Protein Alignment Mhc and myo15ab

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_073805445.1
• Gene: myo15ab / 570113
• ZFINID: ZDB-GENE-090312-149
• Length: 4449
• Species: Danio rerio
• Alignment Length: 1062
• Identity: 313/1062 - (29%)
• Similarity: 506/1062 - (47%)
• Gaps: 162/1062 - (15%)

  Fly    25 RIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGD-IVSVGLQGGETRDLKKDLLQQVNPPKYEKA 88
            |..|::|.      |:||.:     ||.:.|..| :.|:......:..:|:         |.:..
Zfish  2013 RPGQTEPQ------WVPDRE-----GEPRGTWYDKMYSIRSLPTVSYRVKR---------KGDGT 2057

  Fly    89 EDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPP 153
            |||:.:..|.:.:||.||:.|:..:|||||.|...|::|||:.:.:|.......|.|....:.||
Zfish  2058 EDMTQMEQLTEPAVLINLKIRFDQELIYTYIGSILVSVNPYQLFNIYGTDMVLQYEGHAMADNPP 2122

  Fly   154 HIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQ 218
            |:|||::.||..|:....||.::|:||||:||||.||.|:.|..          |...|.::..|
Zfish  2123 HLFAIANVAYTTMMDIKQNQCIIISGESGSGKTEATKLVLRYLT----------AIHHKRNITQQ 2177

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
            :::..|:||:||||||||||||||||||:.| |...|.::||....|||||:|::.|...||:||
Zfish  2178 ILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEEGVISGAITSQYLLEKSRIVFQAKDERNYH 2241

  Fly   284 IFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348
            |||::::|.....|....|.:....|::...|...:...||.|:|.....|.|||.|:.:::..:
Zfish  2242 IFYEMLAGLPSHTKRAFYLQEAETYYYLNQGGNCGITGKDDGEDFRRLQSAMDILHFSTEDQSSI 2306

  Fly   349 YRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVS--------KLFGCDTAELYKNLLKPRIKV 405
            :|:.::::|:|.:.|      .:.|.:.:|..|.||        .|.......|.|.:.....:.
Zfish  2307 FRVLSSILHLGNVFF------HRVETEVQETAGVVSTQEIRAVADLLQISPEGLQKAITFKVTEA 2365

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKC-------NETLDTQQKRQHFIGVLDIAG 463
            ..|.:....:|:...::..|:.|.::..||.||..:.       ||.|.        |.:|||.|
Zfish  2366 MREKIYTPLSVESAVDARDAVAKILYSLLFNWLTDRINGRVYPRNEALS--------ISLLDIYG 2422

  Fly   464 FEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPM 527
            ||...:|.|||||||:.||.||.||:..:|..|||||.||.|.|..:.| .|.|.|||||. ||.
Zfish  2423 FESLVFNSFEQLCINYANETLQFFFSKIIFKQEQEEYIREQINWKELTF-TDNQACIDLISAKPH 2486

  Fly   528 GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITG 592
            |:|.||:::|.||:|||.||.:| .:.|.|.:..:.|||.|.|     .|.:.||||.|:|.:..
Zfish  2487 GLLRILDDQSCFPQATDNTFLQK-CHYHHGNNPLYSKPKMPLP-----EFTVYHYAGRVTYQVHK 2545

  Fly   593 WLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGF-----ATVSSAY 652
            :|:||.|.:...|:|.|.:|||:.:..:|..|:...   .|.||...:.....     :||::.:
Zfish  2546 FLDKNFDQVRQEVLDLFMQSQNRTVSNLFIKHSEML---NQQKGAMNRSSTVTRRYQPSTVAAKF 2607

  Fly   653 KEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYP 717
            ::.|..|:..:....|.|||||.||..|:||:.|..||..||..:|:|:.|||.::|:|.|:.:.
Zfish  2608 QQSLQELLDKMERCNPFFVRCIKPNNNKEPGIFDPELVATQLRYSGILDTIRIRKEGYPIRVPFH 2672

  Fly   718 DFKMRYKIMCPKLLQGVEK-----DKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRD 777
            .|..||     |.|.|::|     ......::.|...:.:..|::|.:|:|.:..|...:|..||
Zfish  2673 KFLNRY-----KALLGMKKPPPSDGDNCVMMLTKLCPINKGDYQVGVSKLFLKEEVYQLLESKRD 2732

  Fly   778 E-----------------------RLGKIMSWMQAWARGYLSRKGFKKLQ----EQRVALKVVQR 815
            .                       :....|:.:||..:|:::|:.|.:::    ..|..::::.
Zfish  2733 RVMHIAALTLQRYVRMFFARRKFLKFRLTMTHLQAHCKGFMARQRFLRMRINLIRHRAMIRLIV- 2796

  Fly   816 NLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLL 880
            |.::|:::.             :|...|.|:|..|||.:....|.::..::.:..||..|
Zfish  2797 NRKRYIRIN-------------VLLARRAEEERRRLELERISREVVNVTQLVIPAELGGL----- 2843

  Fly   881 AEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLR---DIQERLTQE---EDARNQLFQQ- 938
                     |....|..:.:.:..|.:.|.:...:.||.   ||...|..:   ...|..||..
Zfish  2844 ---------LQATAGGRERHSDCLALVQAPRIQTDPQLTLPLDINNHLMTKYIRTHFRELLFGML 2899

  Fly   939 ----KKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAH--------QDELINKL 991
                :....:....||:|..|:.:.:.:...|......|.....:.|..        :||::.::
Zfish  2900 TAPLENSLTRLEDDLKQDAVDVFILILRFMGDPNLNGAQENLFGNYIIQRGLATPPIRDEILAQI 2964

  Fly   992 -NKEKKMQGETNQKTGEELQAA 1012
             |:..:.:...|.:.|..|.||
Zfish  2965 ANQVWRNENSRNAERGWLLMAA 2986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	9/42 (21%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	245/690 (36%)
		Myosin_tail_1	842..1922	CDD:460256	37/191 (19%)
myo15ab	XP_073805445.1	None