DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myh7bb

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_009295034.2	Gene:	myh7bb / 560945	ZFINID:	ZDB-GENE-090311-5	Length:	1935	Species:	Danio rerio

Alignment Length:	1913	Identity:	1016/1913 - (53%)
Similarity:	1390/1913 - (72%)	Gaps:	15/1913 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPK 84
            :|||... ||..:|.||..|||||||.|:..|||.|.||.|.|..:.|.:..:|.|.::::||||
Zfish    21 NLEQLAA-QSHAFDGKKRVWIPDEKEAYIEVEIKDTDGDKVMVETKDGRMLTVKEEDIQQMNPPK 84

  Fly    85 FEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
            |:.:||||.:|.||...||.||.:||...:||||||||||.:||||..|||::.....|:||||:
Zfish    85 FDLMEDMAMLTHLNEASVLFNLSRRYSFWMIYTYSGLFCVTVNPYKWLPVYSSEVVAAYKGKRRS 149

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGS 214
            :|||||::|:|.||.|||.|..|||||||||||||||.|||:||.|||.:.|  ..:...|..|:
Zfish   150 DVPPHIYSIADNAYNDMLKNRENQSMLITGESGAGKTVNTKRVIQYFAIIAA--LGEAGGKKGGT 212

  Fly   215 LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLE 279
            ||||:::.||.:||||||||:|||||||||||||||||||||||.|||:.|||||:|||.||:.|
Zfish   213 LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVIFQQTGE 277

  Fly   280 RSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQE 344
            |||||:|||:|...|.::|:.|::.|.:|||..|||.:||.::||.:|...||.|.|.||||.:|
Zfish   278 RSYHIYYQILSHRKPELQDMLLVSSNPFDYHFCSQGVITVDNMDDGDELLATDHAMDTLGFTPEE 342

  Fly   345 KEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEF 409
            |...|:|...:||.|.||||.:.||||||.||.|...:.|.|.|..:|:|.|.||.||:|||||:
Zfish   343 KYGCYKIVGGIMHFGNMKFKVKQREEQAEADGTESADKASYLMGISSADLIKGLLHPRVKVGNEY 407

  Fly   410 VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQ 474
            :.:|:.|:|||.::|||.|..:||:|||||.:.|:||.|...||.||||||||||||||:|.|||
Zfish   408 IVRGQTVEQVTYAVGALAKATYDRMFKWLVGRINKTLYTAIPRQFFIGVLDIAGFEIFEFNNFEQ 472

  Fly   475 LCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMF 539
            :||||||||||||||||||:|||||||.|||:|.|||||:||.|||||||||:|||||||||.||
Zfish   473 MCINFTNEKLQQFFNHHMFILEQEEYKTEGIEWTFIDFGLDLQACIDLIEKPLGILSILEEECMF 537

  Fly   540 PKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDT 604
            ||||:.:|..||.:..||||..|.||:|.|..:...||.:.||||.|.|||.|||:||:||||:|
Zfish   538 PKATESSFKAKLYDNLLGKSPNFLKPRPDKKRKYDTHFELVHYAGVVPYNINGWLDKNRDPLNET 602

  Fly   605 VVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGG--RGKKGGGFATVSSAYKEQLNSLMTTLRSTQ 667
            ||..|::|.|||:..:|.:......|.|...|.  :.|||..|.|||..:||.||.|||.|||||
Zfish   603 VVGIFQRSSNKLMSSLFENFISLDSGSEAKPGSKEKRKKGASFQTVSQLHKENLNKLMTNLRSTQ 667

  Fly   668 PHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQ 732
            |||||||||||.|.||:::..||:|||.||||||||||||||||||::|.:||.||:|:.|   .
Zfish   668 PHFVRCIIPNEAKNPGMMEPFLVLHQLRCNGVLEGIRICRKGFPNRILYAEFKQRYRILNP---L 729

  Fly   733 GVEKD-----KKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
            .:.:|     :||.|.::..:|:...||:.|::||||:||:|||:|:.|||||.|:::.:||:.|
Zfish   730 AIPEDTYVDSRKAVEKLLGSLDIDHTQYKFGHSKVFFKAGLLGQLEDMRDERLSKVLTLLQAFCR 794

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKK 857
            |.|.|...|::.:::.||.|:|.|:|.:..::.|||..|:.|:||||..:..|.|:|.|:|:.:|
Zfish   795 GKLMRMERKRMMKEKEALMVIQWNIRAFYAVKNWPWMCLFFKIKPLLRSAATEKELATLKEEFQK 859

  Fly   858 AEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            .:| |..:||| |||||.....|:.||..|...|..|:..|.|.::|...|...|..:|.:::::
Zfish   860 LKEALERSEVK-RKELEEKQVSLVQEKNDLSLQLQAEQDNLADAEDRCNLLIKAKIQMEGKIKEL 923

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||:....:..:|:|.:.|...||||::|||:.:.|.|::|...:::::||.:|:|..||
Zfish   924 MERLEDEEEMNATILAKKRKLEDECIELKKDLDDLEITLAKVEKEKHATENKVKNLVEEMAALDE 988

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            .|::|:||||...:.:|:..|:||:.|:|:|.|:|.|.||||.:|:||.|||:|||||.|:|:.|
Zfish   989 TISRLSKEKKALQDAHQQALEDLQSEENKVNMLSKAKIKLEQQVDDLEGSLEQEKKVRMDLERVK 1053

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:||||||:.|:..||:.:|::||:.:::||.|:..|.||:|:||.:|::..::|||||.||||
Zfish  1054 RKLEGDLKLSVESSMDLDNSKQQLEERLKKKDHEMVQIGAKIEEEQALVIQLHKKIKELQTRIEE 1118

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            ||||:||||.||:|:||||:|::||||||.||||||||||:||||:||||||:..|||||||||:
Zfish  1119 LEEELEAERAARSKSEKQRSDVSRELEELSERLEEAGGATTAQIEMNKKREADFIKLRRDLEEAS 1183

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :.||:|:|.||:||.|.||||.||:|.|.::|.|.||||.|...:..||.:.|:|::..|...||
Zfish  1184 LHHETTIAMLRRKHADTVAEMGEQLDNLQRVKQKLEKEKAETRMECEDLASNVEHLSRAKTTTEK 1248

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:..:..|||.::|::|..|.|.|..:.|.:...|::::.|:|||.|..|.||.:.||:.:..:
Zfish  1249 MCRMYEDQLNESKTKIEELQRQLMDVTSQKARAQTESAEVSRRLEEKEVLVMQLQRTKIAFSQTV 1313

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.|:..:|||:.:.:|....::..||.|.||||.|||.|.|::|||.|||||.|...||:|||:
Zfish  1314 EELKKQLEEESKAKNSLAHAVQSSRHDCDLLREQFEEEQEAKSELQRALSKANIEIAQWRTKYET 1378

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|::|||:||:||.|||..:||.:|:.|.||..|||||.||.||:|||.::::|:||:|.|.
Zfish  1379 DAIQRTDELEDAKKKLVARLQGSEEAVEASNAKCASLEKTKHRLQTEIEDLMVDLERSNAVAIAL 1443

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.||:.|.::..:||:.||||.|:.|||||:||.:|||..:|||.::||||||.:
Zfish  1444 DKKQRNFDKVLSEWRQKFEETQSELEGSQKESRSLSTELFKLKNSYEEALDQLETIKRENKNLQE 1508

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.|||.:|.:.|||:|:.:|.|:.||.::||||||||..||.||:|.||.||||||.:.|:
Zfish  1509 EITDLTDQISQGNKTIHELEQMKKVLDHEKCDIQAALEEAEGTLEHEESKTLRVQLELSQTKTEV 1573

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ::::.|::||.:|.|:||||.|:.||.:|:||.:.:.||:|:|||:|.|:||:||.|:|||:...
Zfish  1574 EKKLAERDEEIDNLRRNHQRTLEGMQTTLDAETRARNEAIRVKKKMENDMNEMEIHLNHANRQAV 1638

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            |:||.::..|.|:||:|..|:|.....::.:||:.::|||...|..||||.|.:.||.||.|:.|
Zfish  1639 ESQKMVRNLQLQIKDLQVELDESMHHCEELKEQVAVTERRNTLLSAELEELRGVAEQTDRMRKVA 1703

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            |.||.::.|::|.:.|||..:...|:||||:|..|..::|:...|.:|:|||||||:.|||.:|:
Zfish  1704 EHELLESSERVNLLHAQNTVMLNQKKKLESDLSMLSGEVDDAQQECRNAEEKAKKAITDAAMMAE 1768

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|::::.:||.||:||.||||||..|||||||.|||:|.||||||.|||.||::
Zfish  1769 ELKKEQDTSSHLERMKRNMEQTIKDLQNRLDEAEQIALKGGKKQIQKMEIRVRELETELDCEQKK 1833

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            .|:.||.:||.|||:|||::|:|||||...|||||:||||.|:|::|||.|:|||....|:.:||
Zfish  1834 SAEFQKGIRKYERRIKELTYQTEEDRKTLLRMQDLIDKLQAKVKSFKRQAEDAEEQVNCNMTRFR 1898

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGR 1924
            |.|.:|:|||||||:||..::|.|.:.|
Zfish  1899 KIQHDLDEAEERADMAESQVNKLRVRTR 1926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	18/36 (50%)
		MYSc	81..777	CDD:214580	421/702 (60%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	402/671 (60%)
		Myosin_tail_1	842..1897	CDD:279860	524/1055 (50%)
		V_Alix_like	1557..1877	CDD:187408	164/319 (51%)
		ATP-synt_B	<1671..1771	CDD:304375	46/99 (46%)
		TMPIT	1739..>1825	CDD:285135	49/85 (58%)
myh7bb	XP_009295034.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1098	1.000	Domainoid score	I20
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2094	1.000	Inparanoid score	I40
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24867
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.830