DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo5aa

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_017207607.1	Gene:	myo5aa / 562188	ZFINID:	ZDB-GENE-041027-2	Length:	1854	Species:	Danio rerio

Alignment Length:	2159	Identity:	550/2159 - (25%)
Similarity:	897/2159 - (41%)	Gaps:	577/2159 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WIPDEKEGYLLGEIKATK----GD-IVSVGLQGGEVRDIKSE-KVEKV----NPPKFEKIEDMAD 93
            ||||::|.:...|:  ||    || ::.:.|:.|:..:.|.: |...:    ||.......|:..
Zfish    16 WIPDDEEVWRSAEL--TKDYRQGDGVLQLQLEDGKDLEFKLDPKTNNLPHLRNPDILVGENDLTA 78

  Fly    94 MTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFA 157
            ::.|:.|.|||||:.|:. :||||||.|:..||||||:..|:|.......|.|:...::.|||||
Zfish    79 LSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYETLPIYGADIINAYSGQNMGDMDPHIFA 143

  Fly   158 ISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQT 222
            :::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:.::|::|:.:
Zfish   144 VAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASEANVEEKVLAS 201

  Fly   223 NPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQ 287
            ||::|:.|||||.||||||||||:|.|.|.....:.||::.||||||:||:.|...||:||||||
Zfish   202 NPIMESIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADEERNYHIFYQ 266

  Fly   288 I-MSGSVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYR 350
            : .|..:|..|.:.|...|  |:|...||: ..:..:|||:|.|.|..||.:||..:..:..:::
Zfish   267 LCASAHLPEFKALKLGKAN--DFHYTKQGRNPVIDGVDDAKEMSTTRNAFILLGINESYQMGLFQ 329

  Fly   351 ITAAVMHMGGMKFKQRGREEQAEQDGE---EEGGRVS---KLFGCDTAELYKNLLKPRIKVGNEF 409
            |.|:::|:|.:..|.|      :.|..   ...|.:|   :|.|....::...|...::|...|.
Zfish   330 ILASILHLGNVDVKDR------DSDSSIIPPNNGHLSVFCELMGVTYQDMSHWLCHKKLKTATET 388

  Fly   410 VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQ 474
            ..:.....|..|:..||.|.::.:||.|:|...|:.|.:..|:..|||||||.|||.||.|.|||
Zfish   389 YIKPIPKLQAINARDALAKHIYAKLFNWIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQ 453

  Fly   475 LCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMF 539
            .|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||:|||..||||.:|:||...
Zfish   454 FCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIEAKMGILDLLDEECKM 517

  Fly   540 PKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDT 604
            ||.:|.::::||.||||...|.|:||:.....     |.|.|:|..|.|...|:||||||.:|:.
Zfish   518 PKGSDDSWAQKLYNTHLKTCALFEKPRMSNKA-----FIIQHFADKVEYQCDGFLEKNKDTVNEE 577

  Fly   605 VVDQFKKSQNKLLIEIFADH--AGQSGGGEQAKGGR---------GKKGGGF----ATVSSAYKE 654
            .::..|.|:..||:|:|.|.  |....|.....|||         ||.....    .||...::.
Zfish   578 QINVLKASKFDLLVELFHDEEKATSPTGAAPGPGGRTRLSVKPDKGKSSQASKEHKKTVGLQFRN 642

  Fly   655 QLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF 719
            .|..||.||.:|.||:||||.||:.|.....|....:.||...||||.|||...|||:|..|.:|
Zfish   643 SLQLLMETLNATTPHYVRCIKPNDYKHAFTFDPKRAVQQLRACGVLETIRISAAGFPSRWTYQEF 707

  Fly   720 KMRYKIMCPKLLQGVEKDKKAT--EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL-- 780
            ..||:::..:  :.|..|||.|  .::.|.:..| |:|:.|.||:|||||.:..:|:.|.::|
Zfish   708 FSRYRVLMKQ--KDVLTDKKMTCKNVLEKLVQDP-DKYQFGKTKIFFRAGQVAYLEKLRADKLRA 769

  Fly   781 ------GKIMSWM---------------QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQ-- 822
                  ..|..|:               |.:.|||.:|...|.|:..|.|: ::|:..|.|:|
Zfish   770 ACIRIQKTIRCWLARKKYLRMKHAATTIQRFVRGYQARCLAKFLRRTRAAI-IIQKYQRMYIQKT 833

  Fly   823 ----------------------------------------LRTW---PWYKLWQKVKPLLNVS-- 842
                                                    :|.|   .|:|  :.:|.::.:.
Zfish   834 CYKRKQAAALAMQCILRAYMARQLYKALLREHKAVIIQKMVRGWLARQWFK--RSLKAIVYLQCC 896

  Fly   843 ----RIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQER 903
                |.:.|:.:|:.:|:..|......:.:..::..|..:                  :.|..:.
Zfish   897 IRRMRAKRELKKLKIEARSVEHFKKLNIGMENKIMQLQRR------------------IDDQNKE 943

  Fly   904 NAKLTAQKNDLENQLRDIQERLT--------QEEDARNQLFQQKKKADQEISGLKKDIEDLELNV 960
            |..::.:.|.||.......||:.        .||||:|..        .:::.|.:::|.|..::
Zfish   944 NRSMSERLNTLETSHAVESERMRAEVTRLRGAEEDAKNNA--------NKVTSLLEELERLRKDL 1000

  Fly   961 QKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKM----QGETNQKTGEELQAAEDKI----- 1016
            |..:::|...:...:...||:   :::|::|.::.::    :...||...|:.|...||:
Zfish  1001 QNTQKEKKAIEDWAQTYQDEM---EKMISELKEQNQLLKTEKNNLNQLIQEQSQQWTDKMQRALK 1062

  Fly  1017 -------NHLNKVKA----------KLEQTLDELEDSL--------------------------- 1037
                   |.||:.::          :||:..|:|::.:
Zfish  1063 EETQQLENDLNEERSRYQNLLTEHLRLEEKYDDLKEEITLAVNVPKPGHRRTDSTHSSNESECTY 1127

  Fly  1038 -------EREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLED 1095
                   |...:|..||.||...:...||| |:.|::||:.|:.|:..:.|::::.....|: :|
Zfish  1128 NSEFAESEEGSRVGEDVSKSILDMSLFLKL-QKRVSELEQEKQSLQNELDRREEQFQRARAR-DD 1190

  Fly  1096 EQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGA--TSA 1158
            |:     |::      ||..|||.|....::..::.:|.:.||.:..:.|...:|...||  :.|
Zfish  1191 EE-----HKK------ARGAELEYESLKRQELESENKKLKHDLNQMRQSLRGSVEAGSGAPGSPA 1244

  Fly  1159 QIELNKKREAELSKLRRDLEEANIQHESTLANLRK---------KHNDAVAEMAEQVDQLNKL-K 1213
            ...|       |.:|....||..::.|..|. ||.         :|.|....|.|.:..:..: |
Zfish  1245 YTVL-------LDQLNASNEELEVRKEEVLI-LRSQLVSQKEAMQHKDEKTTMTEPLPYIEDVQK 1301

  Fly  1214 AKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNE------VQSKLDETNRTLNDF 1272
            ....||.::.|..|.|        ||.....:      .|.|||      |...|.||||.|
Zfish  1302 LTDAKEISQAYMGLKD--------TNRSPFPD------YHKLNEDGELWLVYEGLKETNRLL--- 1349

  Fly  1273 DASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEH 1337
                      .|.|..|....:::|..|.          .:...|.:|.:|::..|.   :||
Zfish  1350 ----------ESQLQAQRRSHDNEVEVLR----------GELHSLKEENNRQQQLLA---QNL-- 1389

  Fly  1338 DLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEET 1402
                   |:..||..:|.||.:::
Zfish  1390 -------QLPPEARIEASLQHEIT----------------------------------------- 1406

  Fly  1403 IESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDL-AAEL 1466
                            ||:.|..||..::::.:......:|:.|.|.|       |::|| ..::
Zfish  1407 ----------------RLTNENLDLMEQLEKQDKTVRKLKKQLKVFAK-------KINDLEGGQM 1448

  Fly  1467 DASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKR 1531
            |.|..:..:.......:....::.|..||..:.:...|   ||:::.::...|..::.|......
Zfish  1449 DVSPGQTADEPVHPVNIPRREKDFQGMLEYKKEDELKL---VKNIILELKPRGVAVNLIPGLPAY 1510

  Fly  1532 LEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFE-------NTRKNH 1589
            :      |...|..|:...:.::.:.|     |:.|...|.:.::::.::||       ||
Zfish  1511 I------LFMCLRHADYINDDQKVRSL-----LTSVINSIKKILKKRGDDFETVSFWLANT---- 1560

  Fly  1590 QRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDH-ANKANAEAQKN--IKRYQQQLKD 1651
                              ...|...|:...|    |..:.| :.|.|.....|  :..|:|.|.|
Zfish  1561 ------------------CRFLHCLKQYSGD----EQFMKHNSPKQNEHCLSNFDLAEYRQVLSD 1603

  Fly  1652 IQTALEEEQRARDDAREQLGISERRANALQNELEES--RTLLEQADRGRRQAEQELADAHEQLNE 1714
            :                .:.|.::....::|.|:..  ..:||                ||.:..
Zfish  1604 L----------------AIQIYQQLIKCMENILQPMIVSGMLE----------------HETIQG 1636

  Fly  1715 VSA--------QNASIS-AAKRKLES---ELQTLHSDL------DELLNEAKNSEEKAKKAMVDA 1761
            ||.        :.:||: .....|:|   :|.|.||.:      .||:.:.    .|.:..::.|
Zfish  1637 VSGVKPTGLRKRTSSIADEGTYTLDSIIRQLNTFHSIMCHHGTDPELIKQV----VKQQFYIIGA 1697

  Fly  1762 ARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELD 1826
            ..|.:.|            |||.:....|.:|:|.:             :.:||:.:|:
Zfish  1698 VTLNNLL------------LRKDMCSWSKGMQIRYN-------------VSQLEEWLRD------ 1731

  Fly  1827 GEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL- 1890
                      |||.....:               |.::.|: :..|.::..|:..|:||.|.::
Zfish  1732 ----------KNLMTCGAK---------------ETLEPLI-QAAQLLQVKKKTDEDAEAICSMC 1770

  Fly  1891 ------NLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRATSVRPQF---D 1946
                  .:.|.......:...|||..:......:.|.:.|..|               ||.   .
Zfish  1771 NALSTAQIVKVLNLYTPVNAFEERVSVLFIRTIQTRLRDRKES---------------PQLLMDT 1820

  Fly  1947 GLAFPPRFDLAPEN 1960
            .|.:|..|...|.:
Zfish  1821 KLIYPVTFPFNPSS 1834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	12/38 (32%)
		MYSc	81..777	CDD:214580	290/721 (40%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	281/690 (41%)
		Myosin_tail_1	842..1897	CDD:279860	212/1184 (18%)
		V_Alix_like	1557..1877	CDD:187408	58/349 (17%)
		ATP-synt_B	<1671..1771	CDD:304375	23/119 (19%)
		TMPIT	1739..>1825	CDD:285135	15/91 (16%)
myo5aa	XP_017207607.1	MYSc_Myo5	85..752	CDD:276831	281/690 (41%)
		IQ	766..787	CDD:197470	3/20 (15%)
		IQ	789..811	CDD:197470	5/21 (24%)
		SMC_N	<920..1279	CDD:330553	78/408 (19%)
		SMC_N	<1156..>1445	CDD:330553	88/422 (21%)
		Myo5a_CBD	1480..1854	CDD:271262	84/503 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910