DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and myo1d

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_688008.5	Gene:	myo1d / 559562	ZFINID:	ZDB-GENE-130531-15	Length:	1004	Species:	Danio rerio

Alignment Length:	1034	Identity:	326/1034 - (31%)
Similarity:	509/1034 - (49%)	Gaps:	155/1034 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ADMTVLNTPCV---LHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPP 153
            ||..:|:...:   :.||:.|:....||:|.|...|::|||:...:|.....:.|:|:...|.||
Zfish    12 ADFVLLDNVSLEEFMANLKLRFEKGRIYSYIGEVVVSVNPYRAMNIYGRDVIEQYKGRELYERPP 76

  Fly   154 HIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQ 218
            |:|||:|.||..|...:.:..::|:|||||||||.:|.::.|.|.:....:..|..:.|..|
Zfish    77 HLFAIADAAYKAMKRRNKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNML--- 138

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
             :::|.||||||||||.||||||||||::.|:|...|...|..|..|||||:|||.||..|||:|
Zfish   139 -LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIFQQEGERSFH 202

  Fly   284 IFYQIMSGSVPG-VKDICLLTD-NIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKE 346
            .|||::.|:... ::.:.:..| ..|:|  :..|....:||:|:.||.....|..::|||.:|.:
Zfish   203 SFYQLVKGAPDAQLRSLHIQRDPTAYNY--IKVGGQLKSSINDSAEFKAVADAMKVIGFTTEEIQ 265

  Fly   347 DVYRITAAVMHMGGMKFKQRGREEQAEQDGEE---EGGRVSKLFG--CDTAE--LYKNLLKPRIK 404
            .||:|.|.::|:|.:||         ..||:.   |..::..:.|  ..|.|  :.|.:|...:.
Zfish   266 TVYKILATILHLGNLKF---------GTDGDVTLIENSKLVSVLGDLLSTKEENVEKAMLYRTVA 321

  Fly   405 VGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQ--QKRQH----FIGVLDIAG 463
            .|.:.:.:....|:.:....||.|.:::|||.|:|.:.|:.::.:  ..|.|    .||||||.|
Zfish   322 TGRDVIDKQHTHQEASYGRDALAKAIYERLFCWIVGRINDIIEVKNYDARVHGKNTVIGVLDIYG 386

  Fly   464 FEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKP-M 527
            ||||:.|.|||.|||:.||||||.|...:...|||||:||||.|..||:..:.: .:||:|:. .
Zfish   387 FEIFQNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQI-IVDLVEQQHK 450

  Fly   528 GILSILEEESM-FPKATDQTFSEKLTNTHLGKSAPFQKPK---PPKPGQQAAHFAIAHYAGCVSY 588
            ||.::|:|..| ..|.||:.|.:.| |..|.|.|.:...|   ..|..:....|.|.||||.|:|
Zfish   451 GIFAVLDEACMNVGKVTDEMFLQAL-NGKLAKHAHYTSRKLSPTDKNLEFERDFRIRHYAGDVTY 514

  Fly   589 NITGWLEKNKDPLNDTVVDQFKK----SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVS 649
            ::.|:::|||    ||:...||:    |.|.:|..::.:  |:....|..|..        .|.:
Zfish   515 SVVGFIDKNK----DTLFQDFKRLLYNSSNPVLKAMWPE--GKLSITEVTKRP--------LTAA 565

  Fly   650 SAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRM 714
            :.:|..:.||:..|.|.:|::||||.||::|.|.:.:.....||:...|:||.:|:.|.||.||.
Zfish   566 TLFKNSMISLVEKLASKEPYYVRCIKPNDVKSPLLFEHERCKHQVEYLGLLENVRVRRAGFANRQ 630

  Fly   715 MYPDFKMRYKIMC----PKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRA-GVLGQMEE 774
            .||.|..|||::.    |.  ..:..||:|.:.:::......| ...|.||||.|. ..:..:||
Zfish   631 TYPRFLQRYKMISEFTWPN--HDLSSDKEAVKRLLQGCGFEHD-VAYGKTKVFIRTPRTIFSLEE 692

  Fly   775 FRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLL 839
            .|.|.:.:|:.::|...||.|:|..::::   |.|| ::.|..|:|             |||
Zfish   693 QRAEMVKRIVLFLQKVWRGTLARMRYRRM---RAAL-IIIRAYRRY-------------KVK--- 737

  Fly   840 NVSRIEDEIARLEEKAKKAEEL--HAAEVK-------VRKELEALNA------------KLLAEK 883
              |.|.:.|.|.    |...::  |...||       :||..|||.:            .|..||
Zfish   738 --SYIREVIRRF----KNVRDMKDHGKHVKWPTPPKVLRKFEEALRSIYNRWWAWTLIKPLSPEK 796

  Fly   884 T-------ALLDSLSGEKG--ALQDYQERN----------AKLTAQKNDLENQLRDIQERLTQEE 929
            |       |.|:.|.|::.  .||...|.|          :..|...:||  |.:|...|:....
Zfish   797 TVQIRAKVATLECLKGQRADLGLQRAWEGNYLKKDSPGTASSFTLVSSDL--QRKDKFMRVLFSS 859

  Fly   930 DARNQLFQQKKKADQEISGLKKDIEDLEL-NVQKAEQDKATKDHQIRNLNDEIAH--QDELINKL 991
            :.| ::.:..|..|:.:.     |.|..| .:...:|.|..|...:.|:......  :|:|:...
Zfish   860 NVR-KINRFNKAEDRALL-----ITDRHLYKMDPLKQYKPMKSIPLYNVTGVSISPGKDQLVVFH 918

  Fly   992 NKEKK-----MQGET---NQKTGEELQAAEDKINHLNKVKAKLE-QTLDELEDSLEREK 1041
            .|:.:     :||..   :.:.||.:...   ::|....|.||: .|:..:..|:...|
Zfish   919 TKDNRDLIVCLQGMVPAGDSRIGELVGTL---LSHFKSEKRKLQVNTVSPIHCSMNGRK 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	254/716 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	248/695 (36%)
		Myosin_tail_1	842..1897	CDD:279860	55/252 (22%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
myo1d	XP_688008.5	MYSc_Myo1	23..682	CDD:276829	248/692 (36%)
myo1d	XP_688008.5	Myosin_TH1	803..994	CDD:336273	38/183 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000