Protein Alignment Mhc and myh7bb

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_009295034.2
• Gene: myh7bb / 560945
• ZFINID: ZDB-GENE-090311-5
• Length: 1935
• Species: Danio rerio
• Alignment Length: 1913
• Identity: 1019/1913 - (53%)
• Similarity: 1394/1913 - (72%)
• Gaps: 15/1913 - (0%)

  Fly    20 SLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQVNPPK 84
            :|||... ||..:|.||..|||||||.|:..|||.|.||.|.|..:.|....:|::.:||:||||
Zfish    21 NLEQLAA-QSHAFDGKKRVWIPDEKEAYIEVEIKDTDGDKVMVETKDGRMLTVKEEDIQQMNPPK 84

  Fly    85 YEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149
            ::..|||:.||:||:||||.||.:||...:||||||||||.:||||..|||::.....|:||||:
Zfish    85 FDLMEDMAMLTHLNEASVLFNLSRRYSFWMIYTYSGLFCVTVNPYKWLPVYSSEVVAAYKGKRRS 149

  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGS 214
            :|||||::|:|.||.|||.|..|||||||||||||||.|||:||.|||.:.|  ..:...|..|:
Zfish   150 DVPPHIYSIADNAYNDMLKNRENQSMLITGESGAGKTVNTKRVIQYFAIIAA--LGEAGGKKGGT 212

  Fly   215 LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLE 279
            ||||:::.||.:||||||||:|||||||||||||||||||||||.|||:.|||||:|||.||:.|
Zfish   213 LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVIFQQTGE 277

  Fly   280 RSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQE 344
            |||||:|||:|...|.::|:.|::.|.:|||..|||.:||.::||.:|...||.|.|.||||.:|
Zfish   278 RSYHIYYQILSHRKPELQDMLLVSSNPFDYHFCSQGVITVDNMDDGDELLATDHAMDTLGFTPEE 342

  Fly   345 KEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEF 409
            |...|:|...:||.|.||||.:.||||||.||.|...:.|.|.|..:|:|.|.||.||:|||||:
Zfish   343 KYGCYKIVGGIMHFGNMKFKVKQREEQAEADGTESADKASYLMGISSADLIKGLLHPRVKVGNEY 407

  Fly   410 VTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQ 474
            :.:|:.|:|||.::|||.|..:||:|||||.:.|:||.|...||.||||||||||||||:|.|||
Zfish   408 IVRGQTVEQVTYAVGALAKATYDRMFKWLVGRINKTLYTAIPRQFFIGVLDIAGFEIFEFNNFEQ 472

  Fly   475 LCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPMGILSILEEESMF 539
            :||||||||||||||||||:||||||:.|||||||||||:|||.||||||||:|||||||||.||
Zfish   473 MCINFTNEKLQQFFNHHMFILEQEEYKTEGIEWTFIDFGLDLQACIDLIEKPLGILSILEEECMF 537

  Fly   540 PKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDT 604
            ||||:.:|..||.:..||||..|.||:|.|..:...||.:.||||.|.|||.|||:||:||||:|
Zfish   538 PKATESSFKAKLYDNLLGKSPNFLKPRPDKKRKYDTHFELVHYAGVVPYNINGWLDKNRDPLNET 602

  Fly   605 VVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGG--RGKKGGGFATVSSAYKEQLNSLMTTLRSTQ 667
            ||..|::|.|||:..:|.:......|.|...|.  :.|||..|.|||..:||.||.|||.|||||
Zfish   603 VVGIFQRSSNKLMSSLFENFISLDSGSEAKPGSKEKRKKGASFQTVSQLHKENLNKLMTNLRSTQ 667

  Fly   668 PHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQ 732
            |||||||||||.|.||:::..||:|||.||||||||||||||||||::|.:||.||:|:.|   .
Zfish   668 PHFVRCIIPNEAKNPGMMEPFLVLHQLRCNGVLEGIRICRKGFPNRILYAEFKQRYRILNP---L 729

  Fly   733 GVEKD-----KKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
            .:.:|     :||.|.::..:|:...||:.|::||||:||:|||:|:.|||||.|:::.:||:.|
Zfish   730 AIPEDTYVDSRKAVEKLLGSLDIDHTQYKFGHSKVFFKAGLLGQLEDMRDERLSKVLTLLQAFCR 794

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKK 857
            |.|.|...|::.:::.||.|:|.|:|.:..::.|||..|:.|:||||..:..|.|:|.|:|:.:|
Zfish   795 GKLMRMERKRMMKEKEALMVIQWNIRAFYAVKNWPWMCLFFKIKPLLRSAATEKELATLKEEFQK 859

  Fly   858 AEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921
            .:| |..:||| |||||.....|:.||..|...|..|:..|.|.::|...|...|..:|.:::::
Zfish   860 LKEALERSEVK-RKELEEKQVSLVQEKNDLSLQLQAEQDNLADAEDRCNLLIKAKIQMEGKIKEL 923

  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986
            .|||..||:....:..:|:|.:.|...||||::|||:.:.|.|::|...:::::||.:|:|..||
Zfish   924 MERLEDEEEMNATILAKKRKLEDECIELKKDLDDLEITLAKVEKEKHATENKVKNLVEEMAALDE 988

  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051
            .|::|:||||...:.:|:..|:||:.|:|:|.|:|.|.||||.:|:||.|||:|||||.|:|:.|
Zfish   989 TISRLSKEKKALQDAHQQALEDLQSEENKVNMLSKAKIKLEQQVDDLEGSLEQEKKVRMDLERVK 1053

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116
            ||:||||||:.|:..||:.:|::||:.:::||.|:..|.||:|:||.:|::..::|||||.||||
Zfish  1054 RKLEGDLKLSVESSMDLDNSKQQLEERLKKKDHEMVQIGAKIEEEQALVIQLHKKIKELQTRIEE 1118

  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181
            ||||:||||.||:|:||||:|::||||||.||||||||||:||||:||||||:..|||||||||:
Zfish  1119 LEEELEAERAARSKSEKQRSDVSRELEELSERLEEAGGATTAQIEMNKKREADFIKLRRDLEEAS 1183

  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246
            :.||:|:|.||:||.|.||||.||:|.|.::|.|.||||.|...:..||.:.|:|::..|...||
Zfish  1184 LHHETTIAMLRRKHADTVAEMGEQLDNLQRVKQKLEKEKAETRMECEDLASNVEHLSRAKTTTEK 1248

  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311
            :.:..:..|||.::|::|..|.|.|..:.|.:...|::::.|:|||.|..|.||.:.||:.:..:
Zfish  1249 MCRMYEDQLNESKTKIEELQRQLMDVTSQKARAQTESAEVSRRLEEKEVLVMQLQRTKIAFSQTV 1313

  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376
            |:.|:..:|||:.:.:|....::..||.|.||||.|||.|.|::|||.|||||.|...||:|||:
Zfish  1314 EELKKQLEEESKAKNSLAHAVQSSRHDCDLLREQFEEEQEAKSELQRALSKANIEIAQWRTKYET 1378

  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441
            |.:.|::|||:||:||.|||..:||.:|:.|.||..|||||.||.||:|||.::::|:||:|.|.
Zfish  1379 DAIQRTDELEDAKKKLVARLQGSEEAVEASNAKCASLEKTKHRLQTEIEDLMVDLERSNAVAIAL 1443

  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506
            :|||:.|||::.||:.|.::..:||:.||||.|:.|||||:||.:|||..:|||.::||||||.:
Zfish  1444 DKKQRNFDKVLSEWRQKFEETQSELEGSQKESRSLSTELFKLKNSYEEALDQLETIKRENKNLQE 1508

  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571
            |:.||.|||.:|.:.|||:|:.:|.|:.||.::||||||||..||.||:|.||.||||||.:.|:
Zfish  1509 EITDLTDQISQGNKTIHELEQMKKVLDHEKCDIQAALEEAEGTLEHEESKTLRVQLELSQTKTEV 1573

  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636
            ::::.|::||.:|.|:||||.|:.||.:|:||.:.:.||:|:|||:|.|:||:||.|:|||:...
Zfish  1574 EKKLAERDEEIDNLRRNHQRTLEGMQTTLDAETRARNEAIRVKKKMENDMNEMEIHLNHANRQAV 1638

  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701
            |:||.::..|.|:||:|..|:|.....::.:||:.::|||...|..||||.|.:.||.||.|:.|
Zfish  1639 ESQKMVRNLQLQIKDLQVELDESMHHCEELKEQVAVTERRNTLLSAELEELRGVAEQTDRMRKVA 1703

  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766
            |.||.::.|::|.:.|||..:...|:||||:|..|..::|:...|.:|:|||||||:.|||.:|:
Zfish  1704 EHELLESSERVNLLHAQNTVMLNQKKKLESDLSMLSGEVDDAQQECRNAEEKAKKAITDAAMMAE 1768

  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831
            ||:.|||.:...|::::.:||.||:||.||||||..|||||||.|||:|.||||||.|||.||::
Zfish  1769 ELKKEQDTSSHLERMKRNMEQTIKDLQNRLDEAEQIALKGGKKQIQKMEIRVRELETELDCEQKK 1833

  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896
            .|:.||.:||.|||:|||::|:|||||...|||||:||||.|:|::|||.|:|||....|:.:||
Zfish  1834 SAEFQKGIRKYERRIKELTYQTEEDRKTLLRMQDLIDKLQAKVKSFKRQAEDAEEQVNCNMTRFR 1898

  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGR 1924
            |.|.:|:|||||||:||..::|.|.:.|
Zfish  1899 KIQHDLDEAEERADMAESQVNKLRVRTR 1926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	21/41 (51%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	405/671 (60%)
		Myosin_tail_1	842..1922	CDD:460256	539/1080 (50%)
myh7bb	XP_009295034.2	Myosin_N	33..77	CDD:460670	21/43 (49%)
		Motor_domain	100..767	CDD:473979	405/671 (60%)
		Myosin_tail_1	847..1924	CDD:460256	539/1077 (50%)