Protein Alignment Mhc and myhz1.1

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001108561.1
• Gene: myhz1.1 / 58142
• ZFINID: ZDB-GENE-000322-5
• Length: 1937
• Species: Danio rerio
• Alignment Length: 1922
• Identity: 1061/1922 - (55%)
• Similarity: 1427/1922 - (74%)
• Gaps: 16/1922 - (0%)

  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSV-GLQGGETRDLKKDLLQQVNPPK 84
            |:.|:: |:||:|:|.:|::.|:||.|:.|.||:..|..|:| .|...|.:.:|:|.:..:||||
Zfish    21 EKERVEAQNKPFDAKTACYVVDDKELYVKGTIKSKDGGKVTVITLDTKEEKVVKEDDVHPMNPPK 85

  Fly    85 YEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
            ::|.|||:.:|:||:.|||:||::||...:|||||||||..:||||..|||.......||||:|.
Zfish    86 FDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYDAEVVAAYRGKKRM 150

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASKKTDEAA-K 210
            |.|||||::||.||..|||:..|||:|||||||||||.|||:||.|||||   |..||.::|: |
Zfish   151 EAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGPEKKKEQASGK 215

  Fly   211 SKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQ 275
            .:||||||::..||:|||:|||||||||||||||||||||||.:||||.||||||||||:||..|
Zfish   216 MQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQ 280

  Fly   276 QSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGF 340
            ...||.||||||:|:...|.:.::.|:|.|.||:.:.|||::|||||||.||...||.|.|||||
Zfish   281 LPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVASIDDKEELVATDTAIDILGF 345

  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405
            ..:||..:|:.|.||:|.|.|||||:.||||||.||.||..::..|.|.::|::.|.|..||:||
Zfish   346 NNEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIGYLLGLNSADMLKALCYPRVKV 410

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ||||||:|:.|.||.||:.||.|.:::|:|.|:|.:.|:.|||:|:|..|||||||||||||::|
Zfish   411 GNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVVRINQMLDTKQQRNFFIGVLDIAGFEIFDFN 475

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEE 535
            ..||||||||||||||||||||||||||||::|||.|.||||||||..||:|||||:||.|||||
Zfish   476 SMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPLGIFSILEE 540

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            |.|||||||.:|..||.:.||||...||||||.| |:..|||::.||||.|.|||:|||:|||||
Zfish   541 ECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAK-GKAEAHFSLVHYAGTVDYNISGWLDKNKDP 604

  Fly   601 LNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRS 665
            ||::||..::||..|||..::.....::|||:  |||: ||||...||||.::|.|..|||.|||
Zfish   605 LNESVVQLYQKSSVKLLATLYPPVVEETGGGK--KGGK-KKGGSMQTVSSQFRENLGKLMTNLRS 666

  Fly   666 TQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL 730
            |.||||||:||||.|.||:::..||:|||.||||||||||||||||:|::|.|||.|||::...:
Zfish   667 THPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASV 731

  Fly   731 L---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
            :   |.:: :|||:|.::..||:..|:||.|:|||||:||:||.:||.|||:|..:::..||..|
Zfish   732 IPEGQFID-NKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKLASLVTMTQALCR 795

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEK-AK 856
            .||.|:.|.|:.|:|.|:..:|.|:|.::.::.|||.|::.|:||||..:..|.|:|.::|. .|
Zfish   796 AYLMRREFVKMMERRDAIYTIQYNVRSFMNVKHWPWMKVYYKIKPLLKSAETEKELATMKEDFVK 860

  Fly   857 KAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            ..|:|..||.| :||||.....||.||..|..:::.|...|.|.:||...|...|..||.:|::.
Zfish   861 CKEDLAKAEAK-KKELEEKMVALLQEKNDLQLAVASESENLSDAEERCEGLIKSKIQLEAKLKET 924

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||:...:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|.|||
Zfish   925 TERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAAQDE 989

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            .|.||.||||...|.:|:|.::|||.|||:|.|.|.|.||||.:|:||.|||:|||:|.|:|::|
Zfish   990 SIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1054

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:||||||.||::.|||.:|::.|:.:::||.|.|.:.:|:||||.:..:.|::||||||||||
Zfish  1055 RKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQSLGAQLQKKIKELQARIEE 1119

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            ||||:||||.||||.|||||||:|||||:.||||||||||:||||:|||||||..||||||||:.
Zfish  1120 LEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEST 1184

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :|||:|.|.||||..|:|||:.||:|.|.::|.|.||||:||..:::||.:.::.:...||..||
Zfish  1185 LQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEK 1249

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:.|:..|:|::||.||..|.:||..|.:.:|..||.:..|||||.|:.||||::.|.:.|.|:
Zfish  1250 MCRTLEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQI 1314

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.||..:||.:.:..|....::..||.|.||||.|||.|.||:|||.:||||:|...||:|||:
Zfish  1315 EELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYET 1379

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|:|||||:|:||..||.||||.||::|.||..||||||||..|||||.::|:||||:|...
Zfish  1380 DAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGEVEDLMIDVERANALAANL 1444

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.|||.|.::..|||:.:|||.|:.|||||::|.:|||..:|||.::||||||..
Zfish  1445 DKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRENKNLQQ 1509

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.:|:||.|::|||:||::|.:|.||.|:|.||||||..||.||:|:||.||||:||:.||
Zfish  1510 EISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHEESKILRVQLELNQVKSEI 1574

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ||::.||:||.|..::|.||..||||::|::|.:.:.:|||:|||:|.|:||:||.|.|||:..|
Zfish  1575 DRKLAEKDEEIEQIKRNSQRITDSMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSHANRQAA 1639

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            ||||.::..|.||||.|..|::..|.::|.:||:.:.|||...:|:|:||.|..|||.:|||:.|
Zfish  1640 EAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSEIEELRAALEQTERGRKVA 1704

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            ||||.||.|::..:.:||.|:...|:|||::|..:.|::::.:.||:|:|:|||||:.|||.:|:
Zfish  1705 EQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEARNAEDKAKKAITDAAMMAE 1769

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|:::|.||..:|:||.||||||..|:|||||.:||||.||||||:|::.||||
Zfish  1770 ELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRR 1834

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            .|||.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|||||.|..:|:|.|
Zfish  1835 GADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSEEAEEQANSHLSKLR 1899

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGAS 1933
            |.|.||||||||||:||..::|.|||.|....|:.|:
Zfish  1900 KVQHELEEAEERADIAESQVNKLRAKSRDSGKGKDAA 1936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	16/42 (38%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	412/671 (61%)
		Myosin_tail_1	842..1922	CDD:460256	577/1080 (53%)
myhz1.1	NP_001108561.1	Myosin_N	33..78	CDD:460670	17/44 (39%)
		MYSc_class_II	101..768	CDD:276951	412/671 (61%)
		Myosin_tail_1	848..1925	CDD:460256	577/1077 (54%)