DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myh9b

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_001920098.4	Gene:	myh9b / 561431	ZFINID:	ZDB-GENE-030131-998	Length:	1698	Species:	Danio rerio

Alignment Length:	1692	Identity:	681/1692 - (40%)
Similarity:	1039/1692 - (61%)	Gaps:	26/1692 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL--QGGEVRDI 72
            |.|...|:..:|....:.|: .:.:||..|:|.|:.|:..|.:|...||.|.|.|  .|.::| :
Zfish     3 DVDKFLYVDRNLVNNPLAQA-DWATKKLVWVPSERLGFEAGSLKEEHGDEVVVELADSGKKIR-V 65

  Fly    73 KSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTN 137
            ..:.::|:|||||.|:||||::|.||...|||||::|||:.|||||||||||.|||||..|:|:.
Zfish    66 NKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSE 130

  Fly   138 RCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS 202
            ....||:||:|:|:||||:||:|.||..|:.:..:||:|.||||||||||||||||.|.|.|.:|
Zfish   131 EIVDMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASS 195

  Fly   203 KKT--DEAAK--SKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIE 263
            .||  |:::.  |.|.||.|::|.||:||||||||||:|||||||||||||:|...|.:.||:||
Zfish   196 HKTKKDQSSSVLSHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIE 260

  Fly   264 TYLLEKARVISQQSLERSYHIFYQIMSGSVPGVK-DICLLTDNIYDYHIVSQGKVTVASIDDAEE 327
            ||||||:|.|.|...||::|:||.:::|....:: ::||  :....|..:|.|.||:....|.:.
Zfish   261 TYLLEKSRAIRQAKEERTFHMFYYMLTGVGDKLRSELCL--EGYNKYRFLSNGNVTIPGQQDRDM 323

  Fly   328 FSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTA 392
            :..|.:|..|:||:::|...:.|:.::|:.:|.|.||:....:||....:....:|..|.|.:..
Zfish   324 YVETVEAMRIMGFSEEEHVGLLRVISSVLQLGNMSFKKERHSDQASMPDDTAAQKVCHLMGMNVT 388

  Fly   393 ELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFI 456
            :..:.:|.||||||.::|.:.:..:|...::.||.|..::|:|:|||.:.|:.|| |:::...||
Zfish   389 DFTRAILSPRIKVGRDYVQKAQTQEQAEFAVEALAKATYERMFRWLVMRINKALDKTKRQGASFI 453

  Fly   457 GVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACID 521
            |:||||||||||.|.|||||||:|||||||.|||.||:||||||:||||:|:|||||:||..|||
Zfish   454 GILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCID 518

  Fly   522 LIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYA 583
            |||||.   |||::|:||..||||||::|.||:.... |....|.|||..|   ..|.|.|.|||
Zfish   519 LIEKPASPPGILALLDEECWFPKATDKSFVEKVLQEQ-GTHPKFHKPKKLK---DEADFCIIHYA 579

  Fly   584 GCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFAD-----HAGQSGGGEQAKGGRGKKGG 643
            |.|.|....||.||.|||||.|.....:|.::.:.|::.|     ...:..|..:..|....:.|
Zfish   580 GKVDYKADEWLMKNMDPLNDNVATLLNQSTDRFVSELWKDVDRIVGLDKVAGMSELPGAFKTRKG 644

  Fly   644 GFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRK 708
            .|.||...|||||:.||.|||:|.|:||||||||..|:.|.:|.|||:.||.||||||||||||:
Zfish   645 MFRTVGQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQ 709

  Fly   709 GFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQM 772
            |||||:::.:|:.||:|:.|..: :|....|:|..::|:.::|..:.||:|.:|||||||||..:
Zfish   710 GFPNRIVFQEFRQRYEILTPNSIPKGFMDGKQACMLMIRALELDPNLYRIGQSKVFFRAGVLAHL 774

  Fly   773 EEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKP 837
            ||.||.::..::...|||.|||::||.|.|.|:|..|::|:|||...||:||.|.|::|:.||||
Zfish   775 EEERDMKITDVIINFQAWCRGYVARKAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRLFTKVKP 839

  Fly   838 LLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQE 902
            ||.|||.|:|:...||:..|..|......:...|:|....:|.|||.||.:.|..|.....:..|
Zfish   840 LLQVSRQEEEMQAKEEELSKVREKQQVAEQQLVEMEVKQQQLNAEKMALQEQLQAEMDLCAEADE 904

  Fly   903 RNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDK 967
            ...:|.|:|.:||..|.|::.|:.:||:..|.|..:|||..|.|:.|::.:::.|...||.:.:|
Zfish   905 MRNRLVAKKQELEEILHDLEARVEEEEERANHLQAEKKKMQQNIADLEQQLDEEEAARQKLQLEK 969

  Fly   968 ATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDE 1032
            .|.:.:::...:|:...|:..|||:||||:..|...:....|...|:|...|.|:|.|.|..:.:
Zfish   970 VTMEAKLKKTEEEVMVLDDQNNKLSKEKKLMEERIAEFTTNLAEEEEKSKSLQKLKNKHEAMITD 1034

  Fly  1033 LEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQ 1097
            |||.|.||:|.|.::||::||:|||.....:.:|:|:....||:..:.:|::||....|::|:|.
Zfish  1035 LEDRLRREEKQRQELEKNRRKLEGDSTELHDQIAELQAQIAELKAQLAKKEEELQEALARIEEEA 1099

  Fly  1098 VVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIEL 1162
            ......|::|:||::::.||:|::|.||.||.||||.|.||..|||.|...||:...:|:||.||
Zfish  1100 AQKNLAQKKIRELESQLSELQEDLELERAARTKAEKHRRDLGEELEALKTELEDTLDSTAAQQEL 1164

  Fly  1163 NKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQL 1227
            ..|||.|:::|::.|||....||..:|.:|:||:.|..|:.||::|:.:.|...||.|.....:.
Zfish  1165 RTKRETEVAQLKKALEEDAKVHEQVMAEIRQKHSQAFDELNEQLEQVKRNKVSVEKSKQALESER 1229

  Fly  1228 NDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEE 1292
            |:|:..:..:...|...|...|:.:..|.|:|.|..|:.|...:......|:..|..::...|.:
Zfish  1230 NELQIELQTLMQGKGESEHRRKKAEAQLQELQVKHTESERQRIELAERLTKMQAELDNVNTLLSD 1294

  Fly  1293 AESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQ 1357
            ||.:..:.||...::.:||:|.:.:..||:|::..|..:.|.||.:..:||||:|||.|.|.:|:
Zfish  1295 AEGKSIKASKDCSTVESQLQDVQEVLQEETRQKLALNTRLRQLEDEQHSLREQLEEEEEAKRNLE 1359

  Fly  1358 RQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLST 1422
            :|:....|:....:.|.|.:. ...|..||:::::|..|....:.::..|.....|:|||.||..
Zfish  1360 KQIGTMQAQLVDMKKKMEQES-GSLECAEESRKRVQRDLEAVSQRLDERNAAFDKLDKTKTRLQQ 1423

  Fly  1423 EVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAY 1487
            |::|:.::.|....|.:..|||||.||:::.|.|......|.|.|.::.|.|...|.:..|....
Zfish  1424 ELDDMLVDQDHLRQIVSNLEKKQKKFDQMLAEEKSISARYAEERDRAEAEAREKETRMLALAREL 1488

  Fly  1488 EEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQ 1552
            |...:..|.:.|.||.|..|::||:....:.|:::|::||:::.:|.:.:|::..|||.|..|:.
Zfish  1489 ETLTDMKEELDRTNKLLRAEMEDLVSSKDDVGKSVHDLEKSKRAMEQQLEEMKTQLEELEDELQA 1553

  Fly  1553 EENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKL 1617
            .|:..||.::.:..::.:.:|.:|.::|..|..::...:.:..|:..||.|.|.:..|:..:||:
Zfish  1554 TEDAKLRLEVNMQAMKAQYERDLQGRDELGEEKKRQLLKQVREMEMELEDERKQRTLAMAARKKM 1618

  Fly  1618 EADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQN 1682
            |.|:.|||.|:|.|||...||.|.:|:.|.|:||:...||:.:.:|::...|...:|::..:::.
Zfish  1619 ELDLKELEAAIDQANKNRDEALKQLKKVQAQMKDLLRELEDTRLSREEILAQSKENEKKVKSMEA 1683

  Fly  1683 EL 1684
            |:
Zfish  1684 EM 1685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	14/38 (37%)
		MYSc	81..777	CDD:214580	356/710 (50%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	335/679 (49%)
		Myosin_tail_1	842..1897	CDD:279860	271/843 (32%)
		V_Alix_like	1557..1877	CDD:187408	38/128 (30%)
		ATP-synt_B	<1671..1771	CDD:304375	2/14 (14%)
		TMPIT	1739..>1825	CDD:285135
myh9b	XP_001920098.4	Myosin_N	28..66	CDD:280832	14/38 (37%)
		Myosin_head	81..767	CDD:278492	342/691 (49%)
		Motor_domain	93..767	CDD:277568	335/679 (49%)
		KASH_CCD	937..1120	CDD:291334	60/182 (33%)
		Sec1	<943..>1076	CDD:301618	44/132 (33%)
		Dor1	1018..>1175	CDD:302817	64/156 (41%)
		Filament	1034..1341	CDD:278467	106/306 (35%)
		Rab5-bind	1306..1606	CDD:286404	87/300 (29%)
		GrpE	1532..>1640	CDD:295646	33/107 (31%)
		GBP_C	<1596..1689	CDD:303769	32/90 (36%)
		coiled coil	1660..1669	CDD:293879	1/8 (13%)
		coiled coil	1678..1689	CDD:293879	1/8 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720