DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhc and Myo28B1

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster


Alignment Length:2105 Identity:527/2105 - (25%)
Similarity:848/2105 - (40%) Gaps:518/2105 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 DSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVL 97
            |..|..|:|              .||::       :...|.|:          |.:|||..:..|
  Fly    45 DRNKQFWVP--------------AGDVL-------KAMHITSQ----------EDVEDMITLGDL 78

  Fly    98 NTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGA 162
            ....:|.||:.||..:|||||:|...||||||:..|:||||..::||.|...|:|||||||||.|
  Fly    79 QEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNA 143

  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227
            :..:.....||.::|:|||||||||:||.::.|.|.:......         :|.|:::.||::|
  Fly   144 FQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW---------IEQQIIEANPIME 199

  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG- 291
            ||||||||||||||||||:|.|.|.|.|.:.||.|:.|||||:|::.|...||:|||||.:::| 
  Fly   200 AFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGL 264

  Fly   292 SVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAV 355
            |....:.:.|...:...||.::||. .|:....||::|:....|..:|.|..:|...:..:.||:
  Fly   265 STAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAI 329

  Fly   356 MHMGGMKF--KQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQ 418
            :|:|.::|  .:......||.|......||::|.|...:.|...|.:..|.|..|.||...:.:.
  Fly   330 LHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEA 394

  Fly   419 VTNSIGALCKGVFDRLFKWLVKKCNETLDTQ-QKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNE 482
            ......|..|.::|.:|..:|::.|||::.| .:..:.||||||.|||.|:.|.|||||||:.||
  Fly   395 AIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANE 459

  Fly   483 KLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLI-EKPMGILSILEEESMFPKATDQT 546
            .|||||..|:|.:||:||:.|.|:|..|:| .|....:||| .|||.::|:::|||.|||.||||
  Fly   460 NLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQT 523

  Fly   547 FSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611
            ..|||...| |..:.:.|.|.    .|.:.|.|.||||.|.||..|:||||:|..:..:....::
  Fly   524 LLEKLHVQH-GNRSIYVKGKT----TQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQR 583

  Fly   612 SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIP 676
            |.||.|::||..........:|            .|:...::..|:.||.||....|:|:|||.|
  Fly   584 STNKYLVDIFPHEMPMDTAKKQ------------PTLCVKFRNSLDMLMRTLSQAHPYFIRCIKP 636

  Fly   677 NEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL--LQGVEKDKK 739
            ||.|:|...|..|.:.||..:|::|..||.|.|:|.|..|..|..||:::.|.:  |:..:..|.
  Fly   637 NEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKL 701

  Fly   740 ATEIIIKFIDLPEDQYR-LGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKL 803
            |.:|.  .:.||.|..| .|.||:|.|......:|..|.:.:.|.:..:|...|..|.|:..|:.
  Fly   702 ARQIC--EVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRY 764

  Fly   804 QEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKV 868
            :|   |:..|||..|..||.|.   |::.::     ...|:...||        |::|......|
  Fly   765 RE---AIITVQRYWRGRLQRRK---YQVMRQ-----GFHRLGACIA--------AQQLTTKFTMV 810

  Fly   869 R---KELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEED 930
            |   .:|:||:...|..|                                    |.|::|. |..
  Fly   811 RCRTIKLQALSRGYLVRK------------------------------------DFQKKLL-ERR 838

  Fly   931 ARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEK 995
            .:|||   ||:...:::.:|:..|.|.|...|.::::..::.|.:              :|.:|:
  Fly   839 KQNQL---KKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEK--------------RLQEEQ 886

  Fly   996 KMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKL 1060
            :::.|...:....:.|.:.|                      .|.|.|:.:..|:.         
  Fly   887 RLKAEAAARNALAMAAVQQK----------------------RRTKPVKQEAPKAP--------- 920

  Fly  1061 TQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEE-----E 1120
            |.:|...|......|........:..|::|                      ||..:.|     :
  Fly   921 TLQARNSLPPPPTTLIVAAPLPTRPASAVT----------------------RINTIPESPGTID 963

  Fly  1121 VEAERQA-----RAKAEKQRADLARELEELGE----RLEEA--------------------GGAT 1156
            ||:.:|.     |...::..|.| |:|..:..    ||.::                    ||..
  Fly   964 VESSKQMVDDVFRFLNDEPDAAL-RKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGA 1027

  Fly  1157 SAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKN 1221
            :||.|            |:.|:::.::||           ..:.|||.:...|..|:        
  Fly  1028 TAQHE------------RKPLKKSLLKHE-----------HPIDEMASKAIWLTILR-------- 1061

  Fly  1222 EYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDL 1286
             :.|.|.|:                ::....|..:. ::.:.:....||..|:.|.:|.:..|. 
  Fly  1062 -FMGDLPDV----------------VSSPTLHVFDN-ENLMSDLASLLNTSDSYKPRLFVRQSQ- 1107

  Fly  1287 LRQLE------EAESQ----------VSQLSK---------IKISLTTQL--EDTKRLADEESR- 1323
             |::.      |.|:|          .|.|.|         ||.||..::  :..|:|....|| 
  Fly  1108 -RRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRS 1171

  Fly  1324 --ERATLLGKF--------RNLEHDLDNLREQVEEEAEGKADLQR-QLSKANAEAQVWRSKYESD 1377
              .|..||...        :..|..|.:..:|...:.:....||| :.:..|.......|.:|..
  Fly  1172 SYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELH 1236

  Fly  1378 GVARSEEL-------EEAKRKLQARLAEAEETIESLNQKCIGLEKTKQ-----RLSTEVEDLQLE 1430
            .:.....|       :..:|:||...|....  |::||.|.|:..|..     .:|...:.:.|.
  Fly  1237 AIRGRHPLRLDIHLMDGQQRRLQVDAASTAR--EAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLG 1299

  Fly  1431 VDRANAIANAAEKKQKAFDKIIGEWKL-------------KVDDLAAE---------LDASQKEC 1473
            ..:.:.:...:|.:|:..|   ..|||             .:|..|.:         |...:..|
  Fly  1300 AGQEHVLDAISECEQRQLD---APWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRC 1361

  Fly  1474 RNYST----------------ELFRLK----------------------------GAYEEG---- 1490
            |:...                |:.|||                            ..||:.    
  Fly  1362 RSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVK 1426

  Fly  1491 QEQ----LEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKR-LEAEKDELQAALEEAEAAL 1550
            :||    |||.:|..:::.     |...:....|:....|..||. .:.:.|||...:..|...|
  Fly  1427 EEQNDLLLEAQKRAKEDIC-----LFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFL 1486

  Fly  1551 EQEENKVLRAQL--ELSQVRQEIDRRIQ----------------EKEEEFENTRKNHQRALDSMQ 1597
            ..|..:||.:..  |:.:|..|.|.::.                :...|..|...::.|...|..
  Fly  1487 IDETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYG 1551

  Fly  1598 ASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIK-----RYQQ----QLKDIQ 1653
            .:|:...:|..|...:..  ..|:.|.|..:..|......||...:     ::.|    .::.:.
  Fly  1552 VALDPVVEGDLEDCLVLN--PGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLA 1614

  Fly  1654 TALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAE--QELADAH--EQLNE 1714
            |..:..::.:|..||             ...:|......:|:..||:..  .:||::|  |.|:.
  Fly  1615 TLTKPSEKLQDILRE-------------GRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDS 1666

  Fly  1715 VSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAAR---------------- 1763
            ..|..:..|  ...|::.|......:..|..:|........|.|.|.||                
  Fly  1667 DKAPLSKFS--PEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNTDLIFQPALQ 1729

  Fly  1764 ---LADELRAE-----QDHAQTQEKLR----------------KALEQQIKELQVRLDEAEANAL 1804
               |.|||..:     .|:..::.:.|                ..:.:.|..|::|.|......|
  Fly  1730 HPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALADACL 1794

  Fly  1805 KGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDK 1869
            |..|:::.:.:::......|::|.|:|.......:...:..|:  :|:.|...:..|.:.|:..:
  Fly  1795 KRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVE--AFEIESHTRGAELIADIAQR 1857

  Fly  1870 LQQK--------IKTYKRQIEEAEE 1886
            |:.|        :||..|.....||
  Fly  1858 LELKSPVGYSIFLKTGDRVYAMPEE 1882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 5/36 (14%)
MYSc 81..777 CDD:214580 276/704 (39%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 269/673 (40%)
Myosin_tail_1 842..1897 CDD:279860 226/1287 (18%)
V_Alix_like 1557..1877 CDD:187408 69/398 (17%)
ATP-synt_B <1671..1771 CDD:304375 24/122 (20%)
TMPIT 1739..>1825 CDD:285135 20/125 (16%)
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 278/713 (39%)
MYSc_Myo7 81..726 CDD:276832 269/673 (40%)
IQ 765..785 CDD:197470 9/25 (36%)
DUF4355 827..>887 CDD:290964 18/113 (16%)
MyTH4 1031..1239 CDD:295320 47/258 (18%)
B41 1248..1429 CDD:214604 29/185 (16%)
FERM_N 1248..>1288 CDD:286467 10/41 (24%)
FERM_B-lobe 1342..1429 CDD:271216 10/86 (12%)
PH-like 1454..1547 CDD:302622 19/92 (21%)
MyTH4 1674..1819 CDD:214535 25/146 (17%)
B41 1827..2032 CDD:214604 12/58 (21%)
FERM_N 1829..>1877 CDD:286467 10/49 (20%)
FERM_M 1936..2032 CDD:278785
FERM_C2_MyoVII 2028..2121 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466263
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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