DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo15ab

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_021331574.1	Gene:	myo15ab / 570113	ZFINID:	ZDB-GENE-090312-149	Length:	4355	Species:	Danio rerio

Alignment Length:	1063	Identity:	313/1063 - (29%)
Similarity:	507/1063 - (47%)	Gaps:	162/1063 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIK--SEKVEKVNPPKFEK 87
            |..|::|.      |:||.:     ||.:.|..|.:.      .:|.:.  |.:|::    |.:.
Zfish  1917 RPGQTEPQ------WVPDRE-----GEPRGTWYDKMY------SIRSLPTVSYRVKR----KGDG 1960

  Fly    88 IEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVP 152
            .|||..|..|..|.||.||:.|:..:|||||.|...|::|||:.:.:|.......|.|....:.|
Zfish  1961 TEDMTQMEQLTEPAVLINLKIRFDQELIYTYIGSILVSVNPYQLFNIYGTDMVLQYEGHAMADNP 2025

  Fly   153 PHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLED 217
            ||:|||::.||..|:....||.::|:||||:||||.||.|:.|...:...:...:        :.
Zfish  2026 PHLFAIANVAYTTMMDIKQNQCIIISGESGSGKTEATKLVLRYLTAIHHKRNITQ--------QI 2082

  Fly   218 QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSY 282
            ::::..|:||:||||||||||||||||||:.| |...|.::||....|||||:|::.|...||:|
Zfish  2083 EILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEEGVISGAITSQYLLEKSRIVFQAKDERNY 2146

  Fly   283 HIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKED 347
            ||||::::|.....|....|.:....|::...|...:...||.|:|.....|.|||.|:.:::..
Zfish  2147 HIFYEMLAGLPSHTKRAFYLQEAETYYYLNQGGNCGITGKDDGEDFRRLQSAMDILHFSTEDQSS 2211

  Fly   348 VYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVS--------KLFGCDTAELYKNLLKPRIK 404
            ::|:.::::|:|.:.|      .:.|.:.:|..|.||        .|.......|.|.:.....:
Zfish  2212 IFRVLSSILHLGNVFF------HRVETEVQETAGVVSTQEIRAVADLLQISPEGLQKAITFKVTE 2270

  Fly   405 VGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKC-------NETLDTQQKRQHFIGVLDIA 462
            ...|.:....:|:...::..|:.|.::..||.||..:.       ||.|.        |.:|||.
Zfish  2271 AMREKIYTPLSVESAVDARDAVAKILYSLLFNWLTDRINGRVYPRNEALS--------ISLLDIY 2327

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIE-KP 526
            |||...:|.|||||||:.||.||.||:..:|..|||||.||.|:|..:.| .|..||||||. ||
Zfish  2328 GFESLVFNSFEQLCINYANETLQFFFSKIIFKQEQEEYIREQINWKELTF-TDNQACIDLISAKP 2391

  Fly   527 MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591
            .|:|.||:::|.||:|||.||.:| .:.|.|.:..:.|||.|.|     .|.:.||||.|:|.:.
Zfish  2392 HGLLRILDDQSCFPQATDNTFLQK-CHYHHGNNPLYSKPKMPLP-----EFTVYHYAGRVTYQVH 2450

  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGF-----ATVSSA 651
            .:|:||.|.:...|:|.|.:|||:.:..:|..|:...   .|.||...:.....     :||::.
Zfish  2451 KFLDKNFDQVRQEVLDLFMQSQNRTVSNLFIKHSEML---NQQKGAMNRSSTVTRRYQPSTVAAK 2512

  Fly   652 YKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMY 716
            :::.|..|:..:....|.|||||.||..|:||:.|..||..||..:|:|:.|||.::|:|.|:.:
Zfish  2513 FQQSLQELLDKMERCNPFFVRCIKPNNNKEPGIFDPELVATQLRYSGILDTIRIRKEGYPIRVPF 2577

  Fly   717 PDFKMRYKIMCPKLLQGVEK-----DKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFR 776
            ..|..||     |.|.|::|     ......::.|...:.:..|::|.:|:|.:..|...:|..|
Zfish  2578 HKFLNRY-----KALLGMKKPPPSDGDNCVMMLTKLCPINKGDYQVGVSKLFLKEEVYQLLESKR 2637

  Fly   777 DE-----------------------RLGKIMSWMQAWARGYLSRKGFKKLQ----EQRVALKVVQ 814
            |.                       :....|:.:||..:|:::|:.|.:::    ..|..::::.
Zfish  2638 DRVMHIAALTLQRYVRMFFARRKFLKFRLTMTHLQAHCKGFMARQRFLRMRINLIRHRAMIRLIV 2702

  Fly   815 RNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKL 879
             |.::|:::.             :|...|.|:|..|||.:....|.::..::.:..||..|
Zfish  2703 -NRKRYIRIN-------------VLLARRAEEERRRLELERISREVVNVTQLVIPAELGGL---- 2749

  Fly   880 LAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLR---DIQERLTQE---EDARNQLFQQ 938
                      |....|..:.:.:..|.:.|.:...:.||.   ||...|..:   ...|..||..
Zfish  2750 ----------LQATAGGRERHSDCLALVQAPRIQTDPQLTLPLDINNHLMTKYIRTHFRELLFGM 2804

  Fly   939 -----KKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAH--------QDELINK 990
                 :....:....||:|..|:.:.:.:...|......|.....:.|..        :||::.:
Zfish  2805 LTAPLENSLTRLEDDLKQDAVDVFILILRFMGDPNLNGAQENLFGNYIIQRGLATPPIRDEILAQ 2869

  Fly   991 L-NKEKKMQGETNQKTGEELQAA 1012
            : |:..:.:...|.:.|..|.||
Zfish  2870 IANQVWRNENSRNAERGWLLMAA 2892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	8/36 (22%)
		MYSc	81..777	CDD:214580	251/721 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	243/690 (35%)
		Myosin_tail_1	842..1897	CDD:279860	37/191 (19%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
myo15ab	XP_021331574.1	Atrophin-1	<546..799	CDD:331285
		Atrophin-1	<719..1317	CDD:331285
		FtsK	<1119..>1705	CDD:332908
		Motor_domain	1974..2626	CDD:328930	242/689 (35%)
		MyTH4	2808..2955	CDD:214535	15/85 (18%)
		SH3	3686..3765	CDD:327375
		MyTH4	3875..4028	CDD:214535
		FERM_B-lobe	4137..4234	CDD:271216
		FERM_C_MyoXV	4240..4341	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000