DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myo5c

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_691143.2 Gene:myo5c / 562676 ZFINID:ZDB-GENE-131127-196 Length:1746 Species:Danio rerio


Alignment Length:1938 Identity:518/1938 - (26%)
Similarity:870/1938 - (44%) Gaps:358/1938 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 SKPYDSKKSCWIPDE----KEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKI- 88
            |:.|......||||.    |...:|.:.|....:: .:.|:.|.......|..||:.|.:...| 
Zfish     4 SELYTKYNRVWIPDAEHVWKSAEILTDFKPGDSEL-ELQLEDGTELHYPLEGGEKLPPLRNPDIL 67

  Fly    89 ---EDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
               .|:..::.|:.|.|||||:.|:. :|:||||.|:..||:||||:.|:|.:.....|.|:...
Zfish    68 VGENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQLPIYGDAVIHAYSGQNMG 132

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGS 214
            ::.|||||:::.||..|..|:.|||::::||||||||.:.:..:.|||.|..|       .||..
Zfish   133 DLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMVSKS-------GSKTR 190

  Fly   215 LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLE 279
            :||:|:.:||:.||.|||||.||||||||||:..|.|....::.||::.||||||:||:.|...|
Zfish   191 VEDKVLASNPITEAIGNAKTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENE 255

  Fly   280 RSYHIFYQIMS-GSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQ 343
            |:||||||:.: .:.|..|.:.||....::|..:. |::.:..:||..:.:.|.:.|::||..:.
Zfish   256 RNYHIFYQMCACANQPEFKGLRLLGAEKFNYTRLG-GEIEIEGVDDRADMAETRRTFNLLGLKEN 319

  Fly   344 EKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNE 408
            .:.||:::.||::|:|.:..|.:..|:......:........|.|..|..:.:.|...||.:..|
Zfish   320 FQTDVFKVLAAILHLGNVIIKAKDPEKSFIGSRDPHLAIFCDLMGVSTENMSRWLCHRRIVLSTE 384

  Fly   409 FVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFE 473
            .|.:.:..::..|:..||.|.::..||.|::.|.|..|....|:..|||||||.|||.||.|.||
Zfish   385 TVVKPQPRERAVNARDALAKHIYAHLFNWVIHKINHALMVPGKQHSFIGVLDIYGFETFEINSFE 449

  Fly   474 QLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESM 538
            |.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|....|||||..||||.:|:||.:
Zfish   450 QFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILDLLDEECL 513

  Fly   539 FPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLND 603
            ||:.||:.:.:||.| .||....|:||:.....     |.|.|:|..|.|...|:||||:|.|.:
Zfish   514 FPQGTDKNWLQKLYN-FLGSKPLFEKPRLSNDS-----FMIQHFADKVEYQCKGFLEKNRDTLYE 572

  Fly   604 TVVDQFKKSQNKLLIEIFADHAGQSG---------------GGEQAKGGRGKKGGGFATVSSAYK 653
            .:||..:.||..||...|.:....||               ..:|.:          :||...::
Zfish   573 ELVDIMRASQFALLAGFFKEEEADSGHKIIKVTPAQPRVKASNKQLR----------STVGDKFR 627

  Fly   654 EQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPD 718
            ..|..||.||.:|.||:||||.|||.|.|...|:..|:.||...||||.|||..:.:|:|..|.:
Zfish   628 SSLYLLMETLNATTPHYVRCIKPNEEKLPFEYDSRRVVQQLRACGVLETIRISAQSYPSRWTYVE 692

  Fly   719 FKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKI 783
            |..||.|:..:....:.:.|:....:::.:....:||:.|.||:|||||.:..:|:.|.:.|...
Zfish   693 FYSRYSILMSQSELKLGEKKQTCRTVLQRLIPDSNQYKFGRTKIFFRAGQVAYLEKLRLDHLRAA 757

  Fly   784 MSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRT----------WPWYKLWQKVKPL 838
            ...:|...||:..|:.|..:   |.|..::|..:|...|:|.          |....:.:..:..
Zfish   758 CVTIQKHVRGWRQRRSFLNI---RQAALIIQLYVRGKKQIRCTVTAQALKQGWAAIVIQRHCRGF 819

  Fly   839 LNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQER 903
            | |.||...:.|    |....:........||..:    |::||..||:         ||.|...
Zfish   820 L-VRRIYQLVLR----AAVTIQAFTRGWMARKRYK----KMVAEHKALV---------LQKYARA 866

  Fly   904 ---------------NAKLTAQKNDLENQLRD-------IQERLTQEEDARNQLFQQKKKADQEI 946
                           |.:|:.:...|..::.:       :.|:||...:||.|..::.:..:.|:
Zfish   867 WLVRRRFQTMRRLVINVQLSYRVQQLRKKVEEQNKENCGLMEKLTSLSNARAQGLEKIQALEAEL 931

  Fly   947 SGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQA 1011
            ..|..::..|   ||:|:            .|.|.|:|  .|:.|..:|       :|..||.:|
Zfish   932 GKLTNEMSAL---VQRAK------------TNSEEANQ--AIDVLQNDK-------EKLVEENKA 972

  Fly  1012 AEDKINHLN-KVKAKLEQTLDELEDSLEREKKVRGDVEKSK--RKVEGDLKLTQEAVADLERNKK 1073
            .|.|:.... :::.:.|....:|.:.||||:::|...|.:.  :|.:.|    :|.||..|.|::
Zfish   973 LERKLKDTTVQMQDQFEDVKRKLMEDLEREERLRKVAEHNSELQKEDSD----KEIVAIKEENRR 1033

  Fly  1074 ELEQTI--QRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELE-EEVEAERQARAKAEKQR 1135
            ..|:.|  |.:.:|......:|:::.:.:.||.:.|.:|:..|..|: :..|||:..||:..:.|
Zfish  1034 LREERIRLQTQVEEDVKTNTELQEQMLQLTKHVKVIPDLRKEINNLQIQRAEAEKTLRAQNLQAR 1098

  Fly  1136 AD---LARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHND 1197
            |.   :.|:|  ||:..|:                   ..::|..|||:            .:||
Zfish  1099 AKMNLITRQL--LGDATEQ-------------------DLIQRLNEEAS------------DNND 1130

  Fly  1198 AVAEMAEQVDQLNK----LKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEV 1258
            ..|::....|.:.:    ::.:..::|:.:..||..|....:|::.|.       :|||....| 
Zfish  1131 DGADLITAFDGMERAAKVMETQLREQKDAHESQLEALIFKNEHLSKEN-------EQLQALFQE- 1187

  Fly  1259 QSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESR 1323
               ..:.|:::..   ...:|:.||    ..:.|.:.|||:|::.|..|.:||:|          
Zfish  1188 ---KSDINQSIGQ---EVTRLTAEN----MVIPELKQQVSELNRHKHELESQLQD---------- 1232

  Fly  1324 ERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEA 1388
            :.|.:..|.:.|.   ..|...||||...:..||.:|:::.      |.:.|:|  .:..||:|.
Zfish  1233 QTAEMSAKLKELS---SALHLAVEEEQSQRRRLQEELTESQ------RRREETD--RQISELQEE 1286

  Fly  1389 KRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIG 1453
            .::|:    :|:.| ||..:..:.||.:  ||:.|..|.:.::|..              |::|.
Zfish  1287 NQQLK----KAQIT-ESQAKNTLRLETS--RLTAENMDFEEQLDMK--------------DRLIK 1330

  Fly  1454 EWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEG 1518
            ..:.::..|.....|:||.......|...:....:|.:.:|             ::.|:.::...
Zfish  1331 RLQDQIKALQTHAAANQKAAPAVPKEYLGMLEYKKEDEGRL-------------IRILILELKPR 1382

  Fly  1519 GRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFE 1583
            |..::.|......|      |...:..|:...:..:.|.|     ::.:...:...|.|.:|.||
Zfish  1383 GVGVNMIPGLAAHL------LFMCVRHADYLNDGNKLKCL-----MNNIITAVKEVITEHQENFE 1436

  Fly  1584 NTR---KNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN--IK 1643
            ...   .|....|:.::     :..|:.|.::                .:..:.|....||  :.
Zfish  1437 LLSFWLSNTYHFLNCLK-----QYSGEEEFMK----------------HNTPRQNKNCLKNFDLS 1480

  Fly  1644 RYQQQLKDIQTALEEE-QRARDDA-----------REQL-GISERRANALQNELEESRTLLEQAD 1695
            .::|.|.|:...:..: ....:||           .|.| |||..:...|:   :.|.::.|.  
Zfish  1481 EHRQILSDLAINIYHQFISVMEDALFPMIIPGMLEHESLQGISSMKPTGLR---KRSSSVFED-- 1540

  Fly  1696 RGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQ-------------------TLHSD-- 1739
             |...:..|.......|.::|..|:|:  .::.:|.:||                   .|..|  
Zfish  1541 -GGDSSTSEAFSVSSILQKLSTFNSSM--CQQGMEPQLQGQIVRQLFYLIGSSSVNCILLRKDLC 1602

  Fly  1740 --------------LDELLNEAKNSEEKAKKAMVDAARLADELR----AEQDHAQTQEKLRKALE 1786
                          |:|.|.|.......|.:.:...:::|..|:    .::|.|:.:::..:...
Zfish  1603 SCRKGMQIRCNISYLEEWLREKDLLSSNAMETLGPLSQIAWLLQVNKTTDEDAAEIKQRCSELSA 1667

  Fly  1787 QQIKEL---QVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQ 1836
            .||.::   ...:|:.|       |:......::|:.|..|.:|..:...|:|
Zfish  1668 VQIVKILNSYTPIDDFE-------KRVAPSFVRKVQALLQEREGSSQLMMDSQ 1713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 9/40 (23%)
MYSc 81..777 CDD:214580 274/716 (38%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 265/681 (39%)
Myosin_tail_1 842..1897 CDD:279860 214/1090 (20%)
V_Alix_like 1557..1877 CDD:187408 57/340 (17%)
ATP-synt_B <1671..1771 CDD:304375 24/138 (17%)
TMPIT 1739..>1825 CDD:285135 17/108 (16%)
myo5cXP_691143.2 MYSc 63..750 CDD:214580 273/711 (38%)
MYSc_Myo5 82..739 CDD:276831 265/681 (39%)
IQ 808..826 CDD:197470 4/18 (22%)
IQ 830..849 CDD:197470 4/22 (18%)
Laminin_I 1068..1314 CDD:283627 74/324 (23%)
GBP_C <1176..1291 CDD:303769 36/153 (24%)
coiled coil 1280..1291 CDD:293879 3/10 (30%)
Myo5c_CBD 1366..1740 CDD:271260 66/408 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.