DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myh10

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_009300420.1 Gene:myh10 / 555454 ZFINID:ZDB-GENE-030616-162 Length:2014 Species:Danio rerio


Alignment Length:1998 Identity:779/1998 - (38%)
Similarity:1198/1998 - (59%) Gaps:98/1998 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPKPVANQEDEDPTPYLFVSLEQRRIDQSKPYD--------SKKSCWIPDEKEGYLLGEIKATKG 57
            ||:.......|||..||||       |::..|:        :||..|:|.|:.|:....|:..:|
Zfish     1 MPEMAQRSGQEDPERYLFV-------DRAVVYNPTTQADWTAKKLVWVPSERHGFEAASIREERG 58

  Fly    58 DIVSVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGL 121
            :.|.|.| :.|:...:..:.::|:|||||.|:||||::|.||...|||||:.|||:.||||||||
Zfish    59 EEVLVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGL 123

  Fly   122 FCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKT 186
            |||.|||||..|:|:....:|||||:|:|:||||:|||:.||..||.:..:||:|.|||||||||
Zfish   124 FCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKT 188

  Fly   187 ENTKKVIAYFATVGASKK----------TDEAAKSK------GSLEDQVVQTNPVLEAFGNAKTV 235
            |||||||.|.|.|.:|.|          :.:|.|.:      |.||.|::|.||:||:|||||||
Zfish   189 ENTKKVIQYLAHVASSHKGRKDHNIPPESPKAVKLQNGILFYGELERQLLQANPILESFGNAKTV 253

  Fly   236 RNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDIC 300
            :|||||||||||||:|..||.:.||:||||||||:|.|.|...||::|:|||:::|:...::. .
Zfish   254 KNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHVFYQLLAGAGEHLRS-D 317

  Fly   301 LLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQ 365
            ||.:....|..:|.|.:.:....|.:.|..|.:|..|:.|..:|...:.::.:||:..|.:.||:
Zfish   318 LLLEGFNSYRFLSNGNIPIPGQQDKDNFQETMEAMHIMSFNHEEILSMLKVVSAVLQFGNIVFKK 382

  Fly   366 RGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGV 430
            ....:||.........::..|.|.:..|..:.:|.||||||.::|.:.:..:|...::.||.|..
Zfish   383 ERNTDQASMPENTAAQKLCHLLGMNVMEFTRAILSPRIKVGRDYVQKAQTKEQADFAVEALAKAT 447

  Fly   431 FDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFV 494
            ::|||:|||.:.|:.|| |:::...|||:|||||||||:.|.|||||||:|||||||.|||.||:
Zfish   448 YERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFI 512

  Fly   495 LEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHL 556
            ||||||:||||:|:|||||:||..||||||:|.   |:|::|:||..||||||:||.:||.... 
Zfish   513 LEQEEYQREGIEWSFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVDKLVQEQ- 576

  Fly   557 GKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIF 621
            |....||||:..|   ..|.|.|.||||.|.|....||.||.|||||.|.....:|.:|.:.|::
Zfish   577 GTHGKFQKPRQLK---DKADFCIIHYAGRVDYKADEWLMKNMDPLNDNVATLLHQSTDKFVAELW 638

  Fly   622 ADH------------------AGQ----------SGGGEQAKGGRGK-KGGGFATVSSAYKEQLN 657
            .|.                  .|:          :|..|.|.|...| |.|.|.||...|||.|.
Zfish   639 KDEIQNFQRASFYDVSSLHESPGEVDRIVGLDQVAGMNETAFGAAYKTKKGMFRTVGQLYKESLT 703

  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722
            .||.|||:|.|:||||||||..|:.|.::.|||:.||.||||||||||||:|||||:::.:|:.|
Zfish   704 KLMATLRNTNPNFVRCIIPNHEKRAGKLEPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQR 768

  Fly   723 YKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSW 786
            |:|:.|..: :|....|:|.|.:|:.::|..:.||:|.:|:|||.|||..:||.||.::..|:.:
Zfish   769 YEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDIIIY 833

  Fly   787 MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL 851
            .|:..||||:||.|.|.|:|..||||:|||...||:||.|.|::|:.||||||.|:|.|:|:...
Zfish   834 FQSVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQEEEMQAK 898

  Fly   852 EEKAKKAEELHAAEVKVRKEL---EALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913
            :|:..|.:|   .:|||..||   |..:.:||.||..|.:.|..|.....:.:|..|:|.|:|.:
Zfish   899 DEELIKVKE---RQVKVENELVEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLVAKKQE 960

  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978
            ||..|.|::.|:.:||:....|..:|||....|..|::.:::.|...||.:.:|.|.:.:|:.:.
Zfish   961 LEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQDLEEQLDEEEAARQKLQLEKVTAEAKIKKME 1025

  Fly   979 DEIAHQDELINKLNKEKKM----QGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            ::|...::..:|..||||:    .||...:..||    |:|..:|.|||.|.|..:.:||:.|::
Zfish  1026 EDILLLEDQNSKFLKEKKLLEDRVGEMTSQLAEE----EEKAKNLGKVKNKQEMMMVDLEERLKK 1086

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |:|.|.::||:|||::.:....|:.:|:|:....||:..:.:|::||.::.|:.::|........
Zfish  1087 EEKTRQELEKAKRKLDAETTDLQDQIAELQAQIDELKIQLAKKEEELQAVLARGDEEVAQKNNAL 1151

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            :|::||||::.||:|::|:|:.||.||||.:.||:.|||.|...||:....|:||.||..|||.|
Zfish  1152 KQLRELQAQLAELQEDLESEKAARNKAEKLKRDLSEELEALKTELEDTLDTTAAQQELRSKREQE 1216

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            :::|::.:::....|||.:..:|::|..|:.|::||::|..::|...||.|........:|...|
Zfish  1217 VAELKKAIDDETRNHESQIQEMRQRHGTALEEISEQLEQAKRVKGNLEKNKQTLESDNKELTNEV 1281

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            ..:...|:..|...|:|:..|.||.::..|..:...:......|:..|..::...||:||.:..:
Zfish  1282 KSLQQAKSESEHKRKKLEAQLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLLEDAEKKGIK 1346

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            |:|...||.:||:||:.|..||:|::..|..:.|.||.:.:||.||.|||.|.:.:|::||:...
Zfish  1347 LTKDVSSLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNNLLEQQEEEEESRKNLEKQLATLQ 1411

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIG---LEKTKQRLSTEVED 1426
            |:....:.|.|.| |...|.|||.|||||   .:.|.|.:.|.:|.|.   |||||.||..|::|
Zfish  1412 AQLVETKKKLEDD-VGALEGLEEVKRKLQ---KDMEVTSQKLEEKAIAFDKLEKTKNRLQQELDD 1472

  Fly  1427 LQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQ 1491
            |.:::|....|.:..|||||.||:::.|.|......|.|.|.::.|.|...|:...:..|.:|..
Zfish  1473 LMVDLDHQRQIVSNLEKKQKKFDQMLAEEKTISARYAEERDRAEAEAREKDTKALSMARALDEAL 1537

  Fly  1492 EQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENK 1556
            |..|...|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..|||.|..|:..|:.
Zfish  1538 EAKEEFERLNKQLRAEMEDLISSKDDVGKNVHELEKSKRTLEQQVEEMRTQLEELEDELQATEDA 1602

  Fly  1557 VLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADI 1621
            .||.::.:..::.:.||.:|.::|:.|..::...:.:..|:|.||.|.|.:|.|:..|||||.|:
Zfish  1603 KLRLEVNMQAMKAQFDRDLQARDEQNEEKKRALVKQVREMEAELEDERKQRALAVAAKKKLEMDL 1667

  Fly  1622 NELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEE 1686
            .::|..::.||||..||.|.:::.|.|:||.|..|||.:.:||:...|...:|::..:|:.|:.:
Zfish  1668 KDVEAQIEAANKARDEAIKQLRKLQAQMKDYQRELEEARTSRDEIFTQSKENEKKLKSLEAEILQ 1732

  Fly  1687 SRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE 1751
            .:..|..::|.||.||||..:..::::..::..|::...||:||:.:..|..:|:|   |..|.|
Zfish  1733 LQEDLASSERARRHAEQERDELADEISNSASGKAALLDEKRRLEARIAQLEEELEE---EQSNME 1794

  Fly  1752 ---EKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQK 1813
               ::.:|..:....|..||..|:..||..|..|:.||:|.|:|:.:|.|.|.:.....|.:|..
Zfish  1795 LLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQNKDLKSKLQELEGSVKSKFKASIAA 1859

  Fly  1814 LEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYK 1878
            ||.::.:||.:|:.|.:..|.|.|.:|::|:::||:..|.|::|::.::.::.::|...::|..|
Zfish  1860 LEAKILQLEEQLEQEAKERAAANKIVRRTEKKLKEVFMQVEDERRHADQYKEQMEKANSRMKQLK 1924

  Fly  1879 RQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAG 1926
            ||:|||||.|....|..||.|:||::|.|.::...:.::..:.:.|.|
Zfish  1925 RQLEEAEEEATRANASRRKLQRELDDATEASEGLSREVNTLKNRLRRG 1972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/37 (30%)
MYSc 81..777 CDD:214580 357/745 (48%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 337/714 (47%)
Myosin_tail_1 842..1897 CDD:279860 354/1067 (33%)
V_Alix_like 1557..1877 CDD:187408 99/322 (31%)
ATP-synt_B <1671..1771 CDD:304375 26/102 (25%)
TMPIT 1739..>1825 CDD:285135 28/88 (32%)
myh10XP_009300420.1 Myosin_N 37..75 CDD:280832 11/37 (30%)
Myosin_head 90..812 CDD:278492 344/726 (47%)
MYSc_Myh10 102..812 CDD:276952 337/714 (47%)
Myosin_tail_1 889..1969 CDD:279860 361/1093 (33%)
DUF342 <1085..1170 CDD:302792 26/84 (31%)
RILP-like <1528..1637 CDD:304877 33/108 (31%)
GBP_C <1641..1734 CDD:303769 36/92 (39%)
coiled coil 1705..1714 CDD:293879 2/8 (25%)
coiled coil 1723..1734 CDD:293879 2/10 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.720

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