DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and myh11a

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:XP_021332550.1 Gene:myh11a / 554168 ZFINID:ZDB-GENE-050531-1 Length:1983 Species:Danio rerio


Alignment Length:1931 Identity:773/1931 - (40%)
Similarity:1185/1931 - (61%) Gaps:31/1931 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 YDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMT 95
            :.:||..|:|.||.|:....||...||.|.|.| ..|:...:..:.::|:|||||.|:||||::|
Zfish    29 WSAKKLVWVPSEKHGFESASIKEEHGDEVLVELMDNGKKITVNKDDIQKMNPPKFSKVEDMAELT 93

  Fly    96 VLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISD 160
            .||...||||||:|||:.|||||||||||.:||||..|:|:.:..:||:||:|:||||||::|:|
Zfish    94 CLNEASVLHNLRERYYSGLIYTYSGLFCVVVNPYKMLPIYSEKIIEMYKGKKRHEVPPHIYSITD 158

  Fly   161 GAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASK--KTDEAAKSK------GSLED 217
            .||.:|:.:..:||:|.||||||||||||||||.|.|.|.:|.  |.|.:|:..      |.||.
Zfish   159 NAYRNMMQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDMSAQQSGQQFAYGELEK 223

  Fly   218 QVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSY 282
            |::|.||:|||||||||::|||||||||||||:|..||.:.||:||||||||:|.|.|...||::
Zfish   224 QLLQANPILEAFGNAKTIKNDNSSRFGKFIRINFDVTGFIVGANIETYLLEKSRCIRQAKTERAF 288

  Fly   283 HIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKED 347
            ||||.:::|:...:::. ||.:|..:|..:|.|.|.:....|.|.:..|.:|.:|:||:.:|:.|
Zfish   289 HIFYYMVAGTKDKLREE-LLLENFNNYRFLSAGHVQIPGNQDDEMYDETMEAMEIMGFSVEERAD 352

  Fly   348 VYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQ 412
            |.::.:.|:.:|.::||:...:|||.........:|..|.|.:..:..:.:|.||||||.|.|.:
Zfish   353 VLKVVSTVLQLGNIEFKKERNQEQATMPDNTAAQKVCHLQGINVTDFTRAILTPRIKVGREVVQK 417

  Fly   413 GRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLC 476
            .:..:|...:|.||.|.:::|||:|::.:.|:.|| |:::...|:|:||||||||||.|.|||||
Zfish   418 AQTKEQADFAIEALAKAMYERLFRWILLRVNKALDKTKRQGASFLGILDIAGFEIFENNSFEQLC 482

  Fly   477 INFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEK---PMGILSILEEESM 538
            ||:|||||||.|||.||:||||||:||||:|.|||||:||..||:|||:   |.|||::|:||..
Zfish   483 INYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGILALLDEECW 547

  Fly   539 FPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLND 603
            ||||||.:|.|||.||| .....|.|||..|   ....|::.||||.|.||...||.||.|||||
Zfish   548 FPKATDVSFVEKLCNTH-ANHTKFAKPKQLK---DKTEFSVQHYAGRVDYNAVAWLTKNMDPLND 608

  Fly   604 TVVDQFKKSQNKLLIEIFADHAGQSGGGEQ--------AKGGRGKKGGGFATVSSAYKEQLNSLM 660
            .|......|.|..:.:::.| |.:..|.|.        |......|.|.|.||...|||.|..||
Zfish   609 NVTALLNNSSNPFVQDLWKD-ADRVVGLETIAKMSDSLAPSASKTKKGMFRTVGQLYKESLAKLM 672

  Fly   661 TTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKI 725
            |||.:|||:||||||||..|:.|.:|||||:.||.||||||||||||:|||||:::.:|:.||:|
Zfish   673 TTLHNTQPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 737

  Fly   726 MCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQA 789
            :....: :|....|:|..::||.:|:..:.||:|.:|:|||.|||.|:||.||.::..|:...|:
Zfish   738 LAANAIPKGFMDGKQACCLMIKHLDIDPNLYRIGQSKIFFRTGVLAQLEEERDLKITVIIIAFQS 802

  Fly   790 WARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEK 854
            .|||:|:||.|.|.|:|..|:||:|||...||:||.|.|::|:.||||||.|:|.|:|::..||:
Zfish   803 QARGFLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMSLKEEE 867

  Fly   855 AKKAEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQL 918
            .:||:| ....|::: |::...:.:|:.|:..|.:.|..|.....:.:|...:|.::|.:||..|
Zfish   868 LQKAKESAQKFEIEL-KDIALKHTQLMDERNQLQEKLQAETELYAEAEEMRVRLASKKQELEEIL 931

  Fly   919 RDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAH 983
            .:::.||.:|||....|..:|||..::|..|::.:|:.|...||.:.:|.|.|.:|:.|.|:|..
Zfish   932 HEMEARLEEEEDRGAALQMEKKKMHEQIKDLEEHLEEEEDARQKLQLEKVTCDAKIKKLEDDILI 996

  Fly   984 QDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVE 1048
            .|:..|||.||:|:..|........|...|:|..:|.|:|.|.|..:.|||..|::|:|.|.:::
Zfish   997 MDDQNNKLQKERKILEERIADFSSNLAEEEEKSKNLTKLKNKHESMISELEVRLKKEEKTRQELD 1061

  Fly  1049 KSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQAR 1113
            |:|||:|.:....||.:|||:....:|:..:.:|::||.:..|:||||........::|:||:..
Zfish  1062 KAKRKLEAESNDLQEQIADLQAQIADLKAQLAKKEEELQAALARLEDETGQKNNALKKIRELEGH 1126

  Fly  1114 IEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLE 1178
            |.:|:|::|:||.||.||||.:.||..|||.|...||:....|:.|.||..|||.|::.|:|.:|
Zfish  1127 ISDLQEDLESERAARNKAEKTKRDLGEELEALKSELEDTLDTTATQQELRAKREQEVTLLKRAIE 1191

  Fly  1179 EANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAA 1243
            :.:..||:.:..:|:||..|:.|:.||::|..::|...||.|.....:.::|...:..:|..|..
Zfish  1192 DESRVHEAQVQEMRQKHTQALEELTEQLEQSKRVKVNLEKAKQALEKETSELHVELRSLTQGKQD 1256

  Fly  1244 QEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLT 1308
            .|...|:|:..|.::||:.:::.|...:......|:::|...:...|.|||.:..:|||...||:
Zfish  1257 VEHKKKKLEGQLADLQSRFNDSERHKAELGDRVSKITVELESVTNLLNEAEGKNIKLSKDVASLS 1321

  Fly  1309 TQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSK 1373
            :|::||:.|..||:|::..|..|.|.:|.|.:.|:||::||||.|.:::|.:|..|.:...::.|
Zfish  1322 SQVQDTQELLAEETRQKLQLSTKLRQIEDDRNALQEQLDEEAEAKRNVERHVSTLNIQLSDFKKK 1386

  Fly  1374 YESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIA 1438
            .| :.....|.|||.|::||..|..|....|........|||||.||..|:||..:::|....:.
Zfish  1387 LE-EMTGNVELLEEGKKRLQRDLEAANTQFEEKAAAYDKLEKTKNRLQQELEDTLMDLDNQRQLV 1450

  Fly  1439 NAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKN 1503
            :..|||||.||:::.|.|......|.|.|.::.|.|...|:...|..|.||.||..|...|.||.
Zfish  1451 SNLEKKQKKFDQMLAEEKSISSKYADERDRAEAEAREKETKALSLARALEEAQEAREEFERANKA 1515

  Fly  1504 LADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVR 1568
            |..|::||:....:.|:|:||:||:::.|||:.:|::..|||.|..|:..|:..||.::.:..::
Zfish  1516 LRAEMEDLVSSKDDVGKNVHELEKSKRGLEAQVEEMKTQLEELEDELQAAEDAKLRLEVNMQALK 1580

  Fly  1569 QEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANK 1633
            .:.:|.:|.::|:.|..::...:.:..::..||.|.|.:......|||||.|:.:||..::.:||
Zfish  1581 AQFERDLQGRDEQGEEKKRQLVKQVRELETELEDERKQRTALAASKKKLEGDLKDLEGQIETSNK 1645

  Fly  1634 ANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGR 1698
            ...||.|.:::.|.|:||.|..|::...||::.......:||:|..|:.||.:.:..|..|:|.:
Zfish  1646 GRDEAIKQLRKLQAQMKDFQRELDDAHAAREEVLSSAKENERKAKTLEAELLQLQEDLAAAERAK 1710

  Fly  1699 RQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAAR 1763
            :|.|.|..:..::|...::..:::|..||:||:::|.|..:|:|.....:...::.:|:.....:
Zfish  1711 KQVEAERDELADELASNASGKSALSDEKRRLEAKIQQLEEELEEEQGNMEMLNDRLRKSAQQVDQ 1775

  Fly  1764 LADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGE 1828
            |.:||:||:..:|..|..|:.:|:|.|||:.:|.|.|.......|.:|..||.:|.:||.:|:.|
Zfish  1776 LTNELQAERTTSQKNESARQLMERQNKELKAKLQEMENQVKSKFKSSISALEAKVAQLEEQLEQE 1840

  Fly  1829 QRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLA 1893
            .|...:..|.:|:.::::||:..|.|::||..|:.:|..||...::|..|||:||:||.:....|
Zfish  1841 SRDKQNTAKAVRQKDKKLKEMMTQVEDERKQAEQYKDQADKATARVKQLKRQLEESEEESQRITA 1905

  Fly  1894 KFRKAQQELEEAEERADLAEQAISKFRAKGRAGSVGRGASPAPRAT 1939
            ..||.|:||:||.|..|...:.::..::|.|.|:.....|..||.|
Zfish  1906 ARRKLQRELDEATETNDAMSREVNSLKSKLRRGNETSSFSSTPRRT 1951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 14/37 (38%)
MYSc 81..777 CDD:214580 361/716 (50%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 340/685 (50%)
Myosin_tail_1 842..1897 CDD:279860 346/1055 (33%)
V_Alix_like 1557..1877 CDD:187408 93/319 (29%)
ATP-synt_B <1671..1771 CDD:304375 26/99 (26%)
TMPIT 1739..>1825 CDD:285135 26/85 (31%)
myh11aXP_021332550.1 Myosin_N 32..71 CDD:308391 15/38 (39%)
MYSc_class_II 98..778 CDD:276951 340/685 (50%)
Myosin_tail_1 855..1935 CDD:307627 355/1081 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.720

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