DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYH7B

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_016883475.1	Gene:	MYH7B / 57644	HGNCID:	15906	Length:	2003	Species:	Homo sapiens

Alignment Length:	1927	Identity:	1032/1927 - (53%)
Similarity:	1377/1927 - (71%)	Gaps:	35/1927 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PYDSKKSCWIPDEKEGYLLGEIKA-TKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADM 94
            |:|.||..|:|||::.|:..|:|: ..|..|:|..:..:|..::..:::.:|||:|:.:||||.|
Human    70 PWDGKKRVWVPDEQDAYVEAEVKSEATGGRVTVETKDQKVLMVREAELQPMNPPRFDLLEDMAMM 134

  Fly    95 TVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAIS 159
            |.||...|||||||||...:||||||||||.|||||..||||......|:||||::.||||:|::
Human   135 THLNEASVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTASVVAAYKGKRRSDSPPHIYAVA 199

  Fly   160 DGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV-----GASKKTD-EAAKSKGSLEDQ 218
            |.||.|||.|..|||||||||||||||.|||:||.|||.|     |..||.. .|.|:.|:||||
Human   200 DNAYNDMLRNRDNQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGKKAQFLATKTGGTLEDQ 264

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
            :::.||.:||||||||:||||||||||||||||||:||||.|||::|||||:|||.|...|||||
Human   265 IIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPSGKLASADIDSYLLEKSRVIFQLPGERSYH 329

  Fly   284 IFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348
            ::|||:||..|.::|:.||:.|.||||..|||.:||.:::|.||...||.|.|||||:..||...
Human   330 VYYQILSGRKPELQDMLLLSMNPYDYHFCSQGVITVDNMNDGEELIATDHAMDILGFSVDEKCAC 394

  Fly   349 YRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQG 413
            |:|..|::|.|.|||||:.||||||.||.|...:.:.|.|..:.:|.|.||.||::||||:||:|
Human   395 YKIVGALLHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTKG 459

  Fly   414 RNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCIN 478
            ::|:||..::|||.|..:||||:|||.:.|:||||:..||.||||||||||||||:|.|||||||
Human   460 QSVEQVVFAVGALAKATYDRLFRWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCIN 524

  Fly   479 FTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEK------------------ 525
            |||||||||||.|||||||||||||||||.|||||:||..|||||||
Human   525 FTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDFGLDLQPCIDLIEKVRRLRLSDVGGPHSYSFC 589

  Fly   526 --PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSY 588
              |:|||||||||.|||||:|.:|..||.:.|.|||..||:|:|.|..:..|||.:.||||.|.|
Human   590 SQPLGILSILEEECMFPKASDASFRAKLYDNHAGKSPNFQQPRPDKKRKYQAHFEVVHYAGVVPY 654

  Fly   589 NITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGG---RGKKGGGFATVSS 650
            :|.|||||||||||:|||..|:||||:||..::.::|| |...|..|.|   :.||...|.|||.
Human   655 SIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENYAG-SCSTEPPKSGVKEKRKKAASFQTVSQ 718

  Fly   651 AYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMM 715
            .:||.||.|||.||:|||||||||:|||.|.|||:||.||:|||.||||||||||||:|||||::
Human   719 LHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDAFLVLHQLRCNGVLEGIRICRQGFPNRLL 783

  Fly   716 YPDFKMRYKIMCPKLL--QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDE 778
            |.||:.||:|:.|..:  ......:||||.::..:||...||:.|:|||||:||:||.:||.||:
Human   784 YTDFRQRYRILNPSAIPDDTFMDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRDQ 848

  Fly   779 RLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSR 843
            ||.|:::.:||.:||.|.|..:::|...|.||..:|.|:|.:..::.|.|.||:.|:||||..::
Human   849 RLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQ 913

  Fly   844 IEDEIARLEEKAKKAE-ELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKL 907
            .|:|:|.|..:.:... .|.|||.| |:|||..:..:..||..|...|..|:..|.|.:||...|
Human   914 AEEELAALRAELRGLRGALAAAEAK-RQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLL 977

  Fly   908 TAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDH 972
            ...|..||.:::::.|||..||:....|..:::|.:.|.:.|||||:||||.:.|||::|...::
Human   978 IKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLELTLAKAEKEKQATEN 1042

  Fly   973 QIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSL 1037
            :::||.:|:|..||.:.:|.||||...|.:|:...:|||.||:::.|.|.|.:|||.:::||.||
Human  1043 KVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSL 1107

  Fly  1038 EREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLK 1102
            |:|||:|.|.|::|||:|||||||||:|||..::|::||:.:::||.|||.::.::||||::..:
Human  1108 EQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQ 1172

  Fly  1103 HQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKRE 1167
            .|::|||||||.||||||:||||.|||:.|||||:.|||||||.|||||||||::.|.|..:|||
Human  1173 MQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKRE 1237

  Fly  1168 AELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRA 1232
            |||.:|||:||||.::||:|:|.||:|..:..||:.||||.|.:::.|.||||:|...:::||.|
Human  1238 AELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAA 1302

  Fly  1233 GVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQV 1297
            .|:.:|..||:.||:.:..:..|:|.:.|::|..|.|.|....:.:|..|:.:|.|.|||.|..:
Human  1303 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLI 1367

  Fly  1298 SQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSK 1362
            ||||:.|......||:.:|..:|||:.::.|....:.|.||.|.||||.|||||.:|:|||.|||
Human  1368 SQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK 1432

  Fly  1363 ANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDL 1427
            ||||...||||||:|.:.|:|||||||:||..||.||||.:|:.|.||..|||.|.||.||.||:
Human  1433 ANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1497

  Fly  1428 QLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQE 1492
            .||::||.:.|.|.:|||:..::.:.|.:.:.:::..||:|:|:|.|...||||||:..:||..|
Human  1498 TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE 1562

  Fly  1493 QLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKV 1557
            .||.::||||||.:|:.||.||:...|::|.|:||.:|.||.||.|:||||||||.|||.||.|.
Human  1563 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKT 1627

  Fly  1558 LRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADIN 1622
            ||.|||||||:.|:||::.||:||..|.|:|||||::|:||||:||.:.:.||||:|||:|.|:|
Human  1628 LRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN 1692

  Fly  1623 ELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEES 1687
            :||:.|.||.:...|||...:..|.|||:.|...:||||...:..||....||||:.|..||||.
Human  1693 DLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1757

  Fly  1688 RTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEE 1752
            |..|||.:|.||.|||||.:|.|:||.:.:||..:...|:|||::|..|..:::|...|.:.:||
Human  1758 RAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEE 1822

  Fly  1753 KAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQR 1817
            |||||:.|||.:|:||:.|||.:...|:::|.|||.::|||.||:|||..||:||||.:||||.:
Human  1823 KAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAK 1887

  Fly  1818 VRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIE 1882
            |||||.|||.||::||:|.|.:||.|||||||::|:||||||..||||||||||.|:|:||||.|
Human  1888 VRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE 1952

  Fly  1883 EAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            |||:.|..||||:||||.||::||||||:||...:|.||:.|
Human  1953 EAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTR 1994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	12/37 (32%)
		MYSc	81..777	CDD:214580	438/726 (60%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	419/695 (60%)
		Myosin_tail_1	842..1897	CDD:279860	534/1055 (51%)
		V_Alix_like	1557..1877	CDD:187408	175/319 (55%)
		ATP-synt_B	<1671..1771	CDD:304375	48/99 (48%)
		TMPIT	1739..>1825	CDD:285135	46/85 (54%)
MYH7B	XP_016883475.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1116	1.000	Domainoid score	I20
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2097	1.000	Inparanoid score	I44
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm41736
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.970