DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myh11b

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_017210292.1 Gene:myh11b / 566080 ZFINID:ZDB-GENE-101124-2 Length:2005 Species:Danio rerio


Alignment Length:1978 Identity:763/1978 - (38%)
Similarity:1182/1978 - (59%) Gaps:70/1978 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QEDEDPTPYLFVSLEQRRIDQSK-PYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRD 71
            |:::|...:||:..|.:....:: .:.::|..|||.|::|:....||...|:.|.|.|..|:...
Zfish     4 QDNDDSNKFLFLDSEFKNSGVAQADWSTRKMVWIPSERDGFQSASIKEETGNEVVVELDNGQKVT 68

  Fly    72 LKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYT 136
            :.||.:|::||||:.|.|||:.||.||:||||||||:||::.|||||||||||.|||||..|:|:
Zfish    69 VSKDDIQKMNPPKFNKVEDMAALTCLNEASVLHNLRERYFSGLIYTYSGLFCVVINPYKMLPIYS 133

  Fly   137 NRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA 201
            .:..:||:||:|:||||||::::|.||.:||....:||:|.||||||||||||||||.|.|.|.:
Zfish   134 EKIIEMYKGKKRHEVPPHIYSVTDNAYRNMLQEREDQSILCTGESGAGKTENTKKVIQYLAVVAS 198

  Fly   202 SKK--------TDEAAKSK---------GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRI 249
            |.|        |..:|.:|         |.||.|::|.||:|||||||||::|||||||||||:|
Zfish   199 SHKGKKEATSDTSSSAPNKQQKGSQLAFGELEKQLLQANPILEAFGNAKTIKNDNSSRFGKFIKI 263

  Fly   250 HFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQ 314
            :|..||.:.||:||||||||:|.|.|..:|||:||||.:::|:...:::..||.| ..:|..:..
Zfish   264 NFDNTGYIVGANIETYLLEKSRCIRQAKIERSFHIFYYMVAGAKDKMREELLLED-FANYRFLVA 327

  Fly   315 GKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEE 379
            |.|.|.:..|.|....|.:|.::|||.::|:..:::|.:.|:.:|.::||....:|||.......
Zfish   328 GHVQVQNQQDDEMLEETLEAMEVLGFNEEERIGMFKICSTVLQLGNIEFKAEKNQEQASMPDNTA 392

  Fly   380 GGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNE 444
            ..:|..|.|.:..:..|.:|.|:||||.|.|.:.:..:|...::.||.|.::||||:|::.:.|:
Zfish   393 AQKVCHLQGINVTDFTKAMLTPKIKVGRELVQKAQTKEQADFAVEALAKAMYDRLFRWILGRVNK 457

  Fly   445 TLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWT 508
            .|| |:::...|||:||||||||||.|.|||||||:|||||||.|||.||:||||||::|||||:
Zfish   458 ALDKTKRQGASFIGILDIAGFEIFEDNSFEQLCINYTNEKLQQLFNHTMFILEQEEYKKEGIEWS 522

  Fly   509 FIDFGMDLQLCIDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKP 570
            |||||:|||.||:|||:   |.|||::|:||..||||||.:|.||||||| .....|.|||..| 
Zfish   523 FIDFGLDLQPCIELIERPNNPPGILALLDEECWFPKATDVSFVEKLTNTH-SSHCKFSKPKNLK- 585

  Fly   571 GQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFAD---------HAG 626
              :...|.:.||||.|.||...||.||.|||||.|......|.:..:.:|:.|         .|.
Zfish   586 --EKTFFTVQHYAGKVDYNAMSWLTKNMDPLNDNVTALLSNSSSAFIQDIWKDVDRVVGLETMAK 648

  Fly   627 QSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVM 691
            .:.....|......|.|.|.||...|||.|..|||||.:|||:||||||||..|:.|.:|||||:
Zfish   649 MAKSDSSAPAASKSKKGMFRTVGQLYKESLGKLMTTLHNTQPNFVRCIIPNHEKRAGKIDAHLVL 713

  Fly   692 HQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMC----PKLLQGVEKDKKATEIIIKFIDLPE 752
            .||:||||||||||||:|||||:::.:|:.||:::.    ||   |....|::..::||.:||..
Zfish   714 DQLSCNGVLEGIRICRQGFPNRIVFHEFRQRYEVLAAGSIPK---GFMDGKQSCTLMIKHLDLDP 775

  Fly   753 DQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNL 817
            :.||:|.:|:|||.|||.|:||.||.:|..|:...||.|||:|.||.|...|:|..|:||:|||.
Zfish   776 NLYRIGLSKIFFRTGVLAQLEEERDLKLTDIIIAFQAQARGFLGRKAFSNKQKQLTAMKVLQRNC 840

  Fly   818 RKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAE 882
            ..||.||.|.|::|:.||||||.|:|.|:|:.::||:.:||:|:........||:...:.:::.|
Zfish   841 AVYLTLRNWQWWRLFTKVKPLLQVTRQEEEMNQIEEELQKAKEIAQKSETELKEITQKHDQVVEE 905

  Fly   883 KTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKK-KADQEI 946
            :..|...|..|.....:.:|...:|..:|.:||..|.:::.|| :||:.|:|.|||:| ...|::
Zfish   906 RNKLQAKLQEEAELYAESEEVRIRLETKKQELEEVLHEMEARL-EEEEERSQAFQQEKGNLQQKL 969

  Fly   947 SGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQA 1011
            ..|:..:.:.:...||.:.:....|.:|:.|.:::...::..|||.|||:...|........|..
Zfish   970 KELENHLAEQDATRQKLQLESGAADGKIKKLEEDVLIMEDQKNKLQKEKQQLEERLADFSSNLAE 1034

  Fly  1012 AEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELE 1076
            .|:|..:|.|:|||.|..:.:||..:::|:|.|.||||:|||:|.:....||.:.:|:....||:
Zfish  1035 EEEKSKNLTKLKAKHESMISDLEVRMKKEEKSRQDVEKAKRKLETEHSDLQEQMKNLQTLIAELK 1099

  Fly  1077 QTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARE 1141
            ....|.:.|:..:.|.:|.|........::|.|::..:.||::|:|||:.|..|:||.|.:|..|
Zfish  1100 TQQARSEMEIQELQASVEAESTQKSNALKKIHEMEGLLSELQDELEAEQGAGRKSEKARKELEEE 1164

  Fly  1142 LEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQV 1206
            |..|...||::...|:.|.||..|||.|::.|::.:|:....||:.:..|::||..||.|:::|:
Zfish  1165 LSALRTELEDSLDTTAVQQELRAKREQEVAMLKKLIEDEGRSHEAQVHELKQKHAQAVDELSQQL 1229

  Fly  1207 DQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLND 1271
            ||..:.||..||.|.....::.||...:..:.|.|...|:..|:::..|.::|::.:|:.|...:
Zfish  1230 DQSKRAKATLEKAKQALEKEVGDLNGNLRSLGNAKQDLEQKKKKVETQLADLQTRFNESERKREE 1294

  Fly  1272 FDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLE 1336
            ...:..||:.|.:::...|.||||:..:|||..:||.:||:|.:.|..||:|::.....:.|.:|
Zfish  1295 LGDAVSKLNTEYNNVNSILNEAESKNIKLSKDVVSLNSQLQDAQELLAEETRQKLNFSTRLRQME 1359

  Fly  1337 HDLDNLREQVEEEAEGKADLQRQLSKAN---AEAQVWRSKYESDGVARSEELEEAKRKLQ----A 1394
            .:.:.|.||::||.|.:.:::|.:|..|   :||:....:|.|:    .:.|||:|::||    |
Zfish  1360 DERNGLLEQIDEETEARRNVERHVSSLNTQLSEAKKRLDEYSSN----FQMLEESKKRLQRDLEA 1420

  Fly  1395 RLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKV 1459
            ...|.||...|.::.    ||||..|..|::|:.|::|....:.:..||||:.||:::.:.|...
Zfish  1421 TKGELEEKTASYDKS----EKTKNHLQQELDDVLLDLDNQRQLVSNMEKKQRKFDQMLADEKTLS 1481

  Fly  1460 DDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHE 1524
            ...:.|.|.::.|.|...|:...|..|.||.|..|..:.:.||.|..:::||:.  .:..:|.||
Zfish  1482 SKYSQERDCAEAEAREKETKCLALTRALEECQGSLRELEKLNKTLRTDMEDLIS--SKDNKNAHE 1544

  Fly  1525 IEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNH 1589
            :||.::.|||:.:|:...:||.|..|:..|:..|..::.:..::.:|.|.||.:||:.|..||..
Zfish  1545 LEKTKRALEAQVEEMTIQMEELEDELQAAEDAKLHLEVNMQALKVQIQRDIQGREEQSEEKRKQL 1609

  Fly  1590 QRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQT 1654
            .:.:..::|.||.|.|.:......|||||.|:.:||..:|..::|..||.|.:::.|.|:||.|.
Zfish  1610 LKQVRELEAELEDEQKMRTSLAAAKKKLEGDLQDLEDQVDVNSRARDEAVKQLRKIQTQMKDYQR 1674

  Fly  1655 ALEEEQRAR----DDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELADAHEQLNEV 1715
            .||:.:.:.    .||||    |||:|.|::.|:......|..|::.|:.||:|..:...::...
Zfish  1675 ELEDARASHKEVLSDARE----SERKARAMEAEILHLHEELASAEKARKHAERERDEIAGEMASG 1735

  Fly  1716 SAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEK 1780
            |...:..|..||:|||::|.|..:||:.....:...|:.::::.:..:|.:||..|:.:||..|.
Zfish  1736 SFGKSGTSDEKRRLESKIQHLEEELDDEQATTETLNERLRRSVQEVDQLTNELHTERSNAQRMES 1800

  Fly  1781 LRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERR 1845
            ..:.:|:|.|||:.:|.|.|.......:..:..||.::::.|::||.|.|......|.:|:.:::
Zfish  1801 GWQQMERQNKELRAKLLEMEGQVKSKQRSTVAALESKLQQTEDQLDHESRERQAIAKAMRQKDKK 1865

  Fly  1846 VKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERAD 1910
            :|||..|.|::||..|:.:|..:|...:.:..|.|:||::|.:....|..||.|:||.||.|..|
Zfish  1866 LKELMNQVEDERKQMEQYKDQAEKANLRARQLKMQMEESDEESQRATAARRKLQKELNEAIEAND 1930

  Fly  1911 LAEQAISKFRAKGRAGSVGRGASPAPRA 1938
            ...:.:|..|:|.|.||....::|..|:
Zfish  1931 ALSREVSSLRSKLRRGSDSSFSTPLRRS 1958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 13/41 (32%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 344/698 (49%)
Myosin_tail_1 842..1922 CDD:460256 337/1091 (31%)
myh11bXP_017210292.1 Myosin_N 32..74 CDD:460670 15/41 (37%)
MYSc_class_II 97..788 CDD:276951 344/698 (49%)
Myosin_tail_1 865..1943 CDD:460256 337/1092 (31%)

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