gaps:16/1922 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSV-GLQGGEVRDIKSEKVEKVNPPK 84
            |:.|:: |:||:|:|.:|::.|:||.|:.|.||:..|..|:| .|...|.:.:|.:.|..:||||
Zfish    21 EKERVEAQNKPFDAKTACYVVDDKELYVKGTIKSKDGGKVTVITLDTKEEKVVKEDDVHPMNPPK 85

  Fly    85 FEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
            |:||||||.||.||.|.||:||::||.|.:|||||||||..:||||..|||.......||||:|.
Zfish    86 FDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRM 150

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASKKTDEAA-K 210
            |.|||||::||.||..|||:..|||:|||||||||||.|||:||.|||||   |..||.::|: |
Zfish   151 EAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGK 215

  Fly   211 SKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQ 275
            .:||||||::..||:|||:|||||||||||||||||||||||.:||||.||||||||||:||..|
Zfish   216 MQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQ 280

  Fly   276 QSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGF 340
            ...||.||||||:|:...|.:.::.|:|.|.||:.:.|||::|||||||.||...||.|.|||||
Zfish   281 LPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGF 345

  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405
            ..:||..:|:.|.||:|.|.|||||:.||||||.||.||..::..|.|.::|::.|.|..||:||
Zfish   346 NNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKV 410

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ||||||:|:.|.||.||:.||.|.:::|:|.|:|.:.|:.|||:|:|..|||||||||||||::|
Zfish   411 GNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFN 475

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEE 535
            ..|||||||||||||||||||||||||||||:|||.|.||||||||.|||:|||||:||.|||||
Zfish   476 SMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEE 540

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            |.|||||||.:|..||.:.||||...||||||.| |:..|||::.||||.|.|||:|||:|||||
Zfish   541 ECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAK-GKAEAHFSLVHYAGTVDYNISGWLDKNKDP 604

  Fly   601 LNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRS 665
            ||::||..::||..|||..::.....::|||:  |||: ||||...||||.::|.|..|||.|||
Zfish   605 LNESVVQLYQKSSVKLLATLYPPVVEETGGGK--KGGK-KKGGSMQTVSSQFRENLGKLMTNLRS 666

  Fly   666 TQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL 730
            |.||||||:||||.|.||:::..||:|||.||||||||||||||||:|::|.|||.|||::...:
Zfish   667 THPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASV 731

  Fly   731 L---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
            :   |.:: :|||:|.::..||:..|:||.|:|||||:||:||.:||.|||:|..:::..||..|
Zfish   732 IPEGQFID-NKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQALCR 795

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEK-AK 856
            .||.|:.|.|:.|:|.|:..:|.|:|.::.::.|||.|::.|:||||..:..|.|:|.::|. .|
Zfish   796 AYLMRREFVKMMERRDAIYTIQYNVRSFMNVKHWPWMKVYYKIKPLLKSAETEKELATMKEDFVK 860

  Fly   857 KAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            ..|:|..||.| :||||.....||.||..|..:::.|...|.|.:||...|...|..||.:|::.
Zfish   861 CKEDLAKAEAK-KKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKET 924

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|.|||
Zfish   925 TERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDE 989

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            .|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||:|.|:|::|
Zfish   990 SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1054

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:||||||.||::.|||.:|::.|:.:::||.|.|.:.:|:||||.:..:.|::||||||||||
Zfish  1055 RKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEE 1119

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            ||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||||||:.
Zfish  1120 LEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEST 1184

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :|||:|.|.||||..|:|||:.||:|.|.::|.|.||||:||..:::||.:.::.:...||..||
Zfish  1185 LQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEK 1249

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:.|:..|:|::||.||..|.:||..|.:.:|..||.:..|||||.|:.||||::.|.:.|.|:
Zfish  1250 MCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQI 1314

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.:||||:|...||:|||:
Zfish  1315 EELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYET 1379

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|:|||||:|:||..||.||||.||::|.||..||||||||..|||||.::|:||||:|...
Zfish  1380 DAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANL 1444

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.|||.|.::..|||:.:|||.|:.|||||::|.:|||..:|||.::||||||..
Zfish  1445 DKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQ 1509

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.:|:||.|::|||:||::|.:|.||.|:|.||||||..||.||:|:||.||||:||:.||
Zfish  1510 EISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEI 1574

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ||::.||:||.|..::|.||..||||::|::|.:.:.:|||:|||:|.|:||:||.|.|||:..|
Zfish  1575 DRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAA 1639

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            ||||.::..|.||||.|..|::..|.::|.:||:.:.|||...:|:|:||.|..|||.:|||:.|
Zfish  1640 EAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVA 1704

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            ||||.||.|::..:.:||.|:...|:|||::|..:.|::::.:.||:|:|:|||||:.|||.:|:
Zfish  1705 EQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAE 1769

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|:::|.||..:|:||.||||||..|:|||||.:||||.||||||:|::.||||
Zfish  1770 ELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRR 1834

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            .|||.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|||||.|..:|:|.|
Zfish  1835 GADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLR 1899

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGAS 1933
            |.|.||||||||||:||..::|.|||.|....|:.|:
Zfish  1900 KVQHELEEAEERADIAESQVNKLRAKSRDSGKGKDAA 1936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 13/37 (35%)
MYSc 81..777 CDD:214580 437/702 (62%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 415/671 (62%)
Myosin_tail_1 842..1897 CDD:279860 560/1055 (53%)
V_Alix_like 1557..1877 CDD:187408 171/319 (54%)
ATP-synt_B <1671..1771 CDD:304375 46/99 (46%)
TMPIT 1739..>1825 CDD:285135 47/85 (55%)
myhz1.1NP_001108561.1 Myosin_N 36..74 CDD:280832 13/37 (35%)
Myosin_head 89..768 CDD:278492 424/683 (62%)
MYSc_class_II 101..768 CDD:276951 415/671 (62%)
Myosin_tail_1 848..1925 CDD:279860 577/1077 (54%)
SPEC 881..1043 CDD:295325 74/161 (46%)
MIT_CorA-like <1297..>1409 CDD:294313 58/111 (52%)
TMPIT 1473..>1583 CDD:285135 65/109 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1098 1.000 Domainoid score I20
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2094 1.000 Inparanoid score I40
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm24867
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.970

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