DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhc and MYO5A

DIOPT Version :9

Sequence 1:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster
Sequence 2:NP_001369277.1 Gene:MYO5A / 4644 HGNCID:7602 Length:1904 Species:Homo sapiens


Alignment Length:2067 Identity:549/2067 - (26%)
Similarity:928/2067 - (44%) Gaps:419/2067 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 WIPDEKEGY----LLGEIKATKGD-IVSVGLQGGE----VRDIKSEKVEKV-NPPKFEKIEDMAD 93
            ||||.:|.:    ||.:.|  .|| ::.:.|:.|:    ..|.|::::..: ||.......|:..
Human    38 WIPDPEEVWKSAELLKDYK--PGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTA 100

  Fly    94 MTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFA 157
            ::.|:.|.||||||.|:. :||||||.|:..||||||::.|:|.......|.|:...::.|||||
Human   101 LSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFA 165

  Fly   158 ISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQT 222
            :::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:.::|::|:.:
Human   166 VAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASEANVEEKVLAS 223

  Fly   223 NPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQ 287
            ||::|:.|||||.||||||||||:|.|.|....::.||::.||||||:||:.|...||:||||||
Human   224 NPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQ 288

  Fly   288 I-MSGSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYR 350
            : .|..:|..|  .|...|..:::...| |...:..:|||:|.:.|.||..:||.::..:..::|
Human   289 LCASAKLPEFK--MLRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFR 351

  Fly   351 ITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRN 415
            |.|.::|:|.:.|..|..:........|......:|.|.|..|:...|...::....|...:..:
Human   352 ILAGILHLGNVGFTSRDADSCTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYIKPIS 416

  Fly   416 VQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFT 480
            ..|.||:..||.|.::.:||.|:|...|:.|.:..|:..|||||||.|||.||.|.|||.|||:.
Human   417 KLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYA 481

  Fly   481 NEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQ 545
            ||||||.||.|:|.||||||.:|.|.|..||| .|...||:|||..:|||.:|:||...||.||.
Human   482 NEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIESKLGILDLLDEECKMPKGTDD 545

  Fly   546 TFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFK 610
            |:::||.||||.|.|.|:||:.....     |.|.|:|..|.|...|:||||||.:.:..:...|
Human   546 TWAQKLYNTHLNKCALFEKPRLSNKA-----FIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLK 605

  Fly   611 KSQNKLLIEIFAD--------HAGQSG---------------GGEQAKGGRGKKGGGFATVSSAY 652
            .|:.|:|.|:|.|        .|..||               .|:.||  ..||     ||...:
Human   606 SSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAK--EHKK-----TVGHQF 663

  Fly   653 KEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYP 717
            :..|:.||.||.:|.||:||||.||:.|.|...|....:.||...||||.|||...|||:|..|.
Human   664 RNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQ 728

  Fly   718 DFKMRYKIMCPKLLQGVEKDKKAT--EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERL 780
            :|..||:::..:  :.|..|:|.|  .::.|.| |.:|:|:.|.||:|||||.:..:|:.|.::|
Human   729 EFFSRYRVLMKQ--KDVLSDRKQTCKNVLEKLI-LDKDKYQFGKTKIFFRAGQVAYLEKLRADKL 790

  Fly   781 --------GKIMSW---------------MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQ 822
                    ..|..|               ||.:.|||.:|...|.|:..:.| .::|:..|.|:.
Human   791 RAACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAA-TIIQKYWRMYVV 854

  Fly   823 LRTWP---------------------WYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEV 866
            .|.:.                     :.|:.::.|.::...|:...:||...|    ..:||...
Human   855 RRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYK----RSMHAIIY 915

  Fly   867 KVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNA----KLTAQKNDLENQLRD---IQER 924
                 |:....:::|::.  |..|..|..:::.|::.:.    |:...:..::.|.:|   :.|:
Human   916 -----LQCCFRRMMAKRE--LKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEK 973

  Fly   925 LTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELIN 989
            ||..|...|          .|...|:.|:|.|:|    :|::......::.:|.:|||       
Human   974 LTNLEGIYN----------SETEKLRSDLERLQL----SEEEAKVATGRVLSLQEEIA------- 1017

  Fly   990 KLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDS---LEREKKVRGDVEKSK 1051
            ||.|:.       ::|..|.:..|:   |.::.|.:.||.:..|::.   |::||:....     
Human  1018 KLRKDL-------EQTRSEKKCIEE---HADRYKQETEQLVSNLKEENTLLKQEKEALNH----- 1067

  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRK-DKELSSITAKLEDEQVVVLKHQRQIKE---LQA 1112
                   ::.|:|        ||:.:|:::| .:|...:...|.||:   |::|..:.|   |:.
Human  1068 -------RIVQQA--------KEMTETMEKKLVEETKQLELDLNDER---LRYQNLLNEFSRLEE 1114

  Fly  1113 RIEELEEE----VEAERQARAKAEKQR----------ADLARELEELGERLEEAGGATSAQIELN 1163
            |.::|:||    |...:....:.:...          :::| |:|::..|.||   .:..::.|:
Human  1115 RYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIA-EMEDIPSRTEE---PSEKKVPLD 1175

  Fly  1164 -------KKREAELSKLRRDLEEANIQHESTLANLRKKHNDAV----AEMAEQVDQLNKLKAKAE 1217
                   :||..||.:.::.:::...:.|..:...:.|..:..    ||:..:..:..:|:::.:
Human  1176 MSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEERPQIRGAELEYESLKRQELESENK 1240

  Fly  1218 KEKNEYYGQLNDLRAGVDHITNEKAAQEKIA------KQLQHTLNEVQSKLDETNRTLNDFDASK 1276
            |.|||    ||:||..:    :||:|.|..|      :.|...|..|..:|          |..|
Human  1241 KLKNE----LNELRKAL----SEKSAPEVTAPGAPAYRVLMEQLTSVSEEL----------DVRK 1287

  Fly  1277 KKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDN 1341
            :::.|..|.|:.|.|..:.:..:  ......|..|||.:::.|:....:|.:..|..|....|| 
Human  1288 EEVLILRSQLVSQKEAIQPKDDK--NTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSALD- 1349

  Fly  1342 LREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESL 1406
                              ..:.|.:.::| ..||.        |::|.|.|:::|...:.:.|: 
Human  1350 ------------------YHELNEDGELW-LVYEG--------LKQANRLLESQLQSQKRSHEN- 1386

  Fly  1407 NQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDL----AAELD 1467
                     ..:.|..|::.|:.|.:|                    :.:|...:|    .|.::
Human  1387 ---------EAEALRGEIQSLKEENNR--------------------QQQLLAQNLQLPPEARIE 1422

  Fly  1468 AS-QKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKR 1531
            || |.|....:.|....:..|.:..::.::.|   .:|...:.||::|:.:..:.:.:::|..|.
Human  1423 ASLQHEITRLTNENLYFEELYADDPKKYQSYR---ISLYKRMIDLMEQLEKQDKTVRKLKKQLKV 1484

  Fly  1532 LEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR--RIQEKEEEFENTRKNHQRALD 1594
            ...:..||:..         |.||      :...|:..|..|  .|..||::|:...:..:....
Human  1485 FAKKIGELEVG---------QMEN------ISPGQIIDEPIRPVNIPRKEKDFQGMLEYKKEDEQ 1534

  Fly  1595 SMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQT----A 1655
            .:..:|..|.|.:..|:.:...|.|.|  |.:.:.||:..|.:         |:::.:.|    :
Human  1535 KLVKNLILELKPRGVAVNLIPGLPAYI--LFMCVRHADYLNDD---------QKVRSLLTSTINS 1588

  Fly  1656 LEEEQRARDDAREQ----LGISERRANALQNELEESRTLLEQADRGRRQAEQ-----ELADAHEQ 1711
            :::..:.|.|..|.    |..:.|..:.|:....|...:.....   ||.|.     :||:..:.
Human  1589 IKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTS---RQNEHCLTNFDLAEYRQV 1650

  Fly  1712 LNEVSAQNASISAAKRKLESELQTL-------HSDLDELLNEAKNSEEKAKKAMVDAARLADELR 1769
            |::::.|  ......|.||:.||.:       |..:..:.........|...::.|......:..
Human  1651 LSDLAIQ--IYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSI 1713

  Fly  1770 AEQ---------DHAQTQEKLRKALEQQ--------IKELQVRLDEAEANALKGGKKAIQKLEQR 1817
            ..|         .|....|.:::.::|.        :..|.:|.|....:  ||     .::...
Human  1714 LRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITLNNLLLRKDMCSWS--KG-----MQIRYN 1771

  Fly  1818 VRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIE 1882
            |.:||..|         ..|||..|..:               |.::.|: :..|.::..|:..:
Human  1772 VSQLEEWL---------RDKNLMNSGAK---------------ETLEPLI-QAAQLLQVKKKTDD 1811

  Fly  1883 EAEEIAAL-------NLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927
            :||.|.::       .:.|.......:.|.|||..::.....:.|.:.|..|
Human  1812 DAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLRDRKDS 1863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 13/42 (31%)
MYSc 81..777 CDD:214580 292/723 (40%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 283/692 (41%)
Myosin_tail_1 842..1897 CDD:279860 217/1150 (19%)
V_Alix_like 1557..1877 CDD:187408 62/358 (17%)
ATP-synt_B <1671..1771 CDD:304375 18/111 (16%)
TMPIT 1739..>1825 CDD:285135 14/102 (14%)
MYO5ANP_001369277.1 COG5022 35..1472 CDD:227355 468/1611 (29%)
MYSc_Myo5 107..775 CDD:276831 283/692 (41%)
Myo5a_CBD 1530..1904 CDD:271262 67/382 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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