DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and Myo15a

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	XP_008766109.1	Gene:	Myo15a / 501699	RGDID:	1561873	Length:	3512	Species:	Rattus norvegicus

Alignment Length:	843	Identity:	280/843 - (33%)
Similarity:	445/843 - (52%)	Gaps:	48/843 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYP 133
            :|::.|  |......:.:.:|||..:..|....||.||:.|:...|||||.|...|::|||:.:.
  Rat  1196 IRNLPS--VRSREQHREDGVEDMTQLEDLQETTVLTNLKTRFERNLIYTYIGSILVSVNPYRMFA 1258

  Fly   134 VYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFAT 198
            :|.....:.|.|:...|.|||:|||::.|:..||....||.::|:||||:||||.||.::...|.
  Rat  1259 IYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLLLRCLAA 1323

  Fly   199 VGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIE 263
            :...:...:..|        :::..|:|||||||||||||||||||||:.| |...|.:.||...
  Rat  1324 MNQRRDVMQQIK--------ILEATPLLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITS 1379

  Fly   264 TYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEF 328
            .|||||:|::.|...||:|||||::::|....::....|.:....|::...|...:|...||::|
  Rat  1380 QYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDF 1444

  Fly   329 SLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEE--------EGGRVSK 385
            .....|.::||||.::::.::||.|:::|:|.:.|      |:.|.|.:|        |...|::
  Rat  1445 RRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYF------EKHETDAQEVASVVSAREIQAVAE 1503

  Fly   386 LFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQ 450
            |.......|.|.:.....:...|.:.....|:...::..|:.|.::..||.||:.:.|..:..:|
  Rat  1504 LLQVSPEGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQ 1568

  Fly   451 KRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMD 515
            .... |.:|||.|||...:|.|||||||:.||.||..||..:|..|||||.||.:||..|.|. |
  Rat  1569 DTLS-IAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFA-D 1631

  Fly   516 LLACIDLIE-KPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAI 579
            ...||:||. ||.|||.||:::..||:|||.||.:| .:.|.|.:..:.|||.|.|     .|.|
  Rat  1632 NQPCINLISLKPYGILRILDDQCCFPQATDHTFLQK-CHYHHGANPLYCKPKMPLP-----EFTI 1690

  Fly   580 AHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGG 644
            .||||.|:|.:..:|:||.|.:...|:|.|..|:.:::..:|:.||.|:......|.....:...
  Rat  1691 KHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYK 1755

  Fly   645 FATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKG 709
            ..||::.:::.|..|:..:....|.||||:.||..|:||:.:..::|.||..:||||.:||.::|
  Rat  1756 AHTVAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEG 1820

  Fly   710 FPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEE 774
            ||.|:.:..|..||:.:....|...........::.:...:..|.||:|.:|:|.:..:...:|.
  Rat  1821 FPVRLPFQVFIDRYRCLVALKLNVPADGDMCVSLLSRLCTVTPDMYRVGVSKLFLKEHLHQLLES 1885

  Fly   775 FRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNL---RKYLQLRTWPWYKLWQKVK 836
            .|:..|.:....:|.:.||:.:::.|:.|:::.:.|:...|..   ::|.|:|. ...|....|.
  Rat  1886 MRERVLNRAALTLQRYLRGFFTQRRFRSLRQKIILLQSRARGFLARQRYQQMRQ-SLLKFRSLVH 1949

  Fly   837 PLLNVSRIEDEIARLEEKAKKA-----EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEK 894
            ..:|..|.....|....:|::|     |||...||...:.||     :.||...||.:.:|.|
  Rat  1950 TYVNRRRYLKLRAERRRRAQEAWLREQEELSKREVVPVRHLE-----VPAEVAGLLQAAAGLK 2007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	1/3 (33%)
		MYSc	81..777	CDD:214580	245/704 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	240/673 (36%)
		Myosin_tail_1	842..1897	CDD:279860	17/58 (29%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Myo15a	XP_008766109.1	MYSc	1206..1888	CDD:214580	245/704 (35%)
		MYSc_Myo15	1225..1876	CDD:276838	240/673 (36%)
		MyTH4	2054..2200	CDD:214535
		SH3	2853..2932	CDD:302595
		MyTH4	3032..3186	CDD:214535
		B41	3196..3401	CDD:214604
		FERM_B-lobe	3291..3391	CDD:271216
		FERM_C_MyoXV	3397..3498	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000