Protein Alignment Mhc and myo1cb

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_073779253.1
• Gene: myo1cb / 566459
• ZFINID: ZDB-GENE-090429-3
• Length: 1069
• Species: Danio rerio
• Alignment Length: 1100
• Identity: 329/1100 - (29%)
• Similarity: 523/1100 - (47%)
• Gaps: 204/1100 - (18%)

  Fly    96 YLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISD 160
            :.::.:.:.|||:|:...|||||.|...|::||||...:||.:..:.|||....||.|||:|::|
Zfish    64 HTSEVAFIENLRKRFKENLIYTYIGSVLVSVNPYKDLEIYTKQHMERYRGVNFYEVSPHIYAVAD 128

  Fly   161 GAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPV 225
            .||..|.|...:|.:||:|||||||||.:|||:.|:|.      |..|:....:::|:::|:|||
Zfish   129 NAYRSMRTERRDQCILISGESGAGKTEASKKVLQYYAV------TCPASDHVQTVKDRLLQSNPV 187

  Fly   226 LEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMS 290
            |||||||||:||||||||||::.|.|...|...|..|..|||||:||:.|.:.||::|||||::.
Zfish   188 LEAFGNAKTLRNDNSSRFGKYMDIQFDFKGAPVGGHILNYLLEKSRVVHQSNGERNFHIFYQLIE 252

  Fly   291 GSVPGVKDICL---LTDNIYDYHIVSQGKV-TVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRI 351
            |   |..|:..   |..|...|..:.:|.. .|:||:|..::....:|..::|||..|.|::..|
Zfish   253 G---GEDDLLRRLGLERNAQQYQYLVKGNCPKVSSINDRNDWKTVRKALSVIGFTDDEVEELLNI 314

  Fly   352 TAAVMHMGGMKFKQRGREEQAEQDGEEEGGR----------VSKLFGCDTAELYKNLLKPRIKVG 406
            .|:|:|:|.:::           .||:.|..          :::|.|.|...|.:.|...:|...
Zfish   315 IASVLHLGNVQY-----------GGEDSGSAYITTDTQIKYLARLLGVDGTVLKEALTHKKIIAK 368

  Fly   407 NEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL-----DTQQKRQHFIGVLDIAGFEI 466
            .|.:....|.:|..::..||.|.::.|.|.|||.|.|::|     ....|....||:|||.|||:
Zfish   369 GEELMSPLNQEQAASARDALSKAIYGRTFSWLVNKINDSLAFKDESFSSKNASVIGLLDIYGFEV 433

  Fly   467 FEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLI-EKPMGIL 530
            |:.|.|||.|||:.||||||.|.......|||||:.|||.|..:.:..:..:| ||: ||..||:
Zfish   434 FQNNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGITWEPVQYFNNKIIC-DLVEEKFKGII 497

  Fly   531 SILEEESMFP-KATDQTFSEKLTNTHLGKSAPFQKPK----PPKPGQQAAHFAIAHYAGCVSYNI 590
            |||:||.:.| .|:|.||.|||.|| :|..|.|...|    ..:.......|.:.||||.|:||:
Zfish   498 SILDEECLRPGDASDITFLEKLENT-VGGHAHFLTHKLADGKTRKVMGREEFRLIHYAGEVNYNV 561

  Fly   591 TGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQ 655
            .|:|:||.|.|...:......|:||:|.:.|        ..|:....:..:     |.::.:|..
Zfish   562 KGFLDKNNDLLFRNLKQVMCMSENKILNQCF--------DREELSDKKRPE-----TAATQFKNS 613

  Fly   656 LNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFK 720
            |..||..|.|.:|.:||||.||:.||.|..|..|:.||:...|::|.:|:.|.||..|..|..|.
Zfish   614 LAKLMEILMSKEPSYVRCIKPNDAKQAGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRRYETFL 678

  Fly   721 MRYKIMCPKL---LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFR----------------- 765
            .|||.:||..   ..|.:.|..:|  ::|.:....::|:||.||:|.|
Zfish   679 QRYKSLCPDTWPNWDGRQVDGVST--LVKHLGYKPEEYKLGRTKIFIRFPKTLFATEDALEVRKH 741

  Fly   766 -------AGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQL 823
                   :...|..::.:.:::.....|:|||.||.|:|:..|:   :|.|...::|.::.:: .
Zfish   742 SLATQLQSSWKGYSQKTKYQKMRHSAVWIQAWWRGILARRAAKR---RREAADTIRRFIKGFI-Y 802

  Fly   824 RTWP------WYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAE 882
            |..|      ::..:.:...|:|:.|.:                                    .
Zfish   803 RHQPRCPENEYFLDYVRYSFLMNLHRCQ------------------------------------P 831

  Fly   883 KTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQ---ERLTQEEDARNQLFQQKKK--- 941
            ||.|..|......||.:..:...||..| |.:....::|.   :...:::...:::|:.||.
Zfish   832 KTVLDKSWPTPPPALVEASQHLRKLCMQ-NMVRKYCKNINPEWKHQMEQKVVASKIFKDKKDNYP 895

  Fly   942 -------ADQEISGLKKDI----------EDLELNVQKAEQDKATKDHQIRN-----LNDE--IA 982
                   .:..::|  :||          |.::..|...:.|:  |.::.||     ::|.  |.
Zfish   896 QSVPKLFVNTRLNG--EDINPKVLQALGNEKMKYAVPVIKYDR--KGYKARNRQLLLMSDSAVIV 956

  Fly   983 HQDELINKLNKEK----------------KMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLD 1031
            .:.:|..:::...                .:..|.|::.|:.:...|..|..|.||..    ..|
Zfish   957 EEGKLKQRIDYNSLKGISVSSLSDGMFVFHVASEDNKQKGDVVLQNEHVIETLTKVAI----CAD 1017

  Fly  1032 ELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITA 1091
            :::|....:..::.||.:.|           |.:.|.....:.|  .::.|:..| |:||
Zfish  1018 KMDDININQGSIKFDVAQGK-----------EGIIDFTAGSELL--IVKAKNGHL-SVTA 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	263/692 (38%)
		Myosin_tail_1	842..1922	CDD:460256	47/295 (16%)
myo1cb	XP_073779253.1	None