DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and myh10

DIOPT Version :10

Sequence 1:NP_523587.4 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_009300420.1 Gene:myh10 / 555454 ZFINID:ZDB-GENE-030616-162 Length:2014 Species:Danio rerio


Alignment Length:1998 Identity:785/1998 - (39%)
Similarity:1201/1998 - (60%) Gaps:98/1998 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPKPVANQEDEDPTPYLFVSLEQRRIDQSKPYD--------SKKSCWIPDEKEGYLLGEIKATKG 57
            ||:.......|||..||||       |::..|:        :||..|:|.|:.|:....|:..:|
Zfish     1 MPEMAQRSGQEDPERYLFV-------DRAVVYNPTTQADWTAKKLVWVPSERHGFEAASIREERG 58

  Fly    58 DIVSVGL-QGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGL 121
            :.|.|.| :.|:...:.||.:|::||||:.|.|||:.||.||:|||||||:.|||:.||||||||
Zfish    59 EEVLVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGL 123

  Fly   122 FCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKT 186
            |||.|||||..|:|:....:|||||:|:|:||||:|||:.||..||.:..:||:|.|||||||||
Zfish   124 FCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKT 188

  Fly   187 ENTKKVIAYFATVGASKK----------TDEAAKSK------GSLEDQVVQTNPVLEAFGNAKTV 235
            |||||||.|.|.|.:|.|          :.:|.|.:      |.||.|::|.||:||:|||||||
Zfish   189 ENTKKVIQYLAHVASSHKGRKDHNIPPESPKAVKLQNGILFYGELERQLLQANPILESFGNAKTV 253

  Fly   236 RNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDIC 300
            :|||||||||||||:|..||.:.||:||||||||:|.|.|...||::|:|||:::|:...::. .
Zfish   254 KNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHVFYQLLAGAGEHLRS-D 317

  Fly   301 LLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQ 365
            ||.:....|..:|.|.:.:....|.:.|..|.:|..|:.|..:|...:.::.:||:..|.:.||:
Zfish   318 LLLEGFNSYRFLSNGNIPIPGQQDKDNFQETMEAMHIMSFNHEEILSMLKVVSAVLQFGNIVFKK 382

  Fly   366 RGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGV 430
            ....:||.........::..|.|.:..|..:.:|.||||||.::|.:.:..:|...::.||.|..
Zfish   383 ERNTDQASMPENTAAQKLCHLLGMNVMEFTRAILSPRIKVGRDYVQKAQTKEQADFAVEALAKAT 447

  Fly   431 FDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFV 494
            ::|||:|||.:.|:.|| |:::...|||:|||||||||:.|.|||||||:|||||||.|||.||:
Zfish   448 YERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFI 512

  Fly   495 LEQEEYQREGIEWTFIDFGMDLQLCIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHL 556
            |||||||||||||:|||||:|||.||||||:|.   |:|::|:||..||||||:||.:||.... 
Zfish   513 LEQEEYQREGIEWSFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVDKLVQEQ- 576

  Fly   557 GKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIF 621
            |....||||:..|   ..|.|.|.||||.|.|....||.||.|||||.|.....:|.:|.:.|::
Zfish   577 GTHGKFQKPRQLK---DKADFCIIHYAGRVDYKADEWLMKNMDPLNDNVATLLHQSTDKFVAELW 638

  Fly   622 ADH------------------AGQ----------SGGGEQAKGGRGK-KGGGFATVSSAYKEQLN 657
            .|.                  .|:          :|..|.|.|...| |.|.|.||...|||.|.
Zfish   639 KDEIQNFQRASFYDVSSLHESPGEVDRIVGLDQVAGMNETAFGAAYKTKKGMFRTVGQLYKESLT 703

  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722
            .||.|||:|.|:||||||||..|:.|.::.|||:.||.||||||||||||:|||||:::.:|:.|
Zfish   704 KLMATLRNTNPNFVRCIIPNHEKRAGKLEPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQR 768

  Fly   723 YKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSW 786
            |:|:.|..: :|....|:|.|.:|:.::|..:.||:|.:|:|||.|||..:||.||.::..|:.:
Zfish   769 YEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDIIIY 833

  Fly   787 MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL 851
            .|:..||||:||.|.|.|:|..||||:|||...||:||.|.|::|:.||||||.|:|.|:|:...
Zfish   834 FQSVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQEEEMQAK 898

  Fly   852 EEKAKKAEELHAAEVKVRKEL---EALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913
            :|:..|.:|   .:|||..||   |..:.:||.||..|.:.|..|.....:.:|..|:|.|:|.:
Zfish   899 DEELIKVKE---RQVKVENELVEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLVAKKQE 960

  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978
            ||..|.|::.|:.:||:....|..:|||....|..|::.:::.|...||.:.:|.|.:.:|:.:.
Zfish   961 LEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQDLEEQLDEEEAARQKLQLEKVTAEAKIKKME 1025

  Fly   979 DEIAHQDELINKLNKEKKM----QGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039
            ::|...::..:|..||||:    .||...:..||    |:|..:|.|||.|.|..:.:||:.|::
Zfish  1026 EDILLLEDQNSKFLKEKKLLEDRVGEMTSQLAEE----EEKAKNLGKVKNKQEMMMVDLEERLKK 1086

  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104
            |:|.|.::||:|||::.:....|:.:|:|:....||:..:.:|::||.::.|:.::|........
Zfish  1087 EEKTRQELEKAKRKLDAETTDLQDQIAELQAQIDELKIQLAKKEEELQAVLARGDEEVAQKNNAL 1151

  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169
            :|::||||::.||:|::|:|:.||.||||.:.||:.|||.|...||:....|:||.||..|||.|
Zfish  1152 KQLRELQAQLAELQEDLESEKAARNKAEKLKRDLSEELEALKTELEDTLDTTAAQQELRSKREQE 1216

  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234
            :::|::.:::....|||.:..:|::|..|:.|::||::|..::|...||.|........:|...|
Zfish  1217 VAELKKAIDDETRNHESQIQEMRQRHGTALEEISEQLEQAKRVKGNLEKNKQTLESDNKELTNEV 1281

  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299
            ..:...|:..|...|:|:..|.||.::..|..:...:......|:..|..::...||:||.:..:
Zfish  1282 KSLQQAKSESEHKRKKLEAQLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLLEDAEKKGIK 1346

  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364
            |:|...||.:||:||:.|..||:|::..|..:.|.||.:.:||.||.|||.|.:.:|::||:...
Zfish  1347 LTKDVSSLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNNLLEQQEEEEESRKNLEKQLATLQ 1411

  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIG---LEKTKQRLSTEVED 1426
            |:....:.|.|.| |...|.|||.|||||   .:.|.|.:.|.:|.|.   |||||.||..|::|
Zfish  1412 AQLVETKKKLEDD-VGALEGLEEVKRKLQ---KDMEVTSQKLEEKAIAFDKLEKTKNRLQQELDD 1472

  Fly  1427 LQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQ 1491
            |.:::|....|.:..|||||.||:::.|.|......|.|.|.::.|.|...|:...:..|.:|..
Zfish  1473 LMVDLDHQRQIVSNLEKKQKKFDQMLAEEKTISARYAEERDRAEAEAREKDTKALSMARALDEAL 1537

  Fly  1492 EQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENK 1556
            |..|...|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..|||.|..|:..|:.
Zfish  1538 EAKEEFERLNKQLRAEMEDLISSKDDVGKNVHELEKSKRTLEQQVEEMRTQLEELEDELQATEDA 1602

  Fly  1557 VLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADI 1621
            .||.::.:..::.:.||.:|.::|:.|..::...:.:..|:|.||.|.|.:|.|:..|||||.|:
Zfish  1603 KLRLEVNMQAMKAQFDRDLQARDEQNEEKKRALVKQVREMEAELEDERKQRALAVAAKKKLEMDL 1667

  Fly  1622 NELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEE 1686
            .::|..::.||||..||.|.:::.|.|:||.|..|||.:.:||:...|...:|::..:|:.|:.:
Zfish  1668 KDVEAQIEAANKARDEAIKQLRKLQAQMKDYQRELEEARTSRDEIFTQSKENEKKLKSLEAEILQ 1732

  Fly  1687 SRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE 1751
            .:..|..::|.||.||||..:..::::..::..|::...||:||:.:..|..:|:|   |..|.|
Zfish  1733 LQEDLASSERARRHAEQERDELADEISNSASGKAALLDEKRRLEARIAQLEEELEE---EQSNME 1794

  Fly  1752 ---EKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQK 1813
               ::.:|..:....|..||..|:..||..|..|:.||:|.|:|:.:|.|.|.:.....|.:|..
Zfish  1795 LLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQNKDLKSKLQELEGSVKSKFKASIAA 1859

  Fly  1814 LEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYK 1878
            ||.::.:||.:|:.|.:..|.|.|.:|::|:::||:..|.|::|::.::.::.::|...::|..|
Zfish  1860 LEAKILQLEEQLEQEAKERAAANKIVRRTEKKLKEVFMQVEDERRHADQYKEQMEKANSRMKQLK 1924

  Fly  1879 RQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAG 1926
            ||:|||||.|....|..||.|:||::|.|.::...:.::..:.:.|.|
Zfish  1925 RQLEEAEEEATRANASRRKLQRELDDATEASEGLSREVNTLKNRLRRG 1972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_523587.4 Myosin_N 33..75 CDD:460670 12/50 (24%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 342/714 (48%)
Myosin_tail_1 842..1922 CDD:460256 361/1092 (33%)
myh10XP_009300420.1 Myosin_N 34..79 CDD:460670 14/44 (32%)
MYSc_Myh10 102..812 CDD:276952 342/714 (48%)
Myosin_tail_1 889..1969 CDD:460256 361/1093 (33%)

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