DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myo5ab

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_009296049.3 Gene:myo5ab / 565267 ZFINID:ZDB-GENE-050411-72 Length:1800 Species:Danio rerio


Alignment Length:2016 Identity:562/2016 - (27%)
Similarity:911/2016 - (45%) Gaps:413/2016 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEKEGYLLGEIKA--TKGDIVSVGLQGGETR-----DLKKDLLQQV-NPPKYEKA 88
            |......||||..|.:...|:..  ..||.|...|...||.     |||..:|..: ||......
Zfish     7 YSKLARVWIPDPAEVWRSAELSRDYRPGDPVLHLLLEDETELEYKLDLKSGVLPPLRNPDILVGE 71

  Fly    89 EDMSNLTYLNDASVLHNLRQRYY-NKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVP 152
            .|::.|:||::.:||||||.|:. :||||||.|:..||||||:..|:|.:.....|.|:...::.
Zfish    72 NDLTALSYLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLPIYGSDIINAYSGQNMGDMD 136

  Fly   153 PHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLED 217
            |||||:|:.||..|..:..|||::::||||||||.:.|..:.|||||  |:.:|:|     |:|:
Zfish   137 PHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATV--SESSDDA-----SVEE 194

  Fly   218 QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSY 282
            :|:.:||::||||||||.||||||||||:|.|.|.....:.||::.||||||:||:.|.|.||:|
Zfish   195 KVLASNPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHIIGANMRTYLLEKSRVVFQASEERNY 259

  Fly   283 HIFYQIMS-GSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGFTKQEK 345
            |||||:.: ..:|..|.:.|  .:..|:...:| |...:..::|.:|...|.:||.:||.|:..:
Zfish   260 HIFYQLCACAHLPEFKPLKL--GSADDFPYTNQGGSPVIVGVNDLKEMQATRKAFSLLGITEAHQ 322

  Fly   346 EDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKN-----LLKPRIKV 405
            ..:::|.:|::|:|.::.|:||....:..|   |.|.:...  ||..|:...     |...::|.
Zfish   323 MGLFQILSAILHLGNVEVKERGSSSCSISD---ENGHLDMF--CDLTEVSNESMAHWLCHKKLKT 382

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ..|.:.:.....:..|...||.|.::.:||.|:|.:.|:.|.|..|...|||||||.|||.||.|
Zfish   383 ATETLNKPVTRLEAVNGRDALAKHIYAKLFSWIVSQVNKALSTSSKPHSFIGVLDIYGFETFELN 447

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEE 535
            .|||.|||:.||||||.||.|:|.||||||.:|.|.||.||| .|.|.||:|||..||:|.:|:|
Zfish   448 SFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIEAKMGLLDLLDE 511

  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600
            |...||.:|.::::||.||||.||:.|:||:.....     |.|.|:|..|.|...|:||||||.
Zfish   512 ECTMPKGSDDSWAQKLYNTHLKKSSHFEKPRMSNKA-----FIILHFADKVEYQCDGFLEKNKDT 571

  Fly   601 LNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGF-------ATVSSAYKEQLNS 658
            :|:..::..|.|:..||:|:|.|....:.....|..||.|.|...       .:|...::..|:.
Zfish   572 VNEEQINVLKASKFSLLLELFQDEESPAAPNTTASSGRAKFGRSTQSFREHKKSVGLQFRNSLHL 636

  Fly   659 LMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRY 723
            ||.||.:|.||:||||.||::|.|.::|.|..:.||...||||.|||...|||:|..|.:|..||
Zfish   637 LMETLNATTPHYVRCIKPNDVKAPFMMDPHRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRY 701

  Fly   724 KIMCPKLLQGVEKDKKAT-EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL------- 780
            :::..|  :.:..|:|.| :.:::.:...:|:|:.|.||:|||||.:..:|:.|.::|       
Zfish   702 QVLMTK--KEILLDRKLTCQSVLERLVQNKDKYQFGKTKIFFRAGQVAYLEKLRADKLRTACIHI 764

  Fly   781 -GKIMSW---------------MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWY 829
             ..|..|               :|.:.||:.:|...|.|:..|.|: |.|:|.|.:...|.:   
Zfish   765 QKTIRCWLARKKYLRIRQAAITLQKYTRGHQARCLCKTLRRTRAAV-VFQKNTRMWAARRQY--- 825

  Fly   830 KLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEV---------------KVRKE---LEALN 876
             |.||...:|....:....||||.|....|  |.|.:               ::::.   |:...
Zfish   826 -LRQKTAAVLIQRILRGYTARLEYKRLVCE--HKALLIQRWVRGFLARWRYRRIKRAVVYLQCCV 887

  Fly   877 AKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKK 941
            .::||.:.  |..|..|..:::.|::.|       ..:||::..:|.:|.::.           |
Zfish   888 RRMLARRE--LKKLKIEARSVEHYKKLN-------YGMENKIMQLQRKLDEQH-----------K 932

  Fly   942 ADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTG 1006
            .::|:|                ||..|.:.|.:..|           .||:.:.|          
Zfish   933 ENRELS----------------EQIGAIESHSVVEL-----------EKLHVQLK---------- 960

  Fly  1007 EELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERN 1071
             .||.||::..|       .|..:..|::.||   .||.::||:|..|   ::|.::... |:..
Zfish   961 -TLQEAEEEARH-------REDLVTSLQEELE---LVRRELEKNKEMV---VELNEKNTM-LKSE 1010

  Fly  1072 KKELEQTIQRKD---KELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEE---VEAERQARAK 1130
            |:|:.:.||.::   :|.|.:|.:...|.:     |.|:.|.:.|.:.|..|   :| ||.|..:
Zfish  1011 KEEMNRLIQEQEQQIREKSEVTNEDVTENL-----QTQLNEERFRYQNLLTEHLKLE-ERYADLR 1069

  Fly  1131 AEKQRADLARELEELGERLEEAG--GATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRK 1193
            :||:    |.|:...|:...::|  .:.|..|..:....:|:|.|.::                 
Zfish  1070 SEKE----AAEISTAGDSRADSGYSSSQSESIHSSMLTGSEVSSLEKE----------------- 1113

  Fly  1194 KHNDAVAEMAEQVDQLNKLKAK-AEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNE 1257
               ||| ::|..|..|.||:.: ||.||...     |:::.:|            .|:.|..| |
Zfish  1114 ---DAV-QVAADVSLLLKLQRRVAELEKENM-----DMQSEMD------------TKEEQLVL-E 1156

  Fly  1258 VQSKLDETNRTL---NDFDASKK-KLSIENSDLLRQLEEAESQVSQLSKIKIS---------LTT 1309
            ...:|::..:||   .|::|.|: :|..:|..|.:.|:|....:|:.:..|::         :..
Zfish  1157 KAKELEDCRKTLGAERDYEALKRQELESDNKKLKKDLQELRQSLSKGTGSKVTSPGGRAYNVILE 1221

  Fly  1310 QLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQR----QLSKANAEAQVW 1370
            ||..|..  :.|.|:...|:.:.:.:.|:....:|...|...|  |..|    .|::.|.:.::|
Zfish  1222 QLNSTNE--ELEVRKEEVLILRSQLVSHEAFKHKELGTEGDSG--DSSRSPTLDLTELNEDGELW 1282

  Fly  1371 RSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRAN 1435
            .: |||        |:|..|.|.::|....|:.|.                 |.|.|:.|:..  
Zfish  1283 MA-YES--------LKETNRILVSQLQTQRESHEK-----------------ETESLRAELQH-- 1319

  Fly  1436 AIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTEL---FRLKGAYEEGQEQLEAV 1497
                                      |.|||| .|::..:.|.||   .|::.          ::
Zfish  1320 --------------------------LKAELD-QQQQMLSQSLELPHDARIQA----------SL 1347

  Fly  1498 RRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQL 1562
            :.|...|..:..|||:|:|:..:.:.:::|..|....:..|.:....|..:    .||.:..:..
Zfish  1348 QHEISRLTQQNMDLLEQMGKQDKMVRKLKKQLKIYMKKFGEPEGVHFEQSS----PENMLAESGR 1408

  Fly  1563 ELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIA 1627
            .:|.||         ||.:|:...:..:...:.:..:|..:.|.:..|:.:...|.|.|  |.:.
Zfish  1409 TVSIVR---------KERDFQGMLEYRREDENKLFKTLITDLKPRGVAVNLVPGLPAYI--LFMC 1462

  Fly  1628 LDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLE 1692
            |.||:.||.:.:            :.|.|.....:..:..::.|..|..:..|.|.......|  
Zfish  1463 LRHADYANDDLR------------VSTLLNTSINSIKNTLKKRGDFESISFWLANTCRFLHCL-- 1513

  Fly  1693 QADRGRRQAEQELADAHE--QLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAK 1755
                 ::.:.:|....|.  :.||....|..:|..::.|......::..|..::       |...
Zfish  1514 -----KQYSGEEGYSKHNTPRQNEHCLTNFDLSEYRQVLSDLAIQIYQQLIRVI-------ENIL 1566

  Fly  1756 KAMVDAARLADEL--------------RAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKG 1806
            :.|:..|.|..|.              |....|.:....|...|:|        ||......|:.
Zfish  1567 QPMIAPAMLEQETIQGVMGVKPTGMRKRTSSFHEENSHSLESILKQ--------LDGFYFTLLQH 1623

  Fly  1807 GKKAIQKLEQRVRE---------LENEL---------DGEQRRHADAQKNLRKSERRVKELSFQS 1853
            |..| :.:.|.:::         |.|.|         .|.|.|:     |:.:.|..:.:...|.
Zfish  1624 GNDA-EVVRQVIKQQFYVICSVTLNNLLLRKDMCSWSKGLQIRY-----NVCQLEEWLLDKDLQG 1682

  Fly  1854 EEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEERADL 1911
            ...|::.|.:......||.|    |:..::|:.|..:       .:.|.......:.|.|||..:
Zfish  1683 SGARESLEPLIQAAQLLQIK----KKSQDDADAICTMCTALTTQQIVKILSLYTPVNEFEERVSI 1743

  Fly  1912 A 1912
            :
Zfish  1744 S 1744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 15/48 (31%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 282/680 (41%)
Myosin_tail_1 842..1922 CDD:460256 231/1159 (20%)
myo5abXP_009296049.3 None

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