DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myh13

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001074719.1	Gene:	Myh13 / 544791	MGIID:	1339967	Length:	1938	Species:	Mus musculus

Alignment Length:	1923	Identity:	1062/1923 - (55%)
Similarity:	1424/1923 - (74%)	Gaps:	15/1923 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEK 76
            :..|||....::|...|::|:||||:|:..|:||.|:.|.|::.:.|.|.|.........:.|::
Mouse    12 EAAPYLRKPEKERIEAQNRPFDSKKACFAVDDKEMYVKGMIQSRENDKVIVKTLDDRELTLNSDQ 76

  Fly    77 VEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAK 141
            |..:|||||:||||||.||.|:.|.||:||::||.|.:||||||||||.:||||..|||......
Mouse    77 VFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVA 141

  Fly   142 MYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATV---GASK 203
            .||||:|.|.|||||:|||.||..|||:..|||:|||||||||||.|||:||.||||:   |..|
Mouse   142 AYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKK 206

  Fly   204 KTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLE 268
            |..:..|.:|:||||::|.||:|||||||||||||||||||||||||||.|||||.|||||||||
Mouse   207 KEQQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLE 271

  Fly   269 KARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQ 333
            |:||..|.|.||||||||||||...|.:.|:.|::.|.:|:..||||:||||||||:||...||.
Mouse   272 KSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDN 336

  Fly   334 AFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNL 398
            |.|||||:.:||..:|::|.||||.|.|||||:.||||||.||.|...:...|.|.::||:.|.|
Mouse   337 AIDILGFSPEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGL 401

  Fly   399 LKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAG 463
            ..||:|||||:||:|:||||||||:|||.|.|::::|.|:|.:.|:.|||:|.||:|||||||||
Mouse   402 CCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAG 466

  Fly   464 FEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMG 528
            ||||::|..|||||||||||||||||||||||||||||:|||:|.||||||||.|||:|||||||
Mouse   467 FEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMG 531

  Fly   529 ILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGW 593
            |.||||||.|||||||.:|..||.:.|||||..||||||.| |:..|||::.||||.|.|||.||
Mouse   532 IFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPTK-GKAEAHFSLVHYAGTVDYNIAGW 595

  Fly   594 LEKNKDPLNDTVVDQFKKSQNKLLIEIFADH----AGQSGGGEQAKGGRGKKGGGFATVSSAYKE 654
            |:|||||||:|||..::||..|||..:|:::    ||.|.||:  |||: |||..|.|||:.::|
Mouse   596 LDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAGDSAGGK--KGGK-KKGSSFQTVSAVFRE 657

  Fly   655 QLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDF 719
            .||.|||.||||.||||||:||||.|.|||:|.:||||||.||||||||||||||||:|::|.||
Mouse   658 NLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADF 722

  Fly   720 KMRYKIMCPKLL---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLG 781
            |.||:|:....:   |.:: .|.|:|.::..||:..:|:|.|:|||||:||:||.:||.|||:|.
Mouse   723 KQRYRILNASAIPEGQFID-SKNASEKLLNSIDVDREQFRFGHTKVFFKAGLLGLLEEMRDEKLV 786

  Fly   782 KIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIED 846
            .:|:..||..||||.|..|||:.|:|.::..:|.|:|.::.::.|||..|:.|:||||..:..|.
Mouse   787 TLMTRTQAVCRGYLMRVEFKKMMERRESIFCIQYNVRSFMNVKHWPWMNLFFKIKPLLKSAEAEK 851

  Fly   847 EIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQK 911
            |:|.::|..::|:|..|.....|||||.....||.||..|...:..|...|.|.:||...|...|
Mouse   852 EMATMKEDFERAKEDLARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSK 916

  Fly   912 NDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRN 976
            ..||.:::::.|||.:||:..::|..:|:..:.:.|.||:||:||||.:.|.|::|...:::::|
Mouse   917 IQLEAKVKELNERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKN 981

  Fly   977 LNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREK 1041
            |::|:...:|.|:||.||||...|.:|:|.::||..|||:|.|.|:..||||..|:||.|||:||
Mouse   982 LSEEMTALEETISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINVKLEQQTDDLEGSLEQEK 1046

  Fly  1042 KVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQ 1106
            |:|.|:|:.|||:|||||::||::.|||.:.::||:.:::|:.|:|.:..:::||||:.|:.|::
Mouse  1047 KLRADLERVKRKLEGDLKMSQESIMDLENDTQQLEEKLKKKEFEMSQLQTRIDDEQVLSLQLQKK 1111

  Fly  1107 IKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELS 1171
            |||||||.||||||:|||...|||.||||:||||||||:.||||||.||||||||:|||||:|..
Mouse  1112 IKELQARTEELEEEIEAEHTVRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRESEFQ 1176

  Fly  1172 KLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDH 1236
            |||||||||.:|||:|.|.|||||.|.|||:.||:|.|.::|.|.||||:|...:::|:.:.::.
Mouse  1177 KLRRDLEEATLQHEATAATLRKKHADTVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIET 1241

  Fly  1237 ITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLS 1301
            ::..|:..|::.:.::...||:::|.|:..:.::|.:..|.:|..:|.:|..|:||.||.||||:
Mouse  1242 VSKSKSNMERMCRSVEDQFNEIKAKDDQQTQLIHDLNMQKARLQTQNGELSHQVEEKESLVSQLT 1306

  Fly  1302 KIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAE 1366
            |.|.:||.|||:.||..:||::.:..|....::..||.|.||||.|||.||||:|||.|||||:|
Mouse  1307 KSKQALTQQLEELKRQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1371

  Fly  1367 AQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEV 1431
            ...||:|||:|.:.|:|||||||:||..||.||||..|:.|.||..||||||||..||:||.|::
Mouse  1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTEASNSKCASLEKTKQRLQGEVDDLMLDL 1436

  Fly  1432 DRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEA 1496
            :|||......:|||:.|||::.|||.|:|:..|||:|:|||.|:.|||:|:::.||||..:|||.
Mouse  1437 ERANTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEIFKMRNAYEEVVDQLET 1501

  Fly  1497 VRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQ 1561
            :|||||||.:|:.||.:||.|.|:|:.|:||.:|::|.||.:|||||||.|.:||.||:|:||.|
Mouse  1502 LRRENKNLQEEISDLTEQIAETGKNLQEVEKTKKQVEQEKSDLQAALEEVEGSLEHEESKILRVQ 1566

  Fly  1562 LELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEI 1626
            ||||||:.|:||::.||:||.|..::|.|||:::||:.|:||.:.:.:|||:|||:|.|:||:||
Mouse  1567 LELSQVKSELDRKVTEKDEEIEQIKRNSQRAVEAMQSVLDAEIRSRNDALRLKKKMEGDLNEMEI 1631

  Fly  1627 ALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLL 1691
            .|.|||:..||.||:::..|.||||.|..|::.||:.:|.:|||.|.|||...||.||||.:..|
Mouse  1632 QLSHANRQVAETQKHLRTVQGQLKDSQLHLDDAQRSNEDLKEQLAIVERRNGLLQEELEEMKVAL 1696

  Fly  1692 EQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKK 1756
            ||.:|.||.:||||.|:.:::..:.:||.|:...|:|||::|....::::..:.|::|:||||||
Mouse  1697 EQTERTRRLSEQELLDSSDRVQLLHSQNTSLINTKKKLEADLAQCQAEVENSIQESRNAEEKAKK 1761

  Fly  1757 AMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVREL 1821
            |:.|||.:|:||:.|||.:...|:::|.|||.:|:||.||||||..|||||||.|||||.|||||
Mouse  1762 AITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1826

  Fly  1822 ENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEE 1886
            |:|||.||:|.|:|.|...|.||:|||:::|:||||||..|:||||||||.|:|:||||.|||||
Mouse  1827 ESELDAEQKRGAEALKGAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891

  Fly  1887 IAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGR 1924
            .|...|::.|:.|.||||||||||:||..::|.|||.|
Mouse  1892 QANTQLSRCRRVQHELEEAEERADIAESQVNKLRAKSR 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	11/36 (31%)
		MYSc	81..777	CDD:214580	455/705 (65%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	434/674 (64%)
		Myosin_tail_1	842..1897	CDD:279860	537/1054 (51%)
		V_Alix_like	1557..1877	CDD:187408	171/319 (54%)
		ATP-synt_B	<1671..1771	CDD:304375	44/99 (44%)
		TMPIT	1739..>1825	CDD:285135	50/85 (59%)
Myh13	NP_001074719.1	Myosin_N	36..73	CDD:280832	11/36 (31%)
		Myosin_head	88..770	CDD:278492	442/686 (64%)
		MYSc_Myh13	100..770	CDD:276887	434/674 (64%)
		Myosin_tail_1	850..1927	CDD:279860	553/1076 (51%)
		DUF342	<1506..1582	CDD:302792	44/75 (59%)
		TMPIT	1744..>1837	CDD:285135	55/92 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1105	1.000	Domainoid score	I20
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2092	1.000	Inparanoid score	I42
Isobase	1	0.950	-	0	Normalized mean entropy	S1242
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm43784
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.920