DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhc and MYO5B

DIOPT Version :9

Sequence 1:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster
Sequence 2:	NP_001073936.1	Gene:	MYO5B / 4645	HGNCID:	7603	Length:	1848	Species:	Homo sapiens

Alignment Length:	2083	Identity:	548/2083 - (26%)
Similarity:	891/2083 - (42%)	Gaps:	499/2083 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YDSKKSCWIPDEKEGYLLGEIKATK----GD-IVSVGLQGGEVR----DIKSEKVEKV-NPPKFE 86
            |......||||..|.:...|:  ||    || .:.:.|:...:.    |::..::..: ||....
Human     7 YSQCTRVWIPDPDEVWRSAEL--TKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILV 69

  Fly    87 KIEDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150
            ...|:..::.|:.|.|||||:.|:. :..||||.|:..||||||::.|:|.......|.|:...:
Human    70 GENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGD 134

  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSL 215
            :.|||||:::.||..|..:..|||::::||||||||.:.|..:.||||||.|       .|:.::
Human   135 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS-------ASETNI 192

  Fly   216 EDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLER 280
            |::|:.::|::||.|||||.||||||||||:|:|.|.....:.||::.||||||:||:.|...||
Human   193 EEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDER 257

  Fly   281 SYHIFYQIMSGS-VPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGFTKQ 343
            :||||||:.:.: :|..|::.|.:..  |:...|| |..::..:||||:|..|.|||.:||..:.
Human   258 NYHIFYQLCAAAGLPEFKELALTSAE--DFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKES 320

  Fly   344 EKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEG--------GRVSKLFGCDTAELYKNLLK 400
            .:..:::|.|:::|:|.:..       |||:||:...        ....:|.|.:.:::...|..
Human   321 HQMSIFKIIASILHLGSVAI-------QAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCH 378

  Fly   401 PRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFE 465
            .::...:|...:..::|||.|:..||.|.::.:||.|:|:..|:.|.|..|:..|||||||.|||
Human   379 RKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFE 443

  Fly   466 IFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGIL 530
            .||.|.|||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||||||..:|||
Human   444 TFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAKLGIL 507

  Fly   531 SILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLE 595
            .:|:||...||.|||.:::||.:.| ..|..||||:     .....|.|.|:|..|.|...|:||
Human   508 DLLDEECKVPKGTDQNWAQKLYDRH-SSSQHFQKPR-----MSNTAFIIVHFADKVEYLSDGFLE 566

  Fly   596 KNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFA-------------T 647
            ||:|.:.:..::..|.|:..|:.::|.|...........||...|.....|             |
Human   567 KNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKT 631

  Fly   648 VSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPN 712
            |...::..|:.||.||.:|.||:||||.||:.|.|...|....:.||...||||.|||...|:|:
Human   632 VGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPS 696

  Fly   713 RMMYPDFKMRYKIMCPKLLQGVEKDKKA-----TEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQM 772
            |..|.||..||:::..| .:....||||     .|.:||    ..|:::.|.||:|||||.:..:
Human   697 RWAYHDFFNRYRVLVKK-RELANTDKKAICRSVLENLIK----DPDKFQFGRTKIFFRAGQVAYL 756

  Fly   773 EEFRDE--RLGKIM------SW---------------MQAWARGYLSRKGFKKLQEQRVALKV-- 812
            |:.|.:  |...||      .|               :|.:.||:|:|:..:.|:..|.|:.:
Human   757 EKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQK 821

  Fly   813 -----------------------------VQRNLRKYL----------QLRTWPWYKLWQKVKP- 837
                                         |:|..|:.|          .:|.|...:.:|:::.
Human   822 HYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDA 886

  Fly   838 ---------LLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKL---------LAEKT 884
                     :|...|   |:..|..:|:.||.|....|.:..::..|..|:         |:|:.
Human   887 AIVIQCAFRMLKARR---ELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQL 948

  Fly   885 ALLDS-----LSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQ 944
            ::..|     :...|..|..||:...:.|:.:  |:.::..::..|.:....|..|.....:...
Human   949 SVTTSTYTMEVERLKKELVHYQQSPGEDTSLR--LQEEVESLRTELQRAHSERKILEDAHSREKD 1011

  Fly   945 EISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQ--DELINKLNKEKKMQGETNQKTGE 1007
            |   |:|.:.||       ||:.|....:...||::|..|  ||......||..|:        :
Human  1012 E---LRKRVADL-------EQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMK--------K 1058

  Fly  1008 ELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVE--KSKRKVEGDLKLTQEAVADLER 1070
            ||:....:..:|.|..::|||..|.|.|.:...|:..|...  .::..:|.|......:.:::..
Human  1059 ELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGD 1123

  Fly  1071 NKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQR 1135
            .:..|:|.     :|:....|.:  :..|.||       ||.|:.|||:|       |.|
Human  1124 TEDALQQV-----EEIGLEKAAM--DMTVFLK-------LQKRVRELEQE-------RKK----- 1162

  Fly  1136 ADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVA 1200
                                  .|::|.|:.:.:..|::.:..:.:|.            .|..|
Human  1163 ----------------------LQVQLEKREQQDSKKVQAEPPQTDID------------LDPNA 1193

  Fly  1201 EMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDET 1265
            ::|....:..:|:::.:|.||:    ||:||..|    .::|.|.          |......|..
Human  1194 DLAYNSLKRQELESENKKLKND----LNELRKAV----ADQATQN----------NSSHGSPDSY 1240

  Fly  1266 NRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL--EDTKRLADEESRERATL 1328
            :..||....:.::|.:...::|                  .|.||:  .|.:|||...:......
Human  1241 SLLLNQLKLAHEELEVRKEEVL------------------ILRTQIVSADQRRLAGRNAEPNINA 1287

  Fly  1329 LGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQ 1393
            ...:.|.|..:|  :|...|...|       :.:.|::.:.| .....||     ||..|.:.|:
Human  1288 RSSWPNSEKHVD--QEDAIEAYHG-------VCQTNSKTEDW-GYLNEDG-----ELGLAYQGLK 1337

  Fly  1394 --ARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWK 1456
              |||.||:...:||..     |:..:.|..::|.|:.|:|          |:|:.|
Human  1338 QVARLLEAQLQAQSLEH-----EEEVEHLKAQLEALKEEMD----------KQQQTF-------- 1379

  Fly  1457 LKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRN 1521
                            |:   |.|...:...|.|.:| |..|..|:||  ::|:|::::.:..|
Human  1380 ----------------CQ---TLLLSPEAQVEFGVQQ-EISRLTNENL--DLKELVEKLEKNER- 1421

  Fly  1522 IHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRR--IQEKEEEFEN 1584
                 |.:|:|:....:.|..  ||..||.|.|.|           |.|::|:  :|.||::|:.
Human  1422 -----KLKKQLKIYMKKAQDL--EAAQALAQSERK-----------RHELNRQVTVQRKEKDFQG 1468

  Fly  1585 TRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINE--------------LEIALDHANKAN 1635
            ..:.|:                :.||| :.:.|..|:..              |.:.:.||:..|
Human  1469 MLEYHK----------------EDEAL-LIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTN 1516

  Fly  1636 AE-------------AQKNIKRYQQQLKDIQTALEE--------EQRARDDAREQLGISERRANA 1679
            .:             .:|.:|::....:.....|..        :|.:.|:.......:::..:.
Human  1517 DDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHC 1581

  Fly  1680 LQN-ELEESRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDEL 1743
            |:| :|.|.|.:|....   .|..|:|.    ::.|...|...:||   .||:|      .:..|
Human  1582 LKNFDLTEYRQVLSDLS---IQIYQQLI----KIAEGVLQPMIVSA---MLENE------SIQGL 1630

  Fly  1744 LNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALE-----------------QQIKE 1791
            .........|...:|.|.           |::...|.:.:.:.                 |..|:
Human  1631 SGVKPTGYRKRSSSMADG-----------DNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQ 1684

  Fly  1792 LQVRLDEAEANALKGGKKAI-----QKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSF 1851
            |...::....|.|...|...     .:|...:.:||..|.|         :||.:|..
Human  1685 LFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRG---------RNLHQSGA------- 1733

  Fly  1852 QSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEERA 1909
                    .:.|:.|: :..|.::..|:..|:||.|.:|       .:.|.......|.|.|||.
Human  1734 --------VQTMEPLI-QAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERV 1789

  Fly  1910 DLA 1912
            .:|
Human  1790 TVA 1792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	12/45 (27%)
		MYSc	81..777	CDD:214580	284/724 (39%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	275/693 (40%)
		Myosin_tail_1	842..1897	CDD:279860	224/1143 (20%)
		V_Alix_like	1557..1877	CDD:187408	61/379 (16%)
		ATP-synt_B	<1671..1771	CDD:304375	20/100 (20%)
		TMPIT	1739..>1825	CDD:285135	15/107 (14%)
MYO5B	NP_001073936.1	Requires for interaction with LIMA1. /evidence=ECO:0000269\|PubMed:29880681	21..40		5/20 (25%)
		MYSc	64..760	CDD:214580	284/723 (39%)
		MYSc_Myo5	83..749	CDD:276831	275/693 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630		4/33 (12%)
		Actin-binding. /evidence=ECO:0000255	640..662		13/21 (62%)
		IQ	860..881	CDD:197470	2/20 (10%)
		CCDC144C	895..1172	CDD:291576	73/347 (21%)
		RILP-like	<980..1080	CDD:304877	27/119 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1093..1123		3/29 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1192		5/37 (14%)
		Myo5b_CBD	1474..1845	CDD:271261	66/388 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910