DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myh11b

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_017210292.1 Gene:myh11b / 566080 ZFINID:ZDB-GENE-101124-2 Length:2005 Species:Danio rerio


Alignment Length:1978 Identity:759/1978 - (38%)
Similarity:1178/1978 - (59%) Gaps:70/1978 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QEDEDPTPYLFVSLEQRRIDQSK-PYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRD 71
            |:::|...:||:..|.:....:: .:.::|..|||.|::|:....||...|:.|.|.|..|:...
Zfish     4 QDNDDSNKFLFLDSEFKNSGVAQADWSTRKMVWIPSERDGFQSASIKEETGNEVVVELDNGQKVT 68

  Fly    72 IKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYT 136
            :..:.::|:|||||.|:||||.:|.||...||||||:||::.|||||||||||.|||||..|:|:
Zfish    69 VSKDDIQKMNPPKFNKVEDMAALTCLNEASVLHNLRERYFSGLIYTYSGLFCVVINPYKMLPIYS 133

  Fly   137 NRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA 201
            .:..:||:||:|:||||||::::|.||.:||....:||:|.||||||||||||||||.|.|.|.:
Zfish   134 EKIIEMYKGKKRHEVPPHIYSVTDNAYRNMLQEREDQSILCTGESGAGKTENTKKVIQYLAVVAS 198

  Fly   202 SKK--------TDEAAKSK---------GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRI 249
            |.|        |..:|.:|         |.||.|::|.||:|||||||||::|||||||||||:|
Zfish   199 SHKGKKEATSDTSSSAPNKQQKGSQLAFGELEKQLLQANPILEAFGNAKTIKNDNSSRFGKFIKI 263

  Fly   250 HFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQ 314
            :|..||.:.||:||||||||:|.|.|..:|||:||||.:::|:...:::..||.| ..:|..:..
Zfish   264 NFDNTGYIVGANIETYLLEKSRCIRQAKIERSFHIFYYMVAGAKDKMREELLLED-FANYRFLVA 327

  Fly   315 GKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEE 379
            |.|.|.:..|.|....|.:|.::|||.::|:..:::|.:.|:.:|.::||....:|||.......
Zfish   328 GHVQVQNQQDDEMLEETLEAMEVLGFNEEERIGMFKICSTVLQLGNIEFKAEKNQEQASMPDNTA 392

  Fly   380 GGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNE 444
            ..:|..|.|.:..:..|.:|.|:||||.|.|.:.:..:|...::.||.|.::||||:|::.:.|:
Zfish   393 AQKVCHLQGINVTDFTKAMLTPKIKVGRELVQKAQTKEQADFAVEALAKAMYDRLFRWILGRVNK 457

  Fly   445 TLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWA 508
            .|| |:::...|||:||||||||||.|.|||||||:|||||||.|||.||:|||||||:|||:|:
Zfish   458 ALDKTKRQGASFIGILDIAGFEIFEDNSFEQLCINYTNEKLQQLFNHTMFILEQEEYKKEGIEWS 522

  Fly   509 FIDFGMDLLACIDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKP 570
            |||||:||..||:|||:   |.|||::|:||..||||||.:|.||||||| .....|.|||..| 
Zfish   523 FIDFGLDLQPCIELIERPNNPPGILALLDEECWFPKATDVSFVEKLTNTH-SSHCKFSKPKNLK- 585

  Fly   571 GQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFAD---------HAG 626
              :...|.:.||||.|.||...||.||.|||||.|......|.:..:.:|:.|         .|.
Zfish   586 --EKTFFTVQHYAGKVDYNAMSWLTKNMDPLNDNVTALLSNSSSAFIQDIWKDVDRVVGLETMAK 648

  Fly   627 QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVM 691
            .:.....|......|.|.|.||...|||.|..|||||.:|||:||||||||..|:.|.:|||||:
Zfish   649 MAKSDSSAPAASKSKKGMFRTVGQLYKESLGKLMTTLHNTQPNFVRCIIPNHEKRAGKIDAHLVL 713

  Fly   692 HQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMC----PKLLQGVEKDKKATEIIIKFIDLPE 752
            .||:||||||||||||:|||||:::.:|:.||:::.    ||   |....|::..::||.:||..
Zfish   714 DQLSCNGVLEGIRICRQGFPNRIVFHEFRQRYEVLAAGSIPK---GFMDGKQSCTLMIKHLDLDP 775

  Fly   753 DQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNL 817
            :.||:|.:|:|||.|||.|:||.||.:|..|:...||.|||:|.||.|...|:|..|:||:|||.
Zfish   776 NLYRIGLSKIFFRTGVLAQLEEERDLKLTDIIIAFQAQARGFLGRKAFSNKQKQLTAMKVLQRNC 840

  Fly   818 RKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAE 882
            ..||.||.|.|::|:.||||||.|:|.|:|:.::||:.:||:|:........||:...:.:::.|
Zfish   841 AVYLTLRNWQWWRLFTKVKPLLQVTRQEEEMNQIEEELQKAKEIAQKSETELKEITQKHDQVVEE 905

  Fly   883 KTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKK-KADQEI 946
            :..|...|..|.....:.:|...:|..:|.:||..|.:::.|| :||:.|:|.|||:| ...|::
Zfish   906 RNKLQAKLQEEAELYAESEEVRIRLETKKQELEEVLHEMEARL-EEEEERSQAFQQEKGNLQQKL 969

  Fly   947 SGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQA 1011
            ..|:..:.:.:...||.:.:....|.:|:.|.:::...::..|||.|||:...|........|..
Zfish   970 KELENHLAEQDATRQKLQLESGAADGKIKKLEEDVLIMEDQKNKLQKEKQQLEERLADFSSNLAE 1034

  Fly  1012 AEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELE 1076
            .|:|..:|.|:|||.|..:.:||..:::|:|.|.||||:|||:|.:....||.:.:|:....||:
Zfish  1035 EEEKSKNLTKLKAKHESMISDLEVRMKKEEKSRQDVEKAKRKLETEHSDLQEQMKNLQTLIAELK 1099

  Fly  1077 QTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARE 1141
            ....|.:.|:..:.|.:|.|........::|.|::..:.||::|:|||:.|..|:||.|.:|..|
Zfish  1100 TQQARSEMEIQELQASVEAESTQKSNALKKIHEMEGLLSELQDELEAEQGAGRKSEKARKELEEE 1164

  Fly  1142 LEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQV 1206
            |..|...||::...|:.|.||..|||.|::.|::.:|:....||:.:..|::||..||.|:::|:
Zfish  1165 LSALRTELEDSLDTTAVQQELRAKREQEVAMLKKLIEDEGRSHEAQVHELKQKHAQAVDELSQQL 1229

  Fly  1207 DQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLND 1271
            ||..:.||..||.|.....::.||...:..:.|.|...|:..|:::..|.::|::.:|:.|...:
Zfish  1230 DQSKRAKATLEKAKQALEKEVGDLNGNLRSLGNAKQDLEQKKKKVETQLADLQTRFNESERKREE 1294

  Fly  1272 FDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLE 1336
            ...:..||:.|.:::...|.||||:..:|||..:||.:||:|.:.|..||:|::.....:.|.:|
Zfish  1295 LGDAVSKLNTEYNNVNSILNEAESKNIKLSKDVVSLNSQLQDAQELLAEETRQKLNFSTRLRQME 1359

  Fly  1337 HDLDNLREQVEEEAEGKADLQRQLSKAN---AEAQVWRSKYESDGVARSEELEEAKRKLQ----A 1394
            .:.:.|.||::||.|.:.:::|.:|..|   :||:....:|.|:    .:.|||:|::||    |
Zfish  1360 DERNGLLEQIDEETEARRNVERHVSSLNTQLSEAKKRLDEYSSN----FQMLEESKKRLQRDLEA 1420

  Fly  1395 RLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKV 1459
            ...|.||...|.::.    ||||..|..|::|:.|::|....:.:..||||:.||:::.:.|...
Zfish  1421 TKGELEEKTASYDKS----EKTKNHLQQELDDVLLDLDNQRQLVSNMEKKQRKFDQMLADEKTLS 1481

  Fly  1460 DDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHE 1524
            ...:.|.|.::.|.|...|:...|..|.||.|..|..:.:.||.|..:::||:.  .:..:|.||
Zfish  1482 SKYSQERDCAEAEAREKETKCLALTRALEECQGSLRELEKLNKTLRTDMEDLIS--SKDNKNAHE 1544

  Fly  1525 IEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNH 1589
            :||.::.|||:.:|:...:||.|..|:..|:..|..::.:..::.:|.|.||.:||:.|..||..
Zfish  1545 LEKTKRALEAQVEEMTIQMEELEDELQAAEDAKLHLEVNMQALKVQIQRDIQGREEQSEEKRKQL 1609

  Fly  1590 QRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQT 1654
            .:.:..::|.||.|.|.:......|||||.|:.:||..:|..::|..||.|.:::.|.|:||.|.
Zfish  1610 LKQVRELEAELEDEQKMRTSLAAAKKKLEGDLQDLEDQVDVNSRARDEAVKQLRKIQTQMKDYQR 1674

  Fly  1655 ALEEEQRAR----DDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEV 1715
            .||:.:.:.    .||||    |||:|.|::.|:......|..|::.|:.||:|..:...::...
Zfish  1675 ELEDARASHKEVLSDARE----SERKARAMEAEILHLHEELASAEKARKHAERERDEIAGEMASG 1735

  Fly  1716 SAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEK 1780
            |...:..|..||:|||::|.|..:||:.....:...|:.::::.:..:|.:||..|:.:||..|.
Zfish  1736 SFGKSGTSDEKRRLESKIQHLEEELDDEQATTETLNERLRRSVQEVDQLTNELHTERSNAQRMES 1800

  Fly  1781 LRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERR 1845
            ..:.:|:|.|||:.:|.|.|.......:..:..||.::::.|::||.|.|......|.:|:.:::
Zfish  1801 GWQQMERQNKELRAKLLEMEGQVKSKQRSTVAALESKLQQTEDQLDHESRERQAIAKAMRQKDKK 1865

  Fly  1846 VKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERAD 1910
            :|||..|.|::||..|:.:|..:|...:.:..|.|:||::|.:....|..||.|:||.||.|..|
Zfish  1866 LKELMNQVEDERKQMEQYKDQAEKANLRARQLKMQMEESDEESQRATAARRKLQKELNEAIEAND 1930

  Fly  1911 LAEQAISKFRAKGRAGSVGRGASPAPRA 1938
            ...:.:|..|:|.|.||....::|..|:
Zfish  1931 ALSREVSSLRSKLRRGSDSSFSTPLRRS 1958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 13/36 (36%)
MYSc 81..777 CDD:214580 362/729 (50%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 341/698 (49%)
Myosin_tail_1 842..1897 CDD:279860 326/1066 (31%)
V_Alix_like 1557..1877 CDD:187408 97/323 (30%)
ATP-synt_B <1671..1771 CDD:304375 27/99 (27%)
TMPIT 1739..>1825 CDD:285135 21/85 (25%)
myh11bXP_017210292.1 Myosin_N 33..70 CDD:280832 13/36 (36%)
Myosin_head 85..788 CDD:278492 348/710 (49%)
MYSc_class_II 97..788 CDD:276951 341/698 (49%)
Myosin_tail_1 865..1943 CDD:279860 337/1092 (31%)
FAM76 <1020..1099 CDD:292665 27/78 (35%)
BAR <1156..>1305 CDD:299863 46/148 (31%)
RILP-like <1760..1872 CDD:304877 30/111 (27%)
COG7 1824..>1943 CDD:287200 36/118 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.820

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