Protein Alignment Mhc and myo1b

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: XP_003199241.2
• Gene: myo1b / 541515
• ZFINID: ZDB-GENE-030131-695
• Length: 1165
• Species: Danio rerio
• Alignment Length: 1194
• Identity: 350/1194 - (29%)
• Similarity: 555/1194 - (46%)
• Gaps: 235/1194 - (19%)

  Fly    90 DMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPH 154
            ||..|..|::.|.:.||::|:.:..||||.|...:::||||...:|:....:.||.:...|:.||
Zfish    16 DMVLLEPLSEESFIENLKKRFDHNEIYTYIGSVVISMNPYKSLSIYSAEKVEEYRNRNFYELSPH 80

  Fly   155 IFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQV 219
            |:|::|.||..:.....:|.:||||||||||||.:|.|::|.|.|  ..|..|..|.|    :|:
Zfish    81 IYALADEAYRSLRHQDKDQCILITGESGAGKTEASKFVMSYVAAV--CGKGQEVNKVK----EQL 139

  Fly   220 VQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHI 284
            :|:|||||||||||||||||||||||::.|.|...|...|..|..|||||:||:.|...||::||
Zfish   140 LQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHI 204

  Fly   285 FYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVY 349
            |||::||:...:.....|..:...|:.:|....||..:|||..|.....|..|:||.:.|.:.:.
Zfish   205 FYQLLSGASDDMLKKLKLDRDFSKYNYLSLDSATVNGLDDAASFRTVRNAMQIVGFMEDEVQSIL 269

  Fly   350 RITAAVMHMGGMKFKQRGR----EEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFV 410
            .:.|||:.:|.::||...|    :|...:| :.:...:.:|.|.:.:.|.:......::...|.|
Zfish   270 ELIAAVLKLGNIEFKPESRVNGFDESRVKD-KNDLKEMCELLGIEQSVLERAFSFRTVEAKMEKV 333

  Fly   411 TQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQK-RQHFIGVLDIAGFEIFEYNGFEQ 474
            :...||.|...:..||.|.::.|||.|||.:.||::..|.| |:..:|||||.||||||.|.|||
Zfish   334 STTLNVAQAYYARDALAKNLYSRLFTWLVNRINESIKAQTKTRKKVMGVLDIYGFEIFEDNSFEQ 398

  Fly   475 LCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILEEESM 538
            ..||:.||||||.|.......|||||.|||||||.|::..:..:| |||| ...|||::|:||.:
Zfish   399 FIINYCNEKLQQIFIELTLREEQEEYIREGIEWTNIEYFNNAIIC-DLIENNKNGILAMLDEECL 462

  Fly   539 FP-KATDQTFSEKLT---------NTHLGKSAPFQKPKPPKPGQQAAH--FAIAHYAGCVSYNIT 591
            .| ..||:||.:||.         .:.|.|::.|      .......|  |.|.||||.|.|.:.
Zfish   463 RPGTVTDETFLDKLNTVCAEHQHFESRLSKNSKF------LTDHSLPHNCFRIQHYAGKVLYRVE 521

  Fly   592 GWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQL 656
            |:::||.|.|...:.....|:.:.|:..:|.:       |..||....:.    .|....::..:
Zfish   522 GFVDKNNDLLYRDLSQAMYKANHNLIKLLFPE-------GNPAKVNLKRP----PTAGFQFRASV 575

  Fly   657 NSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKM 721
            .:||..|.:..|:::|||.||:.|...:....||.||:...|::|.:|:.|.|:..|..|.....
Zfish   576 GTLMKNLLTKNPNYIRCIKPNDKKAAHIFTDSLVCHQVRYLGLMENVRVRRAGYAFRQAYEPCLE 640

  Fly   722 RYKIMCPKL---LQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFR-AGVLGQMEEFRDERLGK 782
            |||::|.:.   .:|..::  ..|:::..:.:|.:::..|.:|:|.| ...|..:||.|.:.|..
Zfish   641 RYKMLCKQTWPHWKGPARE--GVEVLLSDLQVPAEEFAYGRSKIFIRNPRTLFFLEEKRRQCLED 703

  Fly   783 IMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNL---RKYLQLRT-----------WPWYKLWQ 833
            :.:.:|...||:..|..|..|::.:|.:....|..   :||.::|.           |...||.:
Zfish   704 LAALIQKIYRGWKCRTHFLLLKKSQVVVAAWYRRFAQQKKYQKIRCSALVVQSFIRGWKARKLLR 768

  Fly   834 KVKPLLNVSRIED----------------EIARLEEKAKKAEELHAAEV--------KVRKELEA 874
            ::|   :..|.|:                |:.||:   |:|...||..|        |.|:||:.
Zfish   769 ELK---HKKRCEEAVTTISAYWHGTQARWELRRLK---KEAWNKHAVSVIWAAWLGTKARRELQK 827

  Fly   875 LNAKLLAEKTAL--------------LDSLSGE---KGAL-------------QDYQE---RNA- 905
            |..:..:::...              |..|..|   |.|:             ::|::   .||
Zfish   828 LKHEACSKQAVSVIWACWQGTKARRELKRLKEEARRKHAIAVIWAYWLGLKVRREYRKFFRANAG 892

  Fly   906 ----KLTAQK-------------------------------NDLENQLRDIQERLTQEEDARNQL 935
                ..|.|:                               :....:||.| ..|.:.:..|:|.
Zfish   893 KKIYDFTIQRIIQKYYLGLKKTMPSMSPIDKSWSTCPYGFLDGTHQELRRI-FHLWRCKKYRSQF 956

  Fly   936 FQQKKKADQE---ISGLKKDIEDL-ELNVQ---KAEQDKATKDHQIRNLN----DEIAHQDELIN 989
            .::||...:|   .|.|.||.:.| ..:|.   |.:..:.||:.:.:.||    |::...| :::
Zfish   957 TEEKKATYEEKLAASELFKDKKALYPSSVSQPFKGDYVEITKNPKYQKLNSLVEDKVLLAD-VVS 1020

  Fly   990 KLNK------------EKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELED---SLER 1039
            |:|:            .||.....:||||:              |||.:  .|.:|..   |.:.
Zfish  1021 KINRANGKGTPRIFLLTKKCLVLADQKTGQ--------------VKASV--PLPDLSSVFVSTQN 1069

  Fly  1040 E------------KKVRGD-VEKSKRKVEGDLKLTQEAVADLERNKKELE--------------- 1076
            :            ...:|| :..|.|.:|...||.....|..|||:.:::
Zfish  1070 DGFFALKLREGATSAAKGDYLLSSDRLIEIITKLYCTGAASAERNQIKIDISDEFLVQFKQDKVC 1134

  Fly  1077 -QTIQRKDKELSSITAKLEDEQVV 1099
             :.||...|..:|::.|.::.:::
Zfish  1135 VKFIQGTPKNSNSVSCKRKNNRLL 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	248/685 (36%)
		Myosin_tail_1	842..1922	CDD:460256	77/406 (19%)
myo1b	XP_003199241.2	MYSc_Myo1	26..685	CDD:276829	248/685 (36%)
		IQCD	740..775	CDD:467745	7/37 (19%)
		Myosin_TH1	967..1162	CDD:461801	43/209 (21%)