DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myo5ab

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_009296049.2 Gene:myo5ab / 565267 ZFINID:ZDB-GENE-050411-72 Length:1800 Species:Danio rerio


Alignment Length:2011 Identity:550/2011 - (27%)
Similarity:906/2011 - (45%) Gaps:403/2011 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEKEGYLLGEIKA--TKGDIVSVGLQGGEVR-----DIKSEKVEKV-NPPKFEKI 88
            |......||||..|.:...|:..  ..||.|...|...|..     |:||..:..: ||......
Zfish     7 YSKLARVWIPDPAEVWRSAELSRDYRPGDPVLHLLLEDETELEYKLDLKSGVLPPLRNPDILVGE 71

  Fly    89 EDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVP 152
            .|:..::.|:.|.||||||.|:. :||||||.|:..||||||:..|:|.:.....|.|:...::.
Zfish    72 NDLTALSYLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLPIYGSDIINAYSGQNMGDMD 136

  Fly   153 PHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLED 217
            |||||:|:.||..|..:..|||::::||||||||.:.|..:.|||||  |:.:|:|     |:|:
Zfish   137 PHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATV--SESSDDA-----SVEE 194

  Fly   218 QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSY 282
            :|:.:||::||||||||.||||||||||:|.|.|.....:.||::.||||||:||:.|.|.||:|
Zfish   195 KVLASNPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHIIGANMRTYLLEKSRVVFQASEERNY 259

  Fly   283 HIFYQIMS-GSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGFTKQEK 345
            |||||:.: ..:|..|.:.|  .:..|:...:| |...:..::|.:|...|.:||.:||.|:..:
Zfish   260 HIFYQLCACAHLPEFKPLKL--GSADDFPYTNQGGSPVIVGVNDLKEMQATRKAFSLLGITEAHQ 322

  Fly   346 EDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN-----LLKPRIKV 405
            ..:::|.:|::|:|.::.|:||....:..|   |.|.::..  ||..|:...     |...::|.
Zfish   323 MGLFQILSAILHLGNVEVKERGSSSCSISD---ENGHLAMF--CDLTEVSNESMAHWLCHKKLKT 382

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ..|.:.:.....:..|...||.|.::.:||.|:|.:.|:.|.|..|...|||||||.|||.||.|
Zfish   383 ATETLNKPVTRLEAVNGRDALAKHIYAKLFSWIVSQVNKALSTSSKPHSFIGVLDIYGFETFELN 447

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEE 535
            .|||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||:|||..||:|.:|:|
Zfish   448 SFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIEAKMGLLDLLDE 511

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            |...||.:|.::::||.||||.||:.|:||:.....     |.|.|:|..|.|...|:||||||.
Zfish   512 ECTMPKGSDDSWAQKLYNTHLKKSSHFEKPRMSNKA-----FIILHFADKVEYQCDGFLEKNKDT 571

  Fly   601 LNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGF-------ATVSSAYKEQLNS 658
            :|:..::..|.|:..||:|:|.|....:.....|..||.|.|...       .:|...::..|:.
Zfish   572 VNEEQINVLKASKFSLLLELFQDEESPAAPNTTASSGRAKFGRSTQSFREHKKSVGLQFRNSLHL 636

  Fly   659 LMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRY 723
            ||.||.:|.||:||||.||::|.|.::|.|..:.||...||||.|||...|||:|..|.:|..||
Zfish   637 LMETLNATTPHYVRCIKPNDVKAPFMMDPHRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRY 701

  Fly   724 KIMCPKLLQGVEKDKKAT-EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL------- 780
            :::..|  :.:..|:|.| :.:::.:...:|:|:.|.||:|||||.:..:|:.|.::|       
Zfish   702 QVLMTK--KEILLDRKLTCQSVLERLVQNKDKYQFGKTKIFFRAGQVAYLEKLRADKLRTACIHI 764

  Fly   781 -GKIMSW---------------MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWY 829
             ..|..|               :|.:.||:.:|...|.|:..| |..|.|:|.|.:...|.:   
Zfish   765 QKTIRCWLARMKYLRIRQAAITLQKYTRGHQARCLCKTLRRTR-ATVVFQKNTRMWAARRQY--- 825

  Fly   830 KLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEV---------------KVRKE---LEALN 876
             |.||...:|....:....||||.|....|  |.|.:               ::::.   |:...
Zfish   826 -LRQKTAAVLIQRILRGYTARLEYKRLVCE--HKALLIQRWVRGFLARWRYRRIKRAVVYLQCCV 887

  Fly   877 AKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKK 941
            .::||.:.  |..|..|..:::.|::.|       ..:||::..:|.:|.::.           |
Zfish   888 RRMLARRE--LKKLKIEARSVEHYKKLN-------YGMENKIMQLQRKLDEQH-----------K 932

  Fly   942 ADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTG 1006
            .::|:|                ||..|.:.|.:..|           .||:.:.|          
Zfish   933 ENRELS----------------EQIGAIESHSVVEL-----------EKLHVQLK---------- 960

  Fly  1007 EELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERN 1071
             .||.||::..|...:...|::.||          .||.::||:|..|   ::|.::... |:..
Zfish   961 -TLQEAEEEARHREDLVTSLQEELD----------LVRRELEKNKEMV---VELNEKNTM-LKSE 1010

  Fly  1072 KKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEE---VEAERQARAKAEK 1133
            |:|:.:.||.:::::...:....::  |....|.|:.|.:.|.:.|..|   :| ||.|..|:||
Zfish  1011 KEEMNRLIQEQEQQIREKSEATNED--VTENLQTQLNEERFRYQNLLTEHLKLE-ERYADLKSEK 1072

  Fly  1134 QRADLARELEELGERLEEAG--GATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHN 1196
            :.|    |:...|:...::|  .:.|..|..:....:|:|.|.::                    
Zfish  1073 EVA----EISTAGDSRADSGYSSSQSESIHSSMLTGSEVSSLEKE-------------------- 1113

  Fly  1197 DAVAEMAEQVDQLNKLKAK-AEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQS 1260
            ||| ::|..|..|.||:.: ||.||...     |:::.:|  |.|           :..:.|...
Zfish  1114 DAV-QVAADVSLLLKLQRRVAELEKENM-----DMQSEMD--TKE-----------EQLILEKAK 1159

  Fly  1261 KLDETNRTL---NDFDASKK-KLSIENSDLLRQLEEAESQVSQLSKIKIS---------LTTQLE 1312
            :|::..:||   .|::|.|: :|..:|..|.:.|:|....:|:.:..|::         :..||.
Zfish  1160 ELEDCRKTLGAERDYEALKRQELESDNKKLKKDLQELRQSLSKGTGSKVTSPGGRAYNVILEQLN 1224

  Fly  1313 DTKRLADEESRERATLLGKFRNLEHDLDNLRE--QVEEEAEGKADLQRQLSKANAEAQVWRSKYE 1375
            .|..  :.|.|:...|:.:.:.:.|:....:|  .|.:..:........|::.|.:.::|.: ||
Zfish  1225 STNE--ELEVRKEEVLILRSQLVSHEAFKHKELGTVGDSGDSSRSPTLDLTELNEDGELWMA-YE 1286

  Fly  1376 SDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANA 1440
            |        |:|..|.|.::|    :|...:::|             |.|.|::|:..       
Zfish  1287 S--------LKETNRILVSQL----QTQREMHEK-------------ETESLRVELQH------- 1319

  Fly  1441 AEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTEL---FRLKGAYEEGQEQLEAVRRENK 1502
                                 |.|||| .|::..:.|.||   .|::.          :::.|..
Zfish  1320 ---------------------LKAELD-QQQQMLSQSLELPHDARIQA----------SLQHEIS 1352

  Fly  1503 NLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQV 1567
            .|..:..|||:|:|:..:.:.:::|..|....:..|.:....|..:    .||.:..:...:|.|
Zfish  1353 RLTQQNMDLLEQMGKQDKMVRKLKKQLKIYMKKFGEPEGVHFEQSS----PENMLAESGRTVSIV 1413

  Fly  1568 RQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHAN 1632
            |         ||.:|:...:..:...:.:..:|..:.|.:..|:.:...|.|.|  |.:.|.||:
Zfish  1414 R---------KERDFQGMLEYRREDENKLFKTLITDLKPRGVAVNLVPGLPAYI--LFMCLRHAD 1467

  Fly  1633 KANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRG 1697
            .||.:.:            :.|.|.....:..:..::.|..|..:..|.|.......|       
Zfish  1468 YANDDLR------------VSTLLNTSINSIKNTLKKRGDFESISFWLANTCRFLHCL------- 1513

  Fly  1698 RRQAEQELADAHE--QLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVD 1760
            ::.:.:|....|.  :.||....|..:|..::.|......::..|..::       |...:.|:.
Zfish  1514 KQYSGEEGYSKHNTPRQNEHCLTNFDLSEYRQVLSDLAIQIYQQLIRVI-------ENILQPMIA 1571

  Fly  1761 AARLADEL--------------RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAI 1811
            .|.|..|.              |....|.:....|...|:|        ||......|:.|..| 
Zfish  1572 PAMLEQETIQGVMGVKPTGMRKRTSSFHEENSHSLESILKQ--------LDGFYFTLLQHGNDA- 1627

  Fly  1812 QKLEQRVRE---------LENEL---------DGEQRRHADAQKNLRKSERRVKELSFQSEEDRK 1858
            :.:.|.:::         |.|.|         .|.|.|:     |:.:.|..:.:...|....|:
Zfish  1628 EVVRQVIKQQFYVICSVTLNNLLLRKDMCSWSKGLQIRY-----NVCQLEEWLLDKDLQGSGARE 1687

  Fly  1859 NHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEERADLA 1912
            :.|.:......||.|    |:..::|:.|..:       .:.|.......:.|.|||..::
Zfish  1688 SLEPLIQAAQLLQIK----KKSQDDADAICTMCTALTTQQIVKILSLYTPVNEFEERVSIS 1744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/43 (28%)
MYSc 81..777 CDD:214580 290/711 (41%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 281/680 (41%)
Myosin_tail_1 842..1897 CDD:279860 220/1137 (19%)
V_Alix_like 1557..1877 CDD:187408 63/353 (18%)
ATP-synt_B <1671..1771 CDD:304375 19/115 (17%)
TMPIT 1739..>1825 CDD:285135 19/108 (18%)
myo5abXP_009296049.2 Myosin_head 7..1324 CDD:332202 458/1519 (30%)
MYSc_Myo5 83..742 CDD:276831 281/680 (41%)
Myo5-like_CBD 1427..1800 CDD:322280 65/364 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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