Protein Alignment Mhc and Myo15a

DIOPT Version :10

• Sequence 1: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Sequence 2: NP_001414755.1
• Gene: Myo15a / 501699
• RGDID: 1561873
• Length: 3512
• Species: Rattus norvegicus
• Alignment Length: 823
• Identity: 278/823 - (33%)
• Similarity: 440/823 - (53%)
• Gaps: 46/823 - (5%)

  Fly    89 EDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPP 153
            |||:.|..|.:.:||.||:.|:...|||||.|...|::|||:.:.:|.....:.|.|:...|.||
  Rat  1214 EDMTQLEDLQETTVLTNLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGENPP 1278

  Fly   154 HIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQ 218
            |:|||::.|:..||....||.::|:||||:||||.||.::...|.:...:...:..|
  Rat  1279 HLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLLLRCLAAMNQRRDVMQQIK-------- 1335

  Fly   219 VVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYH 283
            :::..|:|||||||||||||||||||||:.| |...|.:.||....|||||:|::.|...||:||
  Rat  1336 ILEATPLLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITSQYLLEKSRIVFQAKNERNYH 1399

  Fly   284 IFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDV 348
            |||::::|....::....|.:....|::...|...:|...||::|.....|.::||||.::::.:
  Rat  1400 IFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQDSI 1464

  Fly   349 YRITAAVMHMGGMKFKQRGREEQAEQDGEE--------EGGRVSKLFGCDTAELYKNLLKPRIKV 405
            :||.|:::|:|.:.|      |:.|.|.:|        |...|::|.......|.|.:.....:.
  Rat  1465 FRILASILHLGNVYF------EKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAITFKVTET 1523

  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470
            ..|.:.....|:...::..|:.|.::..||.||:.:.|..:..:|.... |.:|||.|||...:|
  Rat  1524 IREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQDTLS-IAILDIYGFEDLSFN 1587

  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLIE-KPMGILSILE 534
            .|||||||:.||.||..||..:|..|||||.||.::|..|.|. |.|.||:||. ||.|||.||:
  Rat  1588 SFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFA-DNQPCINLISLKPYGILRILD 1651

  Fly   535 EESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKD 599
            ::..||:|||.||.:| .:.|.|.:..:.|||.|.|     .|.|.||||.|:|.:..:|:||.|
  Rat  1652 DQCCFPQATDHTFLQK-CHYHHGANPLYCKPKMPLP-----EFTIKHYAGKVTYQVHKFLDKNHD 1710

  Fly   600 PLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLR 664
            .:...|:|.|..|:.:::..:|:.||.|:......|.....:.....||::.:::.|..|:..:.
  Rat  1711 QVRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKME 1775

  Fly   665 STQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPK 729
            ...|.||||:.||..|:||:.:..::|.||..:||||.:||.::|||.|:.:..|..||:.:...
  Rat  1776 RCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVAL 1840

  Fly   730 LLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGY 794
            .|...........::.:...:..|.||:|.:|:|.:..:...:|..|:..|.:....:|.:.||:
  Rat  1841 KLNVPADGDMCVSLLSRLCTVTPDMYRVGVSKLFLKEHLHQLLESMRERVLNRAALTLQRYLRGF 1905

  Fly   795 LSRKGFKKLQEQRVALKVVQRNL---RKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAK 856
            .:::.|:.|:::.:.|:...|..   ::|.|:|. ...|....|...:|..|.....|....:|:
  Rat  1906 FTQRRFRSLRQKIILLQSRARGFLARQRYQQMRQ-SLLKFRSLVHTYVNRRRYLKLRAERRRRAQ 1969

  Fly   857 KA-----EELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEK 894
            :|     |||...||...:.||     :.||...||.:.:|.|
  Rat  1970 EAWLREQEELSKREVVPVRHLE-----VPAEVAGLLQAAAGLK 2007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	240/673 (36%)
		Myosin_tail_1	842..1922	CDD:460256	17/58 (29%)
Myo15a	NP_001414755.1	None