DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myo18ab

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_021322097.1 Gene:myo18ab / 559005 ZFINID:ZDB-GENE-080423-1 Length:2267 Species:Danio rerio


Alignment Length:1948 Identity:503/1948 - (25%)
Similarity:915/1948 - (46%) Gaps:388/1948 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ANQEDEDPTPYL----------FVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGE-IKATKGDI 59
            :.|.:|||...|          .|..|::...:...|.|:| .|:. .|:|:.|.. :|...|.:
Zfish   521 SEQVEEDPVAILKADHAAAAHPKVKTEEQIAAEQAWYGSEK-VWLV-HKDGFSLATVVKTEAGSL 583

  Fly    60 ----VSVGLQ-GGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYS 119
                |.:.|: .|.|.|:..:.|||.|||.|::.||:|.:..||...|:|:|||||...||:|::
Zfish   584 PEGKVKIKLEHDGTVLDVDEDDVEKANPPSFDRCEDLAALLYLNESSVMHSLRQRYGGNLIHTHA 648

  Fly   120 GLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAG 184
            |...|.:||.....:|:.:...|::|.||.:..|||:|::..||.::||...:||:::.|:||:|
Zfish   649 GPNMVIVNPISAPSMYSEKVMHMFKGCRREDTAPHIYAVAQSAYRNLLTTRQDQSIVLLGKSGSG 713

  Fly   185 KTENTKKVIAYFATV-GASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIR 248
            ||.|.:.::.|..:: |::.|...|.|.      |.|.|  :||||||:.|..|:|:|||.:.:.
Zfish   714 KTTNCQHLVQYLVSIAGSTGKIFTAEKW------QAVYT--ILEAFGNSATSMNNNASRFSQIVS 770

  Fly   249 IHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYD----- 308
            :.|...|::|.|.|:|.||||.||:.:...|.::::||.:|:|:     |..|.|:..::     
Zfish   771 LDFDQAGQVASASIQTMLLEKLRVVKRPETESTFNVFYYMMAGA-----DSTLRTELHFNHFAEN 830

  Fly   309 --YHIVSQGKVTVASIDD----AEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGG-----MK 362
              :.||.|.|.     :|    :::|:....|..:||.:..|::.::.|..|:.|:|.     .:
Zfish   831 SAFGIVPQSKP-----EDKQKASQQFTKLQAAMKVLGISSDEQKALWLILGAIYHLGAAGATKAE 890

  Fly   363 FKQRGREEQAEQDGEEEGGRVSKLFGCDTAEL----YKNLLKPRIKVGNEFVTQGRNVQQVTNSI 423
            ..:.||::.|..:..:   :.:.|.||...||    :|:..|..::....| .||.:.....::.
Zfish   891 ADEAGRKQFARHEWAQ---KAAYLLGCTLEELSSAIFKHQPKGTLQRSTSF-RQGPDDAGTGDNS 951

  Fly   424 G----------ALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN-------- 470
            |          |:..|::..||..::...|..|.:.|.....:.::|..||:    |        
Zfish   952 GPKITALECLEAMAAGLYSELFTLVISLVNRALKSSQHSLCSLLIVDTPGFQ----NPKLAKRER 1012

  Fly   471 --GFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDL---LACID------LI- 523
              .||:||.|:..|:||..|:...||.|.|.||.|.|:.|..|.....   :|.||      |: 
Zfish  1013 GATFEELCHNYAQERLQTLFHERTFVQELERYKEENIELALDDIESSTSLSVAAIDQASSQALVR 1077

  Fly   524 -----EKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKP----KPPKPGQQAAHFAI 579
                 ::..|:|.::|||::.|..:::|..|:|.:.:.......:.|    |..||    .||.:
Zfish  1078 TLARTDEARGLLWLMEEEALQPGGSEETLLERLFSYYSPADGESKGPALLLKSDKP----HHFLL 1138

  Fly   580 AHYAGC--VSYNITGWLEKNK-DPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGG-RGK 640
            .|..|.  |.|:..|||...| :|.:.......:.||.|.:..:|   .|:|||.....|. .|.
Zfish  1139 GHSHGTDWVEYDAGGWLSHAKQNPASQNAAILLQDSQKKNISSLF---MGRSGGATVLSGSIAGL 1200

  Fly   641 KGGG-------------FATVSSAYKE---------QLNSLMTTLRSTQPHFVRCIIPN------ 677
            :||.             |.|..:|.|:         |:::||.|:|.::.|||.|::|.      
Zfish  1201 EGGSQLALRRATSMRKTFTTGVAAVKKKSLCIQVKLQVDALMDTVRRSRVHFVHCLLPKAETLSA 1265

  Fly   678 EMKQPG---------VVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQG 733
            ::|.||         .:|..|:..||..:.:|:.:||.|:|:|:.:::.:|:.|:.::.|.|.:.
Zfish  1266 DVKVPGGESCDTGLMQLDVCLLRAQLRGSKLLDALRIYRQGYPDHLVFSEFRRRFDVLTPHLTKK 1330

  Fly   734 ------VEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792
                  |..:|:|.|.:::.::|.:..|.:|.::||||||||.::||.||.:..:.::..||..|
Zfish  1331 HGRNYIVTDEKRAVEELLESLELEKSSYHMGLSRVFFRAGVLAKLEENRDIQTRRNLTLFQAACR 1395

  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIE-------DEIAR 850
            |||:|:.|||.:.|.:|::.:|:|::|...::.|||:||:..|:||:.|...|       :||..
Zfish  1396 GYLARQAFKKRKIQDLAIRCIQKNIKKNRGVKGWPWWKLFTTVRPLIEVQLTEEQIRGKDEEIQL 1460

  Fly   851 LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLE 915
            |:.|.:|.|       |.|.||...:.:|.::.|.|...|:.|:...:...:.....|:::..||
Zfish  1461 LKSKLEKVE-------KERNELRLNSDRLESKITELSSELADERNTGESASQLLESETSERLRLE 1518

  Fly   916 NQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDE 980
            ..::|:|.:.    ||                 :||..|.:|:.|.:|...:|::      ||.|
Zfish  1519 KDMKDLQAKF----DA-----------------MKKQTESMEMEVMEARLIRASE------LNGE 1556

  Fly   981 IAHQDELINKLNKEKKMQGETNQKTGEELQAA-EDKINHLNKVKAKLEQTLDELEDSLEREKKVR 1044
            :...|                   ||.|.:.. |..|..:...|.:|:|   |.:|.||.|    
Zfish  1557 MDDDD-------------------TGGEWRLKYERAIREIEFTKKRLQQ---EFDDKLEVE---- 1595

  Fly  1045 GDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKE 1109
               :::||::|  .|||     ||:.:.:|:::..|:..|:...:||:|:|.::.:...|.:..:
Zfish  1596 ---QQNKRQLE--RKLT-----DLQADNEEVQRVAQQLKKKCQRLTAELQDTKLHLEGQQSRNHD 1650

  Fly  1110 LQARIEELEEEVEAERQARAKAEK-QRADLARELEELGERLEEAGGATSAQIELNKKREAELSKL 1173
            |:.:..:.:.| :.:.|...:.|| ||..|:||.:.|                     ..|:..|
Zfish  1651 LEKKQRKFDSE-QTQAQEEVQREKSQREKLSREKDML---------------------TGEVFSL 1693

  Fly  1174 RRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHIT 1238
            |:.||:.::  |....||:      :.:|..::..||..::|.|....:...||.||.|.|    
Zfish  1694 RQQLEDKDL--EICAVNLK------LEQMEAELQDLNSQESKDEASLAKIKKQLRDLEAKV---- 1746

  Fly  1239 NEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQL--EEAESQVSQLS 1301
                             .:.:.:|||...|:...:.:|.:|.:| .:.|||.  :|.||:..::.
Zfish  1747 -----------------KDQEEELDEQAGTIQMLEQAKLRLEME-MERLRQTHSKEIESKEDEVE 1793

  Fly  1302 KIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQV-EEEAEGKADLQRQLSKAN- 1364
            :|:.|.:.:|:..:...:||..::..:|.:.|::|..|.:.::|| ..:.|.:..|::.|.:.. 
Zfish  1794 EIRQSCSKKLKQMEVQLEEEYEDKQKVLREKRDMEAKLMSAQDQVSHRDVEAEKRLRKDLKRTKA 1858

  Fly  1365 --AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDL 1427
              |:||:.....:::..:: .|:.:.|.:|:    |:|.|       |....|.::.:..|:|||
Zfish  1859 LLADAQIMLDHLKNNAPSK-REIAQLKNQLE----ESEFT-------CAAAVKARKSMEVEIEDL 1911

  Fly  1428 QLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQE 1492
            .:::|..:       |.::|.::.:...:.:.:||.:.::..|::    ..||.:...|      
Zfish  1912 HVQMDDIS-------KSKQALEEQLSRLQREKNDLQSRMEEDQED----MNELMKKHKA------ 1959

  Fly  1493 QLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEK----ARKRLEAEKDEL---------QAALE 1544
               ||.:.::||| ::.||..|:.|..:...::::    .:.:||.::..:         :|.:.
Zfish  1960 ---AVAQSSQNLA-QISDLQAQLEEAMKEKQDVQEKLTALQSQLEFQEQSMVDKSLVSRQEAKIR 2020

  Fly  1545 EAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEEE--FENTRKNHQRALDSMQASLEAE---- 1603
            |.|..||.|:.:|.|.:..::::::.:::..:|:::.  .||..|...:.|......::.|    
Zfish  2021 ELETKLEFEKTQVKRLESLVARLKENLEKLTEERDQRSASENREKEQNKRLLRQIRDIKEEMAEL 2085

  Fly  1604 AKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDARE 1668
            ||.:|||.|.|.:||.||..||       .||...|.::|...:::.|:|.|:|:|..:.|    
Zfish  2086 AKKEAEASRKKHELEMDIESLE-------AANQSLQADLKLAFKRIGDLQAAIEDEMESDD---- 2139

  Fly  1669 QLGISERRANALQN---ELEESRTLLEQADRGRRQAEQELADAHEQL--NEVSAQNASISAAKRK 1728
                :|...|:||:   :.::.:..:|.|.....:.|..:......|  |:.||:|.|...:   
Zfish  2140 ----NEDLINSLQDMVTKYQKRKNKIEGASDTDSEVEDRVDGVKSWLSKNKGSAKNLSDDGS--- 2197

  Fly  1729 LESELQTLHSDLDELLNEAKNSEE--------KAKKAMVDAARLADELRAEQDHAQTQEKLRK 1783
            |:|....::.|    ..|.|..||        ||.....||..|.|..|      :.::|.||
Zfish  2198 LKSSRYAVNVD----GKEGKEWEEGKEWKESGKAHPPAADAFALTDLTR------KRKKKKRK 2250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 12/42 (29%)
MYSc 81..777 CDD:214580 231/802 (29%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 214/771 (28%)
Myosin_tail_1 842..1897 CDD:279860 222/989 (22%)
V_Alix_like 1557..1877 CDD:187408 61/246 (25%)
ATP-synt_B <1671..1771 CDD:304375 27/112 (24%)
TMPIT 1739..>1825 CDD:285135 15/53 (28%)
myo18abXP_021322097.1 Atrophin-1 14..>529 CDD:331285 3/7 (43%)
Myosin_head 554..2053 CDD:332202 437/1688 (26%)
MYSc_Myo18 629..1368 CDD:276837 214/771 (28%)
SMC_N <1939..>2169 CDD:330553 59/258 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.