DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myo18aa

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_009303852.2 Gene:myo18aa / 566880 ZFINID:ZDB-GENE-080425-5 Length:2508 Species:Danio rerio


Alignment Length:2147 Identity:508/2147 - (23%)
Similarity:943/2147 - (43%) Gaps:434/2147 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EDPTPYLFVSLE---------QRRIDQSKPYDSKKSCWIPDEKEGYLLG-EIKATKGDI----VS 61
            |||...|..:.|         :.::...|.:.:.:..|:. .|:|:.|. ::|...|.:    |.
Zfish   369 EDPVAILQAAHEAACLSKVKTEEQLAAEKAWYNTEKVWLV-HKDGFSLATQLKTDTGSLPEGKVK 432

  Fly    62 VGLQ-GGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVA 125
            :.|: .|.:.::..:.|||.||..::::||::.:..||...:||:|||||...||:||:|...:.
Zfish   433 IRLEHDGTLLEVDEDDVEKANPLSYDRVEDLSSLLYLNESSILHSLRQRYGGNLIHTYAGPNLLL 497

  Fly   126 INPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTK 190
            |||.....:|:.:..:|::|.||.|..|||||::..||..:||...:|::::.|.||:|||.||:
Zfish   498 INPLCSPAMYSEKVMQMFKGCRREETAPHIFAVAQSAYHQLLTTRQDQTIVLLGRSGSGKTTNTQ 562

  Fly   191 KVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTG 255
            .::.|..|:.||     :.|...:.:.|.|.|  |||||||..|..|.|:|||...:.:.|...|
Zfish   563 HLLQYLVTIAAS-----SGKVYSAEKWQAVYT--VLEAFGNCSTAMNGNASRFSHIVSLDFDQAG 620

  Fly   256 KLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQ---GKV 317
            ::|.|.::|.||||.||..:...|.|:::||.:|:|:     |..|.|: ::..|:...   |..
Zfish   621 QVASASVQTMLLEKFRVTRRPEGESSFNVFYYLMAGA-----DAALKTE-LHFNHLAENSTFGLH 679

  Fly   318 TVASIDD----AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEE 378
            ..:.:||    .::|:....|..:||.:.:|.:.|:.|..|:.|:|.     .|..::.:..|.:
Zfish   680 PPSKLDDKQKATQQFTKLQAAMKVLGVSPEELKTVWLILGAIYHLGA-----AGATKETDAAGRK 739

  Fly   379 EGGR------VSKLFGCDTAELYKNLLKPR----------IKVGNEFVTQGRNVQQVTNSIGALC 427
            :..|      .:.|.||...||...:.||:          ::...|......:.......:.::.
Zfish   740 QFARHEWAQKAAYLLGCSLEELSSAIFKPQGKGTLPRSASLRPSTEDTDHAASKATAAECLESMA 804

  Fly   428 KGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGF--------EIFEYNGFEQLCINFTNEKL 484
            .|::..||..::...|..|.:.|.....:.::|..||        :|.....||:||.|:..|:|
Zfish   805 AGLYSELFTLIISLINRALKSSQHSLCSLLIVDTPGFQNPRQVKTQIQRSATFEELCHNYAQERL 869

  Fly   485 QQFFNHHMFVLEQEEYKREGIDWAFIDF---------------GMDLLACIDLIEKPMGILSILE 534
            |..|....||.|.|.||.|.|:....|.               ...|:..:...::..|:..::|
Zfish   870 QTLFQERTFVKELERYKEENIEITLDDLEPSPSRSVAVIDQSSSQTLVRTLSRTDEARGLFWLME 934

  Fly   535 EESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAA-----------HFAIAHYAGC--V 586
            ||.:.|..:::|..::|.:.:           .|..|:...           ||.:.|..|.  |
Zfish   935 EEVLQPGGSEETLLQRLFSYY-----------GPAEGESTGHTVVLKSENTNHFVLGHSHGTDWV 988

  Fly   587 SYNITGWLEKNK-DPLNDTVVDQFKKSQNKLLIEIFADH-----------AGQSGGGEQAKGGRG 639
            .|:..|||...: :|......:....||.|.:..:|...           ||..|..:.|.....
Zfish   989 EYDTYGWLNLARLNPTPQNAANLLLNSQKKSISGMFVGRSSSAAVLTGSIAGLEGVSQLAMRRAT 1053

  Fly   640 KKGGGFATVSSAYKE---------QLNSLMTTLRSTQPHFVRCII-----------PNEMKQPGV 684
            .....|.|..:|.|:         |:::|:.|:|.::.|||.|::           |:|...||:
Zfish  1054 SMRKTFTTGMAAVKKKSLCLQIKLQVDALLDTIRRSKVHFVHCLLPRAEVLRAAGSPDESCDPGL 1118

  Fly   685 --VDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQG------VEKDKKAT 741
              :|..|:..|:....:|:.:||.|:|:|:.|::.:|:.|:.::.|.|.:.      |:.:|:|.
Zfish  1119 MQIDVALLRAQIHGFKLLDSLRIYRQGYPDHMVFSEFRRRFDVLAPHLTKKLGRNYIVKDEKRAV 1183

  Fly   742 EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQ 806
            |.:::.::|.:..|.:|.::||||||.:.::|..|||...:.::..||..||:|||:.|||.:.|
Zfish  1184 EELLESLELEKSSYHMGLSRVFFRAGTVAKLEAQRDEHTRQNITLFQAACRGFLSRQAFKKRKIQ 1248

  Fly   807 RVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKE 871
            .:|::.||:|::|...::.|||:||:..|:||:.|...|::|     :.|..|.:|......|.|
Zfish  1249 DLAIRCVQKNIKKNRGVKDWPWWKLFTTVRPLVEVQLTEEQI-----RGKDEEIMHMKLKLERVE 1308

  Fly   872 LEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLF 936
            .|....:|.:::                .:.|..:|||:.:|..|......:.|..|...|.:|.
Zfish  1309 KERNELRLTSDR----------------LESRITELTAELSDERNTAESTSQLLETETSERLRLE 1357

  Fly   937 QQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGET 1001
            :..|....:...|||..|.:|:.:.:|...:|:      :||.|:...|:               
Zfish  1358 KDMKDLQVKFDALKKQTESMEMEIMEARLLRAS------DLNGEMDDGDD--------------- 1401

  Fly  1002 NQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVA 1066
             ...||.....|..|......|.||:|   |::|.||.|       :::||.:|..|       |
Zfish  1402 -DSGGEWRLKYERAIRDTEFTKKKLQQ---EMDDKLETE-------QQNKRHLERKL-------A 1448

  Fly  1067 DLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQAR-------IEELEEEVEAE 1124
            ||:.:::|.::::|:..|:...:.|:|:|.::.:...:.:..||:.:       ..:::||::.|
Zfish  1449 DLQADQEESQRSVQQLKKKCQRLAAELQDTKLHLENQEGRNHELERKQRKFDVDKSQVQEELQKE 1513

  Fly  1125 RQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLA 1189
            |..|.|..::|..|..|:..:.::|:|              ::.||..:...:|    |.||.|.
Zfish  1514 RNQREKLSRERDMLTSEMFTIKQQLQE--------------KDTELCTVSLKVE----QLESELQ 1560

  Fly  1190 NLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHT 1254
            :|..:.:...|..|:...||..|:||.:.::.|                                
Zfish  1561 DLSSQESKDEASHAKVKKQLRDLEAKVKDQEEE-------------------------------- 1593

  Fly  1255 LNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQL--EEAESQVSQLSKIKISLTTQLEDTKRL 1317
                   |||...::...:.:|.:|.:| .:.|||.  :|.:|:..::.:|::|.:.:|:..:..
Zfish  1594 -------LDEQAGSIQMLEQAKLRLEME-MERLRQTHSKELDSKDEEVEEIRLSCSKKLKQMEVQ 1650

  Fly  1318 ADEESRERATLLGKFRNLEHDLDNLREQV-EEEAEGKADLQRQLSKAN---AEAQVWRSKYESDG 1378
            .:||..::..:|...|:||..|...:||| :::.|.:..|::.|.:..   |:||:.....:|: 
Zfish  1651 LEEEYADKQRVLRDKRDLESKLMTAQEQVGQKDVETEKRLRKDLKRTKVLLADAQIMLDHMKSN- 1714

  Fly  1379 VARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEK 1443
            |....|:...|.||:    |:|..       |....|.::.:..|:|||.:::|.          
Zfish  1715 VPSKREIATLKNKLE----ESEFA-------CAAAVKARKSMELEIEDLHIQMDD---------- 1758

  Fly  1444 KQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLE--------AVRRE 1500
                    |.:.|:.:::..:.|...:.:          |:..:||.||.:.        ||.:.
Zfish  1759 --------ISKAKMSLEEQLSRLQREKND----------LQSRFEEDQEDMNELMKKHKAAVAQS 1805

  Fly  1501 NKNLADEVKDLLDQIGEGGRNIHEIE----KARKRLEAEKDEL---------QAALEEAEAALEQ 1552
            .::|| ::.||..|:.|..:...||:    ..:.:||.::..:         :|.:.|.|..||.
Zfish  1806 TRDLA-QISDLQTQVEEAMKEKQEIQDKLHSLQSQLEFQEQSMVEKSLVSRQEAKIRELETKLEY 1869

  Fly  1553 EENKVLRAQLELSQVRQEIDRRIQEKEEEF--ENTRKNH----QRALDSMQASLEAEAKGKAEAL 1611
            |..:..|.:..::::::.:::..:|:::..  ||..|:.    ||.:..::..:...:|.:|||.
Zfish  1870 ERTQTKRLESLVTRLKENLEKMTEERDQRVGCENREKDQNKRLQRQIRDIKEEMTELSKKEAEAS 1934

  Fly  1612 RMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDD------AREQL 1670
            |.|.:||.||..||       .||...|.::|...:::.|:|.|:|:|....||      .::.:
Zfish  1935 RKKHELEMDIESLE-------AANQSLQADLKLAFKRIGDLQAAMEDEMETDDDDDLINSLQDMV 1992

  Fly  1671 GISERRANA------LQNELEES----RTLLEQADRGRRQAEQELADAHEQ--LNEVSAQNASIS 1723
            ...::|.|.      :.:|:|:.    ::||.::    :.:.:.|:|...|  ....::.||.:.
Zfish  1993 TKYQKRKNKTGDESDMDSEVEDRVDGVKSLLSKS----KGSTKTLSDDGPQKTTRHPNSANADVK 2053

  Fly  1724 AAKRKLESELQTLHSDLDE--------LLNEAKNSEEKA-KKAMVDAARLADELRAEQDHAQTQE 1779
            ..|...|.: :.:..|.||        .|:..|.:.:|. .....|...|...|| ||.....:.
Zfish  2054 DVKEGKEGK-EDVKKDSDESRSVSVISSLSYRKRAHQKDWNGGAGDETSLFSALR-EQPEMPDRL 2116

  Fly  1780 KLRKA-----------LEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHA 1833
            .||||           |:.:...:.....||...|.||       |::|..:...|.|.|....:
Zfish  2117 SLRKAKTKSTDRPGDDLDDRGSVISQAYSEAAIRARKG-------LDRRWTKSSPEFDKESMVSS 2174

  Fly  1834 DAQKNLRKSERRVKELSFQSEEDRKNH------ERMQDLVDKLQQ---KIKTYKRQIEEAEEIAA 1889
            .|..  |.|.||    ....:||.::.      .|....:|..:.   ...|..||...:....:
Zfish  2175 VAPS--RASTRR----GIDEDEDARSGVSSFSLRRSTSWIDDSRSDYGSASTSHRQRSRSRSPGS 2233

  Fly  1890 ------LNLAKFRKAQQ-----ELEEAEERADLAEQAISKF--RAKGRAGSVGRGASPAPRATSV 1941
                  ::||:..:..:     ..::.:|..|:...:::.:  |::||:.|     :||...:|.
Zfish  2234 TSVGSRISLARSTRLSEFGVRLNNDDVDEDDDVDSVSVAAYSPRSQGRSLS-----TPAQMRSSE 2293

  Fly  1942 RP 1943
            .|
Zfish  2294 SP 2295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/42 (21%)
MYSc 81..777 CDD:214580 211/794 (27%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 200/763 (26%)
Myosin_tail_1 842..1897 CDD:279860 241/1147 (21%)
V_Alix_like 1557..1877 CDD:187408 79/372 (21%)
ATP-synt_B <1671..1771 CDD:304375 23/120 (19%)
TMPIT 1739..>1825 CDD:285135 24/105 (23%)
myo18aaXP_009303852.2 Atrophin-1 <36..373 CDD:331285 3/3 (100%)
Myosin_head 397..1944 CDD:332202 424/1735 (24%)
MYSc_Myo18 472..1207 CDD:276837 200/763 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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