DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myo5aa

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_068071029.2 Gene:myo5aa / 562188 ZFINID:ZDB-GENE-041027-2 Length:1892 Species:Danio rerio


Alignment Length:2165 Identity:558/2165 - (25%)
Similarity:916/2165 - (42%) Gaps:551/2165 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 WIPDEKEGYLLGEIKATK----GD-IVSVGLQGGETRDLKKD-----LLQQVNPPKYEKAEDMSN 93
            ||||::|.:...|:  ||    || ::.:.|:.|:..:.|.|     |....||.......|::.
Zfish    16 WIPDDEEVWRSAEL--TKDYRQGDGVLQLQLEDGKDLEFKLDPKTNNLPHLRNPDILVGENDLTA 78

  Fly    94 LTYLNDASVLHNLRQRYY-NKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFA 157
            |:||::.:|||||:.|:. :||||||.|:..||||||:..|:|.......|.|:...::.|||||
Zfish    79 LSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYETLPIYGADIINAYSGQNMGDMDPHIFA 143

  Fly   158 ISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQT 222
            :::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:.::|::|:.:
Zfish   144 VAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASEANVEEKVLAS 201

  Fly   223 NPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQ 287
            ||::|:.|||||.||||||||||:|.|.|.....:.||::.||||||:||:.|...||:||||||
Zfish   202 NPIMESIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADEERNYHIFYQ 266

  Fly   288 I-MSGSVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYR 350
            : .|..:|..|.:.|...|  |:|...||: ..:..:|||:|.|.|..||.:||..:..:..:::
Zfish   267 LCASAHLPEFKALKLGKAN--DFHYTKQGRNPVIDGVDDAKEMSTTRNAFILLGINESYQMGLFQ 329

  Fly   351 ITAAVMHMGGMKFKQRGREEQAEQDGE---EEGGRVS---KLFGCDTAELYKNLLKPRIKVGNEF 409
            |.|:::|:|.:..|.|      :.|..   ...|.:|   :|.|....::...|...::|...|.
Zfish   330 ILASILHLGNVDVKDR------DSDSSIIPPNNGHLSVFCELMGVTYQDMSHWLCHKKLKTATET 388

  Fly   410 VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQ 474
            ..:.....|..|:..||.|.::.:||.|:|...|:.|.:..|:..|||||||.|||.||.|.|||
Zfish   389 YIKPIPKLQAINARDALAKHIYAKLFNWIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQ 453

  Fly   475 LCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEEESMF 539
            .|||:.||||||.||.|:|.||||||.:|.|.||.||| .|.|.||:|||..||||.:|:||...
Zfish   454 FCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIEAKMGILDLLDEECKM 517

  Fly   540 PKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDT 604
            ||.:|.::::||.||||...|.|:||:.....     |.|.|:|..|.|...|:||||||.:|:.
Zfish   518 PKGSDDSWAQKLYNTHLKTCALFEKPRMSNKA-----FIIQHFADKVEYQCDGFLEKNKDTVNEE 577

  Fly   605 VVDQFKKSQNKLLIEIFADH--AGQSGGGEQAKGGR---------GKKGGGF----ATVSSAYKE 654
            .::..|.|:..||:|:|.|.  |....|.....|||         ||.....    .||...::.
Zfish   578 QINVLKASKFDLLVELFHDEEKATSPTGAAPGPGGRTRLSVKPDKGKSSQASKEHKKTVGLQFRN 642

  Fly   655 QLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF 719
            .|..||.||.:|.||:||||.||:.|.....|....:.||...||||.|||...|||:|..|.:|
Zfish   643 SLQLLMETLNATTPHYVRCIKPNDYKHAFTFDPKRAVQQLRACGVLETIRISAAGFPSRWTYQEF 707

  Fly   720 KMRYKIMCPKLLQGVEKDKKAT--EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL-- 780
            ..||:::..:  :.|..|||.|  .::.|.:..| |:|:.|.||:|||||.:..:|:.|.::|  
Zfish   708 FSRYRVLMKQ--KDVLTDKKMTCKNVLEKLVQDP-DKYQFGKTKIFFRAGQVAYLEKLRADKLRA 769

  Fly   781 ------GKIMSWM---------------QAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQ-- 822
                  ..|..|:               |.:.|||.:|...|.|:..|.|: ::|:..|.|:|  
Zfish   770 ACIRIQKTIRCWLARKKYLRMKHAATTIQRFVRGYQARCLAKFLRRTRAAI-IIQKYQRMYIQKT 833

  Fly   823 ----------------------------------------LRTW---PWYKLWQKVKPLLNVS-- 842
                                                    :|.|   .|:|  :.:|.::.:.  
Zfish   834 CYKRKQAAALAMQCILRAYMARQLYKALLREHKAVIIQKMVRGWLARQWFK--RSLKAIVYLQCC 896

  Fly   843 ----RIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQER 903
                |.:.|:.:|:.:|:..|......:.:..::..|..:                  :.|..:.
Zfish   897 IRRMRAKRELKKLKIEARSVEHFKKLNIGMENKIMQLQRR------------------IDDQNKE 943

  Fly   904 NAKLTAQKNDLENQLRDIQERLT--------QEEDARNQLFQQKKKADQEISGLKKDIEDLELNV 960
            |..::.:.|.||.......||:.        .||||:|..        .:::.|.:::|.|..::
Zfish   944 NRSMSERLNTLETSHAVESERMRAEVTRLRGAEEDAKNNA--------NKVTSLLEELERLRKDL 1000

  Fly   961 QKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKM----QGETNQKTGEELQAAEDKI----- 1016
            |..:::|...:...:...||:   :::|::|.::.::    :...||...|:.|...||:     
Zfish  1001 QNTQKEKKAIEDWAQTYQDEM---EKMISELKEQNQLLKTEKNNLNQLIQEQSQQWTDKMQRALK 1062

  Fly  1017 -------NHLNKVKA----------KLEQTLDELEDSL--------------------------- 1037
                   |.||:.::          :||:..|:|::.:                           
Zfish  1063 EETQQLENDLNEERSRYQNLLTEHLRLEEKYDDLKEEITLAVNVPKPGHRRTDSTHSSNESECTY 1127

  Fly  1038 -------EREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLED 1095
                   |...:|..||.||...:...||| |:.|::||:.|:.|:..:.|::::.....|: :|
Zfish  1128 NSEFAESEEGSRVGEDVSKSILDMSLFLKL-QKRVSELEQEKQSLQNELDRREEQFQRARAR-DD 1190

  Fly  1096 EQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGA--TSA 1158
            |:     |::      ||..|||.|....::..::.:|.:.||.:..:.|....|...||  :.|
Zfish  1191 EE-----HKK------ARGAELEYESLKRQELESENKKLKHDLNQMRQSLRGGAEAGSGAPGSPA 1244

  Fly  1159 QIELNKKREAELSKLRRDLEEANIQHESTLANLRK---------KHNDAVAEMAEQVDQLNKLKA 1214
            ...|       |.:|....||..::.|..|. ||.         :|...:.|....::.:.||  
Zfish  1245 YTVL-------LDQLNASNEELEVRKEEVLI-LRSQLVSQKEAMQHKTTMTEPLPYIEDVQKL-- 1299

  Fly  1215 KAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQ------HTLNE------VQSKLDETNR 1267
            ...||.::.|..|.|.... ...|.......::..:|:      |.|||      |...|.||||
Zfish  1300 TDAKEISQAYMGLKDTNRS-PRFTRRPTEVNELMSRLRSPFPDYHKLNEDGELWLVYEGLKETNR 1363

  Fly  1268 TLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKF 1332
            .|             .|.|..|....:::|..|.          .:...|.:|.:|::..|.   
Zfish  1364 LL-------------ESQLQAQRRSHDNEVEVLR----------GELHSLKEENNRQQQLLA--- 1402

  Fly  1333 RNLEHDLDNLREQVEEEAEGKADLQRQLSK-ANAEAQVWRSKYESDGVARSEELEEAKRKLQARL 1396
            :||         |:..||..:|.||.:::: .|...::           .|::.:|.|....:.|
Zfish  1403 QNL---------QLPPEARIEASLQHEITRLTNENLEL-----------HSDDPKEYKAYRISML 1447

  Fly  1397 AEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDD 1461
            ....:.:|.|.::    :||.::|                     :|:.|.|.|       |::|
Zfish  1448 RRMVDLMEQLEKQ----DKTVRKL---------------------KKQLKVFAK-------KIND 1480

  Fly  1462 L-AAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEI 1525
            | ..::|.|..:..:.......:....::.|..||..:.:...|   ||:::.::...|..::.|
Zfish  1481 LEGGQMDVSPGQTADEPVHPVNIPRREKDFQGMLEYKKEDELKL---VKNIILELKPRGVAVNLI 1542

  Fly  1526 EKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFE------- 1583
            ......:      |...|..|:...:.::.:.|     |:.|...|.:.::::.::||       
Zfish  1543 PGLPAYI------LFMCLRHADYINDDQKVRSL-----LTSVINSIKKILKKRGDDFETVSFWLA 1596

  Fly  1584 NTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDH-ANKANAEAQKN--IKRY 1645
            ||                      ...|...|:...|    |..:.| :.|.|.....|  :..|
Zfish  1597 NT----------------------CRFLHCLKQYSGD----EQFMKHNSPKQNEHCLSNFDLAEY 1635

  Fly  1646 QQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEES--RTLLEQADRGRRQAEQELADA 1708
            :|.|.|:                .:.|.::....::|.|:..  ..:||                
Zfish  1636 RQVLSDL----------------AIQIYQQLIKCMENILQPMIVSGMLE---------------- 1668

  Fly  1709 HEQLNEVSA--------QNASIS-AAKRKLES---ELQTLHSDL------DELLNEAKNSEEKAK 1755
            ||.:..||.        :.:||: .....|:|   :|.|.||.:      .||:.:.    .|.:
Zfish  1669 HETIQGVSGVKPTGLRKRTSSIADEGTYTLDSIIRQLNTFHSIMCHHGTDPELIKQV----VKQQ 1729

  Fly  1756 KAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRE 1820
            ..::.|..|.:.|            |||.:....|.:|:|.:             :.:||:.:|:
Zfish  1730 FYIIGAVTLNNLL------------LRKDMCSWSKGMQIRYN-------------VSQLEEWLRD 1769

  Fly  1821 LENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAE 1885
                            |||.....:               |.::.|: :..|.::..|:..|:||
Zfish  1770 ----------------KNLMTCGAK---------------ETLEPLI-QAAQLLQVKKKTDEDAE 1802

  Fly  1886 EIAAL-------NLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRATSVRP 1943
            .|.::       .:.|.......:...|||..:......:.|.:.|..|               |
Zfish  1803 AICSMCNALSTAQIVKVLNLYTPVNAFEERVSVLFIRTIQTRLRDRKES---------------P 1852

  Fly  1944 QF---DGLAFPPRFDLAPEN 1960
            |.   ..|.:|..|...|.:
Zfish  1853 QLLMDTKLIYPVTFPFNPSS 1872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 13/40 (33%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 282/690 (41%)
Myosin_tail_1 842..1922 CDD:460256 220/1215 (18%)
myo5aaXP_068071029.2 None

Return to query results.
Submit another query.