DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhc and myo15aa

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_021330383.1	Gene:	myo15aa / 560592	ZFINID:	ZDB-GENE-080425-2	Length:	2394	Species:	Danio rerio

Alignment Length:	887	Identity:	293/887 - (33%)
Similarity:	466/887 - (52%)	Gaps:	107/887 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 EKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRC 139
            |:.|:      :.:|||..:..|:...||.||::|:...|||||.|...|::||||.:.:|....
Zfish    14 ERAEE------DGVEDMTQLEELHEGAVLLNLKKRFERNLIYTYIGSILVSVNPYKMFNIYGTDM 72

  Fly   140 AKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKK 204
            ...::|....|.|||:|||::.:|..|:....||.::|:||||:||||.||.|:.|.|
Zfish    73 VLQHKGHALGENPPHLFAIANASYTKMMDAKENQCIIISGESGSGKTETTKLVLRYLA------- 130

  Fly   205 TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEK 269
               |...|.::..|:::..|:||:|||||||||||||||||::.| |...|.::||....|||||
Zfish   131 ---AIHHKQNITQQILEATPLLESFGNAKTVRNDNSSRFGKYMEI-FMEEGVISGAITSQYLLEK 191

  Fly   270 ARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQA 334
            :|::.|...||:|||||::::|.....|....|.|....|::...|...:....|.|:|.....|
Zfish   192 SRIVFQAKDERNYHIFYEMLAGLPSQQKQSFYLQDAETYYYLNQGGDCVIVGKSDGEDFRRLLSA 256

  Fly   335 FDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQ--AEQDGEEEGGRVSKLFGCDTAELYKN 397
            .:||.|:.:::..::|:.::::|:|.:.|::...|.|  |.....:|...|::|.......|.|:
Zfish   257 MEILHFSAEDQSGIFRVLSSILHLGNVFFERYETESQEVASVVSAQEIRVVAELLQISPEGLQKS 321

  Fly   398 LLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIA 462
            :.....:...|.:.....|:...::..|:.|.::..||.||..:.|:.:..:.:... |.:|||.
Zfish   322 ITFKVTETMREKIYTPLTVESAIDARDAVAKILYSLLFSWLTDRINKQVYPRNEALS-ISILDIY 385

  Fly   463 GFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLI-EKP 526
            |||...:|.|||||||:.||.||.|||..:|..||:||.||.|.|..:.|. |..|||||| .||
Zfish   386 GFEDLTFNSFEQLCINYANEYLQFFFNRVIFKEEQDEYNREQIIWEEVPFS-DNQACIDLIAAKP 449

  Fly   527 MGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNIT 591
            .|||.||:::|.||:|||.||.:| .:.|.|.:..:.|||.|.|     .|.|.||||.|||.:.
Zfish   450 HGILRILDDQSGFPQATDHTFLQK-CHYHHGNNPLYSKPKMPLP-----EFTIKHYAGKVSYQVH 508

  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGK---KGGGFATVSSAYK 653
            .:|:||.|.:...|:|.|.:|:||::..:|.::| ::...::::.|:..   :....:||::.::
Zfish   509 KFLDKNYDQVRQDVLDLFIQSKNKMVAYLFMNYA-EALNQQRSQIGKNSTVTRRHQASTVAAKFQ 572

  Fly   654 EQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPD 718
            :.|..|:..:....|:|||||.||:.|:|.|.|..||..||..:|:||.:||.|:|:|.||.:..
Zfish   573 QSLLELIEKMERANPYFVRCIKPNQNKEPAVFDMELVSAQLCYSGILETVRIRREGYPIRMPFDV 637

  Fly   719 FKMRYKIMCPKLLQGVEKDKKATE-----IIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDE 778
            |..||     |.|.|:::...|..     ::.|...:....:::|.||:|.:..:...:|..||.
Zfish   638 FLFRY-----KSLLGLKQPPPANGENCVIMLRKLCPVRPGAFQVGVTKLFMKEEIYFLLESKRDR 697

  Fly   779 -------------------------RLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNL- 817
                                     |: ||:. :||..||:|:||.:.|:   ||:| |..|:|
Zfish   698 VRHVAALTLQRYTRMFFVRKRYTAFRM-KIIR-LQAHCRGFLTRKRYVKM---RVSL-VKFRSLV 756

  Fly   818 ------RKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALN 876
                  ::|::||    |:..:|.         |:|..|:|.:..|.|.::...:.:..||.||
Zfish   757 HMYVDRKRYIRLR----YEARRKA---------EEEQRRIEMELSKREVVNVTHLVIPAELGAL- 807

  Fly   877 AKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQL 918
                         |....|..:.:.:..|.:.|....:|.||
Zfish   808 -------------LQAAAGGRELHSDCLALVQAPTVQVETQL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	250/706 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	245/675 (36%)
		Myosin_tail_1	842..1897	CDD:279860	17/77 (22%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
myo15aa	XP_021330383.1	Motor_domain	34..684	CDD:328930	245/674 (36%)
		IQ	723..742	CDD:279006	10/20 (50%)
		MyTH4	866..1013	CDD:214535
		Atrophin-1	<1205..1505	CDD:331285
		SH3_MYO15A	1716..1795	CDD:213000
		MyTH4	1914..2068	CDD:214535
		FERM_B-lobe	2176..2273	CDD:271216
		FERM_C_MyoXV	2279..2380	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000